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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy显示文摘瞄准:为在活体内评估一根最新发达的手持的共焦的探针在啮齿类动物的完全的胃肠道的显微镜的成像。方法:一根新奇僵硬共焦的探针(直径 7 公里) 为 fluorophore 刺激用 488 nm 单身者线激光在人为使用与类似于灵活 endomicroscopy 系统的光特征被设计。轻排放在 505 ~ 750 nm 被检测。看法的地多样地是 475 妈妈 475 妈妈。光片厚度是有 0.7 妈妈的侧面的分辨率的 7 妈妈。在不同深度(到 250 妈妈的表面) 的表面下的连续图象多样地在 1024 点在实时被产生由在轻轻的、稳定的接触把探查放到织物上的 1024 个象素(0.8 frames/s ) 。织物标本为组织病理学说的关联被取样。结果:食管,胃,小并且大肠和中央,肝,胰和胆囊是在在 n = 的高分辨率的视觉 ised 在活体内 48 个鼠标。有共焦的微型显微镜学探查的实时显微镜的成像是容易的完成。不同染色协议(荧光黄,吖啶黄,标记 FITC 的葡聚糖和 L。可食用嗯植物凝血素) 织物的每个加亮的特定的方面,和在活体内成像与常规组织学最优地相关。在活体内血流监视把功能的质量加到词法成像。结论:共焦的显微镜学是在甚至表面下的织物结构的高分辨率允许完全的官方补给的道的可视化的可行在活体内。在这研究评估的新共焦的探查设计与腹腔镜检查兼容并且显著地扩展可能的应用的地到 intra 腹的机关。它允许新在活体内染色和申请选择的立即的测试因此在病人从动物研究允许快速的转移到临床的使用。 | Martin Goetz Beena Memadathil Stefan Biesterfeld Constantin Schneider Sebastian Gregor Peter R Galle Markus F Neurath Ralf Kiesslich | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 4 | An open-label, multicentre biomarker-oriented AIO phase II trial of sunitinib for patients with chemo-refractory advanced gastric cancer显示文摘 | M. Moehler A. Mueller J.T. Hartmann M.P. Ebert S.E. Al-Batran P. Reimer M. Weihrauch F. Lordick T. Trarbach S. Biesterfeld M. Kabisch D. Wachtlin P.R. Galle | 2011 | European Journal of Cancer2011，，10： | 3 |
| 5 | Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy显示文摘 | A. Hoffman C. Kagel M. Goetz A. Tresch J. Mudter S. Biesterfeld P.R. Galle M.F. Neurath R. Kiesslich | 2009 | Digestive and Liver Disease2009，，1： | 2 |
| 6 | Recognition and characterization of small colonic neoplasia with high-definition colonoscopy using i-Scan is as precise as chromoendoscopy显示文摘 | A. Hoffman C. Kagel M. Goetz A. Tresch J. Mudter S. Biesterfeld P.R. Galle M.F. Neurath R. Kiesslich | 2009 | Digestive and Liver Disease2009，，1： | 1 |
| 7 | SHOX2 DNA methylation is a tumour marker in pleural effusions显示文摘 | ILSE P BIESTERFELD S POMJANSKI N | 2013 | Cancer Genomics Proteomics2013，10，5： | 1 |
| 8 | Long-term follow-up and prognostic significance of angiogenic basic fibroblast growth factor (bFGF) expression in patients with breast cancer显示文摘 | Faridi A Rudlowski C Biesterfeld S | 2002 | Pathol Res Pract2002，198，1： | 1 |
| 9 | Quantification of denitrification potential in carbonaceous trickling filters 显示文摘 | Sidney Biesterfeld Greg Farmer Linda Figueroa | 2003 | Water Research2003，37，16： | 1 |
| 10 | High-definition endoscopy with i-Scan and Lugol’s solution for more precise detection of mucosal breaks in patients with reflux symptoms显示文摘 | A. Hoffman N. Basting M. Goetz A. Tresch J. Mudter S. Biesterfeld P. Galle M. Neurath R. Kiesslich | 2009 | Endoscopy2009，，02： | 1 |
| 11 | Comparative studies on the biological significance of the marker forproliferation Ki-67-antigen and PCNA in primary ovarian carcinoma显示文摘 | Rudlowski C Biesterfeld S | 2000 | Zentralbl Gynakol2000，122，： | 1 |
| 12 | Long-term follow-up and prog- nosis significance of angiogenic basic fibroblast growth factor (bFGF)ex- pression in patients with breast cancer 显示文摘 | Faridi A Rudlowski C Biesterfeld S | 2002 | Pathol Res Pract2002，198，1： | 1 |
| 13 | Comparative studies on the biological significance of the marker for proliferation ki-67-antigen and PCNA in primary ovarian carcinoma显示文摘 | Reitmaier M Rudlowski C Biesterfeld S | 2000 | Zentralbl Cynakol2000，122，3： | 1 |
| 14 | Quantification of denitrification potential in carbonaceous trickling filters 显示文摘 | Sidney Biesterfeld Greg Farmer Linda Figueroa | 2003 | Water Research2003，37，16： | 1 |
| 15 | Quantifica- tion of denitrification potential in carbonaceous trickling filters显示文摘 | Biesterfeld S Farmer G Figueroa L | 2003 | Water Research2003，37，16： | 1 |
| 16 | Association of polymorphisms of the transforming growth factor beta1 gene with the rate of progression of HCV-induced liver fibrosis显示文摘 | Gewaltig J Mangasser-Stephan K Gartung C Biesterfeld S Gressner A M | 2002 | Clin Chim Acta2002，316，12： | 1 |
| 17 | Polyploidy in non - neoplastic tissue显示文摘 | Biesterfeld S Gerres K | 1994 | Clin Pathol1994，47，： | 1 |
| 18 | Comparative studies on the biological significance of the marker for proliferation Ki-67-antigen and PCNA in primary ovarian carcinoma显示文摘 | Reitmaier M Rudlowski C Biesterfeld S | 2000 | Zentralbl Cynakol2000，122，3： | 1 |
| 19 | Diagnosis of bronchial carcinoma on sections of paraffin-embedded sputum: sensitivity and specificity of an alternative to routine eytology 显示文摘 | Bocking A Biesterfeld S Chatelain R | 1992 | Acta Cytol1992，36，1： | 1 |
| 20 | Expression of CD44(v5-10) splicing variants in primary ovarian cancer and lymph node metastases显示文摘 | Schroder W Rudlowski C Biesterfeld S | 1999 | J Anticancer Res1999，19，5： | 1 |
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