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| 1 | Cardiac remodeling and physical training post myocardial infarction显示文摘After myocardial infarction(MI), the heart undergoes extensive myocardial remodeling through the accumulation of fibrous tissue in both the infarcted and noninfarcted myocardium, which distorts tissue structure, increases tissue stiffness, and accounts for ventricular dysfunction. There is growing clinical consensus that exercise training may beneficially alter the course of post-MI myocardial remodeling and improve cardiac function. This review summarizes the present state of knowledge regarding the effect of post-MI exercise training on infarcted hearts. Due to the degree of difficulty to study a viable human heart at both protein and molecular levels, most of the detailed studies have been performed by using animal models. Although there are some negative reports indicating that post-MI exercise may further cause deterioration of the wounded hearts, a growing body of research from both human and animal experiments demonstrates that post-MI exercise may beneficially alter the course of wound healing and improve cardiac function. Furthermore, the improved function is likely due to exercise training-induced mitigation of reninangiotensin-aldosterone system, improved balance between matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1, favorable myosin heavy chain isoform switch, diminished oxidative stress, enhanced antioxidant capacity, improved mitochondrial calcium handling, and boosted myocardial angiogenesis. Additionally, meta-analyses revealed that exercise-based cardiac rehabilitation has proven to be effective, and remains one of the least expensive therapies for both the prevention and treatment of cardiovascular disease, and prevents re-infarction. | Michael A Garza Emily A Wason John Q Zhang | 2015 | World Journal of Cardiology2015，7，2： | 28 |
| 2 | Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice显示文摘Objective: To evaluate the insulin sensitivity action of ferulic acid(FA) in skeletal muscle and hypothalamus of high-fat diet(HFD)-induced obese mice. Methods: Obese mouse model was induced by HFD(45 kcal% lard fat) for 16 weeks. After 8 weeks of HFD feeding, these obese mice were orally treated with FA at doses of 25 and 50 mg/kg/day for 8 weeks. At the end of all treatments, the epididymal fat, pancreas, skeletal muscle and hypothalamus were removed for biochemical parameter and protein expression examinations. Results: FA treatment significantly decreased leptin level in fat tissue and insulin level in pancreas(P < 0.05). Interestingly, obese mice treated with FA increased the protein expressions of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and phosphorylated-protein kinase B in both muscle and brain(P < 0.05). The phosphorylations of adenosine monophosphate-activated protein kinase and acetyl-CoA carboxylase in muscle, and leptin receptor protein in hypothalamus were also increased(P < 0.05). The pancreatic islets histology showed smaller size in obese mice treated with FA compared to untreated obese mice. Conclusions: These findings indicate the beneficial effect of FA in improving insulin resistance in HFD-induced obese mice. These effects are probably mediated via modulating the insulin receptor substrate/phosphatidylinositol 3-kinase/protein kinase B or adenosine monophosphate-activated protein kinase pathways. | Jarinyaporn Naowaboot Pritsana Piyabhan Pholawat Tingpej Narongsuk Munkong Wason Parklak Patchareewan Pannangpetch | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，12： | 2 |
| 3 | Case--based Reasoning is a Methodology not a Technology显示文摘 | Wason I | 1999 | Knowledge--based Systems1999，12，56： | 1 |
| 4 | The processing of positive and negative information显示文摘 | Wason P C | 1959 | Quarterly Journal of Experimental Psychology1959，11，： | 1 |
| 5 | On the failure to eliminate hypotheses in a conceptual task 显示文摘 | WASON P C | 1960 | Quarterly Journal of Experimental Psychology1960，，12： | 1 |
| 6 | Reasoning about a rule显示文摘 | Wason P C | 1968 | Quarterly Journal of Experimental Psychology1968，20，： | 1 |
| 7 | Natural and contrived experience ina reasoning problem显示文摘 | Wason P C Shapiro D | 1971 | Quarterly Journal of Experimental Psychology1971，23，： | 1 |
| 8 | Superwarfarin poisoning显示文摘 | Katona B Wason S | 1989 | J Emerg Med1989，7，： | 1 |
| 9 | Wavelength assignment algorithms for WDM optical networks显示文摘 | WASON A KALER R S | 2011 | International Journal for Light and Electron Optics2011，122，10： | 1 |
| 10 | Comparison of deep lamellar keratoplasty and penetrating keratoplasty in patients with keratoeonus 显示文摘 | Wason SL Ramysay A Dart JKG | 2004 | Ophthalmology2004，111，： | 1 |
| 11 | Epithelial regeneration after limbus- to- limbus debridement expression of alpha- enolase in stem and transient amplifying cells显示文摘 | Chun E Degregorio PG Wason M | 1995 | Invest Ophthalmol Vis Sci1995，36，： | 1 |
| 12 | Using physiologically-based pharmacokinetic models to incorporate chemical and non-chemical stressors into cumulative risk assessment: a case study of pesticide exposures显示文摘 | WASON S C SMITH T J PERRY M J | 2012 | International Journal of Environmental Research and Public Health2012，9，5： | 1 |
| 13 | Fluo- roscopy-guided pereutaneous renal aceess显示文摘 | Steinberg P L Semtns M J Wason S E | 2009 | J Endou- rol2009，23，10： | 1 |
| 14 | Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study显示文摘 | CJ Hawkey Z Tulassay L Szczepanski CJ van Rensburg A Filipowicz-Sosnowska A Lanas CM Wason RA Peacock KRW Gillon | 1998 | 1998 (9133)1998，，9133： | 1 |
| 15 | Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects 显示文摘 | Graham TE Wason CJ Blfiher M | 2007 | Diabetologia2007，50，4： | 1 |
| 16 | Conservative management of screen- detected radial scars: role of mammotome excision显示文摘 | Rajah S Wason AM Carder PJ | 2011 | J Clin Pathol2011，64，1： | 1 |
| 17 | Atrial L-type Ca^2+ currents and human atrial fibrillation显示文摘 | van Wasoner DR Pond AL Lamorgese M | 1999 | Circ Res1999，85，： | 1 |
| 18 | Single high-dose pyridoxine treatment for isoniazide overdose显示文摘 | Wason S Laeouture PG Lovejoy FH | 1981 | JAMA1981，246，： | 1 |
| 19 | On the failure to eliminate hypotheses in a conceptual task 显示文摘 | WASON P C | 1960 | Quarterly Journal of Experimental Psychology1960，，12： | 1 |
| 20 | Reasoning about a rule显示文摘 | Wason P.C | | 0，，： | 1 |
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