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| 1 | MicroRNA-23a promotes colorectal cancer cell migration and proliferation by targeting at MARK1显示文摘The functional role of microRNA-23a in tumorigenesis has been investigated;however, the exact mechanism of microRNA-23a (miR-23a) in colorectal cancer development has not been fully explored. In the present study, we aimed to investigate the molecular functional role of miR-23a in colorectal carcinogenesis. Quantitative real-time polymerase chain reaction was conducted to investigate the expression level of miR-23a in tissue samples and cell lines (HCT116 and SW480). CCK-8, colony formation and Transwell assay were used to explore the role of miR-23a in cell proliferation and migration. Dual luciferase reporter assay was used to identify the direct binding of miR-23a with its target, MARK1. Western blot analysis was used to analyze the expression level of MARK1, as well as a confirmed miR-23a target gene, MTSS1, in miR-23a-mimic and miR-23a-inhibit groups. Rescue experiments were conducted by overexpression of MARK1 in miR-23a-mimic-transfected cell lines. The results showed that miR-23a was highly expressed in colorectal cancer tissue and cell lines. MiR-23a could promote proliferation and migration of colorectal cancer cell lines. MARK1 was a direct target of miR-23a and the expression level of MARK1 was down-regulated in miR-23a-mimic-transfected cell lines but up-regulated in miR-23a-inhibit-transfected cells. Overexpression of MARK1 could partly reverse the cancer-promoting function of miR-23a. Our results suggested that miR-23a promotes colorectal cancer cell proliferation and migration by mediating the expression of MARK1. MiR-23a may be a potential therapeutic target for colorectal cancer treatment. | Xiaoli Tang Meiyuan Yang Zheng Wang Xiaoqing Wu Daorong Wang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 11 |
| 2 | Mechanisms of hydrocephalus after intraventricular haemorrhage in adults显示文摘Intraventricular haemorrhage(IVH)is defined as the eruption of blood in the cerebroventricular system and occurs mostly secondary to intracerebral haemorrhage(ICH)in adults.Hydrocephalus is a severe complication of IVH that can serve as an independent predictor of increased mortality.In this mini-review,we focus on the mechanisms of hydrocephalus after adult IVH,including blood-clot blockage,barrier impairment,inflammation and blood components,and attempt to reconcile the current research findings into a unified framework.We expect our theoretical framework to help guide future clinical and basic research leading to improved monitoring and intervention for IVH and subsequent hydrocephalus. | Yaoyao Bu Meiyuan Chen Ting Gao Xiao Wang Xuting Li Feng Gao | 2016 | Stroke & Vascular Neurology2016，1，1： | 4 |
| 3 | STAM2 knockdown inhibits proliferation,migration,and invasion by affecting the JAK2/STAT3 signaling pathway in gastric cancer显示文摘Signal transducing adaptor molecule 2(STAM2)is a phosphotyrosine protein,which regulates receptor signaling and trafficking of mammalian cells.However,its role in gastric cancer(GC)remains undiscovered.In this study,we aimed to investigate the functions of STAM2 in GC.The mRNA and protein expression levels of STAM2 were measured by quantitative real-time PCR,western blot analysis,and immunohistochemistry.STAM2 was stably silenced in AGS and HGC-27 cells using small interfering RNA.The function of STAM2 in GC cells was further investigated by CCK-8 assay,EdU incorporation assay,flow cytometry,and scratch wound healing and Boyden chamber assays.Additionally,we conducted biological pathway enrichment analysis and rescue assays to explore the effects of STAM2 on JAK/STAT signaling pathway.Our results showed that STAM2 is remarkably highly expressed in GC tissues and cells,and overexpressed STAM2 is correlated with tumor size,advanced tumor node metastasis stage,and poor prognosis.In addition,STAM2 knockdown could significantly inhibit proliferation,block cell cycle,and restrain migration and invasion capabilities of GC cells.Mechanistically,we found that STAM2 knockdown effectively decreased the expressions of MMP2 and MMP9 and the phosphorylation levels of JAK2 and STAT3.Taken together,this study revealed that STAM2 knockdown could suppress malignant process by targeting the JAK2/STAT3 signaling pathway in GC. | Yang Yang Qi Zhang Jiakui Liang Meiyuan Yang Zheng Wang Dong Tang Daorong Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 2 |
| 4 | Modeling studies on sulfur deposition and transport in East Asia显示文摘 | Huang Meiyuan Wang Zifa He Dongyang Xu Huaying Zhou Ling | 1995 | Water Air & Soil Pollution1995，，4： | 1 |
| 5 | Size and concentration effects on the photoluminescenee of La202S:Eu3+ nanoerystals 显示文摘 | Dai Qilin Song Hongwei Wang Meiyuan | 2008 | J Phys Chem C2008，112，19： | 1 |
| 6 | Investigation on the improvement of red phosphorescence in CaTiO 3 :Pr 3+ nanoparticles显示文摘 | Xianmin Zhang Jiahua Zhang Meiyuan Wang X. Zhang H. Zhao Xiao-Jun Wang | 2008 | Journal of Luminescence2008，，5： | 1 |
| 7 | Modeling studies on sulfur deposition and transport in East Asia 显示文摘 | HUANG Meiyuan WANG Zifa HE Dongyang | 1995 | Water Air Soil Pollut1995，85，4： | 1 |
| 8 | Research Advances in Functional Constituents of Chickpea显示文摘Based on the generalization and summary of the research on the functional constituents of chickpea at home and abroad in recent years,the research advances in some rich functional constituents including isoflavones,proteins and peptides,carbohydrates,saponins and trace elements in chickpeas was reviewed in this paper. It provides a basis for the research,development and utilization of the functional constituents of chickpea in the future. | Haitian YU Aiqing ZHENG Meiyuan LU Feng YANG Chaoqin HU Xin YANG Yuhua HE Liping WANG | 2019 | Asian Agricultural Research2019，11，4： | 1 |
| 9 | DNA Fingerprinting of Ninety Wild Strains of Agaricus from China显示文摘Ninety wild strains of Agaricus collected in China,including 44 strains preliminarily identified as Agaricus bisporus by isozyme electrophoresis,were studied using SRAP and ISSR techniques.Eighteen specific SRAP bands and 12 specific ISSR bands were scored,and a cluster dendrogram was constructed.The 90 wild strains of Agaricus were separated into two major groups,the first consisting of wild strains of A.bisporus and the second consisting of other Agaricus strains.Forty-one wild strains of A.bisporus collected in Sichuan and Tibet formed four groups according to the geographical location of the collection area.White A.bisporus strains from Xinjiang and Tibet(Xinjiang Wild,AgX04 and AgX042)exhibited unique band patterns resulting in lower similarity coefficient values(10%~13%)when compared with brown or light-brown A.bisporus strains. | CHEN Meiyuan LIAO Jianhua WANG Bo LI Hongrong LU Zhenghui GUO Zhongjie CAI Danfeng WANG Zesheng | 2009 | 食用菌学报2009，16，1： | 0 |
| 10 | Determination of Polydatin in Rat Serum and Its Changes by UPLC Method显示文摘[Objectives]To establish a UPLC-UV method for the determination of polydatin in the serum of Wistar rats.[Methods]Acquity UPLC BEH shield RP18 column(1.7μm,2.1 mm×100 mm,Waters Corporation,USA)was used as the analytical column,acetonitrile-water(55∶45)was used as the mobile phase,the flow rate was 0.5 mL/min,and the column temperature was 30℃and the detection wavelength was 306 nm.[Results]The linear range of the established serum sample analysis method was 1.0-20.0μg/mL,and the correlation coefficient was r=0.9994;the intraday and interday RSD of Wistar rat serum was less than 3.0%,and the accuracy was higher than 90%.[Conclusions]This method is sensitive,accurate,and rapid.It is suitable for monitoring the concentration of polydatin in serum after intragastric administration,and can also be used for pharmacokinetics and bioavailability studies. | Haisheng ZENG Zhiqiang WANG Meiyuan LU Chao ZENG Mengxia YANG Guilin YANG | 2021 | Medicinal Plant2021，12，2： | 0 |
| 11 | Effects of magnetic fluids on crystallization characterizations in a multi-component and multiphase system显示文摘In this study, experiments are carried out on the effects of magnetic fluids on the crystallization char- acterizations in a multi-component and multiphase system, which contains the liquid and the vapor of HCFC141b, water, water vapor, and gas hydrates. The mass transfer phenomena between the phase interfaces of water-HCFC141b and water-vapor are also researched. The experimental results show that in the presence of a rotary magnetic field, magnetic fluids can remarkably enhance the heat and mass transfer between phase interfaces and, therefore, improve the performance of crystallization, especially in improving the formation temperature and velocity. | SHU BiFen SHEN Hui CHEN MeiYuan XIA JianHan WANG Xiang SUN JianWei | 2008 | Science China Chemistry2008，51，4： | 0 |
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