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| 1 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 2 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 3 | Recuperation of severe tumoral calcinosis in a dialysis patient: A case report显示文摘BACKGROUND One of the common late sequela in patients with end-stage renal disease(ESRD)is the calcium phosphate disorder leading to chronic hypercalcemia and hyperphosphatemia causing the precipitation of calcium salt in soft tissues.Tumoral calcinosis is an extremely rare clinical manifestation of cyst-like soft tissue deposits in different periarticular regions in patients with ESRD and is characterized by extensive calcium salt containing space-consuming painful lesions.The treatment of ESRD patients with tumoral calcinosis manifestation involves an increase in or switching of renal replacement therapy regimes and the adjustment of oral medication with the goal of improved hypercalcemia and hyperphosphatemia.CASE SUMMARY We describe a 40-year-old woman with ESRD secondary to IgA-nephritis and severe bilateral manifestation of tumoral calcinosis associated with hypercalcemia,hyperphosphatemia and tertiary hyperparathyroidism.The patient was on continuous ambulatory peritoneal dialysis and treatment with vitamin D analogues.After switching her to a daily hemodialysis schedule and adjusting the medical treatment,the patient experienced a significant dissolution of her soft tissue calcifications within a couple of weeks.Complete remission was achieved 11 mo after the initial diagnosis.CONCLUSION Reduced patient compliance and subsequent insufficiency of dialysis regime quality contribute to the aggravation of calcium phosphate disorder in a patient with ESRD leading to the manifestation of tumoral calcinosis.However,the improvement of the treatment strategy and reinforcement of patient compliance enabled complete remission of this rare disease entity. | Lukas Westermann Lisa K Isbell Marie K Breitenfeldt Frederic Arnold Elvira Rothele Johanna Schneider Eugen Widmeier | 2019 | World Journal of Clinical Cases2019，7，23： | 2 |
| 4 | Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler conductance catheterization study 显示文摘 | Kasner M Westermann D Steendi J K P | 2007 | Circulation2007，116，6： | 1 |
| 5 | Light-induced formation of free radicals in cream cheese显示文摘 | Westermann S Bruggemann D A Olsen K | 2009 | Food chemistry2009，116，4： | 1 |
| 6 | Post-translational modifications regulate the microtubule function显示文摘 | WESTERMANN S WEBER K | 2003 | Nature Rev Mol Cell Biol2003，4，12： | 1 |
| 7 | High Prevalence of Cardiac Parvovirus B19 Infection in Patients With Isolated Left Ventricular Diastolic Dysfunction显示文摘 | C Tsch?pe C -T. Bock M Kasner M Noutsias D Westermann P -L. Schwimmbeck M Pauschinger W -C. Poller U Kühl R Kandolf H -P. Schultheiss | 2005 | Circulation2005，，7： | 1 |
| 8 | Saccharomyces cerevisiae as a model organism to study mitochondrial biology: general considerations and basic procedures 显示文摘 | Altmann K Dun' M Westermann B | 2007 | Methods Molecular Biology2007，372，11： | 1 |
| 9 | Post-translational modifications reg- ulate microtubule function 显示文摘 | Westermann S Weber K | 2003 | Nat Rev Mol Cell Biol2003，4，12： | 1 |
| 10 | lmmunomodula- tion and matrix metalloproteinase in viral myocarditis显示文摘 | Westermann D Savvatis K Schultheiss H | 2010 | J Mol Cell Cardiol2010，48，： | 1 |
| 11 | Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy 显示文摘 | WESTERMANN D SAVVATIS K LINDNER D | 2011 | Circulation2011，124，19： | 1 |
| 12 | High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status显示文摘 | WESTERMANN F HENRICH K O WEI J S | 2007 | Clin Cancer Res2007，13，16： | 1 |
| 13 | Archaeal diversity in icelandic hot springs显示文摘 | Kvist T Ahring B K Westermann P | 2007 | FEMS Microbiol Ecol2007，59，： | 1 |
| 14 | Streamline VariabilityPlots for Characterizing the Uncertainty in Vector FieldEnsembles 显示文摘 | Ferstl F Burger K Westermann R | 2016 | IEEE Transactions on Visualization andComputer Graphics (SI077-2626)2016，22，1： | 1 |
| 15 | Product inhibition of butyrate metabolism by acetate and hydrogen in a thermophilic coculture显示文摘 | Ahfing B K Westermann P | 1988 | Applied and Environmental Microbiology1988，54，10： | 1 |
| 16 | Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction : a comparative Dopplerconductance catheterization study显示文摘 | KASNER M WESTERMANN D STEENDIJ K P | 2007 | Circulation2007，116，6： | 1 |
| 17 | Relative effectiveness and validity of mood induction procedures:a mcta-analysis显示文摘 | Westermann R Spies K Stahl G Hesse F W | | 0，，26： | 1 |
| 18 | Prevention of cardiac dysfunction in acute coxsackievirus B3cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor显示文摘 | Pinkert S Westermann D Wang X Klingel K Drner A Savvatis K Grssl T Krohn S Tschpe C Zeichhardt H Kotsch K Weitmann K Hoffmann W Schultheiss HP Spiller OB Poller W Fechner H | 2009 | Circulation2009，120，23： | 1 |
| 19 | A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)显示文摘 | Carol J Gallione Gabriela M Repetto Eric Legius Anil K Rustgi Susan L Schelley Sabine Tejpar Grant Mitchell éric Drouin Cornelius JJ Westermann Douglas A Marchuk | 2004 | The Lancet2004，，9412： | 1 |
| 20 | Left ventricular enlargement in coxsackievirus-B3induced chronic myocarditis-ongoing inflammation and an imbalance of the matrix degrading system显示文摘 | Rutschow S Leschka S Westermann D Puhl K Weitz A Ladyszenskij L Jaeger S Zeichhardt H Noutsias M Schultheiss HP Tschope C Pauschinger M | 2010 | Eur J Pharmacol2010，630，13： | 1 |
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