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| 1 | China’s first deep manned submersible,JIAOLONG显示文摘A deep manned submersible is indispensable to deep ocean exploration. No other equipment can bring scientists to ex-treme sea floor depths to do research in situ. Marine geology, seafloor geophysics,marine biology,and oceanic chemistry are the fields that scientists are particularly eager to study [1-6]. Chinese scientists have long dreamed of using their own submersible to probe the deep sea. China’s recent fast development of a deep manned submersible has realized that dream. | Liu, Feng Cui, WeiCheng Li, XiangYang | 2010 | Science China Earth Sciences2010，53，10： | 24 |
| 2 | Screening for gastric cancer in China:Advances,challenges and visions显示文摘Gastric cancer(GC)is one of the major cancers in China and all over the world.Most GCs are diagnosed at an advanced stage with unfavorable prognosis.Along with some other countries,China has developed the government-funded national screening programs for GC and other major cancers.GC screening has been shown to effectively decrease the incidence of and mortality from GC in countries adopting nationwide screening programs(Japan and Korea)and in studies based on selected Chinese populations.The screening of GC relies mostly on gastroendoscopy,the accuracy,reliability and safety of which have been indicated by previous studies.However,considering its invasive screening approach,requirements on skilled endoscopists and pathologists,and a high cost,developing noninvasive methods to amend endoscopic screening would be highly needed.Numerous studies have examined biomarkers for GC screening and the combination of biomarkers involving pepsinogen,gastrin,and Helicobacter pylori antibodies has been proposed for risk stratification,seeking to narrow down the high-risk populations for further endoscopy.Despite all the achievements of endoscopic screening,evidence on appropriate screening age,intervals for repeated screening,novel biomarkers promoting precision prevention,and health economics need to be accumulated to inform policymakers on endoscopic screening in China.With the guide of Health China 2030 Planning Outline,we have golden opportunities to promote prevention and control of GC.In this review,we summarize the characteristics of screening programs in China and other East Asian countries and introduce the past and current approaches and strategies for GC screening,aiming for featuring the latest advances and key challenges,and illustrating future visions of GC screening. | Xiaohan Fan Xiangxiang Qin Yang Zhang Zhexuan Li Tong Zhou Jingying Zhang Weicheng You Wenqing Li Kaifeng Pan | 2021 | Chinese Journal of Cancer Research2021，33，2： | 21 |
| 3 | Cellular automata pedestrian movement model considering human behavior显示文摘The pedestrian movement is more complex than vehicular flow for the reason that people are more flexible and intelligent than car. Without the limit of 搇anes?pedestrian movement is loose and free. Furthermore, they are easily affected by other walkers as well as the environ-ment around. In this paper some special technique is intro-duced considering human behavior to make the rules more reasonable. By simulating the two-dimension pedestrian movement, the phase transition phenomena of pedestrian movement, including the up walkers moving from the bottom to the upper boundary and the right walkers moving from the left to the right boundary, are presented. Studying on the effect of the system size on the critical density shows that the critical density is independent of the system size in the scope studied in this paper. | YANG Lizhong, FANG Weifeng, LI Jian, HUANG Rui & FAN Weicheng State Key Laboratory of Fire Science, University of Science and Tech-nology of China, Hefei 230026, China Correspondence should be addressed to Yang Lizhong (e-mail:zxd@ustc. edu.cn) | 2003 | Chinese Science Bulletin2003，48，16： | 16 |
| 4 | Progress in research and application of water mist fire suppression technology显示文摘Water mist technology in fire suppression has been a subject of many investigations over the last decade. This paper introduces the concept of water mist technology and discusses its extinguishment mechanisms in comparison with other fire suppression systems briefly. A survey is made on the recent applications of water mist for (1) Class B spray and pool fires in machinery spaces, gas turbine enclosures, combat vehicles, and flammable liquid storage rooms; (2) Class A fires in residential occupancies, marine accommoda-tions and public spaces, heritage buildings and libraries; (3) Class C fires in electronic equipment and computer rooms; and (4) the fires in aircraft onboard cabin and cargo com-partments. The paper proceeds to review some new applica-tions of water mist for the Class K fires in commercial cook rooms. Use of water mist for total-ship protection as well as the fire protection of heavy goods vehicle shuttle trains is also investigated. At last, the up-to-date development of corresponding test to evaluate the capabilities and limitaions of water mist is discussed. | LIU Jianghong, LIAO Guangxuan, LI Peide, FAN Weicheng & LU Qiang State Key Laboratory of fire Science, University of Science and Tech-nology of China, Hefei 230026, China Correspondence should be addressed to Liu Jianghong (e-mail: ljh@ ustc.edu.cn) | 2003 | Chinese Science Bulletin2003，48，8： | 15 |
| 5 | S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance显示文摘最近的研究证明 UHRF1 被指向 DNMT1 到 DNA 复制 foci 为 DNA methylation 维护要求,大概通过它的唯一的半甲醇化物有 DNMT1 的 DNA 有约束力的活动和相互作用。UHRF2, UHRF 家庭蛋白质的另一个成员,高度类似于在顺序和结构的 UHRF1,关于它在 DNA methylation 的角色的涨的问题。在这研究,我们证明 UHRF2 象 UHRF1 一样,也优先地绑在 methylated histone H3 离氨酸 9 (H3K9 ) 通过它的保存 tudor,通过 SET 和戒指的领域和半甲醇化物 DNA 联系了领域。象 UHRF1 一样, UHRF2 在 pericentric heterochromatin 被充实。heterochromatin 本地化取决于到大程度它的 methylated H3K9 有约束力的活动并且到它的 methylated 上的更少的程度 DNA 有约束力的活动。Coimmunoprecipitation 实验证明 UHRF1 和 UHRF2 与 DNMT1, DNMT3a, DNMT3b 和 G9a 交往。尽管有所有这些保存功能,我们发现 UHRF2 不能在 Uhrf1 空老鼠救 DNA methylation 缺点胚胎的干细胞。这个罐头在房间周期的 S 阶段期间为 UHRF2 被归因于无能到成员 DNMT1 到复制 foci。确实,我们发现当 UHRF1 在房间以一种 S 阶段依赖者方式与 DNMT1 交往时, UHRF2 不做。因此,我们的学习证明 UHRF2 和 UHRF1 不在 DNA methylation 维护是机能上地冗余的并且作为为 DNA methylation 指向 DNMT1 的关键规章的机制揭示在 UHRF1 和 DNMT1 之间的 cell-cycle-dependent 相互作用。 | Jiqin Zhang Qinqin Gao Pishun Li Xiaoli Liu Yuanhui Jia Weicheng Wu Jiwen Li Shuo Dong Haruhiko Koseki Jiemin Wong | 2011 | Cell Research2011，21，12： | 12 |
| 6 | Guanling Biota: A Marker of Triassic Biotic Recovery from the end-Permian Extinction in the Ancient Guizhou Sea显示文摘After a slow recovery from the end-Permian extinction during the Early Triassic and rapid radiation in the Middle Triassic, evolution of organisms reached a new peak phase in the Late Triassic. The Guanling Biota from the Wayao Member (conodont Paragondolella polygnathiformis Zone), Falang Formation, Xinpu, Guanling County, Guizhou Province, southwestern China corresponds to this peak that marks the full recovery from the end-Permian extinction of marine ecosystems. The biota is of high diversity, containing well preserved and completely articulated skeletons of vertebrates comprising marine reptiles, fishes, and invertebrates including crinoids, ammonites, bivalves, and other fossils, and is one of the best examples of marine ecosystem records in life history. The fossil marine reptiles and crinoids are most significant in this biota, especially the marine reptiles, which provide an important link between the Triassic Pacific and Tethys, and between Triassic basal forms and the Jurassic-Cretaceous marine top predators. The most remarkable fossils are the large completely articulated ichthyosaur skeletons up to and more than 10 m, and the first recorded thalattosaurs and placodonts in China. Following our review, of the 17 named reptilian taxa the eight listed here are considered to be valid: three ichthyosaurs (Qianichthyosaurus zhoui Li, 1999; Guizhouichthyosaurus tangae Cao and Luo in Yin et al., 2000, Guanlingsaurus liangae Yin in Yin et al., 2000), three thalattosaurs (Anshunsaurus huangguoshuensis Liu, 1999, Xinpusaurus suni Yin in Yin et al., 2000, Xinpusaurus kohi Jiang et al., 2004), and two placodonts (Sinocyamodus xinpuensis Li, 2000, Psephochelys polyosteoderma Li and Rieppel, 2002). Mixosaurus guanlingensis Cao in Yin et al., 2000 might be a junior synonym of Qianichthyosaurus zhoui Li, 1999, and Cymbospondylus asiaticus Li and You, 2002 and Panjiangsaurus epicharis Chen and Cheng, 2003 might be junior synonyms of Guizhouichthyosaurus tangae Cao and Luo in Yin et al., 2000. It needs to re-describe the holotypes after a complete preparation for clarifying the taxonomic status of Typicusichthyosaurus tsaihuae Yu in Yin et al., 2000, Xinpusaurus bamaolinensis Cheng, 2003, Neosinosaurus hoangi (Zhou in Yin et al., 2000), Wayaosaurus geei Zhou in Yin et al., 2000, Wayaosaurus bellus Zhou in Yin et al., 2000 and Placochelys ? minutus Yin and Luo in Yin et al., 2000. | JIANG Dayong Ryosuke MOTAN LI Chun HAO Weicheng SUN Yuanlin SUN Zuoyu Lars SCHMITZ | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 11 |
| 7 | A systematic review of metabolomic profiling of gastric cancer and esophageal cancer显示文摘Objective:Upper gastrointestinal(UGI)cancers,predominantly gastric cancer(GC)and esophageal cancer(EC),are malignant tumor types with high morbidity and mortality rates.Accumulating studies have focused on metabolomic profiling of UGI cancers in recent years.In this systematic review,we have provided a collective summary of previous findings on metabolites and metabolomic profiling associated with GC and EC.Methods:A systematic search of three databases(Embase,PubMed,and Web of Science)for molecular epidemiologic studies on the metabolomic profiles of GC and EC was conducted.The Newcastle–Ottawa Scale(NOS)was used to assess the quality of the included articles.Results:A total of 52 original studies were included for review.A number of metabolites were differentially distributed between GC and EC cases and non-cases,including those involved in glycolysis,anaerobic respiration,tricarboxylic acid cycle,and protein and lipid metabolism.Lactic acid,glucose,citrate,and fumaric acid were among the most frequently reported metabolites of cellular respiration while glutamine,glutamate,and valine were among the most commonly reported amino acids.The lipid metabolites identified previously included saturated and unsaturated free fatty acids,aldehydes,and ketones.However,the key findings across studies to date have been inconsistent,potentially due to limited sample sizes and the majority being hospital-based case-control analyses lacking an independent replication group.Conclusions:Studies on metabolomics have thus far provided insights into etiological factors and biomarkers for UGI cancers,supporting the potential of applying metabolomic profiling in cancer prevention and management efforts. | Sha Huang Yang Guo Zhexuan Li Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li | 2020 | Cancer Biology & Medicine2020，17，1： | 11 |
| 8 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 9 | ROS signaling cascades:dual regulations for osteoclast and osteoblast显示文摘Accumulating evidence indicates that intracellular reactive oxygen species(ROS)production is highly involved in bone homeostasis by intervening osteoclast or osteoblast differentiation.Interestingly,ROS that are known as oxidizing agents exert dose-dependent biphasic properties in bone remodeling,including preventing osteoblast activity but accelerating osteoclast resorption.ROS mainly composed of superoxide anion radical,hydroxyl radical,nitric oxide,and two-electron reduction product hydrogen peroxide,which are important components to regulate bone cell metabolism and function in mammal skeleton.These free radicals can be partly produced in bone and boosted in an inflammation state.Although numerous researches have emphasized the impacts of ROS on bone cell biology and verified the mechanism of ROS signaling cascades,the recapitulatory commentary is necessary.In this review article,we particularly focus on the regulation of the intracellular ROS and its potential mechanism impacting on cell-signaling transduction in osteoclast and osteoblast differentiation for preferable understanding the pathogenesis and searching for novel therapeutic protocols for human bone diseases. | Huaqiang Tao Gaoran Ge Xiaolong Liang Weicheng Zhang Houyi Sun Meng Li Dechun Geng | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 8 |
| 10 | A newly Found Biotite Syenogranite in the Huangshaping Polymetallic Deposit, South China: Insights into Cu Mineralization显示文摘The W-Sn-Mo-Cu-Pb-Zn polymetallic mineralization in the Huangshaping Deposit is associated with different types of Jurassic granitic intrusions such as quartz porphyry, granophyre and granite porphyry. In this study, we carried out detailed mineralogical, petrological, geochemical, zircon U-Pb geochronological and Hf isotopic studies on a newly found, Cu-mineralization-related finegrained biotite syenogranite at Huangshaping. This syenogranite is mainly composed of quartz(40%), K-feldspar(30%), plagioclase(15%) and biotite(5%), enriching in SiO_2(75.58 wt.%–76.02 wt.%), K_2O(5.24 wt.%–5.78 wt.%), Al_2O_3(12.23 wt.%–12.46 wt.%), Rb(405 ppm–504 ppm), U(18.5 ppm–40.7 ppm), Th(47 ppm–52.3 ppm), Nb(49.6 ppm–57.5 ppm), and Cu(54 ppm–288 ppm) whereas depleting in P_2O_5(0.01 wt.%), TiO_2(0.05 wt.%–0.06 wt.%), Ba(5 ppm–13.1 ppm), Sr(6.8 ppm–23.9 ppm) and Eu(0.04 ppm–0.05 ppm), with A1-type alkaline granite characteristics. Magmatic and hydrothermal zircons were separated from a Cu-mineralized syenogranite sample and yielded the 206 Pb/238 U concordant ages of 156.5±1.8 and 154.4±2.9 Ma, representing the intrusive age of the pluton and probable Cu-mineralization time at the Huangshaping Deposit, respectively. Zircon Hf isotopes suggest a crust-derived(partial melting of Paleoproterozoic basement) magma for the syenogranite, with some degree of crust-mantle interaction. We infer that the syenogranite is a transitional phase between the granophyre and the granite porphyry, not only contributed greatly to the Cu mineralization but also provided W-Sn polymetallic ore-forming metals for the Huangshaping Deposit. | Weicheng Jiang Huan Li Jinghua Wu Zhekai Zhou Hua Kong Jingya Cao | 2018 | Journal of Earth Science2018，29，3： | 7 |
| 11 | A microcosmic discrete occupant evacuation model based on individual characteristics显示文摘The research of occupant evacuation in an emergency is of great benefit to building design and evacuation guidance. In this paper a microcosmic discrete evacuation model based on Cellular Automata (CA) is presented, in which the occupants?individual characteristics are considered. Thus, our model has given a description of evacuation route choice with influencing factors, including: individual knowledge of the building, individual realization of the emergency development, and the attractive and repulsive force between occupants. This model differs somewhat from other models in the attention to the associative and separate effect of influencing factors, based on occupants behaviors. In addition, the model could reveal the phenomenon of escape in fire, as those simulations involving a fire condition have shown. | YANG Lizhong LI Jian ZHAO Daoliang FANG Weifeng FAN Weicheng | 2004 | Science China(Technological Sciences)2004，47，5： | 7 |
| 12 | A New Granular Computing Model Based on Algebraic Structure显示文摘Granular computing is a very hot research field in computer science in recent years.This paper introduces a new granular computing model based on algebraic structure, in which the granule structure is assumed as a binary operator and the granulation is based on a congruence relation. Following the homomorphic consistency principle, the methods of granulation(granularity coarsening) and granularity combination(granularity refinement) are introduced, and the corresponding numerical examples show that these methods are efficient and applicable. These works have enriched the granular computing models from structure and provided theoretical basis for the combination of granular computing theory and algebraic theory. | CHEN Linshu WANG Jiayang WANG Weicheng LI Li | 2019 | Chinese Journal of Electronics2019，28，1： | 6 |
| 13 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 14 | Effect of ultrasonic micro-forging treatment on microstructure and mechanical properties of GH3039 superalloy processed by directed energy deposition显示文摘In this work,ultrasonic micro-forging treatment(UMFT)was introduced to achieve homogeneous microstructure,reduce defects and improve mechanical properties of GH3039 superalloy cladding layer processed by directed energy deposition(DED).The microstructure,defects and mechanical properties of the cladding layers treated by UMFT with different ultrasonic powers(UIPs)were investigated.Results revealed a gradient structure as equiaxed grains distributed at the top,a columnar-to-equiaxed transition(CET)region that mixed of columnar dendrites and equiaxed grains distributed at the middle and columnar dendrites at the bottom of the cladding layer was formed.After UMFT,the proportion of equiaxed grains was increased,the average size of equiaxed grains was refined to 10μm from 16μm,the orientation of grains was more uniform and the phases enriched of Al,Ti,C,Nb and Mo were precipitated.The grain refinement can be attributed to the fracture of columnar dendrites induced by the ultrasonic vibration during solidification.Besides,the porosity of the cladding layer was reduced after UMFT.The microhardness of the cladding layers exhibited a depth-dependent gradient at the top region.The microhardness of the top surface was the highest and showed an increasing trend with the increase of UIP.The microhardness of different grain morphologies exhibited no substantial difference.However,due to grain refinement and precipitation of strengthening phase induced by UMFT,the microhadness of some local locations were improved.These results indicated UMFT has a significant effect on improving the microstructure,defects and mechanical properties of the deposited cladding layer. | Qingqing Li Yong Zhang Jie Chen Bugao Guo Weicheng Wang Yuhai Jing Yong Liu | 2021 | Journal of Materials Science & Technology2021，，11： | 4 |
| 15 | Classification method of cultivated land based on UAV visible light remote sensing显示文摘The accurate acquisition of the grain crop planting area is a necessary condition for realizing precision agriculture.UAV remote sensing has the advantages of low cost use,simple operation,real-time acquisition of remote sensor images and high ground resolution.It is difficult to separate cultivated land from other terrain by using only a single feature,making it necessary to extract cultivated land by combining various features and hierarchical classification.In this study,the UAV platform was used to collect visible light remote sensing images of farmland to monitor and extract the area information,shape information and position information of farmland.Based on the vegetation index,texture information and shape information in the visible light band,the object-oriented method was used to study the best scheme for extracting cultivated land area.After repeated experiments,it has been determined that the segmentation scale 50 and the consolidation scale 90 are the most suitable segmentation parameters.Uncultivated crops and other features are separated by using the band information and texture information.The overall accuracy of this method is 86.40%and the Kappa coefficient is 0.80.The experimental results show that the UAV visible light remote sensing data can be used to classify and extract cultivated land with high precision.However,there are some cases where the finely divided plots are misleading,so further optimization and improvement are needed. | Weicheng Xu Yubin Lan Yuanhong Li Yangfan Luo Zhenyu He | 2019 | International Journal of Agricultural and Biological Engineering2019，12，3： | 3 |
| 16 | Helicobacter pylori antibody responses in association with eradication outcome and recurrence: a population-based intervention trial with 7.3-year follow-up in China显示文摘Objective:To identify serum biomarkers that may predict the short or long term outcomes of anti-Helicobacter pylori(H.pylori)treatment,a follow-up study was performed based on an intervention trial in Linqu County,China.Methods:A total of 529 subjects were selected randomly from 1,803 participants to evaluate total anti-H.pylori immunoglobulin G(Ig G)and 10 specific antibody levels before and after treatment at 1-,2-and 7.3-year.The outcomes of anti-H.pylori treatment were also parallelly assessed by 13C-urea breath test at 45-d after treatment and 7.3-year at the end of follow-up.Results:We found the medians of anti-H.pylori Ig G titers were consistently below cut-off value through 7.3years in eradicated group,however,the medians declined in recurrence group to 1.2 at 1-year after treatment and slightly increased to 2.0 at 7.3-year.While the medians were significantly higher(>3.0 at 2-and 7.3-year)among subjects who failed the eradication or received placebo.For specific antibody responses,baseline seropositivities of Fli D and Hpa A were reversely associated with eradication failure[for Fli D,odds ratio(OR)=0.44,95%confidence interval(95%CI):0.27–0.73;for Hpa A,OR=0.32,95%CI:0.17–0.60].The subjects with multiple positive specific antibodies at baseline were more likely to be successfully eradicated in a linear fashion(Ptrend=0.006).Conclusions:Our study suggested that total anti-H.pylori Ig G level may serve as a potential monitor of longterm impact on anti-H.pylori treatment,and priority for H.pylori treatment may be endowed to the subjects with multiple seropositive antibodies at baseline,especially for Fli D and Hap A. | Tianyi Wang Yang Zhang Huijuan Su Zhexuan Li Lian Zhang Junling Ma Weidong Liu Tong Zhou Weicheng You Kaifeng Pan | 2017 | Chinese Journal of Cancer Research2017，29，2： | 3 |
| 17 | Synthesis and Secondary Conformations of Homochiral β-Oligopeptides Containing Aryl Side Chains显示文摘 | ZHANG Yonghong LI Liangchun YUAN Weicheng ZHANG Xiaomei | 2015 | Chemical Research in Chinese Universities2015，31，3： | 2 |
| 18 | KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma显示文摘Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-p signaling and subsequently affecting the pathophysiological roles of TGF-p,including those in liver malignancy.KLF2,a member of the Kruppel-like factor(KLF)fam ily transcription factors,has been implicated in impeding hepatocellular carcinoma(HCC)development.However,the underlying molecular mechanisms are not fully understood.In the present study,we found that TGF-p stimulates the expression of KLF2 gene in several HCC cell lines.KLF2 protein is able to inhibit TGF-p/Smad signaling in HCC cells as assessed by luciferase reporter assay.Further studies indicated that KLF2 inhibits the transcriptional activity of Smad2/3 and Smad4 and ameliorates TGF-p-induced target gene expression,therefore creating a novel negative feedback loop in TGFp signaling.Functionally,stably expression of KLF2 in HCCLM3 cells attenuated TGF-卜induced cancer cell motility in wound-healing and transwell assays by interfering with TGF-p-mediated upregulation of MMP2.Together,our results revealed that KLF2 protein has a tumor-suppressive function in HCC through a negative feedback loop over TGF-p signaling. | Yining Li Shuo Tu Yi Zeng Cheng Zhang Tian Deng Weicheng Luo Lingyan Lian Ling Chen Xiangyang Xiong Xiaohua Yan | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 19 | Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis显示文摘 | Liu Weicheng Chen Yunzi Golan Maya Aharoni Annunziata Maria L Du Jie Dougherty Urszula Kong Juan Musch Mark Huang Yong Pekow Joel Zheng Changqing Bissonnette Marc Hanauer Stephen B Li Yan Chun | 2013 | Journal of Clinical Investigation2013，，9： | 2 |
| 20 | Efficient Implementation ofRFID Mutual Authentication Protocol 显示文摘 | Yujung Huang Weicheng Lin Hunglin Li | 2012 | IEEE TRANSACTIONS ONINDUSTRIAL ELECTRONICS2012，59，12： | 1 |
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