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| 1 | Induction of apoptosis by TPA and VP-16 is through translocation of TR3显示文摘AIM: To investigate the role of TR3 in induction of apoptosisin gastric cancer cells.METHODS: Human gastric cancer cell line, MGC80-3, wasused. Expression of TR3 mRNA and its protein was detectedby Northern blot and Westem blot. Localization of TR3protein was showed by immunofluorescence analysis underlaser-scanning confocal microscope. Apoptotic morphologywas observed by DAPI fluorescence staining, and apoptoticindex was counted among 1000 cells randomly. Stabletransfection assay was carried out by Lipofectamine.RESULTS: Treatment of MGC80-3 cells with TPA and VP-16resulted in apoptosis, accompanied by the repression ofBcl-2 protein in a time-dependent manner. At the sametime, TPA and VP-16 also up-regulated expression level ofTR3 mRNA in MGC80-3 cells that expressed TR3 mRNA.When antisense-TR3 expression vector was transfected intothe cells, expression of TR3 protein was repressed. In thiscase, TPA and VP-16 did not induce apoptosis. In addition,TPA and VP-16-induced apoptosis involved in translocationof TR3. In MGC80-3 cells, TR3 localized concentrative innucleus, after treatment of cells with TPA and VP-16, TR3translocated from nucleus to cytosol obviously. However,when this nuclear translocation was blocked by LMB,apoptosis was not occurred in MGC80-3 cells even in thepresence of TPA and VP-16.CONCLUSION: Induction of apoptosis by TPA and VP-16 isthrough induction of TR3 expression and translocation of TR3from nucleus to cytosol, which may be a novel signalpathway for TR3, and represent the new biological function ofTR3 to exert its effect on apoptosis in gastric cancer cells. | LiuS WuQ 等 | 2002 | World Journal of Gastroenterology2002，8，3： | 14 |
| 2 | Striking organization of a large family of human neuralcadherin-like cell adhesion genes显示文摘 | WuQ Maniatis T A | 1999 | Cell1999，97，6： | 1 |
| 3 | 考虑调强放疗头颈部收缩的自适应再计划策略[J]显示文摘 | WuQ ChiY ChenPY 等 | | 国际放射肿瘤学一生物学一物理学杂志0，，： | 1 |
| 4 | 青藏铁路冻土层的相互作用[J]显示文摘 | WuQ LiM LiuY | 2010 | 寒区工程2010，24，4： | 1 |
| 5 | Mechanochemical effects ofmicronization on enzymatic hydrolysis ofcomflour显示文摘 | WuQ MiaoY | 2008 | Carbohydrate polymers2008，72，3： | 1 |
| 6 | 离线自适应放疗计划设计与在线图像引导相结合的治疗前列腺癌[J]显示文摘 | LeiY WuQ | | 医学和生物学中的物理学0，，： | 1 |
| 7 | LeafcarbonnitrogenandphosphorusstoichiometryacrossplantspeciesinBeijinganditspe-riphery显示文摘 | HanW-X(韩文轩) WuQ(吴漪) TangL-Y(汤璐瑛) etal | | 北京大学学报:自然科学版0，，： | 1 |
| 8 | Effects of Promoters and Preparation Procedures on Reforming of Methane with Carbon Dioxide over Ni/Al2O3 Catalyst 显示文摘 | ChengZ X WuQ L Li J L | 1996 | Catalysis Today1996，，30： | 1 |
| 9 | 自适应放疗计划设计技术与剂量反馈在图像引导前列腺癌放射治疗的应用研究[J]显示文摘 | LiuH WuQ | | 医疗物理学0，，： | 1 |
| 10 | 查看详情显示文摘 | WuQ SelkeS MohantyAK | | 0，，： | 1 |
| 11 | The Tibetan medicine Zuotai differs from HgC12 and MeHg in producing liver in- jury in mice显示文摘 | WUQ LI W K ZHOU Z P | 2016 | Regulatory toxicology and pharmacology2016，78，4： | 1 |
| 12 | ExpressionofADKGeneandATPSynthesisinSaccharomycescerevisiae显示文摘 | XuBN(徐柏年) ZhangT-Y(张添元) LuoJ-x(罗进贤) wuQ(吴青) WuJ-x(吴江雪) | | 中山大学学报咱然科学版0，，： | 1 |
| 13 | ThedifferentPinelliatubermedicalcontentofguanosineandadenosinefromGuizhoubyHPLC[J]显示文摘 | ZHAOY(赵扬) JINFY(斩凤云) WUQ(伍庆/) etal | | 时珍国医国药0，，： | 1 |
| 14 | Promotion of melanin production by Radix Polygoni Multiflo- ripA Study of Its Mechanism显示文摘 | JiangZQ(姜泽群) WuQ(吴琼) XuJM(徐继敏) eta1 | 2010 | 南京中医药大学学报2010，26，： | 1 |
| 15 | Mixed-ligandrutheniumpolypyridylcomplexesasapoptosisinducersincancercells,thecellulartrans-locationandtheimportantroleofROS-mediatedsignaling显示文摘 | ZhaoZ LuoZ WuQ etal | 2014 | DaltonTrans2014，43，17： | 1 |
| 16 | Depletion of DNMT3Asuppressed cell proliferation and restored PTEN inhepatocellular carcinoma cell显示文摘 | ZHAO Z WUQ CHENG J | 2010 | J Biomed Biotechnol2010，2010，73： | 1 |
| 17 | AnEffectiveMethodfor3DGeologicalModelingwithMultiSourceDataIntegration显示文摘 | WuQ XuH ZouX | 2005 | Computers& Geosciences2005，31，1： | 1 |
| 18 | Ameta-analysis of seed protein concentration QTL in soybean 显示文摘 | QiZ M SunY N WuQ | 2011 | Canadian Journal of Plant Science2011，91，1： | 1 |
| 19 | Ultrasonicassistedextractiontechnologyresearchofpolysaccharide显示文摘 | GaoJ(高健) XuTT(许同桃) WuQ(吴群) | | 时珍国医国药0，，： | 1 |
| 20 | Surface photo-oxidation and photostabilization of photocross-linked polyethylene显示文摘 | WuQ H Qu B J Xu Y H Wu Q | | 0，，： | 1 |
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