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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Charitable programs and the retailer: do they mix?显示文摘 | Pam Scholder Ellen Lois A Mohr Deborah J Webb | 2000 | Journal of Retailing2000，，： | 2 |
| 3 | Emergency thoracnscopy:a logical approach to chest trauma management显示文摘 | Kitahama A Webb WR | 1981 | J Trauma1981，21，： | 1 |
| 4 | How Functional, Psychological, and Social Relationship Benefits Influence Individual and Firm Commitment to the Relationship显示文摘 | JILLIAN SWEENEY DAVID A WEBB | 2007 | Journal of Business & Industrial Marketing2007，22，7： | 1 |
| 5 | Combined distributed temperature and strain sensor based on Brillouin loss in an optical fiber 显示文摘 | BAO X WEBB D J JACKSON D A | 1994 | Opt Lett1994，19，2： | 1 |
| 6 | BCL-2 antisense therapy in patients with non-Hodgkin lymphoma 显示文摘 | Webb A Cunningham D Cotter F | 1997 | lancet1997，349，9059： | 1 |
| 7 | Environmental fate of triclosan in the River Aire Basin, UK 显示文摘 | Sabaliunas D Webb S F Hauk A | 2003 | WaterResearch2003，37，13： | 1 |
| 8 | A computerized acoustical larval detection system 显示文摘 | WEBB J C LITZKOW C A SLAUGHTER D C | 1988 | Applied Engineering in Agriculture1988，4，3： | 1 |
| 9 | A novel protein tightly bound to bacterial magnetic particles in Magnetospirillum mag- neticum strain AMB- 1 显示文摘 | Arakaki A Webb J Matsunaga T | 2003 | The Journal of biological chemis- try2003，278，10： | 1 |
| 10 | Selective NMDA NR2B antagonists induce antinociception without motor dysfunc- tion: correlation with restricted localisation of NR2B subu- nit in dorsal horn 显示文摘 | Boyce S Wyatt A Webb JK | 1999 | Neuropharmacology1999，38，5： | 1 |
| 11 | Recovery of hypopituitarism after neurosurgical treatment of pituitary adenomas 显示文摘 | Webb SM Rigla M Wagner A | 1999 | J Clin En- docrinol Metab1999，84，10： | 1 |
| 12 | A novel protein tightly bound to bacterial magnetic particles in Magnetospirillum magneticum strain AMB-1显示文摘 | Arakaki A Webb J Matsunaga T | | 0，，10： | 1 |
| 13 | In vitro absorption of amino acids by the smallintestine of sheep显示文摘 | Phillips W A Webb K E Fontenot J P | 1976 | Journal of Animal Science1976，42，： | 1 |
| 14 | Cell migration at a glance显示文摘 | Vicente-Manzanares M Webb D J Horwitz A R | 2005 | J Cell Sci2005，118，21： | 1 |
| 15 | Long-term evaluation of phosphorus and zinc interactions in corn 显示文摘 | Mallarino A P Webb J R | 1995 | Journal of Production Agriculture1995，8，1： | 1 |
| 16 | Sound detection of stored-product insects that feed inside kernels of grain 显示文摘 | VICK K M WEBB J C WEABER B A | 1988 | Journal of Economic Entomology1988，81，5： | 1 |
| 17 | Potent im- munogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essentialand induces differential modulation of lymphocyte sub- sets显示文摘 | Nashar T O Webb S Eaglestone N A | 1996 | Proc Natl Acad Sci USA1996，9，1： | 1 |
| 18 | Mastitis duct extension and plasma cell mastitis显示文摘 | WEBB A J | | 0，，05： | 1 |
| 19 | Boardinvited review: peptide absorption and utilization: implications for animal nutrition and health 显示文摘 | GILBERT E R WONG E A WEBB K E Jr | 2008 | Journal of Animal Science2008，86，9： | 1 |
| 20 | Rhythms in pineal immunoreactive somatostatin in the Syrian hamster, mouse and gerbil 显示文摘 | Webb S M Peinado M A Puig-Domingo M | 1988 | J Pineal Res1988，5，3： | 1 |
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