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| 1 | TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells(mESCs)显示文摘Transient receptor potential canonical subfamily member 3(TRPC3) is known to be important for neural development and the formation of neuronal networks. Here, we investigated the role of TRPC3 in undifferentiated mouse embryonic stem cells(mESCs) and during the differentiation of mESCs into neurons. CRISPR/Cas9-mediated knockout(KO) of TRPC3 induced apoptosis and the disruption of mitochondrial membrane potential both in undifferentiated mESCs and in those undergoing neural differentiation. In addition, TRPC3 KO impaired the pluripotency of mESCs. TRPC3 KO also dramatically repressed the neural differentiation of mESCs by inhibiting the expression of markers for neural progenitors, neurons, astrocytes and oligodendrocytes.Taken together, our new data demonstrate an important function of TRPC3 with regards to the survival, pluripotency and neural differentiation of mESCs. | Helen Baixia Hao Sarah E. Webb Jianbo Yue Marc Moreau Catherine Leclerc Andrew L. Miller | 2018 | Science China(Life Sciences)2018，61，3： | 3 |
| 2 | Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution显示文摘 | LaDeana W Hillie Webb Miller Ewan Bimey | 2004 | Nature2004，432，7018： | 1 |
| 3 | Gene expression profiling of leukemic cells and primary thymocytes predicts a signature for apoptotic sensitivity to glucocorticoids显示文摘 | Miller AL Komak S Webb MS | 2007 | Cancer Cell Int2007，7，1： | 1 |
| 4 | Phylogenetic dispersion of host use in a tropical insect herbivore community 显示文摘 | Wei bien G D Webb CO Novotny V Basset Y Miller S E | 2006 | Ecology2006，87，： | 1 |
| 5 | Retrospective on the development of aequorin and aequorin-based imaging to visualize changes in intracellular free 显示文摘 | WEBB S E KARPLUS E MILLER A L | 2015 | MolReprod Dev2015，82，78： | 1 |
| 6 | p38 Mitogen-activated protein kinase(MAPK)is a key mediator in glucocorticoidinduced apoptosis of lymphoid cells:correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211显示文摘 | Miller AL Webb MS Copik AJ | 2005 | Mol Endocrinol2005，19，6： | 1 |
| 7 | Institutional polycentrism, entrepre- neurs' social networks, and new venture growth 显示文摘 | Batjargal B Hitt M A Tsui A S Arregle J L Webb J W Miller T L | 2013 | The Academy of Management Journal2013，56，4： | 1 |
| 8 | Position-specific and clumped stable isotope studies: Comparison of the Urey and Path-Integral Approaches for carbon dioxide, nitrous oxide, methane, and propane显示文摘 | Webb M A Miller T F | 2014 | The Journal of Physical Chemistry A2014，118，： | 1 |
| 9 | p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specifi c phosphorylation of the human glucocorticoid receptor at serine 211 显示文摘 | Miller AL Webb MS Copik AJ | 2005 | Mol Endocrinol2005，19，： | 1 |
| 10 | Crystal and Molecular Structures of Some Metal Tetraphenylporphines 显示文摘 | FLEISHER E B MILLER C K WEBB L E | 1964 | J Am Chem SOc1964，86，12： | 1 |
| 11 | Tumor Necrosis Factor-alpha: A Mediator of Focal Ischemic Brain Injury显示文摘 | F.C. Barone B. Arvin R.F. White A. Miller C.L. Webb NA Willette P.G. Lysko G.Z. Feuerstein | 1997 | Stroke A Journal of Cerebral Circulation1997，，6： | 1 |
| 12 | Tumor Necrosis Factor-alpha: A Mediator of Focal Ischemic Brain Injury显示文摘 | F.C. Barone B. Arvin R.F. White A. Miller C.L. Webb NA Willette P.G. Lysko G.Z. Feuerstein | 1997 | Stroke A Journal of Cerebral Circulation1997，，6： | 1 |
| 13 | Comparison of genomic DNA sequences:solved and unsolved problems显示文摘 | Webb Miller | 2001 | Bioinformatics2001，17，5： | 1 |
| 14 | Activation function 1 of glucocorticoid receptor binds TATA-binding protein in vitro and in vivo显示文摘 | Copik A J Webb M S Miller A L | 2006 | Molecular Endocrinology2006，20，： | 1 |
| 15 | 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial显示文摘 | Michael J Mack Martin B Leon Craig R Smith D Craig Miller Jeffrey W Moses E Murat Tuzcu John G Webb Pamela S Douglas William N Anderson Eugene H Blackstone Susheel K Kodali Raj R Makkar Gregory P Fontana Samir Kapadia Joseph Bavaria Rebecca T Hahn Vinod H | 2015 | The Lancet . 2015 (9986)2015，，： | 1 |
| 16 | Activation function 1 of glucocorticoid receptor binds TATAbinding protein in vitro and in vivo显示文摘 | Copik A J Webb M S Miller A L | 2006 | Molecular Endocrinology2006，20，： | 1 |
| 17 | p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocortieoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activa- tion and site-specific phosphorylation of the human glucocorticoid re- ceptor at serine 211 显示文摘 | Miller A L Webb M S Copik A J | 2005 | Mol Endocrinol2005，19，： | 1 |
| 18 | p38 mitogen - activated protein kinase (MAPK) is a key mediator in glucocorticoid - Induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site - specific phosphorylation of the human glucocorticoid receptor at serine 211 显示文摘 | Aaron L Miller M Webb S | 2005 | Mol Endocrinol2005，19，6： | 1 |
| 19 | Family Ties in Entrepreneurs’ Social Networks and New Venture Growth显示文摘 | Jean‐Luc Arregle Bat Batjargal Michael A. Hitt Justin W. Webb Toyah Miller Anne S. Tsui | 2015 | Entrepreneurship Theory and Practice2015，，2： | 1 |
| 20 | p38 Mitogen-activated protein ki?nase (MAPK) is a key mediator in glucocorticoid-in?duced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211显示文摘 | Miller A L Webb M S Copik AJ Wang Yv Iohnson B H Kumar R et a1 | 2005 | Mol Endocrinol2005，19，： | 1 |
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