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| 1 | Geochronology and Geochemistry of the Radiolarian Cherts of the Mada'er Area,Southwestern Tianshan:Implications for Depositional Environment显示文摘在西南的 Tianshan,因为复杂结构,许多阶层和他们的 depositional 环境的地质的年龄仍然糟糕被抑制。Mada'er 区域位于 Kuokesaleling 带,西南的 Tianshan。从以前的 Wupata'erkan 组的燧石包含丰富的放散虫类的各类动物石块,包括作为迟了被识别的 10 种类泥盆纪到在年龄早含碳。十一件燧石样品有 SiO2 内容为 Al2O3 从 88.80 wt%到 93.28 wt% ,和 2.02 wt% 到 3.72 wt% 。所有样品的 SiO2/Al2O3 比率从 23.84 ~ 46.11 变化,纯燧石(801400 ) 的比那些低的大部分。这些价值建议燧石包含源自陆地的材料的高比率。Al2O3/(Al2O3+Fe2O3 ) 比率在 0.64 和 0.77 之间变化,而 V 和 Cu 集中分别地从 10.92 ppm 到 26.7 ppm 并且从 2.15 ppm 到 34.1 ppm。Ti/V 比率从 25.53 ~ 44.93 变化。燧石的全部的 REE 集中在 30.78 ppm 和 59.26 ppm 之间,平均 45.46 ppm。(La/Ce ) N 比率从 0.81 ~ 1.12,和 0.881.33 为(La/Yb ) N,平均 1.09,它建议大陆人边缘环境。因而,燧石在迟了的泥盆纪期间在剩余海环境形成了到早含碳的时间,这被推断,它建议在 Karakum-Tarim 和 Kazakhstan-Junggar 盘子之间的碰撞没那时发生。另外,地区性的地质的信息显示学习区域经历了一个碰撞以后的阶段在期间早二叠,并且这样在二个盘子之间的碰撞发生了在,是可能的晚含碳。 | KANG Jianli ZHANG Zhaochong ZHANG Dongyang HUANG He DONG Shuyun ZHANG Su | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 8 |
| 2 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 3 | Intestinal OCTN2-and MCT1-targeted drug delivery to improve oral bioavailability显示文摘Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs,thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.In particular,intestinal carnitine/organic cation transporter 2(OCTN2)and mono-carboxylate transporter protein 1(MCT1)possess high transport capacities and complementary distributions.Therefore,we outline recent developments in transporter-targeted oral drug delivery with regard to the OCTN2 and MCT1 proteins in this review.First,basic information of the two transporters is reviewed,including their topological structures,characteristics and functions,expression and key features of their substrates.Furthermore,progress in transporter-targeting prodrugs and nanoparticles to increase oral drug delivery is discussed,including improvements in the oral absorption of anti-inflammatory drugs,antiepileptic drugs and anticancer drugs.Finally,the potential of a dual transporter-targeting strategy is discussed. | Gang Wang Lichun Zhao Qikun jiang Yixin Sun Dongyang Zhao Mengchi Sun Zhonggui He Jin sun Yang Wang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 3 |
| 4 | A high-efficient triboelectric-electromagnetic hybrid nanogenerator for vibration energy harvesting and wireless monitoring显示文摘Scavenging mechanical vibration energy by combining triboelectric nanogenerators(TENGs) and electromagnetic generators(EMGs) is a renewable and low-carbon way to generate electric power. In this paper, we fabricate a cylindrical structure hybrid nanogenerator based on spring structure to effectively scavenge vibration energy. The introduction of spring structure not only enhances the space utilization, but also supports the moving magnet. Owing to its innovative structure, the instantaneous output power of TENG and EMG are 0.88 mW at a load of 10 MΩ and 216.7 mW at a load of 60 Ω, respectively. With the aids of a power management circuit, the hybrid nanogenerator can provide continuous power for two hygrothermographs connected in series. In addition, a self-powered wireless acceleration sensing monitoring system(SWAM) is developed to measure the acceleration signals of vibration sources. This study provides a novel guideline for harvesting mechanical vibration energy. | Jian HE Xueming FAN Dongyang ZHAO Min CUI Bing HAN Xiaojuan HOU Xiujian CHOU | 2022 | Science China(Information Sciences)2022，65，4： | 3 |
| 5 | Extremely low penetrance of deafness associated with the mitochondrial 12S rRNA mutation in 16 Chinese families: Implication for early detection and prevention of deafness显示文摘 | Pu Dai Xin Liu Dongyi Han Yaping Qian Deliang Huang Huijun Yuan Weiming Li Fei Yu Ruining Zhang Hongyan Lin Yong He Youjun Yu Quanzhu Sun Huaiyi Qin Ronghua Li Xin Zhang Dongyang Kang Juyang Cao Wie-Yen Young Min-Xin Guan | 2005 | Biochemical and Biophysical Research Communications2005，，1： | 2 |
| 6 | Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics显示文摘A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2’-deoxy-2’, 2’-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated.The conventional plasma sample preparation method of nucleoside analogues is solidphase extraction(SPE) which is time-consuming and cost-expensive. In this study, gradient elution with small particles size solid phase was applied to effectively separate gemcitabine and JDR, and protein precipitation pretreatment was adopted to remove plasma protein and extract the analytes with high recovery(>81%). Method validation was performed as per the FDA guidelines, and the standard curves were found to be linear in the range of 5–4000 ng/ml for JDR and 4–4000 ng/ml for gemcitabine, respectively. The lower limit of quantitation(LLOQ)of gemcitabine and JDR was 4 and 5 ng/ml, respectively. The intra-day and inter-day precision and accuracy results were within the acceptable limits. Finally, the developed method was successfully applied to investigate the pharmacokinetic studies of JDR and gemcitabine after oral administration to rats. | Gang Wang Dongyang Zhao Hongxiang Chen Dawei Ding Longfa Kou Lifang Sun Chenxia Hao Xincong Li Kai Jia Qiming Kan Xiaohong Liu Zhonggui He Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 2 |
| 7 | Modeling studies on sulfur deposition and transport in East Asia显示文摘 | Huang Meiyuan Wang Zifa He Dongyang Xu Huaying Zhou Ling | 1995 | Water Air & Soil Pollution1995，，4： | 1 |
| 8 | Exploring the relationship of hyaluronic acid molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles显示文摘Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles(NPs) is molecular weight(MW) dependent,the influence of HA MW on targeting efficiency of HA-functionalized NPs and the underlying mechanism remain elusive. In this study,we constituted three HA-functionalized Dox-loaded NPs(Dox/HCVs) different HA MWs(7,63,and 102 k Da) and attempted to illustrate the effects of HA MW on the targeting efficiency.The three Dox/HCVs had similar physiochemical and pharmaceutical characteristics,but showed different affinity to CD44 receptor. Furthermore,Dox/HCV-63 exerted the best targeting effect and the highest cytotoxicity compared with Dox/HCV-7 and Dox/HCV-102. It was interesting to found that both the HA-CD44 binding affinity and induced CD44 clustering by HA-based NPs were HA MW-dependent,the two of which determine the apparent targeting efficacy of Dox/HCV NPs in the conflicting directions. Those results laid a good foundation for rationally designing HA-based NPs in cancer therapy. | Lu Zhong Yanying Liu Lu Xu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 1 |
| 9 | Modeling studies on sulfur deposition and transport in East Asia 显示文摘 | HUANG Meiyuan WANG Zifa HE Dongyang | 1995 | Water Air Soil Pollut1995，85，4： | 1 |
| 10 | Nanofiber self-consistent additive manufacturing process for 3D microfluidics显示文摘3D microfluidic devices have emerged as powerful platforms for analytical chemistry,biomedical sensors,and microscale fluid manipulation.3D printing technology,owing to its structural fabrication flexibility,has drawn extensive attention in the field of 3D microfluidics fabrication.However,the collapse of suspended structures and residues of sacrificial materials greatly restrict the application of this technology,especially for extremely narrow channel fabrication.In this paper,a 3D printing strategy named nanofiber self-consistent additive manufacturing(NSCAM)is proposed for integrated 3D microfluidic chip fabrication with porous nanofibers as supporting structures,which avoids the sacrificial layer release process.In the NSCAM process,electrospinning and electrohydrodynamic jet(E-jet)writing are alternately employed.The porous polyimide nanofiber mats formed by electrospinning are ingeniously applied as both supporting structures for the suspended layer and percolating media for liquid flow,while the polydimethylsiloxane E-jet writing ink printed on the nanofiber mats(named construction fluid in this paper)controllably permeates through the porous mats.After curing,the resultant construction fluid–nanofiber composites are formed as 3D channel walls.As a proof of concept,a microfluidic pressure-gain valve,which contains typical features of narrow channels and movable membranes,was fabricated,and the printed valve was totally closed under a control pressure of 45 kPa with a fast dynamic response of 52.6 ms,indicating the feasibility of NSCAM.Therefore,we believe NSCAM is a promising technique for manufacturing microdevices that include movable membrane cavities,pillar cavities,and porous scaffolds,showing broad applications in 3D microfluidics,soft robot drivers or sensors,and organ-on-a-chip systems. | Bin Qiu Xiaojun Chen Feng Xu Dongyang Wu Yike Zhou Wenchang Tu Hang Jin Gonghan He Songyue Chen Daoheng Sun | 2022 | Microsystems & Nanoengineering2022，8，5： | 0 |
| 11 | Preliminary Breeding of Superior Maize Combinations in Zhaotong,Yunnan显示文摘[Objectives]This study was conducted to select superior maize combinations.[Methods]With the control maize variety Haihe 2 in the middle altitude area of Yunnan Province as the control,adopting a single-factor randomized block three-replicate experiment design,a one-year field cultivation experiment was carried out in Luyin Village,Yongfeng Town,Zhaoyang District,Zhaotong City.[Results]A total of 11 new superior maize combinations including ZT-1 and ZT-2 were obtained.Through comprehensive comparison analysis with Haihe 2(CK),we selected six superior combinations of ZT-1,ZT-3,ZT-4,ZT-6,ZT-7 and ZT-9,which showed overall performance better than the control Haihe 2(CK)in terms of resistance,yield,and ear traits.[Conclusions]The selected 6 superior combinations have promotion value,and are recommended for higher-level trials and demonstrations. | Shimin WANG Jianjun LIU Dongyang KAN Xuangui CHEN Shijun ZHANG Xianzhu HE Jinpeng CHENG | 2021 | Agricultural Biotechnology2021，10，3： | 0 |
| 12 | A color-based FHGC approach facilities DNA-based clinical molecular diagnostics显示文摘The flow-through hybridization and gene chip(FHGC)was developed to used in clinical molecular diagnostics for thalassemia,human papillomavirus(HPV),and other dis-eases.FHGC could improve hybridization efficiency and reduce hands-on time,thus improving precision,repro-ducibility,and traceability.Multiple genotypes can be detected simultaneously without incurring high costs.^(1)During the experiment,the polymerase chain reaction(PCR)product or buffer forced through the membrane matrix,PCR products are apprehended by a probe attached to the membrane. | Ruyi Zhang Dongyang Deng Min Ren Jiangyan He Fang Chen Shujuan Yan | 2023 | Genes & Diseases2023，10，4： | 0 |
| 13 | Scaly-sided Merganser(Mergus squamatus)equalizes foraging costs with depth by switching foraging tactics显示文摘Throughout evolutionary history,animals are finely tuned to adjust their behaviors corresponding to environmental variations.Behavioral flexibility represents an important component of a species'adaptive capacity in the face of rapid anthropogenetic environmental change,and knowledge of animal behaviors is increasingly recognized in conservation biology.In aquatic ecosystem,variation of water depth is a key factor affecting the availability of food;thus,the foraging behaviors of many waterbirds,especially piscivores.In this study,we compared the foraging behaviors of the Scaly-sided Merganser(Mergus squamatus),an endangered migratory diving duck endemic to East Asia,in habitats with different water depths(Shallow waters:0–40 cm;Deep waters:40–300 cm),using video camera records obtained from the known wintering sites during three winters from 2018 to 2020.Further,the energy expenditure of foraging behavior profile and energy intake based on fish sizes were calculated to study the foraging energetics.In total,200 effective video footages that contained 1086 min with 17,995 behaviors and 163 events of catching fish were recorded.Results showed that:1)time length for fishing(including eye-submerging,head-dipping,diving and food handling)of M.squamatus in shallow waters was significantly more than in deep waters;2)M.squamatuss spent significantly more time for preparing(including vigilance,preening and swimming)in deep waters than in shallow waters;3)the mean catch rate was 0.28 fish/min in shallow waters,which is significantly higher than the value of 0.13 fish/min in deep waters;4)despite the distinct foraging behavior profiles and energy intakes,M.squamatus showed similar energetics in shallow and deep waters.We concluded that M.squamatus is a good example of behavioral flexibility that aligns with expectations of optimal foraging theory,in that it behaves in accordance to resource availability in different environments,resulting in high foraging efficiency. | Peizhong Liu Meihan Liu Dongyang Xiao Ying He Rong Fan Cai Lu Li Wen Qing Zeng Guangchun Lei | 2023 | Avian Research2023，14，4： | 0 |
| 14 | Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes显示文摘The unique characteristics of the tumor microenvironment(TME)could be exploited to develop antitumor nanomedicine strategies.However,in many cases,the actual therapeutic effect is far from reaching our expectations due to the notable tumor heterogeneity.Given the amplified characteristics of TME regulated by vascular disrupting agents(VDAs),nanomedicines may achieve unexpected improved efficacy.Herein,we fabricate platelet membrane-fusogenic liposomes(PML/DP&PPa),namely“platesomes”,which actively load the hypoxia-activated pro-prodrug DMG-PR104A(DP)and physically encapsulate the photosensitizer pyropheophorbide a(PPa).Considering the different stages of tumor vascular collapse and shutdown induced by a VDA combretastatin-A4 phosphate(CA4P),PML/DP&PPa is injected 3 h after intraperitoneal administration of CA4P.First,CA4P-mediated tumor hemorrhage amplifies the enhanced permeation and retention(EPR)effect,and the platesome-biological targeting further promotes the tumor accumulation of PML/DP&PPa.Besides,CA4P-induced vascular occlusion inhibits oxygen supply,followed by photodynamic therapy-caused acute tumor hypoxia.This prolonged extreme hypoxia contributes to the complete activation of DP and then high inhibitory effect on tumor growth and metastasis.Thus,such a combining strategy of artificially-regulated TME and bio-inspired platesomes pronouncedly improves tumor drug delivery and boosts tumor hypoxia-selective activation,and provides a preferable solution to high-efficiency cancer therapy. | Wenhui Tao Dongyang Zhao Guanting Li Lingxiao Li Songhao Li Hao Ye Chutong Tian Yutong Lu Shuying Li Yinghua Sun Zhonggui He Jin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 0 |
| 15 | Manipulating micro-electric field and coordination-saturated site configuration boosted activity and safety of frustrated single-atom Cu/O Lewis pair for acetylene hydrochlorination显示文摘Simultaneously boosting acetylene hydrochlorination activity and avoiding formation of explosive copper acetylide over Cu-based catalyst,which represented a promising alternative to Hg-based and noble metal catalysts,remained challenging.Herein,we fabricated a frustrated single-atom Cu/O Lewis pair catalyst(Cu/O-FLP)by coupling epoxide group(C-O-C)with atomdispersed Cu-cis-N_(2)C_(2)Cl center to address this challenge.The basic epoxy site modulated the electron-deficient state of Lewisacidic Cu center and paired with the Cu-cis-N_(2)C_(2)Cl moiety to preferentially break HCl into different electronegative Cu-Clδ-and C-O-H^(δ+)intermediates,which further induced both an extra localized electric field to polarize acetylene and a upshift of the dband center of catalyst,thereby promoting adsorption and enrichment of acetylene by enhancing the dipolar interaction between acetylene and active intermediates.Moreover,the generated Cu-Clδ-and C-O-H^(δ+)drastically reduced the energy barrier of ratelimiting step and made vinyl chloride easier to desorb from the Lewis-basic oxygen-atom site rather than traditional Lewis-acidic Cu center.These superiorities ensured a higher activity of Cu/O-FLP compared with its counterparts.Meanwhile,preferential dissociation of HCl endowed single-atom Cu with the coordination-saturated configuration,which impeded formation of explosive copper acetylide by avoiding the direct interaction between Cu and acetylene,ensuring the intrinsic safety during catalysis. | Junchen Peng Dandan Dong Zongyuan Wang Hong Yang Dongyang Qiao Qinqin Wang Wei Sun Minmin Liu Jiajun Wang Mingyuan Zhu Bin Dai Fei He Chaofeng Huang | 2023 | Nano Research2023，16，7： | 0 |
| 16 | A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates显示文摘Monocarboxylate transporter 1(MCT1)is responsible for oral absorption of short-chain monocarboxylic acids from small intestine,hence,it’s likely to serve as an ideal design target for the development of oral prodrugs.However,potential application of MCT1 to facilitate the oral delivery is still unclear.Irregular oral absorption,poor permeability and bioavailability greatly limit the oral delivery efficiency of 5-fluorouracil(5-FU).Herein,we design three 5-FU-fatty acid conjugates targeting intestinal MCT1 with different lipophilic linkages.Interestingly,due to high MCT1 affinity and good gastrointestinal stability,5-FUoctanedioic acid monoester prodrug exhibited significant improvement in membrane permeability(13.1-fold)and oral bioavailability(4.1-fold)compared to 5-FU.More surprisingly,stability experiment in intestinal homogenates showed that 5-FU prodrugs could be properly activated to release 5-FU within intestinal cells,which provides an ideal foundation for the improvement of oral bioavailability.In summary,good gastrointestinal stability,high membrane permeability and appropriate intestinal cell bioactivation are the important factors for high-efficiency 5-FU oral prodrugs,and such work provides a good platform for the development of novel oral prodrugs targeting intestinal transporters. | Yixin Sun Dongyang Zhao Gang Wang Qikun Jiang Mengran Guo Qiming Kan Zhonggui He Jin Sun | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 0 |
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