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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease 显示文摘 | Wehler T Wolferr F Schimanski C C | 2006 | Oncol Rep2006，16，6： | 1 |
| 3 | The communitychildhood hunger identification project: a model of domestichunger -demonstration project in Seattle, Washington 显示文摘 | Wehler C A Schott R I Anderson J J | 1992 | JNutr Edu1992，，24： | 1 |
| 4 | Calcium and vitamin D supplements reduce tooth loss in the elderly显示文摘 | Krall EA Wehler C Garcia RI | 2001 | Am J Med2001，111，6： | 1 |
| 5 | Does periodontal care improve glycemic control? The Department of Veterans Affairs Dental Diabetes Study显示文摘 | Jones JA Miller DR Wehler C J | 2007 | J Clin Periodontol2007，34，1： | 1 |
| 6 | Calcium and vitamin D supplements reduce tooth loss in the elderly显示文摘 | KRALL E A WEHLER C GARCIA R I | 2001 | Am J Med2001，111，6： | 1 |
| 7 | Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease显示文摘 | Wehler T Wolfert F Schimanski C C | 2006 | Oncol Rep2006，16，6： | 1 |
| 8 | Does periodontal care im- prove glycemic control the Department of Veterans Affairs Den- tal Diabetes Study 显示文摘 | Jones JA Miller DR Wehler C J | 2007 | J Clin Periodontol2007，34，1： | 1 |
| 9 | Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates wit h advanced disease 显示文摘 | Wehler TC Graf C Biesterfdd S | 2008 | J Oncol2008，10，1155： | 1 |
| 10 | Strong expression of chemokine receptor CXCRg by renal cell carcinoma correlates with advanced disease显示文摘 | Wehler TC Graf C Biester S | 2008 | Journal of On cology2008，10，1155： | 1 |
| 11 | Strong exprssion of chemokine receptor CXCR4 by renal cell carcinoma correlates with ad vaneed disease显示文摘 | Wehler T C Graf C Biester S | 2008 | J Oncol2008，10，1155： | 1 |
| 12 | Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease 显示文摘 | Wehler T C Graf C Biester S | 2008 | J Onco12008，10，1155： | 1 |
| 13 | Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis 显示文摘 | OSTERREICHER C H SCHULTHEISS J WEHLER M | 2007 | Mutagenesis2007，22，5： | 1 |
| 14 | Calcium and vitamin D supplements reduce tooth loss in the elderly显示文摘 | Krall EA Wehler C Garcia RI | 2001 | Am J Med2001，111，6： | 1 |
| 15 | Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls ( Aroclor 1254 ) 显示文摘 | Morse D C Wehler E K Wesseling W | 1996 | Toxicology and Applied Pharmacology1996，136，2： | 1 |
| 16 | Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease显示文摘 | WEHLER TC GRAF C BIESTERFELD S | | 0，，10： | 1 |
| 17 | Last line therapy with sorafenib in colorectal cancer: A retrospective analysis显示文摘AIM: To analyze the efficacy of last line sorafenib treatment in colorectal cancer patients. METHODS: All patients receiving chemotherapy for colorectal cancer in the outpatient clinic of the University of Mainz since 2006 were retrospectively analyzed for last line sorafenib exposure. Charts of identified patients were analyzed for clinic-pathological parameters, like data on gender, age, date of initial diagnosis, UICC stage, number and kind of the pretherapies, therapy start and end of sorafenib, sorafenib mediated treatment cessation, side effects, response rates, time to progression and overall survival. RESULTS: Ten patients with a median of 3.0 prior chemotherapy lines had received a last line sorafenib therapy either alone(10%) or in combination with 5-fluorouracil derivates(90%). All patients suffered from colorectal cancer stage UICC 4 and were routinely seen in 2-wk intervals in the oncology outpatient clinic. Median duration of treatment was 142.0 d. At 8 wk 80% of patients showed stable disease but we did not observe any remissions. Median time to progression was 140.5 d(4.7 mo), while median overall survival reached 176.5 d. One patient ceased treatment due to side effects. Reason for treatment stop was bleeding complication in one case and non-specified sorafenib intolerance in another case. Due to the retrospective approach we did not further quantify side effects.CONCLUSION: This retrospective analysis encourages further investigation of sorafenib in colorectal cancer last line therapy. | Ksenia Martchenko Irene Schmidtmann Thomas Thomaidis Verena Thole Peter R Galle Marc Becker Markus Mohler Thomas C Wehler Carl C Schimanski | 2016 | World Journal of Gastroenterology2016，22，23： | 0 |
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