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166篇 您的检索式：作者名="WINTER J P"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Soil microarthropods in longterm no-tillage and conventional corn production显示文摘	Winter J P Voroney R P Ainsworth D A	1990	Canadian Journal of Soil Science1990，70，：	1
3	Lung Injury in Acute Pancreatitis: Mechanisms, Prevention, and Therapy显示文摘	Shields C J Winter D C Redmond H P	2002	Curr Opin Crit Care2002，8，2：	1
4	Critical pressure and multiphase flow in Blake Ridge gas hydrates 显示文摘	Flemings B P Liu X Winters W J	2003	Geology2003，31，：	1
5	The relationship between social anxiety and social support in adoleseents:A test of competing causal models显示文摘	Calsyn R J Winter J P Burger G K	2005	Adolescents2005，40，157：	1
6	Prosthetic positioning in total shoulder arthroplasty显示文摘	Iannotti J P Spencer E E Winter U	2005	J Shoulder Elbow Surg2005，14，1：	1
7	Targeting liver tumor with hyperthermia: ferromagnetic embolization in rabbit liver tumor model显示文摘	Moroz P Jones SK Winter J	2001	J Surg Oncol2001，78，：	1
8	Reduction of Aldehydes and Hydrogen Cyanide Yields in Mainstream Cigarette Smoke Using an A- mine Functionalised Ion Exchange Resin显示文摘	BRANTON P J MCADAM K G WINTER D B	2011	Chem Central J2011，5，：	1
9	Stability of spikes in the shadow Gierer-Meinhardt system显示文摘	Maini P K WEI J uneheng Winter M		0，，3：	1
10	Critical pressure and multi-phase flow in Blake Ridge gas hydrates 显示文摘	Flemings P B Liu X Winters W J	2003	Geology2003，31，12：	1
11	Insertion electrode materials for rechargeable lithium batteries 显示文摘	WINTER M BESENHARD J O SPAHR M E NOV K P	1998	Advanced Materials1998，10，10：	1
12	Surgically Treated Adnexal Masses in Infancy,Childhood,and Adolescence显示文摘	Van Winter J T Simmons P S Podratz K C	1994	Am J Obstet Gynecol1994，170，：	1
13	Apparatus Investigates Geological Aspects of Gas Hydrates显示文摘	Booth J S Winters W J Dillon W P	1999	Oil and Gas Journal1999，97，40：	1
14	The use of acellular dermal graft for vulvovaginal reconstruction in a patient with lichen planus显示文摘	STANY M P WINTER W E ELKAS J C	2005	Obstet Gynecol2005，105，52：	1
15	Nearshore Restoration of the Elwha River Through Removal of the Elwha and Glines Canyon Dams显示文摘	Shaffer J A Crain P Winter B	2008	Northwest Science2008，，：	1
16	Total phosphorus budgets and nitrogen loads:Lake Simcoe,Ontario (1990 to 1998)显示文摘	WINTER J G DILLON P J FUTTER M N	2002	Journal of Great Lakes Research2002，28，3：	1
17	Distinguishing features of endometrial pathology after exposure to the progesterone receptor modulator mifepristone显示文摘	Fiscella J Bonfiglio T Winters P	2011	Human Pathology2011，42，7：	1
18	Control of Arabidopsis rootdevelopment显示文摘	Petricka J J Winter C M Benfey P N	2012	Annual Review of Plant Biology2012，，63：	1
19	Early growth and death from cardiovascular disease in women显示文摘	OSMOND C BARKER D J WINTER P D	1993	BMJ1993，307，6918：	1
20	Radiologic manifestation of pulmonary tuberculosis显示文摘	MCACAMS H P ERASMUS J WINTER J A	1995	Radiol Clin North Am1995，33，4：	1

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