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| 1 | Geotechnical risk management to prevent coal outburst in room-and-pillar mining显示文摘A coal outburst is a severe safety hazard in room-and-pillar mining under deep cover. It is more likely to occur during pillar retreating. Multi-seam mining dramatically increases the risk of coal outburst within the influence zones created by remnant pillars and gob-solid boundaries. Though coal outburst is generally associated with heavy loading of coal pillars,its occurrence is difficult to predict. Risk management provides a proactive tool to minimize coal outburst in room-and-pillar mining under deep cover. Risk assessment is the first step in identifying and quantifying outburst risk factors. The primary risk factors for coal outburst are overburden depth,roof and floor strength,geological anomalies,mining type,multi-seam mining,and panel width. A risk assessment chart can be used to proactively screen out mining sections with high risk of coal outburst for further analysis. Gob-solid boundaries and remnant pillars are critical factors in evaluation of the coal outburst risk of multi-seam mining. Risk identification,risk assessment,geologic influence mapping,geotechnical evaluation,risk analysis,risk mitigation,and monitoring are essential elements of coal outburst risk management process. Training is an integral part of risk management for risk identification and communication between all the stakeholders including management,technical and safety personnel,and miners. | zhang peter peterson scott neilans dan wade scott mc grady ryan pugh joe | 2016 | International Journal of Mining Science and Technology2016，26，1： | 8 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 4 | Targeting of BAFF and APRIL for autoimmunity and oncology显示文摘 | Ryan MC Grewal IS | | 0，，： | 1 |
| 5 | CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers显示文摘 | Smith LM Nesterova A Ryan MC | | 0，，01： | 1 |
| 6 | Effects of chromium propionate supplementation during the periparturient period and early lactation on metabolism,performance,and cytological endometritis in dairy cows显示文摘 | Yasui T Mc Art JA Ryan CM | 2014 | J Dairy Sci2014，97，10： | 1 |
| 7 | Relationships between estimates of adiposity,insulin reristance and nonalcoholic fatty liver disease in a large group of nondiabetic Korean adults显示文摘 | Sung KC Ryan MC Kim BS | 2007 | Diatebes Care2007，30，8： | 1 |
| 8 | Neuropsychiatric symptoms in Alzheimer's disease 显示文摘 | Lyketsos CG Carrillo MC Ryan JM | 2011 | Alzheimers Dement2011，7，5： | 1 |
| 9 | Comparison of waist circumference versus boby mass index in diagnosing met- abolic syndrome and identifying apparently healthy subjects at increased risk of cardiovascular disease显示文摘 | Ryan MC Fenster-Farin HM Abbasi F | 2008 | Am J Cardlol2008，102，11： | 1 |
| 10 | Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia 显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 11 | The novel role of Creactive protein in cardiovascular disease:risk marker or pathogen显示文摘 | Wilson AM Ryan MC Boyle AJ | 2006 | Int J Cardiol2006，106，3： | 1 |
| 12 | The novel role of C-reactive pro-tein in cardiovascular disease:risk marker or pathology显示文摘 | Wilson AM Ryan MC Boyle AJ | 2006 | Int J Cardiol2006，106，： | 1 |
| 13 | The increasing importance of chronic rejection as a cause of renal allograft failure显示文摘 | Dennis MJ Foster MC Ryan JJ | 1989 | Transpl Int1989，2，4： | 1 |
| 14 | Short-terrnlntensiveinsulintherapyinnewl ydiagnosedtype2diabetes显示文摘 | Ryan E Imes S Wallace MC | 2004 | Diabetescare2004，27，： | 1 |
| 15 | Inflammatory cardiovascular risk markers in obstructive sleep apnea syndrome显示文摘 | Ryan S Mc Nicholas WT | | 0，，： | 1 |
| 16 | Growth and gene expression are predominantly controlled by distinct regions of the humanIL-4 receptor显示文摘 | Ryan JJ Mc Reynolds IJ Keegan A etal | 1996 | Immunity1996，4，2： | 1 |
| 17 | The increasing im-portance of chronic rejection as a cause of renal allograft failure显示文摘 | Dennis MJ Foster MC Ryan JJ | 1989 | Transpl Int1989，2，4： | 1 |
| 18 | The increasing importance of chronic rejection as a cause of renal allograft failure显示文摘 | Dennis MJ Foster MC Ryan JJ | 1989 | Transpl Int1989，2，4： | 1 |
| 19 | The novel role of C-reactive protein in cardiovascular disease: risk marker or pathologen 显示文摘 | Wilson AM Ryan MC Boyle AJ | 2006 | Int J Cardiol2006，106，3： | 1 |
| 20 | Impaired fasting glucose tolerance in first-episode,drug-nave patiences with schizophrenia显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，： | 1 |
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