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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | High-dose methylprednisolone can induce remissions in patients with fludarabine- refractory chronic lymphocytic leukaemia显示文摘 | Xu, W Miao, KR Hong, M Zhu, DX Fang, C Dong, HJ Wang, DM Cao, X Li, JY | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 5 |
| 3 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 4 | 可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度显示文摘滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加(主动脉中活性氧水平同时升高),这种现象类似于人类高血压中观察到的现象。 | 刘莉 叶鹏 Zhu W Wang H Wei J Sartor GC Bao MM Pierce CT Wahlestedt CR Dykxhoorn DM Dong C | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 5 | P53 codon 72 polymorphism contributes to breast cancer risk: a metaanalysis based on 39 case-control studies(摘要)显示文摘 | Zhang, ZZ Wang, ML Wu, DM Wang, MM Tong, N Tian, YY Zhang, ZD | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 3 |
| 6 | Cloning and identification of an angiostatic molecule IP-10/crg-2显示文摘AIM To obtain human and murine cDNAsencoding IFN--y inducible protein 10 (lP--10) andcytokine responsive gene--2 (Crg-2).METHODS The encoding genes of lP-10 and Crg2 were amplified by RT--PCR from Cultured humanfibroblast cells and Balb/ c mouse liver treatedby IFN-y and TNF-a, respectively, and clonedinto plasmids of PUC19 and PGEM3Zf(+ ).RESULTS The nucleotide sequences ot theamplified DNA were confirmed by endonucleasesdigestion and sequencing.CONCLUSION Recombinant lP-10/ crg--2 geneclones with 306 hp and 314 hp inserts wereestablished for further research on biologicalactivities and ligands of hiP-10/mCrg--2. | Liu ZG Yang JH An HZ Wang HY He FT Han ZY Han Y Wu HP Xiao B Fan DM | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 7 | Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter显示文摘 | Gao DM Wang LF Liu J Kong YY Wang Y Xie YH | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 8 | Incorporation and integration of implanted myogenic and stem cells into native myocardial fibers:anatomic basis for functional improvements显示文摘 | Wang JS Nguyen DM | 2002 | J Thorac Cardiovasc Surg2002，124，3： | 1 |
| 9 | AccuTyping: new algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays 显示文摘 | Hu Guohong Wang Huiyun Greenawalt DM | 2006 | Nucleic Acids Res2006，34，17： | 1 |
| 10 | Clinical value of com- bined detection of serum tumor markers in lung cancer diag- nosis 显示文摘 | Chen F Li WM Wang DM | 2008 | Sichuan Da Xue Xue Bao Yi Xue Ban2008，39，5： | 1 |
| 11 | Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression:more complicated than we thought显示文摘 | Stocco DM Wang X Jo Y | 2005 | Mol Endocrinol2005，19，11： | 1 |
| 12 | Dobutamine therapy is associated with worse clinical outcomes compared with nesiritide therapy for acute decompen- sated heart failure:a systematic review and meta-analysis显示文摘 | Wang XC Zhu DM Shan YX | 2015 | Am J Cardio- vasc Drugs2015，15，6： | 1 |
| 13 | Effect of flow rate,negative pressure,and duration of modified ultrafiltration on hemodynamics and inflammatory mediators显示文摘 | Wang W Zhu DM Huang HM | 2007 | ASAIO J2007，53，1： | 1 |
| 14 | In-vitro antitumor activity evaluation of hyperforin derivatives显示文摘 | Sun F Liu JY He F Liu Z Wang R Wang DM | 2011 | J Asian Nat Prod Res2011，13，8： | 1 |
| 15 | Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosenso- rsystem in non-human primate and human islets 显示文摘 | Wang W Upshaw L Strong DM | 2005 | J Endocrinol2005，185，3： | 1 |
| 16 | Analytical performances and heart failure research of the BNP and NT proBNP assays on the cobas e601 and ADVIA centaur显示文摘 | Zhang XM Wang WJ Wen DM | 2013 | Clin Lab2013，59，： | 1 |
| 17 | Finite element analysis of antiimpact loading of wrist protectors显示文摘 | Dong XP Wang DM He JY | 2011 | J Clin Rehab Tiss Eng Res2011，15，30： | 1 |
| 18 | Simultaneous deter- mination of five bioactive fiavonoids in Pericarpium Citri Reticulatae from China by high performance liquid chroma- tography with dual wavelength detection 显示文摘 | Zheng GD Yang DP Wang DM | 2009 | Journal of Ag- ricultural and Food Chemistry2009，57，15： | 1 |
| 19 | Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun-N-terminal kinase, cyclin-dependent kinase 5, and P38mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 显示文摘 | Wang Q Walsh DM Rowan M J | 2004 | J Neuresci2004，24，13： | 1 |
| 20 | Modulation of vascular inflammation by PPARs显示文摘 | Tham DM Wang YX Rutledge JC | 2003 | Drug News Perspect2003，16，2： | 1 |
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