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| 1 | Discovery of ~4.0 Ga detrital zircons in the Changdu Block,North Qiangtang,Tibetan Plateau显示文摘在 situ 锆石由 LA-ICP-MS 和 MC-ICP-MS 标明日期使用, 3981 的由岩屑形成的锆石 ??? 鮼铧?? ? 裦蒚铩 ????? 偃 ?? 鮼 ?? 郥趽 ????腘 吗?? | ShiPing He RongShe Li Chao Wang HongFei Zhang WenHua Ji PuSheng Yu PingYang Gu Chao Shi | 2011 | Chinese Science Bulletin2011，56，7： | 9 |
| 2 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 3 | Occurrence, Distribution and Sources of Organochlorine Pesticides (OCPs) in Surface Sediments from the Lijiang River, a Typical Karst River of Southwestern China显示文摘 | Dan Zhang Yinghui Wang Kefu Yu Pingyang Li Ruijie Zhang Yiyin Xu | 2014 | Bulletin of Environmental Contamination and Toxicology2014，，5： | 1 |
| 4 | Visual- ization research on characteristics of the cryogenic slug flow in vertical and inclined tubes显示文摘 | LIU Yipeng WANG Pingyang HU Xueyu | 2012 | The Canadian Jour- nal of Chemical Engineering2012，90，6： | 1 |
| 5 | Collecting performance of an evacuated tubular solar high-temperature air heat- er with concentric tube heat exchanger 显示文摘 | Wang Pingyang Li Shuangfei Liu Zhenhua | 2015 | Energy Conversion and Management2015，，106： | 1 |
| 6 | On the Power System Technology显示文摘PSTC-89,Power System Technology Conference-1989,co-sponsoredby CSEE and IEEE Beijing Section,is jointly organized by four technicalcommittees (Societies) of CSEE.(The Power System Committee.TheLarge Rotating Machines Committee,The Automation and Computer Ap-plication Committee,and the Power System Relaying Committee) todiscuss technical problems recognized to be very important to the electri-cal power industry in China today,and of common interest to these disci-plines.It was held in Beijing on November 26-30.1989.and was attendedby 170 delegates,among which 105 were senior engineers,16 were | Wang Pingyang Vice President of CSEE | 1990 | Electricity1990，，2： | 0 |
| 7 | Study on Differences in Quality Indices of Peanut Oil Obtained by Different Oil-making Processes显示文摘[Objectives]The differences in indices of different peanut oil were found out by analyzing the quality of peanut oil obtained by different oil-making processes.[Methods]The effects of different oil-making processes on the quality of peanut oil were analyzed and compared through the determination of the main physicochemical indices,V_(E) contents and fatty acid compositions of peanut oil obtained by cold pressing,hot pressing and leaching and refining.[Results]The leached refined peanut oil had the lightest color and the lightest fragrance;the hot-pressed peanut oil had the highest V_(E) content;the refractive index,relative density and main fatty acid compositions of the three kinds of peanut oil had no significant differences;and there were trans-fatty acids in the leached refined peanut oil,and the trans-fatty acid contents in the leached refined fresh and aged peanut oil were 1.90%and 4.39%,respectively.The trans-fatty acid content is expected to be a characteristic index to distinguish pressed peanut oil from leached refined peanut oil.[Conclusions]This study can provide a theoretical basis for distinguishing and identifying peanut oil obtained from different oil-making processes. | Zhijun LIU Pingyang SHAN Wenchao XU Di WANG Jidong XU Xiaolong LI Lei WANG | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 8 | Split-Ring Structured All-Inorganic Perovskite Photodetector Arrays for Masterly Internet of Things显示文摘Photodetectors with long detection distances and fast response are important media in constructing a non-contact human-machine interface for the Masterly Internet of Things(MIT).All-inorganic perovskites have excellent optoelectronic performance with high moisture and oxygen resistance,making them one of the promising candidates for high-performance photodetectors,but a simple,low-cost and reliable fabrication technology is urgently needed.Here,a dual-function laser etching method is developed to complete both the lyophilic split-ring structure and electrode patterning.This novel split-ring structure can capture the perovskite precursor droplet efficiently and achieve the uniform and compact deposition of CsPbBr3 films.Furthermore,our devices based on laterally conducting split-ring structured photodetectors possess outstanding performance,including the maximum responsivity of 1.44×105 mA W^(−1),a response time of 150μs in 1.5 kHz and one-unit area<4×10-2 mm2.Based on these split-ring photodetector arrays,we realized three-dimensional gesture detection with up to 100 mm distance detection and up to 600 mm s^(−1) speed detection,for low-cost,integrative,and non-contact human-machine interfaces.Finally,we applied this MIT to wearable and flexible digital gesture recognition watch panel,safe and comfortable central controller integrated on the car screen,and remote control of the robot,demonstrating the broad potential applications. | Bori Shi Pingyang Wang Jingyun Feng Chang Xue Gaojie Yang Qingwei Liao Mengying Zhang Xingcai Zhang Weijia Wen Jinbo Wu | 2023 | Nano-Micro Letters2023，15，1： | 0 |
| 9 | Main Problems and Countermeasures of Chinese Chive Quality and Safety in China显示文摘In recent years,the problem of pesticide residues in Chinese chives has attracted widespread attention from society.This paper comprehensively analyzed the production and planting situation,quality and safety status and changes in pesticide standards of Chinese chives,and deeply discussed the main quality and safety problems of Chinese chives and their causes.On this basis,it was proposed to improve the quality and safety level of Chinese chives from three aspects:improving limit standards,promoting green production prevention and control techniques,and strengthening supervision on input products. | Pingyang SHAN Haoshuang DONG Lei WANG Zhe MENG Jianhua WANG Jinlu LI Yue HUANG | 2023 | Agricultural Biotechnology2023，12，6： | 0 |
| 10 | Simultaneous Determination of 14 β-Receptor Agonists Residues in Mutton by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS)显示文摘[Objectives]A high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)method was established for the determination of 14β-receptor agonist residues in mutton.[Methods]Samples were hydrolyzed byβ-glucuronidase and extracted with 5%acetic acid-acetonitrile(1:99,V/V)solution.An Eclipse plus C 18 column was used for separation,and the MRM mode was used for qualitative analysis,and the external standard method was used for quantitative analysis of matrix standard solutions.[Results]Under the optimal conditions,the retention time of the 14 kinds ofβ-receptor agonists ranged from 1.0 to 9.5 min.When the mass concentration was in the range of 0.05-0.50μg/ml,the linear relationship ofβ-receptor agonists was good,with correlation coefficients(r)≥0.9992.The detection limits of the method were in the range of 0.04-0.87μg/kg,and the quantitative limits were in the range of 0.35-1.86μg/kg.The average recovery values were in the range of 82.8%-108.9%,with RSDs(n=6)in the range of 1.9%-6.7%.[Conclusions]The method is simple,sensitive,reproducible,accurate,and can be used for simultaneous determination of the 14 kinds ofβ-receptor agonist residues in mutton. | Zhe MENG Jianhua WANG Bo LIU Yuhang GUO Haoshuang DONG Pingyang SHAN Dawei WANG Yajuan SONG | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 11 | KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B显示文摘Epilepsy is a common and severe brain disease affecting>65 million people worldwide.Recent studies have shown that kinesin superfamily motor protein 17(KIF17)is expressed in neurons and is involved in regulating the dendrite-targeted transport of N-methyl-D-aspartate receptor subtype 2B(NR2B).However,the effect of KIF17 on epileptic seizures remains to be explored.We found that KIF17 was mainly expressed in neurons and that its expression was increased in epileptic brain tissue.In the kainic acid(KA)-induced epilepsy mouse model,KIF17 overexpression increased the severity of epileptic activity,whereas KIF17 knockdown had the opposite effect.In electrophysiological tests,KIF17 regulated excitatory synaptic transmission,potentially due to KIF17-mediated NR2B membrane expression.In addition,this report provides the first demonstration that KIF17 is modified by SUMOylation(SUMO,small ubiquitin-like modifier),which plays a vital role in the stabilization and maintenance of KIF17 in epilepsy. | Yan Liu Xin Tian Pingyang Ke Juan Gu Yuanlin Ma Yi Guo Xin Xu Yuanyuan Chen Min Yang Xuefeng Wang Fei Xiao | 2022 | Neuroscience Bulletin2022，38，8： | 0 |
| 12 | Simulated Research of Enhanced Heat Transfer Characteristics of LNG in Rectangular Small Channels with Circumference Micro-Grooves显示文摘In view of the technical development bottleneck of 3D printing manufacturing compact heat exchanger for supercritical LNG,a new passive enhanced heat transfer technology is proposed by developing circumferential micro-grooves on the top and bottom walls of rectangular small channels.Numerical simulation of heat transfer enhancement and flow resistance characteristics of LNG in the enhanced channels with micro-grooves is performed.The geometrical dimensions such as the groove depth,the groove width and the center distance between two adjacent micro-grooves were optimized,and then the heat transfer enhancement and flow of LNG within the range of 120 K-250 K which across the critical temperature after the use of the strengthening technology were discussed.Then,further effects of working fluid temperature,mass flow(Reynolds number),and inlet pressure on heat transfer coefficient(Nusselt number),friction factor,and comprehensive coefficient were investigated.In addition,by the analysis of local flow characteristics near the micro-grooves,the heat transfer mechanism is discussed. | WANG Pingyang ZHAO Xinglin LIU Zhenhua | 2023 | Journal of Thermal Science2023，32，3： | 0 |
| 13 | Ultrasonic evaluation of the relationship between left ventricular hypertrophy or left ventricular geometry and endothelial function in patients with essential hypertension显示文摘Objective: To assess the relationship between left ventricular hypertrophy (LVH) or left ventricular geometry (LVG) and endothelial function in patients with essential hypertension (EH). Methods: Seventy-six patients and 30 normal subjects were first examined by echocardiography. Brachial artery dilatation induced by reactive hyperemia (DIRH) or nitroglycerin (DING) was detected using high-resolution ultrasonography. Results: DIRH was lower in patients with hypertension than in the controls, and the decrease in DIRH was greater in the patients with LVH than that in patients without LVH (4 .36±2.54% vs 8.56±1.87 %; P < 0.0001). There were no significant differences in age, serum concentrations of total cholesterol, triglycerides or sugar, blood pressure and the brachial artery dilatation induced by nitroglycerin between the two groups (P > 0.05). While there was no significant difference in DIRH between the patients with normal left ventricular geometry or cardiac remodeling, the patients showing either eccentric or concentric left ventricular hypertrophy had lower DIRH than the patients with normal left ventricular geometry or cardiac remodeling. The DIRH was the lowest in patients with concentric hypertrophy. Although bivariate analysis showed that the left ventricular mass index (LVMI) correlated well with the brachial artery dilatation induced by reactive hyperemia, diastolic blood pressure and mean blood pressure (r=-0.61, P < 0.0001; r=0.27, P < 0.05; r=0.31, P < 0.05, respectively), a multivariate stepwise regression demonstrated that LVMI correlated only with the brachial artery dilatation induced by reactive hyperemia. Conclusion: Left ventricular hypertrophy was related to endothelial dysfunction in essential hypertension. The endothelial dysfunction might be basic and important in the progression of left ventricular hypertrophy. | Jing Dong Pingyang Zhang Xuehong Feng Chong Wang Pei Wang | 2009 | Journal of Nanjing Medical University2009，23，6： | 0 |
| 14 | The Application of Fuzzy Image Recognition in Power System显示文摘Electrified railway is an important but disturbing load in power system. In China railway electrification is gaining momentum at the end of this century.The Ministry of Railway has a clear indication that the development trend of railway transportation is the coexistence of internal-combustion engine locomotive and electrified locomotive. Meanwhile it will make strenuous efforts to develop the electrified railWay for the plain land, the main lines and the busy areas of transportation. It is obvious that the importance of electrified railway in railWay transpoftation will be enhanced more and more. It is going to be an important load to power systems all over China. But it is a disturbing load It gives serious harmonics pollution to power system if not properly maintained. This paper describes a new advanced method, fuzzy image recognition technique, to improve the adjustment during maintenance of the supply line so that good contact of the pantograph with the power line is ensured. This case also serves as an example to illustrate how the work on the demand side effectively improves the operation of the power system. | Lu Dezheng Wang Pingyang Zen Yuejin(Electric Power Research institute Fuzzy Lab, Beijing Normal UniversityQinghe, Beijing, P.R.China Beijing, P.R. China) | 1998 | Electricity1998，，3： | 0 |
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