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| 1 | xperimental investigation on cumulative propagation of thin film buckling under cyclic load显示文摘As instrument technology is needed for rapid determination of the smaller,thinner and lighter specimens,more stringent demands are related to thin films such as micro-electro-mechanical systems(MEMS),dielectric coatings and electronic packaging.Therefore,the requirement for testing platforms for rapidly determine the mechanical properties of thin films is increasing.Buckling of a film/substrate system could offer a variety of applications,ranging from stretchable electronics to micro-nanoscale metrology.In this paper,a fatigue-loading device has been designed to make the cyclic loading available for investigating the cumulative propagation of thin film buckling.The straight side buckling of thin compressed titanium film with the thickness of 50 nm deposited on organic glass substrates is investigated by using an optical microscope.The cumulative buckling propagation under the cyclic loading of a sequence of peak compression with the frequency 1 Hz is recorded by CCD camera.The buckling extension lengths are calculated by digital image measurement technology. | WANG ShiBin JIA HaiKun LI LinAn SUN Heng CUI DiQiang GUO ZhenShan XUE XiuLi | 2011 | Science China(Technological Sciences)2011，54，6： | 4 |
| 2 | Determination of the metastable zone and induction time of thiourea for cooling crystallization显示文摘The solubility,metastable zone width(MSZW),and induction time of thiourea for cooling crystallization were experimentally determined in the temperature range of 283-323 K.The solubility data could be well described by the Apelblat equation model as lnx=-99.55+1071.66/T+16.27 lnT.The determinations of the effects of various stirring and cooling rates indicated that the MSZW increased with increasing and decreasing cooling and stirring rates,respectively.Furthermore,the induction times at various temperatures and supersaturation ratios were also measured.The results indicated that homogeneous nucleation could occur at high supersaturation,whereas heterogeneous nucleation was more likely to occur at low supersaturation.Based on the classical nucleation theory and induction period data,the calculated solid-liquid interfacial tensions of thiourea in deionized water at 302.46 and 312.58 K were 2.86 and 2.94 mJ·m^(-2),respectively. | Tong Zhou Chunzhao Tu Ya Sun Linan Ji Chuangxian Bian Xiaohua Lu Changsong Wang | 2021 | Chinese Journal of Chemical Engineering2021，34，3： | 3 |
| 3 | Preparation and evaluation of sustained-release diltiazem hydrochloride pellets显示文摘In this study,diltiazem hydrochloride(DTZ)pellets were prepared successfully by extrusionespheronization method.Then methacrylic acid and ethylcellulose coating formulations were employed to make the DTZ pellets sustained release.The pellets with different coatings were investigated by in vitro dissolution tests.At last,the pellets with the best coating copolymer were subjected to pharmacokinetic studies in beagle dogs.The dissolution profiles of pellets coated with EudragitNE30D were similar to Herbesser,one of the marketed sustained release capsules.In the bioavailability study,the principal pharmacokinetic parameters of self-made pellets and the marketed ones were comparable;the relative bioavailability of DTZ sustained release capsules compared with Herbesserwas 98.536.4%.All the data indicated self-made sustained pellets could prolong the release of DTZ,decrease the fluctuation of drug level in vivo,and increase the compliance of patients. | Xiaopeng Han Linan Wang Yinghua Sun Xiaohong Liu Wanjun Liu Yuqian Du Lin Li Jin Sun | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，4： | 3 |
| 4 | Doxorubicin-loaded zein in situ gel for interstitial chemotherapy of colorectal cancer显示文摘The aim of this research was to evaluate doxorubicin(DOX)-loaded zein in situ gels,a new drug delivery system in which a liquid state drug can be transformed into semi-solid after intratumoral injection.In vitro release of DOX-loaded zein was investigated and the pharmacokinetics,biodistribution and therapeutic efficacy of these DOX-loaded zein formulations were investigated using BAI B/c nude tumor-bearing mice.In vitro release of DOX from the gels extended up to 7 days.Efficient accumulation of DOX in the tumor with lower drug concentration in blood and normal organs was obtained resulting in effective inhibition of tumor growth and fewer off-target side effects.In conclusion,a DOX-loaded in situ gel was developed with sustained release,enhanced anti-cancer efficacy for colorectal cancer in vivo,and especially with reduced off-target side effects. | Ning Shen Jie Hu Linan Zhang Li Zhang Yongjun Sun Yinghua Xie Shaomei Wu Lei Liu Zibin Gao | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 3 |
| 5 | Characterization of Genome-Wide Microsatellites of Saccharina japonica Based on a Preliminary Assembly of Illumina Sequencing Reads显示文摘Microsatellites or simple sequence repeats(SSR) function widely and locate dependently in genome. However, their characteristics are often ignored due to the lack of genomic sequences of most species. Kelp(Saccharina japonica), a brown macroalga, is extensively cultured in China. In this study, the genome of S. japonica was surveyed using an Illumina sequencing platform, and its microsatellites were characterized. The preliminarily assembled genome was 469.4 Mb in size, with a scaffold N_(50) of 20529 bp. Among the 128370 identified microsatellites, 90671, 25726 and 11973 were found in intergenic regions, introns and exons, averaging 339.3, 178.8 and 205.4 microsatellites per Mb, respectively. These microsatellites distributed unevenly in S. japonica genome. Mononucleotide motifs were the most abundant in the genome, while trinucleotide ones were the most prevalent in exons. The microsatellite abundance decreased significantly with the increase of motif repeat numbers, and the microsatellites with a small number of repeats accounted for a higher proportion of the exons than those of the intergenic regions and introns. C/G-rich motifs were more common in exons than in intergenic regions and introns. These characteristics of microsatellites in S. japonica genome may associate with their functions, and ultimately their adaptation and evolution. Among the 120140 pairs of designed microsatellite primers, approximately 75% were predicted to be able to amplify S. japonica DNA. These microsatellite markers will be extremely useful for the genetic breeding and population evolution studies of kelp. | ZHANG Linan PENG Jie LI Xiaojie CUI Cuiju SUN Juan YANG Guanpin | 2016 | Journal of Ocean University of China2016，15，3： | 2 |
| 6 | NACC-1 regulates hepatocellular carcinoma cell malignancy and is targeted by miR-760显示文摘Hepatocellular carcinoma(HCC)is the most prominent form of presentation in liver cancer.It is also the fourth most common cause of cancer-associated deaths globally.The role of nucleus accumbens associated protein-1(NACC-1)has been evaluated in several cancers.This protein is a transcriptional regulator that regulates a number of significant cellular processes.In the current study,we aimed to understand the role of NACC-1 in HCC.Primarily,we measured the expression of NACC-1 using quantitative real time polymerase chain reaction and western blot analysis.We knocked down the expression of NACC-1 in HCC cell lines Huh7 and HepG2 by transferring a commercially synthesized small interfering RNA and explored the impact of NACC-1 knockdown on cellular growth,migration,invasion,and chemoresistance to doxorubicin.Through bioinformatic analysis,we identified NACC-1 as a potential target of miR-760.Using a dual reporter luciferase assay,we confirmed the predicted target and assessed miR-760-mediated regulation of NACC-1 and rescue of tumorigenic phenotypes.We observed increased expression of NACC-1 in HCC.Furthermore,knockdown of NACC-1 resulted in reduced cell proliferation and invasion and increased susceptibility to doxorubicin-mediated chemosensitivity.Overexpression of miR-760 in HCC cell lines rescued NACC-1-mediated migration and invasion.We revealed that miR-760 regulated NACC-1 expression in HCC.Our data indicated that both miR-760 and NACC-1 could be used as prognostic markers,and miR-760 may have therapeutic benefits for HCC and other cancers. | Linan Yin Tingting Sun Ruibao Liu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，3： | 2 |
| 7 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 8 | Effects of topography and vegetation on distribution of rare earth elements in calcareous soils显示文摘This study investigated the impact of topography and vegetation on distribution of rare earth elements(REEs)in calcareous soils using methods of single extraction and mass balance calculation. The purposes of the study were to set a basis for further research on the biogeochemical REE cycle and to provide references for soil–water conservation and REE-containing fertilizer amendments. The results show a generally flat Post-Archean Average Australian Shale—normalized REE pattern for the studied calcareous soils. REE enrichment varied widely. The proportion of acidsoluble phases of heavy REEs was higher than that of light REEs. From top to bottom of the studied hills, dominant REE sources transitioned from limestone in-situ weathering to input from REE-containing phases(e.g., clay minerals,amorphous iron, REE-containing fluids). Our results indicate that the REE content of calcareous soils is mainly controlled by slope aspect, while the enrichment degree of REEs is related to geomorphological position and vegetation type.Furthermore, the proportion of acid-soluble phases of REEs is mainly controlled by geomorphological position. | Zhaoliang Song Yuntao Wu Xiaomin Yang Zijuan Xu Linan Liu Xiaodong Zhang Qian Hao Shaobo Sun Guilin Han Congqiang Liu | 2017 | Acta Geochimica2017，36，3： | 1 |
| 9 | Low complexity hybrid power distribution combined with subcarrier allocation algorithm for OFDMA显示文摘To improve the total throughput of the uplink orthogonal frequency division multiple access system,a low complexity hybrid power distribution(HPD) combined with subcarrier allocation scheme is proposed.For the fairness mechanism for the subcarrier,the inter-cell interference is first analyzed to calculate the capacity of the multi-cell.The user selects the subcarrier with the largest channel gain.Based on the above subcarrier allocation scheme,a new kind of HPD scheme is proposed,which adopts the waterfilling-power-distributed scheme and the equal-power-distributed scheme in the cell-boundary and the cellcenter,respectively.Simulation results show that compared with the waterfilling-power-distributed scheme in the whole cell,the proposed HPD scheme decreases the system complexity significantly,meanwhile its capacity is 2% higher than that of the equal-powerdistributed scheme over the same subcarrier allocation. | Weilin Jiang Zhongzhao Zhang Xuejun Sha Linan Sun | 2011 | Journal of Systems Engineering and Electronics2011，22，6： | 0 |
| 10 | Fragments of Comet Hyakutake (C/1996 B2)显示文摘Several fragments of Comet Hyakutake were observed in March and April of 1996. This leads to the impression that the splitting of Comet Hyakutake on a small scale occurred frequently. Data analysis points to a rotation period of about 6 2 h if the fragments of April 11 are the condensations within a jet. | Daohan Chen Aidi Zhao Qindi Wu Yi Song Yixin Fan Shousheng Sun Yan Zhang Linan Sun | 1998 | Chinese Science Bulletin1998，43，2： | 0 |
| 11 | 汽车暖通空调系统气动噪声的分析与研究显示文摘汽车空调HVAC总成的气动噪声是汽车空调系统主要的噪声来源之一。本文研究了HVAC总成的气动噪声产生的机理,并对某车型HVAC总成的气动噪声表现性能进行了改进。作者通过对空调分配箱壳体与鼓风机蜗壳的结构型线的修改,以及模式风门位置的调整,对暖通空调系统的内部流场进行了模拟和优化。 | Wang Linan Zhang Zhenyu Sun Qiang.Chen Jiangping | 2019 | 家电科技2019，0，2： | 0 |
| 12 | OUTBURSTS OF COMET HALE-BOPP显示文摘In this paper, we present the observations of Comet Hale-Bopp by means of photoelectric and photographic photometry during the period from September to November of 1996. It is shown that there appears to have been 3 outbursts around 24 Sept., 26 Oct. and 13 Nov.; and it is also possible that an event of outburst has taken place around 9 Oct. | Yang Benyou 1 Zhang Chunsheng 1 Fan Yixin 1 Cai Hongfang 1 Sun Shousheng 2 Zhang Yan 2 Sun Linan 2 (1. Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008) (2. Qingdao Station of Purple Mountain Observatory, Qingdao 266 | 2000 | 中国科学院上海天文台年刊2000，，S1： | 0 |
| 13 | FRAGMENTS OF COMET HYAKUTAKE (C/1996 B2)显示文摘Several fragments of Comet Hyakutake were observed in March and April of 1996. This leads to the impression that the splitting of Comet Hyakutake on a small scale occurred frequently. Data analysis points to a rotation period of about 6.2h if the fragments of April 11 are the condensations within a jet. | Chen Daohan 1 Zhao Aidi 1 Wu Oindi 1 Song Yi 1 Fan Yixin 1 Sun Shousheng 2 Zhang Yan 2 Sun Linan 2 (1. Purple Mountain Observatory, Chinese Acadeniy of Sciences, Nanjing 210008) (2. Qingdao Station of Purple Mountain Observatory, Qingdao | 2000 | 中国科学院上海天文台年刊2000，，S1： | 0 |
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