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| 1 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 2 | A wireless pressure measurement system using a SAW hybrid sensor显示文摘 | Schimetta G Dollinger F Weigel R | 2000 | IEEE Trans Microwave Theory Tech2000，48，12： | 1 |
| 3 | Systemic sclerosis - a systematic overview: part 2 - immunosuppression, treatment of SSc - associated vasculopathy, and treatment of pulmonary arterial hyperten- sion 显示文摘 | Opitz C Klein- Weigel PF Riemekasten G | 2011 | Vasa2011，40，1： | 1 |
| 4 | Hypernatraemia in criti- cally ill patients: too little water and too much salt显示文摘 | Hoorn E J Betjes M G Weigel J | 2008 | Nephrol Dial Transplant2008，23，5： | 1 |
| 5 | Extracellular matrix 1 ( ECM1 ) expression is a novel prognostic marker for poor long-term survival in breast cancer: a hospital-based cohort study in iowa 显示文摘 | Lal G Hashimi S Weigel RJ | 2009 | Ann Surg Oneol2009，16，8： | 1 |
| 6 | Treatment con- cept of chronic subdural haematoma according to an algo rithm using evidence-based medicine-derived key factors: A prospective controlled study显示文摘 | Weigel R Schlickum L Weisser G | 2015 | Br J Neurosurg2015，29，53： | 1 |
| 7 | Field trial to evaluate the immunogenicity of pseudorabies virus vaccines with deletions for glycoproteins G and E 显示文摘 | FIRKINS L D WEIGEL R M BIEHL L G | 1997 | Am J Vet Res1997，58，9： | 1 |
| 8 | Stem cells that make stems显示文摘 | WEIGEL D JURGENS G | 2002 | Nature2002，415，6873： | 1 |
| 9 | Successful treatment of thromboangiitis obliterans (Buerger's disease) with immunoadsorption: results of a pilot study显示文摘 | Baumann G Stangl V Klein Weigel P | 2011 | Clin Res Cardiol2011，100，8： | 1 |
| 10 | The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis显示文摘 | Wu G Park MY Conway SR Wang JW Weigel D Poethig RS | | 0，，4： | 1 |
| 11 | Combining SSH and cD- NA microarrays for rapid identification of differentially ex- pressed genes显示文摘 | Yang G P Kuang W W Weigel R J | 1999 | Nucleic Acids Research1999，27，6： | 1 |
| 12 | 3mbroxol for prcven,tion and treatment of hyaline mem- brane disease显示文摘 | Wauer RR Schmalisch G Hammer H Buttenberg S Weigel H Hnth M | 1989 | Eur Respir J Suppl1989，3，1： | 1 |
| 13 | The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo显示文摘 | WEIGEL D JRGENS G KTTNER F | 1989 | Cell1989，57，4： | 1 |
| 14 | Treatment concept of chronic subdural haematoma according to an algorithm using evidence-based me- dicine-derived key factors:a prospective controlled study显示文摘 | Weigel R Schlickum L Weisser G | 2015 | Br J Neuro- surg2015，29，4： | 1 |
| 15 | Molecular detection of viable bacterial pathogens in water by ratiometric pre-rRNA analysis 显示文摘 | Cangelosi G A Weigel K M Lefihand-Begay C | 2010 | Applied and environmental microbiology2010，76，3： | 1 |
| 16 | PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer显示文摘 | Ghosh M G Thompson D A Weigel R J | 2000 | Cancer Res2000，60，22： | 1 |
| 17 | AP2 transcription factors regulate expression of CRABPII in hor- mone responsive breast carcinoma显示文摘 | MCPHERSON L A WOODFIELD G W WEIGEL R J | 2007 | Journal of Surgical Re- search2007，138，1： | 1 |
| 18 | LFY blooms in a spen显示文摘 | Coupland G | 1995 | Nature1995，377，： | 1 |
| 19 | Early failure of the tissue-engineered porcine heart valve SynerGraftTM in pediatric patients显示文摘 | Simon P Kasimir MT Weigel G | 2003 | Eur J Cardio Thorac Surg2003，23，： | 1 |
| 20 | Effect of mycophenolate mofetil therapy on inosine monophos?phate dehydrogenase induction in red blood cells of heart transplant recipients显示文摘 | Weigel G Griesmacher A Zuckermann AO | 2001 | Clin Pharmacal Ther2001，69，3： | 1 |
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