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| 1 | Lipid Distribution in Marine Sediments from the Northern South China Sea and Association with Gas Hydrate显示文摘The distributions of lipids in surface and subsurface sediments from the northern South China Sea were determined. The n-alkanes were in bimodal distribution that is characterized by a centre at n-C16 –n-C20 with maximum at C18(or C19) and n-C27 –n-C31 as well as at C29(or C31). The short-chain alkanes suffered from significant losses due to their slow deposition in the water column, and their presence with a slight even carbon predominance in shallow seafloor sediments was ascribed mainly to the direct input from the benthos. The long-chain alkanes with odd predominance indicate transportion of terrigenous organic matter. Immature hopanoid biomarkers reflect the intense microbial activity for bacteria–derived organic matter and the gradual increase of maturity with burial depth. Abundant n-fatty acid methyl esters(n-FAMEs) that are in distributions coincident with fatty acids were detected in all samples. We proposed that the observed FAMEs originated from the methyl esterification of fatty acids; methanol production by methanotrophs and methanogenic archaea related to the anaerobic oxidation of methane, and sulfate reduction provided an O–methyl donor for methylation of fatty acids. The CH4 released from hydrate dissociation at oxygen isotope stage II of Cores ZD3 and ZS5, which had been confirmed by the occurrence of negative δ13C excursion and spherical pyrite aggregates, could have accelerated the above process and thus maximized the relative content of FAMEs at ZD3-2(400–420 cm depth) and ZS5-2(241–291 cm depth). | OU Wenjia LEI Huaiyan LU Wanjun ZHANG Jie SHI Chunxiao GONG Chujun HAN Chao | 2014 | Acta Geologica Sinica(English Edition)2014，88，1： | 4 |
| 2 | Simulation of the Accumulation Process of Biogenic Gas Hydrates in the Shenhu Area of Northern South China Sea显示文摘Objective Previous work has largely discussed the relations between sediment structures and accumulation of gas hydrates in the Shenhu area of South China Sea,but has not documented why the gas hydrates occurred at the seafloor topographic highs.Many gas hydrate exploration examples abroad also indicate that the saturation of | LIAO Jing GONG Jianming Lü Wanjun WU Nengyou YUE Baojing LUAN Xiwu HU Gaowei | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 3 |
| 3 | Fe-porphyrin:A redox-related biosensor of hydrogen molecule显示文摘Hydrogen molecule(H_(2))exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases,but its molecular mechanism is unclear and its targeting molecule is unknown so far.Herein,we originally reveal that Fe-porphyrin is a H_(2)-targeted molecule.We have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H_(2)to catalytically scavenge∙OH,and can also catalytically hydrogenate to reduce CO_(2)into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor,confirming that Fe-porphyrin is a redox-related biosensor of H_(2)and H_(2)is an upstream signaling molecule of CO.These discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2,and helpful for development of innovative drugs and hydrogen energy/agricultural materials. | Zhaokui Jin Penghe Zhao Wanjun Gong Wenjiang Ding Qianjun He | 2023 | Nano Research2023，16，2： | 1 |
| 4 | Pd-Catalyzed Ortho-Directed C-H Glycosylation of Arenes Using N-linked Bidentate Auxiliaries显示文摘Main observation and conclusion A set of Pd-catalyzed ortho-directed C-H glycosylation reactions with glycosyl chloride donors using various N-linked bidentate auxil-iaries has been developed for synthesis of C-aryglycosides.A broad range of pyranose and furanose moieties can be installed on the ortho position of arylamine,carbazole,indole and benzylamine type substrates in high yield and with high regio-and diastereoselec-tivity.These auxiliaries can be readily installed and removed under relatively mild conditions. | Quanquan Wang Wanjun Zhu Qikai Sun Gang He Gong Chen | 2021 | Chinese Journal of Chemistry2021，39，3： | 1 |
| 5 | CDK1、CDK2 siRNA干扰对肿瘤细胞凋亡和细胞周期的影响(英文)显示文摘Objective:We investigated the influence of CDK1 and CDK2 expression inhibited by cotransfection of CDK1 and CDK2 siRNA on cell cycle and apoptosis,explored the exact role of cell cycle master regulator in tumor cell apoptosis process.Methods:The siRNA targeting the CDK1 and CDK2 genes were synthesized and simultaneously cotransfected into Hela cells by lipofectamine 2000.48 or 60 h after the cotransfection,CDK1 and CDK2 protein expressions were examined by Western blot.Cell cycle distribution was analyzed by flow cytometry.Cell apoptosis was detected by the Annexin V/PI method.The changes of the transfected cell morphological under a microscope after Wright-Giemsa Staining were studied.Results:CDK1 and CDK2 protein expression was decreased at 48 or 60 h after cotransfection.The accumulation of the G2/M and S phase population in cell cycle of the cotransfected cells at 48 or 60 h after transfection was enhanced obviously compared with control.The ratio of apoptotic cell of cotransfected cells at 48 or 60 h after transfection was increased significantly compared with control.More binucleate or multinucleate cells among cotransfected cells were observed under the microscope.Conclusion:The decreased expression of CDK1 and CDK2 by cotransfection of CDK1 and CDK2 siRNA not only leads to tumor cell cycle arrest in S phase and G2/M phase,but also induces tumor cell apoptosis. | Hui Xiao Wanjun Gong Jingpeng Cao Xiaolan Li Deding Tao Junbo Hu Jianping Gong | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，7： | 1 |
| 6 | A nano- sized solid acid synthesized from rice hull ash for biodiesel production显示文摘 | Zeng Danlin Liu Shenglan Gong Wanjun | 2014 | RSC Adv2014，4，20： | 1 |
| 7 | ASBase:The universal database for aggregate science显示文摘This paper reports the first universal and versatile database on aggregate materials for the field of aggregate science research.At the current stage,the database(http://gffzzf21103ad36c048aah0qkovo6c69wu6f59.ffgz.tsg.suse.edu.cn/)contains over 1000 entries of organic aggregate material systems(mainly luminescent systems at the current stage)with a unique data structure which is designed particularly for aggregate materials and containing the photophysics and physicochemical properties of the compounds in different statuses of aggregation,including dilute solution form,pristine solid-state,stable crystalline,and nanoaggregates formed in solvents.The web-based interface of the database provided functions to index,search,manipulate,fetch and deposit data entries.In addition,a background calculation service optimizes the chemical structure of new entries on different levels of accuracies.The database also provided background API for interactive developments of prediction or regression models based on machine-learning algorithms. | Junyi Gong Wanjun Gong BoWu Haoran Wang Wei He Zhongyang Dai Yangzhong Li Yong Liu Zhiming Wang Xiaojun Tuo Jacky W.Y.Lam Zijie Qiu Zheng Zhao Ben Zhong Tang | 2023 | Aggregate2023，4，1： | 0 |
| 8 | Synthesis of 2-Deoxy-C-Glycosides via Iridium-Catalyzed sp^(2)and sp^(3)C-H Glycosylation with Unfunctionalized Glycals显示文摘A new protocol for the synthesis of 2-deoxy-C-aryl-glycosides and 2-deoxy-C-alkyl-glycosides via iridium-catalyzed directed C—H glycosylation with glycals is reported.The method is amenable for both the C_(2)C—H glycosylation of indoles and the methyl C—H glycosylation of secondary methyl amines under the control of an N-linked benzoxazole directing group.The benzoxazole group can be cleanly removed by the treatment of KOH or LiAlH_(4). | Wanjun Zhu Qikai Sun Hai Chang Hui-Xing Zhang Quanquan Wang Gong Chen Gang He | 2022 | Chinese Journal of Chemistry2022，40，5： | 0 |
| 9 | Total Synthesis of C-α-Mannosyl Tryptophan via Palladium-Catalyzed C-H Glycosylation显示文摘The C2-α-mannosyl-tryptophan amino acid is produced by a unique posttranslational modification(PTM)of proteins and poses a significant synthetic challenge.A new strategy based on Pd-catalyzed auxiliary-directed remote C-H glycosylation of tryptophan was developed,which generates the C2-α-mannopyranose(Man)-Trp unit in a highly efficient and stereoselective fashion.Density functional theory(DFT)computational studies support a concerted oxidative addition mechanism for the stereospecific functionalization of a Pd(II)palladacycle intermediate with anα-mannosyl chloride donor.The utility of this method was demonstrated in the first total synthesis of insect C-glycopeptide hormone Cam-HrTH-I. | Quanquan Wang Yue Fu Wanjun Zhu Shuang An Qianyi Zhou Shou-Fei Zhu Gang He Peng Liu Gong Chen | 2021 | CCS Chemistry2021，3，6： | 0 |
| 10 | Super-resolution imaging of the dynamic cleavage of intercellular tunneling nanotubes显示文摘As a new method of cell-cell communication,tunneling nanotubes(TNTs)play important roles in cell-cell signaling and mass exchanges.However,a lack of powerful tools to visualize dynamic TNTs with high temporal/spatial resolution restricts the exploration of their formation and cleavage,hindering the complete understanding of its mechanism.Herein,we present the first example of using stochastic optical reconstruction microscopy(STORM)to observe the tube-like structures of TNTs linking live cells with an easily prepared fluorescent dye.Because of this new imaging microscopy,the cleavage process of TNTs was observed with a high spatial resolution. | Wanjun GONG Wenhui PAN Ying HE Meina HUANG Jianguo ZHANG Zhenyu GU Dan ZHANG Zhigang YANG Junie QU | 2020 | Frontiers of Optoelectronics2020，13，4： | 0 |
| 11 | Palladium-Catalyzed O- and N-Glycosylation with Glycosyl Chlorides显示文摘Despite the significant progress in carbohydrate chemistry,there remains a pressing need for efficient and practical glycosylationmethods using simple glycosyl donors and with high atom economy.Herein,a new protocol for glycosylation with glycosyl chloride donors under palladium-catalyzed conditions is developed.PdII complex serves as a Lewis acid to promote the activation of glycosyl chloride for the formation of oxocarbeniumion intermediate.This new method is operationally simple,robust,and enables efficient synthesis of both O-and N-glycosides with a broad substrate scope.In particular,it offers an easy access to a range of N-ribonucleoside analogs. | Shuang An Quanquan Wang Wanjun Zhu Qikai Sun Gang He Gong Chen | 2021 | CCS Chemistry2021，3，7： | 0 |
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