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| 1 | Optimal operation of electricity, natural gas and heat systems considering integrated demand responses and diversified storage devices显示文摘In recent years, the increasing penetration level of renewable generation and combined heat and power(CHP) technology in power systems is leading to significant changes in energy production and consumption patterns. As a result, the integrated planning and optimal operation of a multi-carrier energy(MCE) system have aroused widespread concern for reasonable utilization of multiple energy resources and efficient accommodation of renewable energy sources. In this context, an integrated demand response(IDR) scheme is designed to coordinate the operation of power to gas(P2 G) devices, heat pumps,diversified storage devices and flexible loads within an extended modeling framework of energy hubs. Subsequently, the optimal dispatch of interconnected electricity,natural gas and heat systems is implemented considering the interactions among multiple energy carriers by utilizing the bi-level optimization method. Finally, the proposed method is demonstrated with a 4-bus multi-energy systemand a larger test case comprised of a revised IEEE 118-bus power system and a 20-bus Belgian natural gas system. | Linna NI Weijia LIU Fushuan WEN Yusheng XUE Zhaoyang DONG Yu ZHENG Rui ZHANG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 30 |
| 2 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 3 | Fate of Vibrio parahaemolyticus on shrimp after acidic electrolyzed water treatment显示文摘 | Jing Jing Wang Wen Shou Sun Meng Tong Jin Hai Quan Liu Weijia Zhang Xiao Hong Sun Ying Jie Pan Yong Zhao | 2014 | International Journal of Food Microbiology2014，，： | 2 |
| 4 | Microwave Transmission Through Metallic Hole Arrays: Surface Electric Field Measurements 显示文摘 | Hou Bo Hang Zhi Hang Wen Weijia | 2006 | Applied Physics Letters2006，89，13： | 1 |
| 5 | The giant electrorheological effect in suspension of nanoparticles显示文摘 | Wen Weijia Huang Xianxiang Yang Shihe | 2003 | Nat Mater2003，2，11： | 1 |
| 6 | Frequency dependent electrorheological properties:Origin and bounds显示文摘 | Ma Hongru Wen Weijia Wing Y T | 1996 | Phys Rev Lett1996，77，12： | 1 |
| 7 | Analysis and fabrication ofpatterned magnetorheological elastomers显示文摘 | ZHANG Xianzhou PENG Suili WEN Weijia | 2008 | Smart Mater Struct2008，17，04： | 1 |
| 8 | The giantelectrorheological effect in suspensions ofnanoparticles显示文摘 | Weijia Wen Xianxiang Hang | 2003 | nature materials2003，2，： | 1 |
| 9 | Paperlike thermochromic display 显示文摘 | Liu Liyu Peng Suili Wen Weijia | 2007 | Applied Physics Letters2007，90，21： | 1 |
| 10 | 显示文摘 | Zhou Lei Wen Weijia Sheng Ping | 1998 | Physical Review Letters1998，81，： | 1 |
| 11 | The giant electrorheological effect in suspensions of nanoparti- eles显示文摘 | Wen Weijia Huang Xianxiang Yang Shihe | 2003 | Nature Materials2003，2，11： | 1 |
| 12 | TiO2 based electrorheologieal fluids with high yield stress 显示文摘 | Shen Rong Wang Xuezhao Wen Weijia | 2005 | International Journal of Modern Physics B2005，19，789： | 1 |
| 13 | High performance calcium titanate nanoparticle ER fluids 显示文摘 | Wang Xuezhao Shen Rong Wen Weijia | 2005 | International Journal of Modern Physics B2005，19，789： | 1 |
| 14 | Subwavelength Photonic Band Gaps from Planar Fractals显示文摘 | Wen Weijia Zhou Lei Li Jensen | 2002 | Phys Rev Lett2002，89，22： | 1 |
| 15 | Multiband Subwavelength Magnetic Reflectors Based on Fractals显示文摘 | Zhou Lei Wen Weijia Chan C T | 2003 | Appl Phys Lett2003，83，16： | 1 |
| 16 | Design andfabrication of magnetically functionalized core/shell micro-spheres for smart drug delivery显示文摘 | Gong Xinqing Peng Suili Wen Weijia | 2009 | Advanced FunctionalMaterials2009，19，2： | 1 |
| 17 | The giant electrorheological effeet in suspensions of nanoparticles显示文摘 | Weijia Wen Xianxiang Huang Shihe Yang | 2003 | Nature Materials2003，2，11： | 1 |
| 18 | Analysis and optimization of the preferences of decision makers in black-start group decision makering显示文摘 | Weijia Liu Zhenzhi Lin Fushuan Wen | 2013 | IET Generation Transmission& Distribution2013，7，1： | 1 |
| 19 | Paperlike thermo- chromic display显示文摘 | Liu Liyu Peng Suili Wen Weijia | 2007 | Appl Phys Lett2007，90，： | 1 |
| 20 | Subwavelength Photonic Band Gaps from Planar Fractals显示文摘 | Wen Weijia Zhou Lei Li Jenson | 2002 | Phys Rev Lett2002，89，22： | 1 |
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