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| 1 | Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers显示文摘Cervical cancer is the leading cause of death among women with cancer worldwide.Here,we performed an integrative analysis of Illumina HumanMethylation450K and RNA-seq data from TCGA to identify cervical cancer-specific DNA methylation markers.We first identified differentially methylated and expressed genes and examined the correlation between DNA methylation and gene expression.The DNA methylation profiles of 12 types of cancers,including cervical cancer,were used to generate a candidate set,and machine-learning techniques were adopted to define the final cervical cancer-specific markers in the candidate set.Then,we assessed the protein levels of marker genes by immunohistochemistry by using tissue arrays containing 93 human cervical squamous cell carcinoma samples and cancer-adjacent normal tissues.Promoter methylation was negatively correlated with the local regulation of gene expression.In the distant regulation of gene expression,the methylation of hypermethylated genes was more likely to be negatively correlated with gene expression,while the methylation of hypomethylated genes was more likely to be positively correlated with gene expression.Moreover,we identified four cervical cancer-specific methylation markers,cg07211381(RAB3C),cg12205729(GABRA2),cg20708961(ZNF257),and cg26490054(SLC5A8),with 96.2%sensitivity and 95.2%specificity by using the tenfold cross-validation of TCGA data.The four markers could distinguish tumors from normal tissues with a 94.2,100,100,and 100%AUC in four independent validation sets from the GEO database.Overall,our study demonstrates the potential use of methylation markers in cervical cancer diagnosis and may boost the development of new epigenetic therapies. | Wanxue Xu Mengyao Xu Longlong Wang Wei Zhou Rong Xiang Yi Shi Yunshan Zhang Yongjun Piao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 2 | Using irrigation intervals to optimize water-use efficiency and maize yield in Xinjiang,northwest China显示文摘Worldwide, scarce water resources and substantial food demands require efficient water use and high yield.This study investigated whether irrigation frequency can be used to adjust soil moisture to increase grain yield and water use efficiency(WUE) of high-yield maize under conditions of mulching and drip irrigation.A field experiment was conducted using three irrigation intervals in 2016: 6, 9, and 12 days(labeled D6, D9, and D12) and five irrigation intervals in 2017: 3, 6, 9, 12, and 15 days(D3, D6, D9, D12, and D15).In Xinjiang, an optimal irrigation quota is 540 mm for high-yield maize.The D3, D6, D9, D12, and D15 irrigation intervals gave grain yields of 19.7, 19.1–21.0, 18.8–20.0, 18.2–19.2, and 17.2 Mg ha^-1 and a WUE of 2.48, 2.53–2.80, 2.47–2.63, 2.34–2.45, and 2.08 kg m-3, respectively.Treatment D6 led to the highest soil water storage, but evapotranspiration and soil-water evaporation were lower than other treatments.These results show that irrigation interval D6 can help maintain a favorable soil-moisture environment in the upper-60-cm soil layer, reduce soilwater evaporation and evapotranspiration, and produce the highest yield and WUE.In this arid region and in other regions with similar soil and climate conditions, a similar irrigation interval would thus be beneficial for adjusting soil moisture to increase maize yield and WUE under conditions of mulching and drip irrigation. | Guoqiang Zhang Dongping Shen Bo Ming Ruizhi Xie Xiuliang Jin Chaowei Liu Peng Hou Jun Xue Jianglu Chen Wanxu Zhang Wanmao Liu Keru Wang Shaokun Li | 2019 | The Crop Journal2019，7，3： | 4 |
| 3 | Dynamic mechanical loading facilitated chondrogenic differentiation of rabbit BMSCs in collagen scaffolds显示文摘Mechanical signals have been played close attention to regulate chondrogenic differentiation of bone marrow mesenchymal stem cells(BMSCs).In this study,dynamic mechanical loading simulation with natural frequencies and intensities were applied to the 3D cultured BMSCs–collagen scaffold constructs.We investigated the effects of dynamic mechanical loading on cell adhesion,uniform distribution,proliferation,secretion of extracellular matrix(ECM)and chondrogenic differentiation of BMSCs–collagen scaffold constructs.The results indicated that dynamic mechanical loading facilitated the BMSCs adhesion,uniform distribution,proliferation and secretion of ECM with a slight contraction,which significantly improved the mechanical strength of the BMSCs–collagen scaffold constructs for better mimicking the structure and function of a native cartilage.Gene expression results indicated that dynamic mechanical loading contributed to the chondrogenic differentiation of BMSCs with higher levels of AGG,COL2A1 and SOX9 genes,and prevented of hypertrophic process with lower levels of COL10A1,and reduced the possibility of fibrocartilage formation due to down-regulated COL1A2.In conclusion,this study emphasized the important role of dynamic mechanical loading on promoting BMSCs chondrogenic differentiation and maintaining the cartilage phenotype for in vitro reconstruction of tissue-engineered cartilage,which provided an attractive prospect and a feasibility strategy for cartilage repair. | Wanxu Cao Weimin Lin Hanxu Cai Yafang Chen Yi Man Jie Liang Qiguang Wang Yong Sun Yujiang Fan Xingdong Zhang | 2019 | Regenerative Biomaterials2019，6，2： | 3 |
| 4 | Adsorption and aggre- gation behavior of surface active trisiloxane room - temperature ionic liquids 显示文摘 | LI PING WANG WANXU DU ZH1PING | 2014 | Colloids and Surfaces A : Physicochemical and Engineering Aspects2014，450，： | 1 |
| 5 | Synthesis and properties of a branched short-alkyl polyoxyethylene ether alcohol sulfate surfactant显示文摘 | Wang Wanxu Li Jianbo Yang Xiaoyi | 2015 | J Mol Liq2015，212，： | 1 |
| 6 | Formation and characterization of fully dilutable microemulsion with fatty acid methyl esters as oil phase显示文摘 | Wang Wanxu Wei Hongtu Du Zhiping | 2015 | ACS Sust Chem Eng2015，3，3： | 1 |
| 7 | Adsorption and aggregation behavior of surface active trisiloxane room - temperature ionic liquids 显示文摘 | LI PING WANG WANXU DU ZHIPING | 2014 | Colloid Surface A2014，450，： | 1 |
| 8 | Investigation of Propoxylation and Ethoxylation of 2-Ethylhexanol in the Presence of an Alkaline and DMC Type Catalyst at Initial Stages of the Syntheses显示文摘 | Wieslaw Hreczuch Karolina Dabrowska Arkadiusz Chrusciel Katarzyna Materna Agata Sznajdrowska Krystyna Czaja Wanxu Wang Qiuxiao Li Yongqiang Sun | 2016 | China Detergent & Cosmetics2016，1，1： | 0 |
| 9 | Development of Standardization in Surfactant Industry显示文摘Surfactants are the most essential active substances in detergents,and their standardization process has a significant impact on the development of the surfactant industry.The development history of the standardization of detergents has been introduced previously.Herein,from the perspective of standardization,the development history of various surfactant products has been reviewed and analyzed in detail.Moreover,the development history of the main raw materials for surfactant synthesis has also been introduced briefly. | Xue Wei Yao Chenzhi Wang Wanxu | 2022 | China Detergent & Cosmetics2022，7，1： | 0 |
| 10 | Biodegradation of Nonylphenol Ethoxylates in the Continuous Flow Activated Sludge Simulation Test显示文摘 | Ying Liu Lianlian Sun Wanxu Wang Zhiping Du | 2016 | China Detergent & Cosmetics2016，1，4： | 0 |
| 11 | Wish a Perseveringly and Fantastic 2019显示文摘Dear readers: The year of 2018 is the fourth decade of China’s Reform and Opening Up. After the great endeavour of past forty years, China has developed into the world’s second largest consumer market in terms of daily chemical industry, which has also made tremendous achievements till now. | Wang wanxu | 2019 | China Detergent & Cosmetics2019，4，1： | 0 |
| 12 | Letter from the Editor-in-Chief: Hello 2018显示文摘Dear all:Happy New Year and welcome to 2018!As we welcome this New Year, we take this opportunity to thank you for your love and support. Without you, we can't imagine our success.I would first like to thank our Scientific Advisory Board, the Editorial Board, the Managing Editor and all staff, and the reviewers for their valuable time and expertise in maintaining the high quality of journal. | Wang Wanxu | 2018 | China Detergent & Cosmetics2018，3，1： | 0 |
| 13 | A Fightfor COVID-19 by China Daily Chemical Industry显示文摘Dear readers:At the beginning of 2020,a sudden“storm”swept across China—the outbreak of COVID-19 of Wuhan City,Hubei Province,spread rapidly in the whole nation.In the face of this crisis,all the parties within China’s daily chemical industry actively responded to the event and meticulously organized for assisting,played a vital role and became the indispensable backbone of the fight against the outbreak of COVID-19. | Wang Wanxu | 2020 | China Detergent & Cosmetics2020，5，1： | 0 |
| 14 | Thinking on Cleaning Industry under the Epidemic of COVID-19显示文摘The year of 2020 must be recorded as a year with major events in Chinese history.Similarly,the unique way of Chinese people to celebrate the Spring Festival will be also recorded.When the whole nation was prepared to celebrate the Spring Festival,a highly contagious novel coronavirus called COVID-19 broke out,unscrupulously eroding the lungs of the human body and threatening people’s lives.The virus developed so rapidly that spread around China and even the whole world in a short time.The Chinese government fights against the epidemic with the whole nation’s strength.Undoubtedly,the disaster will make great and deep influence on China’s society and economy,but eventually,the epidemic will be defeated,and the disaster will go away.As a man engaging in the cosmetic and cleaning industry,I’d like to examine the epidemic’s influence on the daily chemical industry,especially the cleaning industry,analyze and think about problems,discuss opportunities and revolutions and propose strategies.It is hoped to have some practical significance. | Wang Wanxu | 2020 | China Detergent & Cosmetics2020，5，1： | 0 |
| 15 | The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants显示文摘Coronavirus disease 2019(COVID-19),the disease caused by infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Since the first SARS-CoV-2 genome was released[1],thousands of genetic variants have been identified in SARS-CoV-2 strains isolated from worldwide patients. | Ben Hu Ran Liu Xiaolu Tang Yuchen Pan Ming Wang Yongqing Tong Guangming Ye Gaigai Shen Ruochen Ying Aisi Fu Di Li Wanxu Zhao Jing Peng Jie Guo Dong Men Xinmin Yao Yirong Wang Hong Zhang Zhihui Feng Junping Yu Liangjun Chen Zixin Deng Xuemei Lu Ya-Ping Zhang Yirong Li Bende Liu Lilei Yu Yan Li Jian Lu Tiangang Liu | 2021 | National Science Review2021，8，8： | 0 |
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