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| 1 | Potential land for plantation of Jatropha curcas as feedstocks for biodiesel in China显示文摘As a renewable energy,biofuel has attracted great attention in China and the rest of world.Concerned with the national food security,China recently has shifted its biofuel development priority from grain-based to non-grain-based biofuels,including forest-based biodiesel,since 2007.Jatropha curcas is one of major biodiesel feedstocks.However,there is rising debate on availability of land for expanding Jatropha curcas areas.The overall goal of this paper is to evaluate potential land for Jatropha curcas used as feedstock for biodiesel in China.Based on remote sensing data on land use,data on meteorological,soil and land slope,and suitable environment for Jatropha curcas plantation,this study uses Agro Ecological Zone method and considers social-economic constraints to evaluate potential suitable land for Jatropha curcas plantation in China's major Jatropha curcas production region,Southwest China.The results show that while there are some potential lands to expand Jatropha curcas areas,amount of these lands will hardly meet the government's target for Jatropha curcas-based biodiesels development in the future.China may need to reconsider its long-term targets on the development of Jatropha curcas-based biodiesels. | WU WeiGuang 1,2,3,HUANG JiKun 1,3 & DENG XiangZheng 1,3 1 Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Sciences,Beijing 100101,China 2 Department of Economics and Management,Zhejiang Forestry University,Linan 311300,China 3 Center for Chinese Agricultural Policy,Chinese Academy of Sciences,Beijing 100101,China | 2010 | Science China Earth Sciences2010，53，1： | 7 |
| 2 | Doxorubicin-loaded zein in situ gel for interstitial chemotherapy of colorectal cancer显示文摘The aim of this research was to evaluate doxorubicin(DOX)-loaded zein in situ gels,a new drug delivery system in which a liquid state drug can be transformed into semi-solid after intratumoral injection.In vitro release of DOX-loaded zein was investigated and the pharmacokinetics,biodistribution and therapeutic efficacy of these DOX-loaded zein formulations were investigated using BAI B/c nude tumor-bearing mice.In vitro release of DOX from the gels extended up to 7 days.Efficient accumulation of DOX in the tumor with lower drug concentration in blood and normal organs was obtained resulting in effective inhibition of tumor growth and fewer off-target side effects.In conclusion,a DOX-loaded in situ gel was developed with sustained release,enhanced anti-cancer efficacy for colorectal cancer in vivo,and especially with reduced off-target side effects. | Ning Shen Jie Hu Linan Zhang Li Zhang Yongjun Sun Yinghua Xie Shaomei Wu Lei Liu Zibin Gao | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 3 |
| 3 | Ecological stoichiometry of nitrogen, phosphorous, and sulfur in China's forests显示文摘Much attention has been paid to the stoichiometry of carbon(C), nitrogen(N), and phosphorus(P) because of their significance for plant growth and climate change. However, other nutrients, such as sulfur(S), are often ignored. In this study, we analyzed the stoichiometry of N, P, and S in leaves of 348 plant species in China's forests. The results show higher N content and higher molar ratios of N/P and P/S in Angiospermae than in Gymnospermae. At the family level, Ulmaceae absorbed more N and P from soils than other families, and Cupressaceae absorbed more S than other families. In addition,except for bamboo and other tropical forests, leaf N and P content of China's forests generally increased from low to middle latitudes and then slightly decreased or plateaued at high latitudes. Plant ecotypes, taxonomic groups, environmental conditions, atmospheric S precipitation, and soil-available N and P significantly affected the distribution and stoichiometry of leaf N, P, and S in China's forests.Our study indicates that China's forests are likely limited by P and S deficiencies which may increase in the future. | Yuntao Wu Hongyan Liu Zhaoliang Song Xiaomin Yang Zichuan Li Qian Hao Linan Liu | 2017 | Acta Geochimica2017，36，3： | 2 |
| 4 | Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression显示文摘Despite being a common therapy for hepatocellular carcinoma(HCC),insufficient thermal ablation can leave behind tumor residues that can cause recurrence.This is believed to augment M2 inflammatory macrophages that usually play a pro-tumorigenic role.To address this problem,we designed D-mannose-chelated iron oxide nanoparticles(man-IONPs) to polarize M2-like macrophages into the antitumor Ml phenotype.In vitro and in vivo experiments demonstrated that man-IONPs specifically targeted M2-like macrophages and accumulated in peri-ablation zones after macrophage infiltration was augmented under insufficient microwave ablation(MWA).The nanoparticles simultaneously induced polarization of pro-tumorigenic M2 macrophages into antitumor M1 phenotypes,enabling the transformation of the immunosuppressive microenvironment into an immunoactivating one.Post-MWA macrophage polarization exerted robust inhibitory effects on HCC progression in a well-established orthotopic liver cancer mouse model.Thus,combining thermal ablation with man-IONPs can salvage residual tumors after insufficient MWA.These results have strong potential for clinical translation. | Rui Cui Luo Wang Dongyun Zhang Kun Zhang Jianping Dou Linan Dong Yixuan Zhang Jiapeng Wu Longfei Tan Jie Yu Ping Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 5 | Iron isotopic analyses of geological reference materials on MC-ICP-MS with instrumental mass bias corrected by three independent methods显示文摘Here we report iron(Fe) isotopic data of three pure Fe solution standards(IRMM-014, GSB Fe, and NIST3126a) and five widely used geological reference materials(RMs) from the United States Geological Survey and Geological Survey of Japan obtained on a Neptune Plus multi-collector–inductively coupled plasma–mass spectrometer(MC-ICP-MS) in our laboratory over the past 3 years. The instrumental mass bias was corrected by three independent methods: sample-standard bracketing(SSB),Ni doping + SSB, and ^(57)Fe–^(58)Fe double spike + SSB.Measurements reveal that both the Ni doping and double spike methods helped calibrate short-term fluctuations in mass bias. Collectively, almost all measurements of RMs yielded δ^(56)Fe within ± 0.05 of recommended values,provided that each sample was measured four times on MC-ICP-MS. For the first time, new recommended values for NIST SRM3126a are reported(δ^(56)Fe = 0.363 ± 0.006,2SE, 95% CI; and δ^(57)Fe = 0.534 ± 0.010, 2SE). | Chuanwei Zhu Wenning Lu Yongsheng He Shan Ke Hongjie Wu Linan Zhang | 2018 | Acta Geochimica2018，37，5： | 2 |
| 6 | Efficacy of percutaneous ethanol injection in the adjuvant treatment of hepatocellular carcinoma after TACE显示文摘在 transcatheter 以后在肝细胞癌(HCC ) 的辅佐疗法评估经皮的乙醇注射(PEI ) 的功效的目的动脉的 chemoembolization (不作声) 由进步(TTP ) 的时间的主要终点。学习人口与不能实行的 HCC (中国分类系统 IIA/IIB ) 由 73 个连续病人组成了的方法。在他们之中, 22 个病人被对待与不作声并且 PEI (试验性的组) ,和剩余的 51 与仅仅被对待不作声(控制组) ,然后进行的时间(TTP ) 和这二个组的全面幸存(OS ) 被分析。结果中部的 TTP 是 10 个月[95% 信心间隔(CI ) , 7.9 12.1 个月] 在试验性的组和 6 个月(95% CI, 4.7 7.3 个月) 在控制组。第 3-month,6-mon,并且 1 年的前进免费幸存(PFS ) 率是分别地 77.3% , 63.6% ,和 48.1% 在试验性的组,并且 76.5% , 42.15% ,和 24.8% 在控制组。试验性的组的 TTP 比控制组的显著地长(P <
0.05 ) 。中部的幸存时期是 17 个月[95% 信心间隔(CI ) , 11 23 个月] 试验性的组和 12 个月(95% CI, 10 14 个月) 控制组(P >
0.05 ) 。结论与单身者相比不作声,联合不作声, PEI 能显然推迟疾病进步并且延长 HCC 病人的幸存。 | Mingzhi Hao Hailan Lin Youhong Shen Linan Tang Ruoyuan Yan Jianxiong Zheng Ojzhong Chen Jing Chen Zhougui Wu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 2 |
| 7 | Generation of squeezed states by parametric down conversion 显示文摘 | WU Linan KIMBLE H J HALL J L | 1986 | Phys Rev Lett1986，57，20： | 1 |
| 8 | Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line 显示文摘 | WANG Ningning ZHAO Lijun WU Linan | 2013 | Asian pacific journal of cancer prevention2013，10，9： | 1 |
| 9 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 10 | Effects of topography and vegetation on distribution of rare earth elements in calcareous soils显示文摘This study investigated the impact of topography and vegetation on distribution of rare earth elements(REEs)in calcareous soils using methods of single extraction and mass balance calculation. The purposes of the study were to set a basis for further research on the biogeochemical REE cycle and to provide references for soil–water conservation and REE-containing fertilizer amendments. The results show a generally flat Post-Archean Average Australian Shale—normalized REE pattern for the studied calcareous soils. REE enrichment varied widely. The proportion of acidsoluble phases of heavy REEs was higher than that of light REEs. From top to bottom of the studied hills, dominant REE sources transitioned from limestone in-situ weathering to input from REE-containing phases(e.g., clay minerals,amorphous iron, REE-containing fluids). Our results indicate that the REE content of calcareous soils is mainly controlled by slope aspect, while the enrichment degree of REEs is related to geomorphological position and vegetation type.Furthermore, the proportion of acid-soluble phases of REEs is mainly controlled by geomorphological position. | Zhaoliang Song Yuntao Wu Xiaomin Yang Zijuan Xu Linan Liu Xiaodong Zhang Qian Hao Shaobo Sun Guilin Han Congqiang Liu | 2017 | Acta Geochimica2017，36，3： | 1 |
| 11 | An injectable alginate/fibrin hydrogel encapsulated with cardiomyocytes and VEGF for myocardial infarction treatment显示文摘Myocardial infarction(MI)is one of the typical cardiovascular diseases,which persist as the leading cause of death globally.Due to the poor regenerative capability of endogenous cardiomyocytes(CMs),the transplantation of exogenous CMs becomes a promising option for MI treatment.However,the low retention and survival of transplanted cells still limit the clinical translation of cell therapy.Herein,an alginate/fibrin-based injectable hydrogel was prepared for the delivery of neonatal CMs and an angiogen-esis agent vascular endothelial growth factor(VEGF)locally to the infarcted area of the heart.This hydro-gel combined the specific advantages of alginate and fibrin with proper mechanical properties and cell affinity,showing good biocompatibility to support the retention and integration of the transplanted CMs to the host myocardium.Moreover,the delivered VEGF was favorable for the blood recovery to mitigate the ischemic microenvironment of the infarcted area and thus improved the survival of the transplanted CMs.Intramyocardial injection of this hydrogel to the infarcted area of the heart promoted angiogenesis,inhibited fibrosis,and improved cardiac function,exhibiting great potential for MI treatment. | Chunxia Liu Yong Wu Hong Yang Kunyan Lu Haixin Zhang Yuanyuan Wang Jingjing Wang Linan Ruan Zhenya Shen Qian Yu Yanxia Zhang | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 12 | 關注立法修法和司法實務的法律人显示文摘經常關注中國政治的人們不會陌生,一年一度的全國兩會是外界觀察中國的一個重要窗口。在此期間,數千名全國人大代表和政協委員提出的議案提案和各類建議也都備受關注。法律人(文中指稱全國人大代表和全國政協委員中的法學學者和律師),是每年兩會上最為活躍的群體,他們以其獨特的視角建言國家大政方針,議案提案一般具有强烈的身份色彩,涵盖的内容除了立法修法之外,还包括各类具体的司法完善建议、当下社会热点问题的法律思考等等。 | 陳霄 TIAN Linan WU Feifei | 2016 | 中国法律(中英文版)2016，，2： | 0 |
| 13 | Fragments of Comet Hyakutake (C/1996 B2)显示文摘Several fragments of Comet Hyakutake were observed in March and April of 1996. This leads to the impression that the splitting of Comet Hyakutake on a small scale occurred frequently. Data analysis points to a rotation period of about 6 2 h if the fragments of April 11 are the condensations within a jet. | Daohan Chen Aidi Zhao Qindi Wu Yi Song Yixin Fan Shousheng Sun Yan Zhang Linan Sun | 1998 | Chinese Science Bulletin1998，43，2： | 0 |
| 14 | FRAGMENTS OF COMET HYAKUTAKE (C/1996 B2)显示文摘Several fragments of Comet Hyakutake were observed in March and April of 1996. This leads to the impression that the splitting of Comet Hyakutake on a small scale occurred frequently. Data analysis points to a rotation period of about 6.2h if the fragments of April 11 are the condensations within a jet. | Chen Daohan 1 Zhao Aidi 1 Wu Oindi 1 Song Yi 1 Fan Yixin 1 Sun Shousheng 2 Zhang Yan 2 Sun Linan 2 (1. Purple Mountain Observatory, Chinese Acadeniy of Sciences, Nanjing 210008) (2. Qingdao Station of Purple Mountain Observatory, Qingdao | 2000 | 中国科学院上海天文台年刊2000，，S1： | 0 |
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