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| 1 | Autoantibodies against G-Protein-Coupled Receptors Modulate Heart Mast Cells显示文摘Mast cells are believed to be involved in myocardial tissue remodelling under pathophysiological conditions. We examined the effects of autoantibodies against G-protein-coupled receptors in sera of patients with heart diseases on myocardial mast cells in the cultured neonatal Sprague-Dawley rat heart cells. Cells collected at day 3 and 10 of the culture were preincubated with autoantibodies against α1-adrenoceptor and angiotensin II AT1-receptor, agonist phenylephrine and angiotensin II, and control IgG. The pretreated cultured cells were stained for selected mast cell markers tryptase, chymase and TNF-α. The cultured cells were also processed for observation with electron microscopy. The autoantibodies-treatment of the 3-day cultured cells caused both increased intensity of immunofluorescence (p < 0.05) and their enlarged diameters of the mast cells when compared to age-matched ones. In contrast, the fluorescence of preincubated 10-day-old mast cells was decreased compared with controls (p < 0.01). In control samples, the fluorescence of 10-day-old mast cells was significantly higher than that of 3-day-old ones (p < 0.001). Results of electron microscopy examination demonstrated there was an increased granulation of treated 3-day-old mast cells, while a degranulation of mast cells at day 10 of application. The results suggest the modulation effect of the autoantibodies against G-protein-coupled receptors on mast cells, indicating a potential functional link between the autoantibodies against G-protein-coupled receptors and the mast cells in progression of heart disease. | Ludmila Okruhlicova Rosemarie Morwinski Wolfgang Schulze Sabine Bartel Peter Weismann Narcisa Tribulova Gerd Wallukat | 2007 | Cellular & Molecular Immunology2007，4，2： | 6 |
| 2 | Ultrastructure and histochemistry of rat myocardial capillary endothelial cells in response to diabetes and hypertension显示文摘Insufficient growth and rarefaction of capillaries, followed by endothelial dysfunction may represent one of the mostcritical mechanisms involved in heart damage. In this study we examined histochemical and ultrastructural changes inmyocardial capillary endothelium in two models of heart failure streptozotocin-induced diabetes mellitus (STZ) and NO-deficient hypertension in male Wistar rats. Diabetes was induced by a single i.v. dose of STZ (45 mg/kg) and chronic 9-week stage was analysed. To induce NO-deficient hypertension, animals were treated with inhibitor of NO synthase L-nitroarginine methylester (L-NAME) (40 mg/kg) for 4 weeks. Left ventricular tissue was processed for enzyme cata-lytic histochemistry of capillary alkaline phosphatase (AlPh), dipeptidyl peptidase IV (DPP IV), and endothelial NOsynthase/NADPH-diaphorase (NOS) and for ultrastructural analysis. In diabetic and hypertensive rats, lower/absentAlPh and DPP IV activities were found in focal micro-areas. NOS activity was significantly reduced and persisted onlylocally. Quantitative evaluation demonstrated reduction of reaction product intensity of AlPh, DPP and NOS by 49.50%,74.36%, 20.05% in diabetic and 62.93%, 82.71%, 37.65% in hypertensive rats. Subcellular alterations of endothelialcells were found in heart of both groups suggesting injury of capillary function as well as compensatory processes.Endothelial injury was more significant in diabetic animals, in contrast the adaptation was more evident in hypertensiveones. Concluding: both STZ-induced diabetes- and NO-deficient hypertension-related cardiomyopathy were accompa-nied by similar features of structural remodelling of cardiac capillary network manifested as angiogenesis and angiopathy.The latter was however, predominant and may accelerate disappearance of capillary endothelium contributing to myo-cardial dysfunction. | Ludmila OKRUHLICOVA Narcis TRIBULOVA1 Peter WEISMANN Ruzena SOTNIKOVA | 2005 | Cell Research2005，15，7： | 4 |
| 3 | Bio-markers for egg quality determination in cyprinid fish显示文摘 | F. Lahnsteiner B. Urbanyi A. Horvath T. Weismann | 2001 | Aquaculture2001，，3： | 2 |
| 4 | Level of glycemic control and pregnancy outcome in type 1 diabetes: A comparison between multiple daily insulin injections and continuous subcutaneous insulin infusions显示文摘 | Chen R Ben H A Weismann B A | 2007 | Am J Obstet Gynecol2007，197，4： | 1 |
| 5 | The naturalhistory of primary dysmen orrhea:a longitudinal study显示文摘 | Weismann A M Hartz A J Hansen M D | 2004 | Br J Obstet Gynaecol2004，111，4： | 1 |
| 6 | Fractal dimension of dielectric breakdown显示文摘 | Niemeyer L Piotronero L Weismann H J | 1984 | Physical Review Letters1984，52，14： | 1 |
| 7 | Motility of spermatozoa of Alburnus a!burus (Cyprinidae) and its relationship to seminal plasma composition and sperm metabolism显示文摘 | Lahnsteiner F Berger B Weismann T | 1996 | Fish Physiol Biochem1996，15，： | 1 |
| 8 | Monosaccharidsas energy resources during motility of permatozoa in Leuciscus cephalus (Cyprinidae Teleostet)显示文摘 | Lahnsteiner F Patzner R A Weismann T | 1992 | Fish Physiol Biochem1992，10，： | 1 |
| 9 | Complement factor Hbinds malondialdehyde epitopes and protects from oxidative stress显示文摘 | Weismann D Hartvigsen K Lauer N | 2011 | Nature2011，478，7367： | 1 |
| 10 | Diagnostic algorithm: how to make use ofnew 2D, 3D and4D ultrasound technologies in breast imaging显示文摘 | Weismann CF Datz L | 2007 | Eur J Radiol2007，64，2： | 1 |
| 11 | Physiological and biochemical parameters for egg quality determination in lake trout Salmo trutta lacustris显示文摘 | Lahnsteiner F Weismann T Patzner R A | 1999 | Fish Physiology and Biochemistry1999，20，： | 1 |
| 12 | An argument against the use of podophyllotoxin显示文摘 | Petersen C S Weismann K Q Kaempherol | 1995 | Genitourin Med1995，71，2： | 1 |
| 13 | Fine structural changes in spermatozoa of the grayling, Thymallus thymallus (Pisces: Teleosteri) during routine cryopreservation显示文摘 | Lahnsteiner F Weismann T Patzner R A | 1992 | Aquaculture1992，103，： | 1 |
| 14 | Management of adrenocortical carcinoma显示文摘 | ALLOLIO B HAHNER S WEISMANN D | 2004 | Clin Endocrinol(Oxf)2004，60，3： | 1 |
| 15 | 显示文摘 | Jensen BL Weismann K Sindrup J | 2000 | Acta Derm Venereol2000，80，2： | 1 |
| 16 | Incidence, clin- ical presentation and treatment of neurosyphilis in Denmardk 1980 - 1997显示文摘 | Danielsen AG Weismann K Jorgensen BB | 2004 | Acta Derm Venereol2004，84，： | 1 |
| 17 | New targets and therapeutic approaches for endocrine malignancies显示文摘 | FASSNACHT M KREISSL MC WEISMANN D | 2009 | Pharmacol Therap2009，123，1： | 1 |
| 18 | The genetics of congenital heart disease: A review of recent developments显示文摘 | Weismann CG Gelb BD | 2007 | Curr Opin Cardiol2007，22，： | 1 |
| 19 | Thyroid hormone receptor-p agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pat hways显示文摘 | Vatner DF Weismann D Beddow SA | 2013 | Am J Physiol Endocrinol Me- tab2013，305，1： | 1 |
| 20 | Diagnostic algorithm: how to make use of new 2D, 3D and 4D ultrasotmd technologies in breast imaging显示文摘 | Weismann CF Datz L | 2007 | Eur J Radiol2007，64，2： | 1 |
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