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| 1 | Selenoprotein W cDNAs From Five Species of Animals显示文摘The nucleotide sequences of the open reading frames of cDNAs for selenoprotein W from skeletal muscle of rat, mouse, sheep, rhesus monkey and human are reported. Theoretical translation of the coding sequences indicated highly similar proteins of 88 (mouse and rat) or 87 (human, monkey and sheep) amino acids. In 73 of 88 positions the specified amino acids are identical for all five proteins. TGA encoding selenocysteine is the 13th codon of all the cDNAs. The rnouse, rat and sheep open reading frames terminate with TGA but the human and rhesus monkey coding regions terminate with TAA. The encoded amino acid sequences are identical for the rat and mouse proteins, and for the human and monkey proteins. The similarity of the cDNAs continues in the 3’ noncoding regions through the putative selenocysteine insertion sequence (SEClS) elements which are required for correct interpretation of the selenocysteine codon. The region between the SECIS elements and the polyadenylation signals showed much lower similarity. The cloned rat gene for selenoprotein W is 5000 bases long,with the 663 bases of the cDNA in six exons. The transcription start site was identified by nuclease protection assay to be 16 bases upstream of the longest cDNA clone. A canonical TATA box occurs 150 bases upstream, but the assay did not indicate the presence of longer | P. D. WHANGER S. C. VENDELAND Q-P GU M. A. BEILSTEIN AND L. W. REAM(Department of Agricultural Chemistry, Oregon State University,Corvallis, Oregon 97331, USA) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 4 |
| 2 | Selenium and its relationship to cancer: an update 显示文摘 | WHANGER P D | 2004 | Br J Nutr2004，91，1： | 1 |
| 3 | Selenoprotein W during development and oxidative stress 显示文摘 | Loflin J Lopez N Whanger PD | 2006 | J Inorg Biochem2006，100，： | 1 |
| 4 | lnfluence of Dietary Methionine on the Metabolism of Selenomethionine in Rats 显示文摘 | Butler J A Beilstein M A Whanger P D | 1989 | Journal of Nutrition1989，119，： | 1 |
| 5 | Selenoprotein W during development and oxidative stress 显示文摘 | Loflin J Lopez N Whanger PD | 2006 | Journal of inorganic biochemistry2006，100，10： | 1 |
| 6 | Seleno compounds in plants and animals and their biological significance显示文摘 | Whanger P D | 2002 | J Amer Coll Nutri2002，21，3： | 1 |
| 7 | Selenoprotein: a review 显示文摘 | Whanger P D | 2000 | Cell Mol Life Sci2000，57，： | 1 |
| 8 | Selenium and Mercury Interactions with Emphasis on Fish Tissue显示文摘 | Peterson S A Ralston N V C Whanger P D | | 0，，04： | 1 |
| 9 | Selenium and its relationship to cancer: an update dagger显示文摘 | WHANGER P D | 2004 | J Brit Nutr2004，91，1： | 1 |
| 10 | Selenium induced redistuvibution of cadmium binding to tissre protein: A possoble mechanism of protection against cadmium toxicity显示文摘 | Chen RW Whanger PD Weswig PH | 1975 | Bionorg Chem1975，4，2： | 1 |
| 11 | Selenocompounds in plants and animals and their biological significance显示文摘 | Whanger P D | 2002 | Journal of the American College of Nu- trition2002，21，3： | 1 |
| 12 | Effects of selenium dificiency on vitamin E metabolism in rats显示文摘 | Fischer W C Whanger P D | 1977 | J Nutr Sci Vitaminol1977，23，： | 1 |
| 13 | Selenium and its relationship to cancer: An up date 显示文摘 | Whanger P D | 2004 | Br J Nutr2004，91，： | 1 |
| 14 | Intestinal a sorption of selenite,selenate,and selenomethionine in the rat显示文摘 | Vendeland S C Butler J A Whanger P D | | 0，，07： | 1 |
| 15 | Selenocompounds in plants and animals and their biological significance显示文摘 | Whanger PD | 2002 | J Am Coll Nutr2002，21，： | 1 |
| 16 | Arsenic levels in Oregon waters显示文摘 | Whanger P D Weswing P H Stoner J C | 1997 | Environment Health Perspect1997，19，： | 1 |
| 17 | 硒与致癌物的相互作用显示文摘 | Whanger PD 吴柏龄 | 1984 | 国外医学(卫生学分册)1984，，05： | 1 |
| 18 | 硒与致癌物的相互作用显示文摘 | Whanger PD 吴柏龄 | 1984 | 国外医学(卫生学分册)1984，，05： | 1 |
| 19 | Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis 显示文摘 | Whanger PD | 1992 | J Trace Elem Electrolytes Health Dis1992，6，4： | 1 |
| 20 | Selenium and its relationship to cancer:an update显示文摘 | Whanger PD | 2004 | Br J Nutr2004，91，： | 1 |
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