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| 1 | Host cellular signaling induced by influenza virus显示文摘A wide range of host cellular signal transduction pathways can be stimulated by influenza virus infection. Some of these signal transduction pathways induce the host cell's innate immune response against influenza virus, while others are essential for efficient influenza virus replication. This review examines the cellular signaling induced by influenza virus infection in host cells, including host pattern recognition receptor (PRR)-related signaling, protein kinase C (PKC), Raf/MEK/ERK and phosphatidylinositol-3-kinase (PI3K)/Akt signaling, and the corresponding effects on the host cell and/or virus, such as recognition of virus by the host cell, viral absorption and entry, viral ribonucleoprotein (vRNP) export, translation control of cellular and viral proteins, and virus-induced cell apoptosis. Research into influenza virus-induced cell signaling promotes a clearer understanding of influenza virus-host interactions and assists in the identification of novel antiviral targets and antiviral strategies. | DAI XinXian ZHANG LiShu HONG Tao | 2011 | Science China(Life Sciences)2011，54，1： | 12 |
| 2 | Spatial-temporal Variation of Extreme Precipitation Events in Northwest China During 1961-2010显示文摘Using the daily precipitation data of 118 meteorological stations in Northwest China from January 1,1961 to December 31,2010,we analyzed extreme precipitation events from prime precipitation data by applying R-language Climate Index( RClimDex).The spatial-temporal change characteristics in the past 50 years have been examined using the method of trend analysis,Mann-Kendall and the spatial analysis module of Arcgis9.2.The results show that the spatial distribution of the indices for extreme precipitation in Northwest China is greatly influenced by geographic location,atmospheric circulation and topography,and the spatial difference of extreme precipitation events is very evident,while the indices reduce from the southeast to the northwest except Consecutive Dry Days( CDD).In Xinjiang region,high values appear in Tianshan Mountains and decrease towards the south and north respectively.In the past 50 years,the temporal variation tendency of the indices for extreme precipitation in Northwest China has a great spatial distinction.It shows that the variation tendency is opposite between the east( decrease) and the west( increase),and CDD has a decreasing tendency while other indices increase.For each region,it is found that the indices for extreme precipitation in Xinjiang and Qinghai Province shows an increasing trend,and it is remarkable in Tianshan Mountains,the north of Xinjiang and the northeast of Qinghai Province.The temporal variation tendency of the indices for extreme precipitation in Ningxia,Shaanxi and Gansu has a large spatial distinction.The stations which have an increasing tend are mainly found in the north of Ningxia,south of Shaanxi and Hexi Corridor of Gansu.However,the south of Ningxia,north of Shaanxi and Longnan of Gansu Province mainly present a decreasing trend.The temporal variation tendency of the indices for extreme precipitation in Inner Mongolia is not obvious.Overall,the east part of Northwest China has a dry tendency,while the west part has an opposite trend. | Lian Lishu Xu Shujing Li Zhifu Sun Xiaoyin | 2014 | Meteorological and Environmental Research2014，5，1： | 5 |
| 3 | Immune responses of a designed HIV-1 DNA vaccine on rhesus monkeys显示文摘An effective HIV-1 vaccine will be the ultimate solution for the prevention of HIV/AIDS, though HAART plays important roles in treating the disease. In this study, a large-scale recombinant DNA plasmid containing a designed HIV-1 multi-epitope- p24 chimeric gene was prepared and purified. Rhesus monkeys were then inoculated muscularly with the plasmid for four times in week 0, 4, 8 and 18. Whole blood was collected two weeks after the third and fourth inoculation, followed by serum and pe- ripheral blood mononuclear cell (PBMC) separation. The CTL activity and proliferation of PBMCs stimu- lated by macaque MHC-I-restricted HIV-1 CTL epi- tope peptide were analyzed by MTT and LDH release assay, respectively. Th1 cytokines in supernatant of cultured PBMC stimulated by HIV-1 CTL epitope peptide and anti-HIV-1 antibody in serum were as- sayed by ELISA. The results showed that increased CTL target-killing activity, higher secretion of Th1 cytokines (IFN-γ and IL-2) and promoted proliferative reaction of monkey PBMCs stimulated by HIV-1 CTL epitope peptide were detected in the immunization group inoculated by the recombinant DNA vaccine for three times, which were further enhanced by the fourth inoculation. At the same time, HIV-1 specific antibody in serum of immunized monkeys was higher than that in controls. We concluded that the designedHIV-1 DNA vaccine may induce HIV-1 specific cellular and humoral immunity on monkeys. | ZHANG Lishu JIN Ningyi SONG Yingjin SUN Yansong WANG Hong ZHAN Dawei MA Hewen SHANG Yupu JIN Hongtao HONG Baoqing LI Chang | 2006 | Chinese Science Bulletin2006，51，13： | 3 |
| 4 | Exact analysis of the azimuth resolution characters of squint SAR显示文摘Based on the motion of platform and the scanning rules of the squint SAR, this paper constructs an exact slant range model between a point target and APC, then presents a novel analysis method of the high resolution characters in azimuth of squint SAR. By deeply researching the length of synthetic aperture and the azimuth resolution, we give the application conditions of various formulae about the two important parameters, which is vital to the exact imaging and brief but reasonable processing. | LiShu WangYing ZhaoYigong | 2004 | Journal of Systems Engineering and Electronics2004，15，4： | 2 |
| 5 | Relation of nm23 gene expression to CT sign and prognosis in peripheral nonsmall cell lung cancer显示文摘CT observations and the cellular factors of molecular biology each enable one to recognize macro/micro changes in lung cancer. Growing pattern, characteristic shapes, degree of malignancy, relapse and metastasis of lung cancer are mainly determined by their molecular biology. Change of tumour shape, determined by the tumour's biological behaviour, is the basis of CT observations. That is, the pathological change acts as a bridge which links the CT observation to molecular biology and makes the investigation of internal relationship between CT sign and molecular biology behaviour possible. As a tumour suppressor gene, nm23 gene is located in chromosome 17q21.3, encoding a nucleoside diphosphate kinase.1,2 We studied the expression of nm23 in peripheral nonsmall cell lung cancer (NSCLC) using the streptavidin peroxidase (SP) immunohistochemical method and investigated retrospectively the relationship between nm23 gene, CT observation, biological behaviour and prognosis of NSCLC. | MAShu-hua XUKe HUANGTao HUANGBao-jun ZHUYu-sen LIJun LIShu SUNLi-hua | 2005 | Chinese Medical Journal2005，，6： | 2 |
| 6 | Application of Pruning Algorithm on Voice Service Platform of Cow Disease Diagnosis Expert System显示文摘Expert System(ES) is considered effective and effi cient in agricultural production,as agricultural informationization becomes a main trend in agricultural development.ES,however,is applied unsatisfactorily in most rural areas of China and it has considerably affected and restricted the development of the agricultural informationization.This paper proposed a solution to voice service system of ES,which was suitable for the information transmission,and it especially could help the peasants in remote regions obtain knowledge from ES through the voice service system.As for the disadvantages of massive knowledge data and slow deduction,in this system the classifi cation method could be adopted based on the decision tree.Designing pruning algorithm to〝trim off〞the unrelated knowledge to the users in query course would simplify the structure of the decision tree and accelerate the speed of deduction before the inference engine deduced the knowledge required by users. | WANG Lishu | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，4： | 1 |
| 7 | Phosphorus Efficacy in Four Chinese Long-Term Experiments with Different Soil Properties and Climate Characteristics显示文摘 | Linping Zhao Yibing Ma Guoqing Liang Shutian Li Lishu Wu | 2009 | Communications in Soil Science and Plant Analysis . 2009 (19-2)2009，，19： | 1 |
| 8 | Tunable excitonic emission of monolayer WS2 for the optical detection of DNA nucleobases显示文摘 | Shun Feng Chunxiao Cong Namphung Peimyoo Yu Chen Jingzhi Shang Chenji Zou Bingchen Cao Lishu Wu Jing Zhang Mustafa Eginligil Xingzhi Wang Qihua Xiong Arundithi Ananthanarayanan Peng Chen Baile Zhang Ting Yu | 2018 | Nano Research2018，11，3： | 1 |
| 9 | Lignansfrom Saururus chinensis 显示文摘 | Wang Lishu Zhou Xuefeng Xu Tunhai | 2010 | Chem Nat Com2010，46，3： | 1 |
| 10 | Increasing temperature anomalies reduce coral growth in the Weizhou Island, northern South China Sea显示文摘 | CHEN Tianran LIShu YU Kefu ZHENG Zhaoyong WANG Lirong CHEN Tegu | 2013 | Estuarine Coastal and Shelf Science2013，130，： | 1 |
| 11 | ent -Sauchinone from Saururus chinensis 显示文摘 | Lishu Wang Daqing Zhao Dongyan Cheng | 2008 | Heterocycles2008，75，5： | 1 |
| 12 | Lignans from Saururus chinensis 显示文摘 | Lishu Wang Xaefeng Zhou Tnnhai Xu | 2010 | Chemistry of Natural Compounds2010，46，3： | 1 |
| 13 | The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride in- duced hepatic fibrosis in rats 显示文摘 | Lishu Wang Dongyan Cheng Haisheng Wang | 2009 | J Ethnopharmacol2009，126，3： | 1 |
| 14 | Synthesis of a thin-layer MnO2 nanosheet-coated Fe3O4 nanocomposite as a magnetically separable photocatalyst显示文摘 | ZHANG Lishu LIAN Jianshe WU Longyun | 2014 | Langmuir2014，30，23： | 1 |
| 15 | 显示文摘 | YINLu—Qiao(殷桥) YANGWei—Qiao(杨卫桥) LIShu—Zhi(李抒智) eta1 | 2011 | 光学学报2011，31，5： | 1 |
| 16 | Anthocyanins and their role in cancer prevention显示文摘 | WANG Lishu STONIER G D | 2008 | Cancer letters2008，269，： | 1 |
| 17 | The difference of potassium dynamics between yellowish red soil and yellow cinnamon soil under rapeseed (Brassica napus L.)–rice (Oryza sativa L.) rotation显示文摘 | Xiaokun Li Jianwei Lu Lishu Wu Fang Chen | 2009 | Plant and Soil (-)2009，，1： | 1 |
| 18 | Dimeric proanth ocyanidins from the roots of Ephedra sinica 显示文摘 | Tao Huaming Wang Lishu Cui Zhanchen | 2008 | Planta Medica2008，74，15： | 1 |
| 19 | Construction and characterization of a recombinant fowlpox virus containing HIV-1 multi-epitope-p24 chimeric gene in mice显示文摘The epidemic of HIV/AIDS is sweeping across the world. It is of great importance to figure out new ways to curb this disease. Epitope-based vaccine is one of these solutions. In this study, a chimeric gene was obtained by combination of a designed HIV-1 multi-epitope gene (MEG) and HIV-1 p24 gene. A re- combinant plasmid pUTA2-MEGp24 was then constructed by inserting MEGp24 gene into the down- stream of the promoter (ATI-P7.5×20) of fowlpox virus (FPV) transfer vector pUTA2. The recombinant plasmid and wild-type FPV 282E4 strain were then co-transfected into CEF cells and homologous re- combination occurred. A recombinant virus expressing HIV-1 protein MEGp24 was screened by ge- nome PCR and Western blot assay. Large scale preparation and purification of the recombinant fowl- pox virus (rFPV) were then carried out. BALB/c mice were immunized intramuscularly with the rFPV for three times on day 0, 14 and 42. Mice were executed and sampled one week after the third inoculation. Anti-HIV-1 antibody in serum and Th1 cytokines in the supernatant of cultured spleen cells were as- sayed by ELISA. The count of T lymphocyte subsets and the CTL activity of spleen lymphocytes were analyzed by flow cytometry and lactate dehydrogenase (LDH) release assay, respectively. The results showed that HIV-1 specific antibody in serum and increased T lymphocyte subsets (CD4+ T, CD8+ T) were detected in the immunization group. CTL target-killing activity and higher secretion of Th1 cyto- kines (IFN-γ and IL-2) of spleen lymphocytes stimulated by H-2d-restricted CTL peptide were observed in immunized mice. We concluded that the rFPV may induce HIV-1 specific immunity especially cellular immunity in mice. | ZHANG LiShu JIN NingYi SONG YingJin WANG Hong MA HeWen LI ZiJian JIANG WenZheng | 2007 | Science China(Life Sciences)2007，50，2： | 1 |
| 20 | Markedly enhanced coercive field and Congo red adsorption capability of cobalt ferrite induced by the doping of non-magnetic metal ions显示文摘 | Lishu Zhang Jianshe Lian Lixia Wang Jun Jiang Zhenrong Duan Lijun Zhao | 2013 | Chemical Engineering Journal2013，，： | 1 |
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