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| 1 | 口服抗栓药物预防非瓣膜性房颤患者的卒中:美国心脏协会/美国卒中协会的科学建议显示文摘成年房颤患者的卒中发生率,依据合并症和既往脑血管事件史,为每年1%~20%不等(平均每年为4.5%)。对卒中风险的分层非常重要,因为用抗栓药降低房颤导致卒中的主要风险是出血。如华法令在减少缺血性事件风险的同时,每年有1%~12% | 戴若莲 糜建华 华驾略 董荃 苏爱萍 李焰生 Furie KL Goldstein LB Albers GW Khatri P Neyens R Turakhia MP Turan TN Wood KA | 2012 | 神经病学与神经康复学杂志2012，9，3： | 12 |
| 2 | 酒精相关性肝病的研究进展和临床现状显示文摘酒精相关性肝病的研究进展和临床现状张育明,段芳龄,吴醒民JameswWoodJosephRBertino酒精问题目有人类文字记载以来就已存在,唯其与肝病的关系只是从17世纪才引起人们的注意(4-7)。肝硬化在酗酒人群中的发病率高于非饮酒人群七倍以上(... | 张育明 段芳龄 吴醒民 James w wood Joseph R Bertinno | 1996 | 胃肠病学和肝病学杂志1996，5，3： | 8 |
| 3 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 4 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 5 | EU-Citizen.Science:A Platform for Mainstreaming Citizen Science and Open Science in Europe显示文摘Citizen Science(CS)is a prominent field of application for Open Science(OS),and the two have strong synergies,such as:advocating for the data and metadata generated through science to be made publicly available[1];supporting more equitable collaboration between different types of scientists and citizens;and facilitating knowledge transfer to a wider range of audiences[2].While primarily targeted at CS,the EU-Citizen.Science platform can also support OS.One of its key functions is to act as a knowledge hub to aggregate,disseminate and promote experience and know-how;for example,by profiling CS projects and collecting tools,resources and training materials relevant to both fields.To do this,the platform has developed an information architecture that incorporates the public participation in scientific research(PPSR)-Common Conceptual Model.This model consists of the Project Metadata Model,the Dataset Metadata Model and the Observation Data Model,which were specifically developed for CS initiatives.By implementing these,the platform will strengthen the interoperating arrangements that exist between other,similar platforms(e.g.,BioCollect and SciStarter)to ensure that CS and OS continue to grow globally in terms of participants,impact and fields of application. | Katherin Wagenknecht Tim Woods Francisco García Sanz Margaret Gold Anne Bowser Simone Rüfenacht Luigi Ceccaroni Jaume Piera | 2021 | Data Intelligence2021，3，1： | 2 |
| 6 | Novel and economical purification of recombinant proteins:intein-mediated protein purification using in vivo polyhydroxybutyrate (PHB) matrix association显示文摘 | BANKI M R GERNGROSS T U WOOD D W | 2005 | Protein Science2005，14，： | 1 |
| 7 | The sand erosion performance of coatings 显示文摘 | Wood R J K | 1999 | Mater1999，20，： | 1 |
| 8 | Extraction of high-viscosty gums from oats显示文摘 | WOOD P J SIDDIQUI L R PATON 19 | 1978 | Cereal Chem1978，55，6： | 1 |
| 9 | Effect of feeding organic acids on selected intestinal content measurements at varying times postweaning in pigs显示文摘 | Risley C R Kornegay E T Lindemann M D Wood C M Eigel W N | 1992 | Journal of Animal Science1992，70，： | 1 |
| 10 | On linear layout of graphs 显示文摘 | Dujmovie V wood D R | 2004 | Discrete Mathematics and Theoretical Computer Science2004，6，： | 1 |
| 11 | Loss of T cell precursors after spaceflight and exposure to vector-averaged gravity显示文摘 | Woods CC Banks KE Gruener R | 2003 | FASEBJ2003，17，11： | 1 |
| 12 | Potted - plant/growth media interactions and capacities for removal of volatiles from indoor air 显示文摘 | Wood R A Orwell R L Tartan J | 2002 | Journal of Horticulture Science & Biotechnology2002，77，1： | 1 |
| 13 | Genotyping Taenia tapeworms by singles-trand conformation pol-ymorphism of mitochondrial DNA显示文摘 | GASSER R B ZHU X WOODS W | 1999 | Electrophore-sis1999，20，14： | 1 |
| 14 | Effects of breed,diet and muscle on fat deposition and eating quality in pigs显示文摘 | Wood J D Nute G R Richardson R I | 2004 | Meat Science2004，67，4： | 1 |
| 15 | Resistive Interchange Mode in the Presence of Equilibrium Flow显示文摘 | HOU L PARIS R B WOOD A D | 1996 | Physics of Plasmas American Institute of Physics1996，3，2： | 1 |
| 16 | Effects of transverse air flow on burning rates of rectangular methanol pool fires显示文摘 | Woods J A R Fleck B A Kostiuk L W | 2006 | Combustion and Flame2006，146，12： | 1 |
| 17 | Development of PCR-based techniques to identify porcine transmissible gastroenteritis coronavirus isolates显示文摘 | Woods R D | 1997 | Can J Vet Res1997，61，3： | 1 |
| 18 | Activa- tion of EphB2 and its ligands promotes vascular smooth muscle cell proliferation 显示文摘 | WOODS T C BLYSTONE C R YOO J | 2002 | J Biol Chem2002，277，3： | 1 |
| 19 | Development of a Functional Basis for Design显示文摘 | Stone R B Wood K L | 2000 | Journal of Mechanical Design2000，122，4： | 1 |
| 20 | The use of the Memo- kath slent in the treatment of detmsor sphincter dyssynergia in spinal cord injury patients: a single-centre seven-year ex- perience显示文摘 | Hamid R Arya M Wood S | 2003 | Eur Urol2003，43，5： | 1 |
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