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| 1 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 2 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 3 | Sources of heavy metals in sediments of the Hudson rivere stuary显示文摘 | Williams SC Simpson HJ Olsen CR | 1978 | Mar Chem1978，6，3： | 1 |
| 4 | Isolation of high affinity human antibodies directly from large synthetic repertoirea 显示文摘 | Griffiths AD Williams SC Hsrtley O | 1994 | EMBO1994，13，： | 1 |
| 5 | Functional MR imaging of confounded hypofrontality显示文摘 | Bullmore E Brammer M Williams SC | 1999 | Hum Brain Mapp1999，8，23： | 1 |
| 6 | Measles among adults, UnitedStates, 1985 -1995显示文摘 | Miller M Williams WW Redd SC | 1999 | Am J Prev Med1999，17，： | 1 |
| 7 | Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease 显示文摘 | Roberts TJ Price J Williams SC | 2006 | Neuroscience2006，139，4： | 1 |
| 8 | Mutations in the heparin-binding domains of human basic fibroblast growth factor alter its biological activity 显示文摘 | William FH Amanda SC Nancy GM | 1991 | Biochemistry1991，30，22： | 1 |
| 9 | High frequency probe tone tympanometry in infants with middle ear effusion显示文摘 | Williams MJ Purdy SC Barber C | 1995 | Aus J Otolarygol1995，2，： | 1 |
| 10 | Epitope mapping ofbovine alpha- lactalbumin using a random phage display peptidelibrary显示文摘 | Hunt AC1 Williams SC Davis PJ | 1997 | Biochem Soc Trans1997，25，2： | 1 |
| 11 | Estrogein creases cGMP inselected brain regions and in cerebral microvesels显示文摘 | Palmon SC Williams MJ Littleton2Kearney MT | 1998 | J Cereb Blood Flow Metab1998，18，： | 1 |
| 12 | Determination of the drug-DNA binding modes using fluorescence-based assays显示文摘 | Williams AK Dasilva SC Bhatta A | 2012 | Anal Biochem2012，422，2： | 1 |
| 13 | Measles among adults, United States, 1985-1995 显示文摘 | Miller M Williams WW Redd SC | 1999 | Am J Prey Med1999，17，2： | 1 |
| 14 | Sequence and evolution of the human germline V lambda repertoire 显示文摘 | Williams SC Frippiat JP Tomlinson IM | 1996 | J Mol Biol1996，264，2： | 1 |
| 15 | Effects of experimental conditions on absorption of glycolethers through human skin in vitro显示文摘 | Wilkinson SC Williams FM | 2002 | Int Arch Occup Environ Health2002，75，8： | 1 |
| 16 | 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Spencer B. King Sidney C. Smith John W. Hirshfeld Alice K. Jacobs Douglass A. Morrison David O. Williams Sidney C. Smith Ted E. Feldman John W. Hirshfeld Alice K. Jacobs Morton J. Kern Spencer B. King Douglass A. Morrison William W. O'Neill Hartzell V. Sc | 2008 | Circulation2008，，2： | 1 |
| 17 | High frequency tympanometry: a valid and reliable immittance test protocol for young infants 显示文摘 | Purdy SC Williams MJ | 2000 | New Z Audiol Soc Bulletin2000，10，3： | 1 |
| 18 | Dietary supplement of neosugar alerts the fecal flora and decreases activities of some reductive enzymes in human subjects显示文摘 | Buddington RK Williams CH Chen SC | 1996 | Am J Clin Nutr1996，63，： | 1 |
| 19 | Isolation of high affinity human antibody directlyfrom large synthetic repertoires显示文摘 | Griffiths AD Williams SC | 1994 | EMBO J1994，13，： | 1 |
| 20 | Surface expression of the netrin receptor UNC5HI is regulated through a protein kinase C-interacting protein/protein kinasedependent mechanism 显示文摘 | Williams ME Wu SC McKenna WL | 2003 | J Neurosci2003，23，11： | 1 |
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