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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | A smoothed EM approach to indirect estimation problems, with particular reference to stereology and emission tomography显示文摘 | Jones MC Wilson JD | 1990 | J Roy Stat Soc B1990，52，3： | 1 |
| 3 | The effect of cell-basod bone tissue engineering in a goat transverse process model显示文摘 | Kruyt MC Wilson CE Joost D | 2006 | Biomaterials2006，27，29： | 1 |
| 4 | A Kinetic Study of the System γ-AlOOH/Al2O3显示文摘 | Wilson S J Mc Connell J D C | 1980 | J Solid State Chem1980，34，3： | 1 |
| 5 | The novel role of Creactive protein in cardiovascular disease:risk marker or pathogen显示文摘 | Wilson AM Ryan MC Boyle AJ | 2006 | Int J Cardiol2006，106，3： | 1 |
| 6 | The novel role of C-reactive pro-tein in cardiovascular disease:risk marker or pathology显示文摘 | Wilson AM Ryan MC Boyle AJ | 2006 | Int J Cardiol2006，106，： | 1 |
| 7 | Fetal soft markers in obstetric ultra- sound 显示文摘 | Van den Hof MC Wilson RD | 2005 | J Obstet Gynaecol Can2005，27，6： | 1 |
| 8 | Fetal soft markers in obstetric ultrasound显示文摘 | Van den Hof MC Wilson RD | 2005 | J Obstet Gynaecol Can2005，27，6： | 1 |
| 9 | Fetal soft markers in obstetric ultrasound显示文摘 | Van den Hof MC Wilson RD Diagnostic Imaging Committee etal | 2005 | J Obstet GynaecolCan2005，27，6： | 1 |
| 10 | Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands 显示文摘 | Horowitz MC Xi Y Wilson K | 2001 | Cytokine Growth Factor Rev2001，12，1： | 1 |
| 11 | Prolonged-release oxycodone enhances the effects of existing gabapentin therapy in painful dia- betic neuropathy patients 显示文摘 | Hanna M O' Brien C Wilson MC | 2008 | Eur J Pain2008，12，6： | 1 |
| 12 | GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma显示文摘 | Milbrandt JC Holder TM Wilson MC | 2000 | Hear Res2000，147，： | 1 |
| 13 | Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands显示文摘 | Horowitz MC Xi Y Wilson K | 2001 | Cytokine Growth Factor Rev2001，12，： | 1 |
| 14 | The novel role of C-reactive protein in cardiovascular disease: risk marker or pathologen 显示文摘 | Wilson AM Ryan MC Boyle AJ | 2006 | Int J Cardiol2006，106，3： | 1 |
| 15 | Fetal soft markers in obstetric ultrasound显示文摘 | Van den Hof MC Wilson RD Diagnostic Imaging Committee | 2005 | J Obstet Gynaecol Can2005，27，6： | 1 |
| 16 | Salivary symptoms in Parkinson disease显示文摘 | Bateson MC Gibberd FB Wilson RS | | 0，，： | 1 |
| 17 | Fractures of the tibial plateau value of spiral CT coronal plane reconstruction for detecting displacemernt in vitro显示文摘 | Mc Enery KW Wilson AJ Pilgrarn JK | 1994 | AJR1994，163，6： | 1 |
| 18 | The requirement for polymorphonuclear leukocytes in the late asthmatic response and heightened ainray reactivity in an animal model显示文摘 | Murphy KR Wilson MC Irvin CG | 1986 | Am Rev Respir Dis1986，134，1： | 1 |
| 19 | Economic and environmental benefits of biodiversity显示文摘 | Pimental D Wilson C Mc Cullum C | 1997 | Biological Science1997，47，11： | 1 |
| 20 | Structure and biosynthesis of the marine Streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit显示文摘 | Wilson MC Nam S J Guider TA | 2011 | Journal of the American Chemical Society2011，133，6： | 1 |
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