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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | In vitro absorption of amino acids by the smallintestine of sheep显示文摘 | Phillips W A Webb K E Fontenot J P | 1976 | Journal of Animal Science1976，42，： | 1 |
| 3 | Long-term evaluation of phosphorus and zinc interactions in corn 显示文摘 | Mallarino A P Webb J R | 1995 | Journal of Production Agriculture1995，8，1： | 1 |
| 4 | Meat quality of designated South African indigenous goat and sheep breeds 显示文摘 | Tshabalala P A Strydom P E Webb E C | 2003 | Meat Science2003，65，： | 1 |
| 5 | Building Corporate Associations:Consumer Attributions for Corporate Socially Responsible Programs 显示文摘 | Ellen P S Webb D J Mohr L A | 2006 | Journal of the Academy of Marketing Science2006，34，2： | 1 |
| 6 | A Prospective Randomised Comparison of the DHS and Gamma Locking Nail 显示文摘 | Radford P J Needoff M Webb J K A | 1993 | J Bone Joint Surg(Br)1993，75，： | 1 |
| 7 | Attenuation of solar radiation by a water mist from the ultraviolet to the infrared range 显示文摘 | DOMBROVSKY L A SOLOVJOV V P WEBB B W | 2011 | Journal of Quantitative Spectroscopy &Radiative Transfer2011，112，7： | 1 |
| 8 | Shivering during epidural analgesia in women in labor显示文摘 | Webb P J James F M Wheeler A S | | 0，，06： | 1 |
| 9 | Morhpological comparison of Machupo with lymphocytic choriomeningitis vires : basis for a new taxonomic group显示文摘 | Murphy F A Webb P A Johnson K M | 1969 | J Virol1969，4，： | 1 |
| 10 | Nueleotide sequence of human monocyte interleukin 1 precursor cDNA Proc Natl Acad Sci USA显示文摘 | AURON P E WEBB A C ROSENWASSER L J | 2007 | J Immunol2007，178，9： | 1 |
| 11 | The influence of terminal sire genetype,sex,slaughter weight,feeding regime and slaughter-house on growth performance and carcass and meat quality in pigs and on organoleptic properties of fresh pork 显示文摘 | Ellis M Webb A J Avery P J | 1996 | Journal of Animal Science1996，62，3： | 1 |
| 12 | Dose and dura- tion of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve in- jury in the rat显示文摘 | Kemp S W P Webb A A Dhaliwal S etal | 2011 | Experimental Neurology2011，229，2： | 1 |
| 13 | Measurement of small forces using an optical trap显示文摘 | Lucien P Ghislain Neil A Switz Watt W Webb | 1994 | American Institute of Physics1994，65，9： | 1 |
| 14 | Building corporate associa?tions: consumer attributions for corporate socially responsi?ble programs显示文摘 | Ellen P S Webb DJ Mohr L A | 2006 | Journal of the Academy of Marketing Sci?ence2006，34，2： | 1 |
| 15 | All optical loop mirror switch employing an asymmetric amplifier/attenuator combination 显示文摘 | ONEILL A W WEBB R P | 1990 | Electron Lett1990，26，24： | 1 |
| 16 | Sedation for pediatric 'dental patients 显示文摘 | WEBB M D MOORE P A | 2002 | Dent Clin North Am2002，46，4： | 1 |
| 17 | Claudins play a rele in normal and tumor cell motility显示文摘 | Webb P G SpiUman M A Baumgartner H K | 2013 | BMC Cell Biol2013，14，： | 1 |
| 18 | Land use dynamics and landscape change pattern in a mountain watershed in Nepal显示文摘 | Ambika P Gautam Edward L Webb Ganesh P Shivakoti Michael A Zoebisch | 2003 | Agriculture Ecosystems and Environment2003，，1： | 1 |
| 19 | Signaling pathways in Ras-mediated tumorigenicity and metastasis显示文摘 | Webb C P Van A L Wigler M H | 1998 | Proc Natl Acad Sci USA1998，95，15： | 1 |
| 20 | Charitable Programs and the Retailer: Do They Mix? 显示文摘 | Ellen P S Mohr L A Webb D J | 2000 | Journal of Retailing2000，76，3： | 1 |
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