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| 1 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 2 | Effects of environment lighting on the growth,photosynthesis,and quality of hydroponic lettuce in a plant factory显示文摘Leafy vegetable production under controlled environment using artificial lighting has many advantages over conventional greenhouses and open-field production.However,high initial investment and operation costs are restricting the wide application of this technology.In order to design an optimal artificial lighting environment for lettuce production,effects of different combinations of light intensity,photoperiod,and light quality on growth,quality,photosynthesis,and energy use efficiency of lettuce(Lactuca sativa L.cv Ziwei)were investigated under a closed plant factory.Lettuce transplants were grown under photosynthetic photon flux density(PPFD)at 150μmol/m^(2)·s,200μmol/m^(2)·s,250μmol/m^(2)·s,and 300μmol/m^(2)·s provided by fluorescent lamps(FL)with a red to blue ratio(R:B ratio)of 1.8 and light-emitting diode(LED)lamps with R:B ratio of 1.2 and 2.2,in combination with photoperiod of 12 and 16 h/d.In order to examine the“long term”photosynthetic characteristics,net photosynthetic rates of hydroponic lettuce leaves were continuously measured for 2 d(15^(th) and 16^(th) day after transplanting)before harvest.There was no difference in leaf fresh weight(FW)between PPFD of 250μmol/m^(2)·s and 300μmol/m^(2)·s with photoperiod of 16 h/d,regardless of light quality,and same results showed in contents of nitrate,soluble sugar,and vitamin C,respectively.The results of continuous measurements of net photosynthetic rate of lettuce leaves before harvest indicated that plants grown at PPFD of 250μmol/m^(2)·s had consistently higher compared to those grown at PPFD of 300μmol/m^(2)·s.Combining the results from growth,photosynthesis,quality,and energy consumption,it can be concluded that PPFD at 250μmol/m^(2)·s with photoperiod of 16 h/d under LED with R:B ratio of 2.2 is a suitable light environment for maximum growth and high quality of commercial lettuce(cv.Ziwei)production under indoor controlled environment. | Xin Zhang Dongxian He Genhua Niu Zhengnan Yan Jinxiu Song | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 8 |
| 3 | Reliable fuzzy control with domain guaranteed cost for fuzzy systems with actuator failures显示文摘The reliable fuzzy control with guaranteed cost for T S fuzzy systems with actuator failure is proposed in this paper. The cost function is a quadratic function with failure input. When the initial state of such systems is known, a design method of the reliable fuzzy controller with reliable guaranteed cost is presented, and the formula of the guaranteed cost is established. When the initial state of such systems is unknown but belongs to a known bounded closed domain, a notion of the reliable domain guaranteed cost (RDGC) for such systems is proposed. For two classes of initial state domain, polygon domain and ellipsoid domain, some design methods for reliable fuzzy controllers with the RDGC are provided. The efficiency of our design methods is finally verified by numerical design and simulation on the Rossler chaotic system. | JIAXinchun ZHENGNanning | 2004 | Progress in Natural Science:Materials International2004，14，12： | 8 |
| 4 | MRF model and FRAME model-based unsupervised image segmentation显示文摘This paper presents a method for unsupervised segmentation of images consisting of multiple textures. The images under study are modeled by a proposed hierarchical random field model, which has two layers. The first layer is modeled as a Markov Random Field (MRF) representing an unobservable region image and the second layer uses 'Filters, Random and Maximum Entropy (Abb. FRAME)' model to represent multiple textures which cover each region. Compared with the traditional Hierarchical Markov Random Field (HMRF), the FRAME can use a bigger neighborhood system and model more complex patterns. The segmentation problem is formulated as Maximum a Posteriori (MAP) estimation according to the Bayesian rule. The iterated conditional modes (ICM) algorithm is carried out to find the solution of the MAP estimation. An algorithm based on the local entropy rate is proposed to simplify the estimation of the parameters of MRF. The parameters of FRAME are estimated by the ExpectationMaximum (EM) algorithm. Finally, an experiment with synthesized and real images is given, which shows that the method can segment images with complex textures efficiently and is robust to noise. | CHENGBing WANGYing ZHENGNanning JIAXinchun | 2004 | Science in China(Series F)2004，47，6： | 4 |
| 5 | All VN-graphene architecture derived self-powered wearable sensors for ultrasensitive health monitoring显示文摘The booming of wearable electronics has nourished the progress on developing multifunctional energy storage systems with versatile flexibility, which enable the continuous and steady power supply even under various deformed states. In this sense, the synergy of flexible energy and electronic devices to construct integrative wearable microsystems is meaningful but remains quite challenging by far. Herein, we devise an innovative supercapacitor/sensor integrative wearable device that is based upon our designed vanadium nitride-graphene (VN-G) architectures. Flexible quasi-solid-state VN-G supercapacitor with ultralight and binder-free features deliver a specific capacitance of^53 F·g^-1 with good cycle stability. On the other hand, VN-G derived pressure sensors fabricated throughout a spray-printing process also manifest favorably high sensitivity (40 kPa^-1 at the range of 2-10 kPa), fast response time (~130 ms), perfect skin conformability, and outstanding stability under static and dynamic pressure conditions. In tum, their complementary unity into a self-powered wearable sensor enables the precise detecti on of physiological motions ranging from pulse rate to phonetic recognition, holding promise for in-practical health monitoring applications. | Lianghao Yu Yuyang Yi Ting Yao Yingze Song Yiran Chen Qiucheng Li Zhou Xia Nan Wei Zhengnan Tian Baoqing Nie Li Zhang Zhongfan Liu Jingyu Sun | 2019 | Nano Research2019，12，2： | 4 |
| 6 | Growth,nutritional quality,and energy use efficiency in two lettuce cultivars as influenced by white plus red versus red plus blue LEDs显示文摘Red plus blue light-emitting diodes(LEDs)are commonly applied in plant factories with artificial lighting due to photosynthetic pigments,which absorb strongly in red and blue light regions of the spectrum.However,plants grown under natural environment are used to utilizing broad-wide spectrum by long-term evolution.In order to examine the effects of addition light added in red plus blue LEDs or white LEDs,green and purple leaf lettuces(Lactuca sativa L.cv.Lvdie and Ziya)were hydroponically cultivated for 20 days under white LEDs,white plus red LEDs,red plus blue LEDs,and red plus blue LEDs supplemented with ultraviolet,green or far-red light,respectively.The results indicated that the addition of far-red light in red plus blue LEDs increased leaf fresh and dry weights of green leaf lettuce by 28%and 34%,respectively.Addition of ultraviolet light did not induce any differences in growth and energy use efficiency in both lettuce cultivars,while supplementing green light with red plus blue LEDs reduced the vitamin C content of green leaf lettuce by 44%and anthocyanin content of purple leaf lettuce by 30%compared with red plus blue LEDs,respectively.Spectral absorbencies of purple leaf lettuce grown under red plus blue LEDs supplemented with green light were lower in green light region compared with those grown under red plus blue LEDs,which was associated with anthocyanin contents.White plus red LEDs significantly increased leaf fresh and dry weights of purple leaf lettuce by 25%,and no significant differences were observed in vitamin C and nitrate contents compared with white LEDs.Fresh weight,light and electrical energy use efficiencies of hydroponic green and purple leaf lettuces grown under white plus red LEDs were higher or no significant differences compared with those grown under red plus blue LEDs.In conclusion,white plus red LEDs were suggested to substitute for red plus blue LEDs in hydroponic lettuce(cv.Lvdie and Ziya)production in plant factories with artificial lighting. | Zhengnan Yan Dongxian He Genhua Niu Qing Zhou Yinghua Qu | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 4 |
| 7 | Vibration Measurement of Pedestrian Bridge Using Double Magnetic Suspension Vibrator Based on Wavelet Analysis显示文摘Aiming at the problem of pedestrian bridge vibration measurement,a vibration measurement system of pedestrian bridge with dual magnetic suspension vibrator structure was designed according to absolute vibration measurement principle. The relationship between the magnetic repulsion force of vibrator and its displacement was obtained by the experimental method and the least square fitting method. The vibration equations of two magnetic suspension vibrators were deduced respectively,and the measurement sensitivity of the system was deduced. The amplitude-frequency characteristic of the system was studied. A simulation model of vibrator measurement system with double magnetic suspension vibrator was established. The analysis shows that the sensitivity of the vibration measurement system with double magnetic suspension vibrator is higher than that with single magnetic suspension vibrator. The four vibration waveforms were measured,that is,no one passes through a pedestrian bridge,there are cars running under the pedestrian bridge,single pedestrian passes through the pedestrian bridge and multiple pedestrians pass through the pedestrian bridge. The multi-scale one-dimensional wavelet decomposition function was used to analyze the vibration signals. The vibration characteristics were obtained using one dimension wavelet decomposition function under four different conditions. Finally,the vibration waveforms of four cases were reconstructed. The measured results show that the vibration measurement system of pedestrian bridge with double magnetic suspension vibrator structure has high measurement sensitivity. The design has a certain value to monitor a pedestrian bridge. | JIANG Dong KONG Deshan ZHANG Zhengnan WANG Deyu | 2017 | Instrumentation2017，4，3： | 4 |
| 8 | A new,direct approach toward modeling thermo-coupled fatigue failure behavior of metals and alloys显示文摘The objective of this study is two-fold. Firstly, new finite strain elastoplasticity models are proposed from a fresh standpoint to achieve a comprehensive representation of thermomechanical behavior of metals and alloys over the whole deformation range up to failure. As contrasted with the usual elastoplasticity models, such new models of much simpler structure are totally free, in the sense that both the yield condition and the loading–unloading conditions need not be introduced as extrinsic coercive conditions but are automatically incorporated as inherent constitutive features into the models. Furthermore, the new models are shown to be thermodynamically consistent, in a further sense that both the specific entropy function and the Helmholtz free energy function may be presented in explicit forms, such that the thermodynamic restriction stipulated by Clausius–Duhem inequality for the intrinsic dissipation may be identically satisfied. Secondly, it is then demonstrated that the thermo-coupled fatigue failure behavior under combined cyclic changes of stress and temperature may be derived as direct consequences from the new models. This novel result implies that the new model can directly characterize the thermo-coupled fatigue failure behavior of metals and alloys, without involving any usual damage-like variables as well as any ad hoc additional criteria for failure. In particular, numerical examples show that, under cyclic changes of temperature, the fatigue characteristic curve of fatigue life versus temperature amplitude may be obtained for the first time from model prediction both in the absence and in the presence of stress. Results are in agreement with the salient features of metal fatigue failure. | Zhaoling Wang Hao Li Zhengnan Yin Heng Xiao | 2017 | Acta Mechanica Solida Sinica2017，30，1： | 3 |
| 9 | Controllable Protein Adsorption and Bacterial Adhesion on Polypyrrole Nanocone Arrays显示文摘In this research, polypyrrole nanocone arrays doped with β-Naphthalene sulphonic acid(PPy-NSA) were built. This film was expected to control protein adsorption and bacterial adhesion by potential-induced reversibly redox. The scanning Kelvin probe microscopy(SKPM) and surface contact angles(SCA) tests suggested that the surface potential and wettability of PPy-NSA nanocone arrays could be controlled by simply controlling its redox property via applying potential. The controllable surface potential and wettability in return controlled the adsorption of protein and adhesion of bacteria. The proposed material might find application in the preparation of smart biomaterial surfaces that can regulate proteins and bacterial adhesion by a simple potential switching. | Zhengnan Zhou Weiping Li Tianrui He Peng Yu Guoxin Tan Chengyun Ning | 2016 | Journal of Materials Science & Technology2016，32，9： | 2 |
| 10 | Structure dependent elastic properties of supergraphene显示文摘Complete replacement of aromatic carbon bonds in graphene by carbyne chains gives rise to supergraphene whose mechanical properties are expected to depend on its structure. However, this dependence is to date unclear. In this paper, explicit expressions for the in-plane stiffness and Poisson's ratio of supergraphene are obtained using a molecular mechanics model. The theoretical results show that the in-plane stiffness of supergraphene is drastically(at least one order) smaller than that of graphene, whereas its Poisson's ratio is higher than 0.5. As the index number increases(i.e., the length of carbyne chains increases and the bond density decreases), the in-plane stiffness of supergraphene decreases while the Poisson's ratio increases. By analyzing the relation among the layer modulus, in-plane stiffness and Poisson's ratio, it is revealed that the mechanism of the faster decrease in the in-plane stiffness than the bond density is due to the increase of Poisson's ratio. These findings are useful for future applications of supergraphene in nanomechanical systems. | Juan Hou Zhengnan Yin Yingyan Zhang Tien-Chong Chang | 2016 | Acta Mechanica Sinica2016，32，4： | 2 |
| 11 | Linkages Between Tropical Cyclones and Extreme Precipitation over China and the Role of ENSO显示文摘This research investigated the linkages between tropical cyclones(TCs)and extreme precipitation,and their associations with El Nino-Southern Oscillation(ENSO)over China.The contribution of TC-induced to total extreme precipitation events along the southeast coast of China was higher than 50%,and the values gradually decreased as TCs moved inland.However,the precipitation extremes(magnitude and frequency)related to TCs did not show statistically significant changes over the most recent 57 years.The impacts of TCs on precipitation extremes are evidently modulated by the ENSO phases.We found less extreme precipitation linked with TCs in southeastern China during El Nino phase,because of the fewer TC tracks over this region and less TC genesis in the western North Pacific(WNP).The small TC track density over southeastern China is due to the prevalent westerly steering flow and abnormal integrated vapor transport from northern to southern China during El Nino years.Additionally,warmer sea surface temperature,more vigorous westerlies,larger vorticity in 250 hPa,and higher divergence in 850 hPa in an El Nino phase jointly displaced the mean genesis of the WNP TCs eastward and this led to fewer TCs passing through southeastern China. | Licheng Wang Zhengnan Yang Xihui Gu Jianfeng Li | 2020 | International Journal of Disaster Risk Science2020，11，4： | 2 |
| 12 | Effect of Surface Modifications on the Magnetic Properties of Ni_(0.5)Zn_(0.5)Fe_2O_4 Nanoparticles显示文摘Two different silica sources have been used for the preparation of Ni0.5Zn0.5Fe2O4/SiO2 nanocomposites,and their effects on the particle size,crystallinity and the magnetic properties have been investigated by Xray diffraction(XRD),transmission electron microscopy(TEM) and physical property measurement system(PPMS).In both cases,Ni0.5Zn0.5Fe2O4 nanoparticles of 11 nm in mean particle size were well dispersed in silica matrix.The coercivity and the blocking temperature of Ni0.5Zn0.5Fe2O4 nanoparticles modified with the silicon coupling agent show little decrease,whereas the saturation magnetization increases obviously with respect to nanoparticles dispersed directly in silica matrix.It is considered that the decrease of the surface anisotropy resulting from the change in the surface coordination is responsible for the observed behavior. | Wei Zhang Hongxia Wang Faling Zhang Zhengnan Qian Wenhui Su | 2010 | Journal of Materials Science & Technology2010，26，6： | 1 |
| 13 | FAST SYMBOL-LEVEL SYNCHRONIZATION FOR TR-UWB SIGNALS USING DOUBLE HYBRID DS-TH SPREADING显示文摘A Transmitted Reference (TR) Ultra WideBand (UWB) signal with double hybrid Direct Sequence and Time Hopping (DS-TH) spreading is proposed and its symbol-level synchronization scheme is designed and analyzed. The proposed signaling format can significantly reduce the search space while reducing the spectral lines and eliminating inter-frame interference and multi-user inter- ference. Detailed analysis of the proposed scheme is carried out. Synchronization performance of the proposed signaling format in multipath channel is derived and supported by computer simulation. The search step which is closely associated with the delay of data modulated pulses is analyzed. Using the TH code, the proposed signaling format and synchronization scheme especially works well in moderate and low data rate systems. | Zhang Zhuo Ji Zhengnan Zhang Shijie Yin Hao | 2008 | Journal of Electronics(China)2008，25，3： | 1 |
| 14 | DNA methylation affects photoperiodic tuberization in potato (Solanum tuberosum L.) by mediating the expression of genes related to the photoperiod and GA pathways显示文摘Overcoming short-day-dependent tuberization to adapt to long-day conditions is critical for the widespread geographical success of potato.The genetic pathways of photoperiodic tuberization are similar to those of photoperiodic flowering.DNA methylation plays an important role in photoperiodic flowering.However,little is known about how DNA methylation affects photoperiodic tuberization in potato.Here,we verified the effect of a DNA methylation inhibitor on photoperiodic tuberization and compared the DNA methylation levels and differentially methylated genes(DMGs)in the photoperiodic tuberization process between photoperiod-sensitive and photoperiod-insensitive genotypes,aiming to dissect the role of DNA methylation in the photoperiodic tuberization of potato.We found that a DNA methylation inhibitor could promote tuber initiation in strict short-day genotypes.Whole-genome DNA methylation sequencing showed that the photoperiod-sensitive and photoperiod-insensitive genotypes had distinct DNA methylation modes in which few differentially methylated genes were shared.Transcriptome analysis confirmed that the DNA methylation inhibitor regulated the expression of the key genes involved in the photoperiod and GA pathways to promote tuber initiation in the photoperiod-sensitive genotype.Comparison of the DNA methylation levels and transcriptome levels identified 52 candidate genes regulated by DNA methylation that were predicted to be involved in photoperiodic tuberization.Our findings provide a new perspective for understanding the relationship between photoperiod-dependent and GA-regulated tuberization.Uncovering the epigenomic signatures of these pathways will greatly enhance potato breeding for adaptation to a wide range of environments. | Yanjun Ai Shenglin Jing Zhengnan Cheng Botao Song Conghua Xie Jun Liu Jun Zhou | 2021 | Horticulture Research2021，8，1： | 1 |
| 15 | Effects of electrode structure on mass transfer and performance of PEM fuel cell显示文摘 | Jin Zhengnan Sun Hong Zhao Shengnan | 2011 | Advanced Materials Research2011，，4： | 1 |
| 16 | Mapping Genome-wide Binding Sites of Prox1 in Mouse Cochlea Using the CUT&RUN Approach显示文摘Dear Editor,Our auditory organ,the cochlea,resides in the ventral portion of the inner ear,and its sensory epithelium,the organ of Corti,contains hair cells(HCs)and supporting cells(SCs),which are both descendants of the same progenitors.HCs are prone to damage by multiple ototoxic factors,and how to regenerate damaged HCs using key genes involving cochlear development is of importance[1,2].Cochlear progenitor cells express Sox2 and prolif-erate before embryonic day 12.5(E12.5)in the mouse but become quiescent in an apical-to-basal gradient between E12.5 and E14.5[3]. | Zhengnan Luo Jixiang Zhang Lianyong Qiao Falong Lu Zhiyong Liu | 2021 | Neuroscience Bulletin2021，37，12： | 1 |
| 17 | Effects of temperature on the impedance of pem ftiel cell显示文摘 | LIU Qian SUN Hong JIN Zhengnan | 2011 | Advanced materials re- search2011，297，： | 1 |
| 18 | Effects of electrode structure on mass transfer and performance of PEM fuel cell显示文摘 | JIN Zhengnan SUN Hong ZHAO Shengnan | 2011 | Advanced materials research2011，，4： | 1 |
| 19 | Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization显示文摘Pathological angiogenesis frequently occurs in tumor tissue, limiting the efficiency of chemotherapeutic drug delivery and accelerating tumor progression. However, traditional vascular normalization strategies are not fully effective and limited by the development of resistance. Herein, inspired by the intervention of endogenous bioelectricity in vessel formation, we propose a wireless electrical stimulation therapeutic strategy, capable of breaking bioelectric homeostasis within cells, to achieve tumor vascular normalization. Polarized barium titanate nanoparticles with high mechano-electrical conversion performance were developed, which could generate pulsed open-circuit voltage under low-intensity pulsed ultrasound. We demonstrated that wireless electrical stimulation significantly inhibited endothelial cell migration and differentiation in vitro. Interestingly, we found that the angiogenesis-related eNOS/NO pathway was inhibited, which could be attributed to the destruction of the intracellular calcium ion gradient by wireless electrical stimulation. In vivo tumor-bearing mouse model indicated that wireless electrical stimulation normalized tumor vasculature by optimizing vascular structure, enhancing blood perfusion, reducing vascular leakage, and restoring local oxygenation. Ultimately, the anti-tumor efficacy of combination treatment was 1.8 times that of the single chemotherapeutic drug doxorubicin group. This work provides a wireless electrical stimulation strategy based on the mechano-electrical conversion performance of piezoelectric nanoparticles, which is expected to achieve safe and effective clinical adjuvant treatment of malignant tumors. | Changhao Li Cairong Xiao Lizhen Zhan Zhekun Zhang Jun Xing Jinxia Zhai Zhengnan Zhou Guoxin Tan Jinhua Piao Yahong Zhou Suijian Qi Zhengao Wang Peng Yu Chengyun Ning | 2022 | Bioactive Materials2022，7，12： | 1 |
| 20 | Application of Linearized Anisotropic Diffusion Equation to Edge-Preserving Image Smoothing显示文摘A stable anisotropic diffusion model for edge-preservlng image smoothing is presented. By comparison with existing diffusion models~ this model has two significant new features. The first is that the diffusion model has the ability to adjust the diffusion coefficient and to regulate diffusion orientation simultaneously. The second is that the diffusion model being nonlinear in essence is linearized along time coordinates which makes the model more stable and thus the complexity of computation is reduced greatly. We use an Additive operator splitting scheme (AOS) that is an efficient and stable numerical method to implement the edge-preservlng image smoothing. The experimental results show that the model proposed in this paper is not only stable and efficient but can preserve image edge. | YUANZejian ZHENGNanning ZHANGYuanlin | 2004 | Chinese Journal of Electronics2004，13，1： | 1 |
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