|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The cellular labeling and pH-sensitive responsive-drug release of celastrol in cancer cells based on Cys-CdTe QDs显示文摘As one of the active compounds derived from Traditional Chinese Medicine,Celastrol(CSL)had cytotoxicity for human leukemia cancer cells K562 and its multidrug-resistant cell line K562/A02.Here,we introduced cysteamine-modified CdTe QDs as the labeling and drug carrier into CSL research and found that the self-assembly and conjugation of anticancer molecular CSL with the Cys-CdTe QDs could significantly increase the drug’s cytotoxicity for K562 cells.More important,these CSL-Cys-CdTe nanocomposites could overcome the multidrug resistance of K562/A02 cells and efficiently inhibit the cancer cell proliferation by realizing the pH-sensitive responsive release of CSL to cancer cells.The enhanced cytotoxicity was caused by the increase of the G2/M phase arrest for K562/A02 cells as well as for K562 cells.Cys-CdTe QDs can readily bind on the cell plasma membranes and be internalized into cancer cells to trace and detect human leukemia cancer cells in real time.In addition,these Cys-CdTe QDs can facilitate the inhibition of the multidrug resistance of K562/A02 cells and readily induce apoptosis.As a good photosensitizer for the therapy,labeling,and tracing of cancer cells,the combination of CSL with Cys-CdTe QDs can optimize the use of and a new potential therapy method for CSL and yield new tools to explore the mechanisms of active compounds from Traditional Chinese Medicine. | LI JingYuan SHI LiXin SHAO YiXiang SELKE Matthias CHEN BaoAn JIANG Hui WANG XueMei | 2014 | Science China Chemistry2014，57，6： | 6 |
| 2 | Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study显示文摘 | L. G. Hemkens U. Grouven R. Bender C. Günster S. Gutschmidt G. W. Selke P. T. Sawicki | 2009 | Diabetologia2009，，9： | 3 |
| 3 | Enhanced in vitro anticancer activity of quercetin mediated by functionalized CdTe QDs显示文摘We report in this study the effects of red-emitting CdTe QDs capped with cysteamine(Cys-CdTe) on the in vitro anticancer activity of the well-known flavenoid quercetin(Qu). Various techniques, including the methylthiazolyldiphenyl-tetrazolium bromide assay, the real-time cell electronic sensing system, the optical and fluorescence imaging, and electrochemical methods have been utilized to study the potential interactions of Cys-CdTe QDs with Qu. The observations demonstrate that the safe-dosage Cys-CdTe QDs can greatly improve the drug uptake and enhance the inhibition efficiency of Qu towards the proliferation of cancer cells such as HepG2 cells. This study implies that Cys-CdTe QDs may be used for cancer therapy and that they exert a synergic anticancer effect when bound to drug molecules. | WU ChunHui SHI LiXin WU ChangYu GUO DaDong SELKE Matthias WANG XueMei | 2014 | Science China Chemistry2014，57，11： | 2 |
| 4 | Microcellular foam of polymer blends of HDPE/PP and their composites with wood fiber显示文摘 | Rachtanapun P Selke S E M Matuana L M | 2003 | Journal of Applied Polymer Science2003，88，12： | 2 |
| 5 | Relationship between cell morphology and impact strength of microcellular foamed high-density polythylene/polypropylene blends 显示文摘 | RACHTANAPUN P SELKE S E M MATUANA L M | 2004 | Polym Eng Sci2004，44，8： | 1 |
| 6 | Vitamin A requirement of the gestating and lactating sow显示文摘 | Selke M R Barnhart C E Chaney C H | 1967 | J Anim Sci1967，26，： | 1 |
| 7 | Microcellular foam of polymer blends of HDPE/PP and their composites with wood fiber显示文摘 | P Rachtanapun Selke S E M Matuana L M | 2003 | Journal of Applied Polymer Science2003，88，12： | 1 |
| 8 | Re- lationship between cell morphology and impact strength of mi- crocellular foamed high-density polyethylene/polypropyleneblends 显示文摘 | RACHTANAPUN P SELKE S E M MATUANA L M | 2004 | Polym Eng Sci2004，44，8： | 1 |
| 9 | Poly (lactic acid) and zeoite composites prepared by melt processing: morphological and physical-mechanical properties 显示文摘 | YUZAY I E AURAS R SELKE S | 2010 | Journal of Applied Polymer Science2010，115，4： | 1 |
| 10 | Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells显示文摘 | Klumpp S Selke D Ahlemeyer B | 2002 | Neurochem Int2002，41，： | 1 |
| 11 | An overview of polylactides as packaging materials显示文摘 | Auras R Harte B Selke S | 2004 | Macromolecular Bioscience2004，4，9： | 1 |
| 12 | A population-based study of primary human herpesvirus 6 infection 显示文摘 | Zerr DM Meier AS Selke SS | 2005 | N Engl J Med2005，352，8： | 1 |
| 13 | Quasicrystalline microstructures in Alss_x Cu Crl splats 显示文摘 | Selke H Ryder P L | 1991 | Materials Science and Engineering1991，134，： | 1 |
| 14 | Firing pattern and calbindin- D28k content of human epileptic granule cells 显示文摘 | Selke K Mailer A Kukley M | 2006 | Brain Res2006，1120，： | 1 |
| 15 | Mi- crocellular foam of polymer blends of HDPE/PP and their composites with wood fiber 显示文摘 | RACHTANAPUN P SELKE S E M MATUANA L M | 2003 | J Appl Polym Sci2003，88，12： | 1 |
| 16 | Re- lationship between cell morphology and impact strength of mi- crocellular foamed high-density polyethylene/polypropylene blends 显示文摘 | RACHTANAPUN P SELKE S E M MATUANA L M | 2004 | Polym Eng Sci2004，44，8： | 1 |
| 17 | Aoverviewofpolylactidesaspackagingmaterials显示文摘 | AurasR HarteB SelkeS | 2004 | MacromolBiosci2004，4，9： | 1 |
| 18 | Decomposition of icosahedral quasicrystals in A1-Cu-Cr alloy显示文摘 | Selke H Ryder P L | 1993 | Materials Science and Engineering1993，165，1： | 1 |
| 19 | Diesel Fuel from Thermal Decomposition of Soybean Oil 显示文摘 | SCHWAB A W DYKSTRA G J SELKE E | 1988 | JAOCS1988，65，11： | 1 |
| 20 | Singlet oxygen generation from water-soluble quantum dot-organic dye nanocomposites显示文摘 | Shi L Hernandez B Selke M | 2006 | J Am Chem Soc2006，128，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员