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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Student learning with concept mapping of care plans in community-based education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 3 | Prediction of radiative transfer in aluminum-recycling furnace 显示文摘 | SOLOVJOV V P WEBB B M | 2005 | Journal of the Institute of Energy2005，78，1： | 1 |
| 4 | Poly(acrylate/siloxane) hybrid adhesives for polymers with low surface energy显示文摘 | Sonnenschein M F Webb S P Wendt B L | 2008 | International Journal of Adhesion & Adhesives2008，28，3： | 1 |
| 5 | Student Learning with Concept Mapping of Care Plans in Community-Based Education显示文摘 | Hinck S M Webb P Sims-Giddens S | 2006 | J Prof Nurs2006，22，1： | 1 |
| 6 | A Prospective Randomised Comparison of the DHS and Gamma Locking Nail 显示文摘 | Radford P J Needoff M Webb J K A | 1993 | J Bone Joint Surg(Br)1993，75，： | 1 |
| 7 | A comparison of formulations for the vector finite element analysis of waveguides显示文摘 | DILLON B M WEBB J P | 1991 | Trans Microwave Theory and Tech1991，42，2： | 1 |
| 8 | Isolation of a eDNA clone and localization of the human glutathione S - transferase 3 genes to chromosome bands llq13 and 12q13 -14显示文摘 | BOARD P G WEBB G C COGGAN M | 1989 | Ann Hum Genet1989，53，3： | 1 |
| 9 | Shivering during epidural analgesia in women in labor显示文摘 | Webb P J James F M Wheeler A S | | 0，，06： | 1 |
| 10 | Isolation of ac DNA clone and localization of the human glutathione S transferase 3 genes to chromosome bands 11q13 and 12q13 14显示文摘 | Borad P G Webb G C Coggan M | 1989 | Ann Hum Genet1989，33，3： | 1 |
| 11 | Isolation of a Cdna clone and localization of the human glutathione Stransferase 3 genes to chromosome bands llq13 and 12q 12-14显示文摘 | Board P G Webb G3 C Coggan M | 1989 | Aum Genet1989，53，： | 1 |
| 12 | Morhpological comparison of Machupo with lymphocytic choriomeningitis vires : basis for a new taxonomic group显示文摘 | Murphy F A Webb P A Johnson K M | 1969 | J Virol1969，4，： | 1 |
| 13 | Site-Specific Fertilizer Recommendations for Oil Palm Smallholders Using Information From Large Plantations显示文摘 | Webb M J Nelson P N Rogers L G | 2011 | Journal of Plant Nutrition and Soil Science2011，174，2： | 1 |
| 14 | The influence of terminal sire genetype,sex,slaughter weight,feeding regime and slaughter-house on growth performance and carcass and meat quality in pigs and on organoleptic properties of fresh pork 显示文摘 | Ellis M Webb A J Avery P J | 1996 | Journal of Animal Science1996，62，3： | 1 |
| 15 | Signaling pathways in ras-mediated tumorigenicity and metastasis 显示文摘 | WEBB C P VAN AELST L WIGLER M H | 1998 | Proc Natl Acad Sci1998，95，15： | 1 |
| 16 | A prospective randomized comparison of the dynamic hip screw and the Gamma locking nail显示文摘 | Radford P J Needoff M Webb J K | 1993 | J Bone Joint Surg Br1993，75，5： | 1 |
| 17 | Membrane destabilization during freeze-induced dehydration显示文摘 | Steponkus P L Uemura M Webb M S | 1993 | Curr Topics Plant Physiol1993，，10： | 1 |
| 18 | Me-thionine-ontaining peptides can be used as nine sources for protein accretion in culttured methicr C 12 and MAC-T cells 显示文摘 | Pan Y Bender P K Akers R M Webb K E | 1996 | Journal of Nutrition1996，126，10： | 1 |
| 19 | Effects of immunization with somatostatin on growth and arterio-venous differences of metabolites across muscle tissue of growing lambs 显示文摘 | Webb M M S McDowell G H Gooden J M Hoskinson R M Wynn P C | 1986 | Prod Nutr Soc Aust1986，11，： | 1 |
| 20 | A prospective randomised comparison of the dynamic hip screw and the Gamma locking nail显示文摘 | Radford P J Needoff M Webb J K | 1993 | J Bone Joint Surg Br1993，75，： | 1 |
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