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| 1 | The point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province,a non HCC prevalent area in China显示文摘AIM:In hepatocellular carcinoma(HCC)prevalent areas of China,the point mutation of p53 exon7 is highly correlated with hepatitis B virus(HBV)infection and aflatoxin B intake While in non-HCC_prevalent areas of China,these factors are not so important in the etiology of HCC.Therefore,the point mutation of p53 exon7 may also be different than that in HCC-pervalent areas of China.The aim of this study is to investigate the status and carcinogenic role of the point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province,a non-HCC-prevalent area in China.METHODS:RCR,PCR-SSCP and PCR-RFLP were applied to analyze the homozygous deletion and point mutation of p53 exon7 in HCC samples from Anhui,which were confimed by DNA sequencing and Genbak comparison.RESULTS:In the 38 samples of hepatocellular carcinoma,no homozygous deletion of p53 exon7 was detected and point mutations of p53 exon7 were found in 4 cases,which were found to be heterozygous mutation of codon 249 with a mutation rate of 10.53%(4/38).The third base mutation(G→T)of p53 codon 249 was found by DNA sequencing and Genbank comparison.CONCLUSION:The incidence of point mutation of p53 codon 249 is lower in hepatocellular carcinoma and the heterozygous mutation of p53 exon7 found in these patients only indicate that they have genetic susceptibility to HCC p53 codon 249 is a hotspot of p53 exon7 point mutation suggesting that the point mutation of p53 exon 7 may not play a majuor role in the carcinogenesis of HCC in Anhui Province,a non-HCC-prevalent area in China. | LiuH WangY 等 | 2002 | World Journal of Gastroenterology2002，8，3： | 13 |
| 2 | Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia显示文摘Several molecular and histopathologieal prognostic markers have been proposed for the therapeutic stratification of meduUoblastoma patients. Amplification of the c-mye oneogene, elevated levels of c-mye mRNA, or tumor anaplasia have been associated with worse clinical outcomes. In contrast, high TrkC mRNA expression generally presages longer survival. The goal of this study was to evaluate | EberhartCG KratzJ WangY SummersK StearnsD CohenK DangCV BurgerPC | 2004 | 中国神经肿瘤杂志2004，2，3： | 9 |
| 3 | Short-term Exposure to Fine Particles and Risk of Cause-Specific Mortality--China,2013-2018显示文摘What is already known about this topic?Short-term exposure to PM2.5 has been associated with population excess death.This issue is of critical concern in China given its high level of exposure to PM2.5 compared to that of the rest of the world.What is added by this report?Existing studies were conducted from 2013-2015 and have failed to capture the full effects of China’s actions towards cleaner air in recent years,such as the first Action Plan for Air Pollution Prevention and Control issued in 2013.This study uses the longest time series data to date from 2013-2018,provides the latest evidence on PM2.5 and cause-specific death nationwide,and identifies regional patterns of PM2.5-related effects as well as PM2.5-related susceptible populations.What are the implications for public health practice?This study suggests that the development of standards and the implementation of actions to clean the air and protect public health should be tailored to PM2.5-related sensitive diseases,susceptible populations,and regional patterns. | Chen Chen Tiantian Li Lijun Wang Jinlei Qi Wangying Shi Mike Z He Qinghua Sun Jiaonan Wang Huanhuan Zhu Xiaoming Shi | 2019 | China CDC weekly2019，1，1： | 5 |
| 4 | MRF model and FRAME model-based unsupervised image segmentation显示文摘This paper presents a method for unsupervised segmentation of images consisting of multiple textures. The images under study are modeled by a proposed hierarchical random field model, which has two layers. The first layer is modeled as a Markov Random Field (MRF) representing an unobservable region image and the second layer uses 'Filters, Random and Maximum Entropy (Abb. FRAME)' model to represent multiple textures which cover each region. Compared with the traditional Hierarchical Markov Random Field (HMRF), the FRAME can use a bigger neighborhood system and model more complex patterns. The segmentation problem is formulated as Maximum a Posteriori (MAP) estimation according to the Bayesian rule. The iterated conditional modes (ICM) algorithm is carried out to find the solution of the MAP estimation. An algorithm based on the local entropy rate is proposed to simplify the estimation of the parameters of MRF. The parameters of FRAME are estimated by the ExpectationMaximum (EM) algorithm. Finally, an experiment with synthesized and real images is given, which shows that the method can segment images with complex textures efficiently and is robust to noise. | CHENGBing WANGYing ZHENGNanning JIAXinchun | 2004 | Science in China(Series F)2004，47，6： | 4 |
| 5 | MSA in Beijing aerosol显示文摘Methane sulphonate (MSA) and sulfate (SO4^2-),the main oxidation products of dirnethyl sulfide (DMS), arethe target of atmospheric chemistry study, as sulfate aerosolwould have important impact on the global climate change. It is widely believed that DMS is rnainly emitted from phyto-plankton production in marine boundary layer (MBL), andMSA is usually used as the tracer of non-sea-salt sulfate (nss-SO4^2-) in marine and coastal areas/MSA/SO4^2- = 1/18) Manyobservations of MSA were in marine and coastal aerosols. Toour surprise, MSA was frequently (>60%) deteeted in BeijingTSP. PM10, and PM2.5 aerosols, even in the samples collectedduring the dust storm period. The concentrations of MSAwere higher than those measured in marine aerosols. Factoranalysis, correlation analysis and meteorology analysis indi-cated that there was no obvious marine influence on Beljiagaerosols. DMS from terrestrial emissions and dimethyl sulphoxide (DMSO) from industrial wastes could be the twopossible precursors of MSA. Warm and low-pressure airmasses and long time radiation were beneficial to the forma-tion of MSA. Anthropogenlc pollution from regional andlocal sources might be the dominant contributor to MSA inBeijing aerosol. This was the first report of MSA in aerosolscollected in an inland site in China. This new finding wouldlead to the further study on the balance af sulfur in inlandcities and its global bingcoehemical cycle. | YUANHui WANGYing ZHUANGGuoshun | 2004 | Chinese Science Bulletin2004，49，10： | 4 |
| 6 | Environmental and biogeo- chemical process of accumula- tion of iron-phosphorus in marine sediments显示文摘This paper discusses the environmental and biogeochemical process of accumulation of iron-phosphorus in marine sediments for the north aktian of the South China Sea and analyzes the relationships between the contents of iron, phosphorus and calcium carbonate as well as their ex-istent characteristics. The results show that the variances of phosphorus and calcium carbonate contents with depths are opposite and those of iron and calcium carbonate contents are almost accordant. It is not only related to the biogeo-chemical process of accumulation of biogenous calcium car-bonate in sediments, which resulted from the fact that the marine primary productivity was stimulated by part of ter-rigenous phosphorus dissolved into seawater due to decline of superficial water temperature and increase of carbon di-oxide content in the glacial period, but also related to iron impelled oxidation and accelerated deposit by the dissolved oxygen from the atmosphere and the photosynthesis of hy-drophytes in seawater. The variance of soluble iron-phos- phorus species (Fe-P) in sediment columns can sensitively reflect the changes of climate and environment, which sug-gests that the accumulative characteristics and existent states of iron-phosphorus species (Fe-P) in marine sediments have the significance as an indicator of the changes of paleocli-mate and paleoenvironment. | WENGHuanxin ZHANGXingmao WUNengyou CHENLihong CHENJingfeng WANGYing QINYachao TIANRongxiang | 2004 | Chinese Science Bulletin2004，49，9： | 3 |
| 7 | Natural Products and Derivatives Targeting at Cancer Energy Metabolism:A Potential Treatment Strategy显示文摘In the 1920s,Dr Otto Warburg first suggested the significant difference in energy metabolism between malignant cancer cells and adjacent normal cells.Tumor cells mainly adopt the glycolysis as energy source to maintain tumor cell growth and biosynthesis under aerobic conditions.Investigation on energy metabolism pathway in cancer cells has aroused the interest of cancer researchers all around the world.In recent years,plentiful studics suggest that targeting the peculiar cancer energy metabolic pathways,including glycolysis,mitochondrial respiration,amino acid metabolism,and fatty acid oxidation may be an effective strategy to starve cancer cells by blocking essential nutrients.Natural products (NPs)are considered as the “treasure trove of small molecules drugs” and have played an extremely remarkable role in the discovery and development of anticancer drugs.And numerous NPs have been reported to act on cancer energy metabolism targets.Herein,a comprehensive overview about cancer energy metabolism targets and their natural-occurring inhibitors is prepared. | Qi-qi WANGI Ming-xue LI Chen LI Xiao-xia GU Meng-zhu ZHENG Li-xia CHEN Hua LI | 2020 | Current Medical Science2020，40，2： | 2 |
| 8 | Exact analysis of the azimuth resolution characters of squint SAR显示文摘Based on the motion of platform and the scanning rules of the squint SAR, this paper constructs an exact slant range model between a point target and APC, then presents a novel analysis method of the high resolution characters in azimuth of squint SAR. By deeply researching the length of synthetic aperture and the azimuth resolution, we give the application conditions of various formulae about the two important parameters, which is vital to the exact imaging and brief but reasonable processing. | LiShu WangYing ZhaoYigong | 2004 | Journal of Systems Engineering and Electronics2004，15，4： | 2 |
| 9 | Electrochemical behaviors of metol on hydrophilic ionic liquid 1 - ethyl - 3 - methylimidazolium tetrafluoroborate - modified electrode 显示文摘 | Sun W Jiang Q WangY | 2009 | Sens Actuators B2009，136，2： | 1 |
| 10 | Oxidativedesulphurizationof4,6-dimethyldibenzothiophene withhydrogenperoxideoverTi-HMS显示文摘 | WangY LiG WangXS etal | 2007 | Energy& Fuels2007，21，： | 1 |
| 11 | Methaneproductioninrelationwithtemperature,substrateandsoildepthinZoigewetlandsonTibetanPlateau显示文摘 | TianJ ChenH WangY etal | 2011 | ActaEcologicaSinica2011，31，： | 1 |
| 12 | Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy显示文摘 | TianT WangY WangH | 2010 | J Cell Biochem2010，111，2： | 1 |
| 13 | Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up- regula- tion of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells显示文摘 | WangY Moreland M Waqner JG | 2011 | J Nutr Biochem2011，151，： | 1 |
| 14 | TheeffectofBitonglingparticlesonsplenocyteproliferationononadjuvantarthritisAArat显示文摘 | WangY(汪悦) GuoHY(郭海鹰) GengYQ(耿元卿) | | #国中医药科技0，，： | 1 |
| 15 | Roleofaquaporin5inanti-gen-inducedairwayinflammationandmucoushyperproduc-tioninmice显示文摘 | ShenY WangY ChenZ etal | 2011 | JCellMolMed2011，15，6： | 1 |
| 16 | Sex-based differences in the effect of digoxin for the treatment of heart failure显示文摘 | Rathore SS WangY Krumholz HM | 2002 | N Eng J Med2002，347，： | 1 |
| 17 | Review of the development of China rare earth[J]显示文摘 | HanXY(韩晓英) LiP(李平) WangY(王勇) etal | | 中国有色金属学报0，，： | 1 |
| 18 | High thermal stability and photoluminescence of Si-N co-doped BaMgAl10O17:Eu2 +phosphors显示文摘 | WangY F XuX Yin L J Hao LY | | 0，，06： | 1 |
| 19 | AnalysisoffungalcommunitystructureinthesoilofZoigeAlpinewetland显示文摘 | FengS ZhangH WangY etal | 2009 | ActaEcologicaSinica2009，29，： | 1 |
| 20 | Postoperativedeliri-um:theimportance ofpain and pain managemen显示文摘 | VaufioLE SandsLP WangY etal | 2006 | AnesthAnalg2006，102，4： | 1 |
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