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| 1 | Prognostic factors for transarterial chemoembolization combined with sustained oxaliplatin-based hepatic arterial infusion chemotherapy of colorectal cancer liver metastasis显示文摘Objective: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis(CRCLM)patients treated by transarterial chemoembolization(TACE) and sustained hepatic arterial infusion chemotherapy(HAIC).Methods: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60(range, 26–83) years.Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses.Results: The median survival time(MST) and median progression-free survival(PFS) of the 162 patients from first TACE/HAIC were 15.6 months and 5.5 months respectively. Normal serum carbohydrate antigen 19-9(CA19-9, <37 U/m L)(P<0.001) and carbohydrate antigen 72-4(CA72-4, <6.7 U/m L)(P=0.026), combination with other local treatment(liver radiotherapy or liver radiofrequency ablation)(P=0.034) and response to TACE/HAIC(P<0.001) were significant factors related to survival after TACE/HAIC in univariate analysis. A multivariate analysis revealed that normal serum CA19-9(P<0.001), response to TACE/HAIC(P<0.001) and combination with other local treatment(P=0.001) were independent factors among them.Conclusions: Our findings indicate that serum CA19-9 <37 U/m L and response to TACE/HAIC are significant prognostic indicators for this combined treatment, and treated with other local treatment could reach a considerable survival benefit for CRCLM. This could be useful for making decisions regarding the treatment of CRCLM. | Hangyu Zhang Jianhai Guo Song Gao Pengjun Zhang Hui Chen Xiaodong Wang Xiaoting Li Xu Zhu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 12 |
| 2 | Multi-stage attack weapon target allocation method based on defense area analysis显示文摘For better reflecting the interactive defense between targets in practical combat scenarios,the basic weapon-target allocation(WTA)framework needs to be improved.A multi-stage attack WTA method is proposed.First,a defense area analysis is presented according to the targets’positions and the radii of the defense areas to analyze the interactive coverage and protection between targets’defense areas.Second,with the coverage status and coverage layer number,a multi-stage attack planning method is proposed and the multi-stage attack objective function model is established.Simulation is conducted with interactive defense combat scenarios,the traditional WTA method and the multi-stage WTA method are compared,and the objective function model is validated with the Monte-Carlo method.The results suggest that if the combat scenario involves interactive coverage of targets’defense areas,it is imperative to analyze the defense areas and apply the multi-stage attack method to weakening the target defense progressively for better combat effectiveness. | JIA Zhengrong LU Faxing WANG Hangyu | 2020 | Journal of Systems Engineering and Electronics2020，31，3： | 9 |
| 3 | Pristine PN junction toward atomic layer devices显示文摘In semiconductor manufacturing,PN junction is formed by introducing dopants to activate neighboring electron and hole conductance.To avoid structural distortion and failure,it generally requires the foreign dopants localize in the designated micro-areas.This,however,is challenging due to an inevitable interdiffusion process.Here we report a brand-new junction architecture,called'layer PN junction',that might break through such limit and help redefine the semiconductor device architecture.Different from all existing semiconductors,we find that a variety of van der Waals materials are doping themselves from n-to p-type conductance with an increasing/decreasing layer-number.It means the capability of constructing homogeneous PN junctions in monolayers'dimension/precision,with record high rectification-ratio(>10^(5))and low cut-off current(<1 pA).More importantly,it spawns intriguing functionalities,like gate-switchable-rectification and noise-signal decoupled avalanching.Findings disclosed here might open up a path to develop novel nanodevice applications,where the geometrical size becomes the only critical factor in tuning charge-carrier distribution and thus functionality. | Hui Xia Man Luo Wenjing Wang Hailu Wang Tianxin Li Zhen Wang Hangyu Xu Yue Chen Yong Zhou Fang Wang Runzhang Xie Peng Wang Weida Hu Wei Lu | 2022 | Light(Science & Applications)2022，11，7： | 4 |
| 4 | Optimal observation configuration of UAVs based on angle and range measurements and cooperative target tracking in three-dimensional space显示文摘This article investigates the optimal observation configuration of unmanned aerial vehicles(UAVs) based on angle and range measurements, and generalizes predecessors' researches in two dimensions into three dimensions. The relative geometry of the UAVs-target will significantly affect the state estimation performance of the target, the cost function based on the Fisher information matrix(FIM) is used to derive the FIM determinant of UAVs' observation in three-dimensional space, and the optimal observation geometric configuration that maximizes the determinant of the FIM is obtained. It is shown that the optimal observation configuration of the UAVs-target is usually not unique, and the optimal observation configuration is proved for two UAVs and three UAVs in three-dimension. The long-range over-the-horizon target tracking is simulated and analyzed based on the analysis of optimal observation configuration for two UAVs. The simulation results show that the theoretical analysis and control algorithm can effectively improve the positioning accuracy of the target. It can provide a helpful reference for the design of over-the-horizon target localization based on UAVs. | SHI Haoran LU Faxing WANG Hangyu XU Junfei | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 4 |
| 5 | Ethylenediamine promoted the hydrogenative coupling of nitroarenes over Ni/C catalyst显示文摘Azobenzene and its derivatives are key raw materials and it is an environmentally friendly method for the preparation of azobenzene by hydrogenative coupling of nitrobenzene. The development of nickel based catalyst for organic transformations is of importance because of its relatively low cost and toxicity. In this work, we found that ethylenediamine can enrich the electron state of Ni and make the azobenzene easily desorb from the surface of the catalyst, which inhibits the hydrogenation of azobenzene to aniline. The selectivity of azobenzene is greatly improved. When the ratio of Ni and ethylenediamine is 1:10, the yield of the azobenzene can reach 95.5%. | Youdi Yang Shaopeng Li Chao Xie Hangyu Liu Yanyan Wang Qingqing Mei Huizhen Liu Buxing Han | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 6 | Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells显示文摘Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’performance.In this work,we use a facile ion-imprinting method(IIM)to synthesize isolated Fe-N-C single-atomic site catalysts(IIM-Fe-SASC).With this method,the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites.The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references.Due to its excellent properties,IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide(H_(2)O_(2)).Using IIM-Fe-SASC as the nanoprobe,in situ detection of H_(2)O_(2)generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity.This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H_(2)O_(2)detection. | Zhaoyuan Lyu Shichao Ding Maoyu Wang Xiaoqing Pan Zhenxing Feng Hangyu Tian Chengzhou Zhu Dan Du Yuehe Lin | 2021 | Nano-Micro Letters2021，13，9： | 2 |
| 7 | Regulating the growth of lithium dendrite by coating an ultra-thin layer of gold on separator for improving the fast-charging ability of graphite anode显示文摘With the ever-growing application of lithium-ion batteries(LIBs), their fast-charging technology has attracted great interests of scientists. However, growth of lithium dendrites during fast charge of the bat teries with high energy density may pose great threats to the operation and cause serious safety issues Herein, we prepared a functional separator with an ultra-thin(20 nm) layer of Au nanoparticles deposited by evaporation coating method which could regulate growth direction and morphology of the lithium dendrites, owing to nearly zero overpotential of lithium meal nucleation on lithiated Au. Once the Li den drites are about to form on the graphite anode during fast charging(or lithiation), they plate predomi nantly on the Au deposited separator rather than on the graphite. Such selective deposition does no compromise the electrochemical performance of batteries under normal cycling. More importantly, i enables the better cycling stability of batteries at fast charge condition. The Li/Graphite cells with Au nanoparticles coated separator could cycle stably with a high areal capacity retention of 90.5% over 95 cycles at the current density of 0.72 m A cm^(-2). The functional separator provides an effective strategy to adjust lithium plating position at fast charge to ensure high safety of batteries without a compromise on the energy density of LIBs. | Shuaishuai Yan Xiaoxia Chen Pan Zhou Peican Wang Hangyu Zhou Weili Zhang Yingchun Xia Kai Liu | 2022 | Journal of Energy Chemistry2022，31，4： | 2 |
| 8 | Degradation of metronidazole by dielectric barrier discharge in an aqueous solution显示文摘Degradation of metronidazole (MNZ) which is a representative and stable antibiotic by dielectric barrier discharge (DBD) in an aqueous solution has been studied. Effects of initial MNZ concentration, solution pH and coexisting organics on the degradation were investigated. The results illustrated that increasing the input power and the discharge frequency can improve the removal of MNZ. At low initial concentration, the removal of MNZ can reach up to 99.1%. Acidic and neutral conditions are more favorable for MNZ removal than alkaline condition in the early stage of degradation. However, the difference in MNZ removal between those in acidic or neutral media and that in alkaline one could be neglected with prolonging of the treatment time. Therefore, this method can be applied to MNZ degradation with a wide pH range. Coexisting organic matter in water can attenuate the removal to some extent. This study could provide valuable references for the degradation of nitroimidazole antibiotics by DBD. | Zhipeng Yang Anxing Lai Hangyu Chen Youxiang Yan Ye Yang Weiwei Zhang Lei Wang | 2019 | Frontiers of Environmental Science & Engineering2019，13，3： | 1 |
| 9 | New Exact Solutions of the CDGSK Equation Related to a Non-local Symmetry显示文摘A non-local symmetry of the Caudrey-Dodd-Gibbon-Sawada-Kotera(CDGSK)equation has been used for finding exact solution in two different ways.Firstly,using the standard prolongation approach,we obtain the finite Lie Bäcklund transformation and the single soliton solution.Secondly,combining some local symmetries and the nonlocal symmetry,we get the group invariant solution which is described by the Weierstrass elliptic function and is deduced to the so-called interacting soliton for a special parameter. | LOU Senyue RUAN Hangyu CHEN Weizhong WANG Zhenli CHEN Lili | 1994 | Chinese Physics Letters1994，11，10： | 1 |
| 10 | Friction study of a Ni nanodot-patterned surface显示文摘 | WANG Hangyu PREMACHANDRAN N R ZOU Min | 2007 | Tribology Letters2007，28，2： | 1 |
| 11 | Co‑packaged optics(CPO):status,challenges,and solutions显示文摘Due to the rise of 5G,IoT,AI,and high-performance computing applications,datacenter trafc has grown at a compound annual growth rate of nearly 30%.Furthermore,nearly three-fourths of the datacenter trafc resides within datacenters.The conventional pluggable optics increases at a much slower rate than that of datacenter trafc.The gap between application requirements and the capability of conventional pluggable optics keeps increasing,a trend that is unsustainable.Copackaged optics(CPO)is a disruptive approach to increasing the interconnecting bandwidth density and energy efciency by dramatically shortening the electrical link length through advanced packaging and co-optimization of electronics and photonics.CPO is widely regarded as a promising solution for future datacenter interconnections,and silicon platform is the most promising platform for large-scale integration.Leading international companies(e.g.,Intel,Broadcom and IBM)have heavily investigated in CPO technology,an inter-disciplinary research feld that involves photonic devices,integrated circuits design,packaging,photonic device modeling,electronic-photonic co-simulation,applications,and standardization.This review aims to provide the readers a comprehensive overview of the state-of-the-art progress of CPO in silicon platform,identify the key challenges,and point out the potential solutions,hoping to encourage collaboration between diferent research felds to accelerate the development of CPO technology. | Min Tan Jiang Xu Siyang Liu Junbo Feng Hua Zhang Chaonan Yao Shixi Chen Hangyu Guo Gengshi Han Zhanhao Wen Bao Chen Yu He Xuqiang Zheng Da Ming Yaowen Tu Qiang Fu Nan Qi Dan Li Li Geng Song Wen Fenghe Yang Huimin He Fengman Liu Haiyun Xue Yuhang Wang Ciyuan Qiu Guangcan Mi Yanbo Li Tianhai Chang Mingche Lai Luo Zhang Qinfen Hao Mengyuan Qin | 2023 | Frontiers of Optoelectronics2023，16，1： | 1 |
| 12 | Fluorescence properties of ternary complexes of polymer bond triphenyl phosphine,triphenylarsine, triphenylstibine, and trephinylbismuthine, rare earth metal ions, and the- noyltrifluoroacetone显示文摘 | Feng Hangyu Jian Shuhua Wang Yunpu etal | | J Appl Poly0，，： | 1 |
| 13 | Fluorescence properties of ternary complexes of polymer bond triphenyl phosphine, triphenylarsine, triphenylstibine, and trephinylbismuthine, rare earth metal ions, and thenoyltrifluoroacetone显示文摘 | Feng Hangyu Jian Shuhua Wang Yunpu etal | 1998 | J Appl Polym Sci1998，68，9： | 1 |
| 14 | Commonalities and characteristics of aqueous extracts from three Uighur medicines were analyzed by using three-stage infrared spectroscopy combined with ultra-performance liquid chromatography-time of flight-mass spectra显示文摘OBJECTIVE: To establish a method to analyze the commonalities and characteristics of the aqueous extracts from three Uighur medicines.METHODS: In this study, a combination method of three-stage infrared spectroscopy and ultra-performance liquid chromatography-time of flight-mass spectra(UPLC-TOF-MS) method was used to analyze the commonalities and characteristics of the aqueous extracts from Hezi(Fructus Chebulae),Maohezi(Terminalia Belliricae Fructus) and Xiqingguo(Chebulae Fructus Immaturus).RESULTS: In Fourier transform-infrared spectroscopy spectra, all three samples showed the characteristic absorption peaks of tannins similarly. According to UPLC-TOF-MS data analysis, the difference of the position and intensity of the peaks at 1713-1707 cm^(-1) in the three samples were related to the difference in the relative content of tannin and pentacyclic triterpenoids. In second derivative infrared spectroscopy spectra, further analysis of the differences in the infrared spectra of the three samples was performed by increasing the apparent resolution. In combination with UPLC-TOF-MS data, some features infrared absorption peaks were assigned.The absorption peaks at 1032-1030 cm^(-1) assigned to the stretching vibration of C-O-C(ether bond)groups of tannins; 1164-1163, 1063-1062, 1009-1005, 904 cm^(-1) attributed to the stretching vibration of C-O(ether bond) and C-O-C groups of glycosidic compounds. 1385-1383 cm^(-1) attributed to the bending vibration of C-H(alkyl hydrogen) of methoxyl group of pentacyclic triterpenoids. Peak 835 cm^(-1) was assigned to the characteristic absorption peak of bending vibration of = C-H groups of pentacyclic triterpenoids. The two dimensional correlation infrared spectroscopy could further quickly distinguish three samples through the dynamic structural information of their chemical components and discrepancy of auto-peaks and cross-peaks intuitively in the range of 1720-419 cm^(-1).CONCLUSION: By comparing the intensity of the infrared characteristic absorption peaks, the main chemical components were assigned, which significantly enriched and perfected the data analysis of the infrared spectra of three Uighur Medicines. It provided a rationale for the identification of medicinal materials with complex and similar chemical components using the three-stage infrared spectroscopy and UPLC-TOF-MS. | Qu Tiange Zhu Yun Zhang Ke Huang Jian Wang Hangyu Gao Le Liang Xu Chen Long Wang Jinhui Pang Xiaobo Duan Xingwu | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 1 |
| 15 | Prediction of fuel cell performance degradation using a combined approach of machine learning and impedance spectroscopy显示文摘Accurate prediction of performance degradation in complex systems such as solid oxide fuel cells is crucial for expediting technological advancements.However,significant challenges still persist due to limited comprehension of degradation mechanisms and difficulties in acquiring in-situ features.In this study,we propose an effective approach that integrates long short-term memory(LSTM) neural network and dynamic electrochemical impedance spectroscopy(DEIS).This integrated approach enables precise prediction of future evolutions in both current-voltage and EIS features using historical testing data,without prior knowledge of degradation mechanisms.For short-term predictions spanning hundreds of hours,our approach achieves a prediction accuracy exceeding 0.99,showcasing promising prospects for diagnostic applications.Additionally,for long-term predictions spanning thousands of hours,we quantitatively determine the significance of each degradation mechanism,which is crucial for enhancing cell durability.Moreover,our proposed approach demonstrates satisfactory predictive ability in both time and frequency domains,offering the potential to reduce EIS testing time by more than half. | Zewei Lyu Yige Wang Anna Sciazko Hangyue Li Yosuke Komatsu Zaihong Sun Kaihua Sun Naoki Shikazono Minfang Han | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 16 | Isoforsythiaside confers neuroprotection against Alzheimer's disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro显示文摘Ferroptosis and neuroinflammation contribute to the development of Alzheimer's disease(AD). Isoforsythiaside(IFY)is a phenylethanoid glycoside isolated from the dried fruit of Forsythia suspensa(Thunb.)Vahl that has been confirmed to improve the memory and cognitive abilities of APP/PS1 mice in our previous study. The purpose of this study was to explore the anti-ferroptosis and anti-neuroinflammatory properties of IFY-mediated neuroprotection. In APP/PS1 mice, erastin-damaged HT22 cells, and LPS-exposed BV2 cells, the neuroprotective effects against ferroptosis and neuroinflammation were investigated using immunohistochemistry, label-free proteomics, western blot, ELISA, MTT, fluorescence, and TEM. IFY alleviated the expression levels of NO, IL-6, and IL-1β in LPS-exposed BV2 cells and improved the morphology of mitochondria in erastin-damaged HT22 cells. Additionally, IFY upregulated the expression levels of GPX4, FTH, FTL, p-GSK-3β, Nrf2, and NQO1, and downregulated the expression of TFR1, DMT1, p-Fyn, GFAP, p-IKKα+β, p-IκBα, p-NF-κB, and pro-inflammatory factors in the brains of APP/PS1 mice and erastin-damaged HT22 cells. In conclusion, IFY inhibits ferroptosis and neuroinflammation in erastin-damaged HT22 cells and APP/PS1 mice, at least partially by regulating the activation of Nrf2 and NF-κB signaling. IFY may prevent ferroptosis and neuroinflammation in AD and provide a new treatment strategy for AD. | Chunyue Wang Hongbo Jiang Honghan Liu Shanshan Chen Hangyu Guo Shuoshuo Ma Weiwei Han Yu Li Di Wang | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 17 | Strategies for high-performance perovskite solar cells from materials, film engineering to carrier dynamics and photon management显示文摘In recent years,halide perovskite solar cells(HPSCs)have attracted a great atten-tion due to their superior photoelectric performance and the low-cost of processing their quality films.In order to commercialize HPSCs,the researchers are focusing on developing high-performance HPSCs.Many strategies have been reported to increase the power conversion efficiency and the long-term stability of HPSCs over the past decade.Herein,we review the latest efforts and the chemical-physical principles for preparing high-efficiency and long-term stability HPSCs in particu-lar,concentrating on the perovskite materials,technologies for perovskite films,charge transport materials and ferroelectric effect to reduce the carrier loss,and photon management via plasmonic and upconversion effects.Finally,the key issues for future researches of HPSCs are also discussed with regard to the require-ments in practical application. | Huilin Li Chong Chen Hangyu Hu Yu Li Zhitao Shen Fumin Li Ying Liu Rong Liu Junwei Chen Chao Dong Sally Mabrouk Raja Sekhar Bobba Abiral Baniya Mingtai Wang Quinn Qiao | 2022 | InfoMat2022，4，7： | 0 |
| 18 | N-vinyl pyrrolidone promoted aqueous-phase dehydrogenation of formic acid over PVP-stabilized Ru nanoclusters显示文摘In this work, we fabricated the poly(N-vinyl-2-pyrrolidone)(PVP)-stabilized ruthenium(0) nanoclusters by reduction of RuCl_3 using different reducing agents, and studied their catalytic activity in hydrogen generation from the decomposition of formic acid.It was demonstrated that N-vinyl-2-pyrrolidone(NVP), which is a monomer of PVP, could promote the reaction by coordination with Ru nanoparticles. The Ru nanoparticles catalyst reduced by sodium borohydride(NaBH_4) exhibited highest catalytic activity for the decomposition of formic acid into H_2 and CO_2. The turnover of numenber(TOF) value could reach 26113 h^(–1) at 80 °C. We believe that the effective catalysts have potential of application in hydrogen storage by formic acid. | Hangyu Liu Qingqing Mei Yanyan Wang Huizhen Liu Buxing Han | 2016 | Science China Chemistry2016，59，10： | 0 |
| 19 | Graphene/MoS_(2-x)O_(x)/graphene photomemristor with tunable non-volatile responsivities for neuromorphic vision processing显示文摘Conventional artificial intelligence(Al)machine vision technology,based on the von Neumann architecture,uses separate sensing,computing,and storage units to process huge amounts of vision data generated in sensory terminals.The frequent movement of redundant data between sensors,processors and memory,however,results in high-power consumption and latency.A more efficient approach is to offload some of the memory and computational tasks to sensor elements that can perceive and process the optical signal simultaneously.Here,we proposed a non-volatile photomemristor,in which the reconfigurable responsivity can be modulated by the charge and/or photon flux through it and further stored in the device.The non-volatile photomemristor has a simple two-terminal architecture,in which photoexcited carriers and oxygen-related ions are coupled,leading to a displaced and pinched hysteresis in the current-voltage characteristics.For the frst time,non-volatile photomemristors implement computationally complete logic with photoresponse-stateful operations,for which the same photomemristor serves as both a logic gate and memory,using photoresponse as a physical state variable instead of light,voltage and memresistance.The polarity reversal of photomemristors shows great potential for in-memory sensing and computing with feature extraction and image recognition for neuromorphic vision. | Xiao Fu Tangxin Li Bin Cai Jinshui Miao Gennady NPanin Xinyu Ma jinjin Wang Xiaoyong Jiang Qing Li Yi Dong Chunhui Hao Juyi Sun Hangyu Xu Qixiao Zhao Mengjia Xia Bo Song Fansheng Chen Xiaoshuang Chen Wei Lu Weida Hu | 2023 | Light(Science & Applications)2023，12，2： | 0 |
| 20 | Fully solution processed liquid metal features as highly conductive and ultrastretchable conductors显示文摘Liquid metal represents a highly conductive and inherently deformable conductor for the development of stretchable electronics.The widespread implementations of liquid metal towards functional sensors and circuits are currently hindered by the lack of a facile and scalable patterning approach.In this study,we report a fully solution-based process to generate patterned features of the liquid metal conductor.The entire process is carried out under ambient conditions and is generally compatible with various elastomeric substrates.The as-prepared liquid metal feature exhibits high resolution(100μm),excellent electrical conductivity(4.15×10^(4)S cm^(−1)),ultrahigh stretchability(1000%tensile strain),and mechanical durability.The practical suitability is demonstrated by the heterogeneous integration of light-emitting diode(LED)chips with liquid metal interconnects for a stretchable and wearable LED array.The solution-based technique reported here is the enabler for the facile patterning of liquid metal features at low cost,which may find a broad range of applications in emerging fields of epidermal sensors,wearable heaters,advanced prosthetics,and soft robotics. | Hangyu Zhu Shaolei Wang Menghu Zhang Tingyu Li Gaohua Hu Desheng Kong | 2021 | npj Flexible Electronics2021，5，1： | 0 |
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