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| 1 | Molecular mechanism about lymphogenous metastasis of hepatocarcinoma cells in mice显示文摘AIM To investigate the correlation between lymphogenous metastasis and matrix metalloproteinases (MMPs) activity and the expression of Fas Iigand of tumor cells in lymph nodes.METHODES Fifty-six inbred 615-mice were equally divided into 2 groups and inoculated with Hca-F and Hca-P cells. Their lymph node metastatic rates were examined.Growth fraction of lymphocytes in host lymph nodes was detected by flow cytometry. The Hca-F and Hca-P cells were cultured with extract of lymph node, liver or spleen.The quantity of MMPs in these supernatants was examined by zymographic analysis. The expression of Fas ligand,PCNA, Bcl-2 protein of Hca-F and Hca-P cells in the mice were examined by immunohistochemistry. The apoptosis signals of macrophages in lymph nodes were observed with in situ DNA fragmentation.RESULTS On the 28th day post-inoculation, the lymph node metastatic rate of Hca-F was 80% (16/20), whereas that of Hca-P was 25% (5/20). The growth fraction of lymphocytes was as follows: in the Hca-F cells, the proliferating peak of lymphocytes appeared on the 14th day post-inoculation and then decreased rapidly, while in HcaP cells, the peak appeared on the 7th day post-inoculation and then kept at a high level. With the extract of lymph node, the quantity of the MMP-9 activity increased (P<0.01) and active MMP-9 and MMP-2 were produced by both Hca-F and Hca-P tumor cells, which did not produce MMPs without the extract of lymph node or with the extracts of the liver and spleen. The expression of Fas Ligand of Hca-F cells was stronger than that of Hca-P cells (P<0.01). The expressions of PCNA and Bcl-2 protein of Hca-F cells in the tumors of inoculated area were the same as that of Hca-P cells. In situ DNA fragmentation showed that the positive signals of macrophages were around HcaF cells.CONCLUSION Secretion of MMPs which was associated with metastatic ability of Hca-F and Hca-P tumor cells depends on the environment of lymph nodes. The increased expression of Fas ligand protein of Hca-F tumor cells with high lymphogenous metastatic potential in lymph nodes may help tumor cells escape from being killed by host lymphocytes. | Li Hou Ying Li Yong-Hua Jia Bo Wang Yi Xin Mao-Ying Ling Shen Lü Department of Pathology,Dalian Medical University,Dalian 116027,Liaoning Province,ChinaDepartment of Biochemistry,Dalian Medical University,Dalian 116027,Liaoning Province,China | 2001 | World Journal of Gastroenterology2001，7，4： | 47 |
| 2 | Underplating in the middle-lower Yangtze Valley and model of geodynamic evolution:Constraints from geophysical data显示文摘The lower crust and Moho are the most active boundary layers in the process of continental evolution, in which marks left by tectonic and magmatic activities during the process are preserved. The evolutionary process of the continental lithosphere may be reconstructed by exploring the structures of the lower crust and Moho. According to a study of the deep seismic reflection data obtained from the middle-lower Yangtze Valley, the authors find bright layered reflections ubiquitous in the lower crust and think that the bright reflections are caused by un-derplating of basic or ultrabasic magmas, which might be related to delamination of the lithosphere. On the basis of an integrated analysis of the geophysical and geological data of the region, the authors propose a model for geodynamic evolution of the middle-lower Yangtze Valley. This model suggests that the middle-lower Yangtze Valley had undergone such geodynamic processes as collision-compression, delamination-extension and underplating-melting since the end of the Permian, finally forming the gigantic middle-lower Yangtze Valley metallogenic belt. | Lü Qingtian, HOU Zengqian, YANG Zhusen & SHI Danian Institute of Mineral Resources,Chinese Academy of Geological Sciences,Beijing 100037,China | 2005 | Science China Earth Sciences2005，48，7： | 24 |
| 3 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 4 | Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome显示文摘 | Ma,X Fan,L Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 20 |
| 5 | Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats显示文摘AIM:To explore the therapeutic effects of Morinda officinalis capsules(MOP) on osteoporosis in ovariectomized rats.METHOD:Six-month-old female Sprague–Dawley rats were induced for postmenopausal osteoporosis(PMOP) by bilateral ovariectomy and divided into seven groups as follows:sham-operated group,ovariectomized(OVX) control group,OVX treated with xianlinggubao(XLGB)(270 mg·kg-1·d-1),OVX treated with alendronate sodium(ALN)(3 mg·kg-1·d-1),and OVX treated with Morinda officinalis capsule(MOP) of graded doses(90,270 and 810 mg·kg-1·d-1) groups.Oral treatments were administered daily on the 4th week after ovariectomy and lasted for 12 weeks.The bone mineral density was evaluated by dual-energy X-ray absorptiometry.The tartrate-resistant acid phosphatase(TRAP),alkaline phosphatase(AKP),and osteocalcin(OC) levels in the serum and plasma were determined by standard colorimetric and enzyme immunoassays methods.Bone biomechanical properties and morphological parameters were analyzed by three-point bending test and histomorphometry respectively.RESULTS:Morinda officinalis capsules at all doses were able to significantly prevent the OVX-induced loss of bone mass due to diminishing serum AKP and TRAP levels while elevating OC level in the plasma.Morinda officinalis capsules also enhanced the bone strength and prevented the deterioration of trabecular microarchitecture.CONCLUSION:Morinda officinalis capsules possess potent anti-osteoporotic activity in OVX rats which could be an effective treatment for postmenopausal osteoporosis. | LI Ye Lü Shan-Shan TANG Gui-Ying HOU Min TANG Qing ZHANG Xiao-Na CHEN Wei-Hai CHEN Gang XUE Qiang ZHANG Cong-Cong ZHANG Ji-Fen CHEN Yi XU Xiao-Yu | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 10 |
| 6 | Bond strength of different adhesives to normal and caries-affected dentins显示文摘背景当前,牙质的几个系统反应底层的粘合剂为在对龋的补药处理的使用是可得到的。然而,到影响龋的牙质的不同粘合剂系统的契约有效性和性质充分没被理解。这研究的目的是评估不同粘合剂的契约力量到正常牙质(ND ) 和影响龋的牙质(CAD ) 并且分析有龋的损害随机被分到四的花冠媒介的 28 提取人的 molars 根据粘合剂组织的不同种族的 characteristics.Methods 使用了的牙质 / 粘合剂。ND 和 CAD 与 etch-and-rinse 粘合剂 Adper^(TM ) 被结合单身的邦德 2 (SB2 ) 或自我蚀刻的粘合剂克雷尔菲尔·塞·邦德(CSE ) , Clearfil S^3 邦德(CS3 ) , iBond 官方补给(IB ) 。树脂牙质的矩形的棍子结合了接口 0.9 mm^2 被获得。标本受到以 1 mm/min 的小标题速度测试的 microtensile 契约力量(TBS ) 。吝啬的 TBS 统计上与变化(ANOVA ) 的分析被分析, Student-Newman-Keuls 测试。界面的形态学被扫描电子显微镜学(SEM ) 分析 .Results Etch-and-rinse 粘合剂 Adper^(TM ) 单身者结合当适用于正常和影响龋的牙质时, 2 产出高契约力量。自我蚀刻的粘合剂克雷尔菲尔·塞·邦德产生了的二拍子的圆舞到在所有粘合剂之中的 ND 的最高的契约力量测试了但是显著地减少的力量当适用于 CAD 时。为一步舞自我蚀刻的粘合剂, Clearfil S^3 邦德和 iBond 官方补给,契约力量不管牙质类型是相对低的。SEM 界面的分析比在为所有粘合剂 tested.Conclusion 的 ND etch-and-rinse 粘合剂比自我蚀刻的粘合剂更有效地表现到影响龋的牙质的表明混合的层在 CAD 与更差的树脂标签形成和不太充满树脂的侧面的分支是更厚的。 | XUAN Wei HOU Ben-xiang Lü Ya-lin | 2010 | Chinese Medical Journal2010，，3： | 7 |
| 7 | Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma:Dysregulation and implications for early detection,diagnosis and therapy显示文摘Hepatitis C virus(HCV)infection is one of main causes of hepatocellular carcinoma(HCC)and the prevalence of HCV-associated HCC is on the rise worldwide.It is particularly important and helpful to identify potential markers for screening and early diagnosis of HCC among high-risk individuals with chronic hepatitis C,and to identify target molecules for the prevention and treatment of HCV-associated-HCC.Small noncoding RNAs,mainly microRNAs(miRNAs),and long non-coding RNAs(lncRNAs)with size greater than 200nucleotides,are likely to play important roles in a variety of biological processes,including development and progression of HCC.For the most part their underlying mechanisms of action remain largely unknown.In recent years,with the advance of high-resolution of microarray and application of next generation sequencing techniques,a significant number of non-coding RNAs(ncRNAs)associated with HCC,particularly caused by HCV infection,have been found to be differentially expressed and to be involved in pathogenesis of HCVassociated HCC.In this review,we focus on recent studies of ncRNAs,especially miRNAs and lncRNAs related to HCV-induced HCC.We summarize those ncRNAs aberrantly expressed in HCV-associated HCC and highlight the potential uses of ncRNAs in early detection,diagnosis and therapy of HCV-associated HCC.We also discuss the limitations of recent studies,and suggest future directions for research in the field.miRNAs,lncRNAs and their target genes may represent new candidate molecules for the prevention,diagnosis and treatment of HCC in patients with HCV infection.Studies of the potential uses of miRNAs and lncRNAs as diagnostic tools or therapies are still in their infancy. | Weihong Hou Herbert L Bonkovsky | 2013 | World Journal of Gastroenterology2013，19，44： | 6 |
| 8 | Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells显示文摘AIM:To investigate effects of iron on oxidative stress, heme oxygenase-1(HMOX1)and hepatitis C viral(HCV) expression in human hepatoma cells stably expressing HCV proteins. METHODS:Effects of iron on oxidative stress,HMOX1, and HCV expression were assessed in CON1 cells. Measurements included mRNA by quantitative reverse transcription-polymerase chain reaction,and protein levels by Western blots. RESULTS:Iron,in the form of ferric nitrilotriacetate,increased oxidative stress and up-regulated HMOX1 gene expression.Iron did not affect mRNA or protein levels of Bach1,a repressor of HMOX1.Silencing the up-regulation of HMOX1 nuclear factor-erythroid 2-related factor 2(Nrf2)by Nrf2-siRNA decreased FeNTA-mediated up-regulation of HMOX1 mRNA levels.These iron effects were completely blocked by deferoxamine(DFO).Iron also significantly decreased levels of HCV core mRNA and protein by 80%-90%, nonstructural 5A mRNA by 90%and protein by about 50%in the Con1 full length HCV replicon cells, whereas DFO increased them. CONCLUSION:Excess iron up-regulates HMOX1 and down-regulates HCV gene expression in hepatoma cells.This probably mitigates liver injury caused by combined iron overload and HCV infection. | Wei-Hong Hou Lisa Rossi Ying Shan Jian-Yu Zheng Richard W Lambrecht Herbert L Bonkovsky | 2009 | World Journal of Gastroenterology2009，15，36： | 5 |
| 9 | Closing the nitrogen use efficiency gap and reducing the environmental impact of wheat-maize cropping on smallholder farms in the Guanzhong Plain,Northwest China显示文摘A high crop yield with the minimum possible cost to the environment is generally desirable.However,the complicated relationships among crop production,nitrogen(N) use efficiency and environmental impacts must be clearly assessed.We conducted a series of on-farm N application rate experiments to establish the linkage between crop yield and N_2 O emissions in the Guanzhong Plain in Northwest China.We also examined crop yield,partial factor productivity of applied N(PFPN) and reactive N(Nr) losses through a survey of 1 529 and 1 497 smallholder farms that grow wheat and maize,respectively,in the region.The optimum N rates were 175 and 214 kg ha^(-1) for winter wheat and summer maize,respectively,thereby achieving the yields of 6 799 and 7 518 kg ha^(-1),correspondingly,with low N_2 O emissions based on on-farm N rate experiments.Among the smallholder farms,the average N application rates were 215 and 294 kg ha^(-1) season^(-1),thus producing 6 490 and 6 220 kg ha^(-1) of wheat and maize,respectively.The corresponding PFPN values for the two crops were 36.8 and 21.2 kg N kg^(-1),and the total N_2 O emissions were 1.50 and 3.88 kg ha^(-1),respectively.High N balance,large Nr losses and elevated N_2 O emissions could be explained by the overdoses of N application and low grain yields under the current farming practice.The crop yields,N application rates,PFPN and total N_2 O for wheat and maize were 18 and 24% higher,42 and 37% less,75 and 116% higher,and 42 and 47% less,correspondingly,in the high-yield and high-PFPN group than in the average smallholder farms.In conclusion,closing the PFPN gap between the current average and the value for the high-yield and high-PFPN group would increase crop production and reduce Nr losses or the total N_2 O emissions for the investigated cropping system in Northwest China. | Lü Feng-lian HOU Miao-miao ZHANG Hong-tao Asif Khan Muhammad Ayaz QIANGJIU Ciren HU Chang-lu YANG Xue-yun SUN Ben-hua ZHANG Shu-lan | 2019 | Journal of Integrative Agriculture2019，18，1： | 5 |
| 10 | Gleaning insights from German energy transition and large-scale underground energy storage for China’s carbon neutrality显示文摘The global energy transition is a widespread phenomenon that requires international exchange of experiences and mutual learning.Germany’s success in its first phase of energy transition can be attributed to its adoption of smart energy technology and implementation of electricity futures and spot marketization,which enabled the achievement of multiple energy spatial–temporal complementarities and overall grid balance through energy conversion and reconversion technologies.While China can draw from Germany’s experience to inform its own energy transition efforts,its 11-fold higher annual electricity consumption requires a distinct approach.We recommend a clean energy system based on smart sector coupling(ENSYSCO)as a suitable pathway for achieving sustainable energy in China,given that renewable energy is expected to guarantee 85%of China’s energy production by 2060,requiring significant future electricity storage capacity.Nonetheless,renewable energy storage remains a significant challenge.We propose four large-scale underground energy storage methods based on ENSYSCO to address this challenge,while considering China’s national conditions.These proposals have culminated in pilot projects for large-scale underground energy storage in China,which we believe is a necessary choice for achieving carbon neutrality in China and enabling efficient and safe grid integration of renewable energy within the framework of ENSYSCO. | Yachen Xie Xuning Wu Zhengmeng Hou Zaoyuan Li Jiashun Luo Christian Truitt Lüddeke Liangchao Huang Lin Wu Jianxing Liao | 2023 | International Journal of Mining Science and Technology2023，33，5： | 4 |
| 11 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 12 | A Possible Long-tailed Bird with a Pygostyle from the Late Mesozoic Yixian Formation, Western Liaoning, China显示文摘An incomplete caudal vertebral series (IVPP V11309) from the Yixian Formation of late Mesozoic, Jianshangou area of Beipiao, western Liaoning Province, may represent a new bird. The tail is composed of at least 12 free caudal vertebrae and the most distal 5 caudal vertebrae co-ossified into a pygostyle. The pygostyle is plate-like and slightly curved dorsally. The anterior free caudals are amphiplatyan. The anterior caudal surfaces of the last three free caudals are concave, but their posterior articular surfaces are convex. The pygostyle is regarded as the first appeared flight apparatus during the evolutionary process from Archaeopteryx to neornithes. The pygostyle appeared in most early fossil birds and almost all the modern birds. Although their morphologies are different, they are basically formed by at least four last caudal vertebrae. The specimen V11309 is regarded as a bird rather than a non-avian theropod dinosaur based on the following characters: short caudal vertebrae, numerous pits present on the surfaces of the centra and, a foramen present between the basal part of the fused neural spines, which is similar to that of Struthio camelus. The discoveries of pygostyles from the therizinosauroids and oviraptorosaurs may provide strong evidence for supporting the origin of birds from small theropod dinosaurs. The structure of the pygostyle in specimen V11309 is different from those of Beipiaosaurus (Therizinosauroid) and Nomingia (oviraptorosaur). The most parsimonious interpretation is that these pygostyle-like structures are independently acquired by Beipiaosaurus and Nomingia during their evolutionary process. | L Junchang1 and HOU Lianhai2 1 Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037 2 Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044 Department of Biology, Capital Normal University, Beijing 100037 | 2005 | Acta Geologica Sinica(English Edition)2005，79，1： | 3 |
| 13 | Effect of carbonate additive on the microstructure and corrosion resistance of plasma electrolytic oxidation coating on Mg-9Li-3Al alloy显示文摘Carbonate was added to the silicate system electrolyte to improve the corrosion resistance of the plasma electrolytic oxidation coating on Mg-9Li-3Al(wt%,LA93)alloy.The influences of carbonate on the morphology,structure,and phase composition of the coating were investigated by scanning electron microscopy,energy dispersive spectrometry,X-ray diffraction,and X-ray photoelectron spectroscopy.The corrosion resistance of the coating was evaluated by electrochemical experiment,hydrogen evolution,and immersion test.The results showed that the addition of carbonate resulted in a denser coating with increased hardness,and the corrosion-resistant Li_(2)CO_(3) phase was formed.Electrochemical experiments showed that compared with the coating without carbonate,the corrosion potential of the carbonate coating positively shifted(24 mV),and the corrosion current density was reduced by approximately an order of magnitude.The coating with carbonate addition possessed a high corrosion resistance and long-term protection capability. | Siyuan Jin Xiaochun Ma Ruizhi Wu Tingqu Li Jiaxiu Wang Boris L Krit Legan Hou Jinghuai Zhang Guixiang Wang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 14 | Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial显示文摘 | Yi-Long Wu Caicun Zhou Cheng-Ping Hu Jifeng Feng Shun Lu Yunchao Huang Wei Li Mei Hou Jian Hua Shi Kye Young Lee Chong-Rui Xu Dan Massey Miyoung Kim Yang Shi Sarayut L Geater | 2014 | Lancet Oncology2014，，2： | 3 |
| 15 | Antioxidant Effects of Oats Avenanthramides on Human Serum显示文摘The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present study.Healthy people were randomized to supplementation with oats-derived avenanthramides capsules or placebo for 1 mon.Plasma lipid peroxides and antioxidant status were measured.For 8 capsules (containing 3.12 mg avenanthramides) groups,the levels of serum superoxide dismutase (SOD) and reduced glutathione hormone (GSH) were significantly increased by 8.4 and 17.9%,respectively (P<0.05),and malondialdehyde (MDA) level significantly decreased by 28.1%.The total cholesterol (TC),triglyceride (TG),and low density lipoprotein cholesterol (LDL-C) levels were lowered by 11.1,28.1,and 15.1%,respectively (P<0.05).The high density blood lipoprotein cholesterol (HDL-C) levels in the same treat was increased by 13.2%.Based on our research,it can be concluded that oats extract containing avenanthramides possessed a high antioxidative activity on humans.It indicated that oat avenanthramides could be used to prevent hyperlipemic and angiocardiopathy. | LIU Sen YANG Nan HOU Zhao-hua YAO Yang Lü Li ZHOU Xian-rong REN Gui-xing | 2011 | Agricultural Sciences in China2011，10，8： | 3 |
| 16 | Sierpiński-triangle fractal crystals with the C_(3v)point group显示文摘Self-similar fractals are of importance in both science and engineering. Metal-organic Sierpin′ ski triangles are particularly attractive for applications in gas separation, catalysis and sensing. Such fractals are constructed in this study by using 1208 V-shaped 4,400-dicyano-1,10:30,100-terphenyl molecules and Fe atoms on Au(1 1 1), and studied in detail by low-temperature scanning tunneling microscopy. Density functional theory calculations are employed to rationalize the invisible Fe atoms in STM images. Monte Carlo simulations are performed to understand the formation mechanism of the surface-supported fractal crystals. | Na Li Xue Zhang Gao-Chen Gu Hao Wang Damian Nieckarz Pawel Szabelski Yang He Yu Wang Jing-Tao Lü Hao Tang Lian-Mao Peng Shi-Min Hou Kai Wu Yong-Feng Wang | 2015 | Chinese Chemical Letters2015，26，10： | 2 |
| 17 | Resistive Interchange Mode in the Presence of Equilibrium Flow显示文摘 | HOU L PARIS R B WOOD A D | 1996 | Physics of Plasmas American Institute of Physics1996，3，2： | 1 |
| 18 | Improving both bond strength and corrosion resistance of steel rebar in concrete by water immersion or sand blasting of rebar显示文摘 | Hou Jiangyuan Fu Xuli Chung D D L | 1997 | Cement and Concrete Research1997，27，5： | 1 |
| 19 | The friction and wear of Ni-P-PTFE composite deposite and water lubrication 显示文摘 | Ming Der Ger Hou K H WANG L M | 2002 | Materials Chemistry and Physics2002，77，3： | 1 |
| 20 | Maps preserving numerical radius of products of self-adjoint operators显示文摘 | He K Hou J C Zhang X L | 2010 | Acta Math Sinca-Eng-lish Series2010，6，： | 1 |
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