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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017，25，4： | 5 |
| 3 | A rat model of bone cancer pain显示文摘 | S.J Medhurst K Walker M Bowes B.L Kidd M Glatt M Muller M Hattenberger J Vaxelaire T O’Reilly G Wotherspoon J Winter J Green L Urban | 2002 | Pain2002，，： | 2 |
| 4 | Recombinant spider silk particles for controlled delivery of protein drugs 显示文摘 | HOFER M WINTER G MYSCHIK J | 2012 | Bio- materials2012，33，5： | 1 |
| 5 | Cyclic and acyclic sulfites: new solvents and electrolyte additives for lithium ion batteries with graphitic anodic显示文摘 | WRODNIGG G H BESENHARD J O WINTER M | 2001 | Journal of Power Sources2001，9798，： | 1 |
| 6 | Driven-right-leg circuit design显示文摘 | WINTER B B WEBSTER J G | | 0，，01： | 1 |
| 7 | Modeling and Simulation of Heat Front Propagation in the Iron Ore Sintering Process显示文摘 | MITTERLEHNER J LOEFFLER G WINTER F | 2004 | ISIJ International2004，44，： | 1 |
| 8 | The relationship between social anxiety and social support in adoleseents:A test of competing causal models显示文摘 | Calsyn R J Winter J P Burger G K | 2005 | Adolescents2005，40，157： | 1 |
| 9 | Application of activated carbon tocyanidation 显示文摘 | Crabtree J E H Winters V W Chapman T G | 1951 | Transactions of the American Institute of Mining Metallurgical and Petroleum Engineers1951，187，： | 1 |
| 10 | Stable hydrogen and oxygen isotope ratios of bottled waters of the world显示文摘 | Bowen G J Winter D A Spero H J | 2005 | Rapid communications in mass spectrometry2005，19，23： | 1 |
| 11 | Catalytic effect of biomass ash on CO,CH4 and HCN oxidation under fluidised bedcombustor conditions 显示文摘 | LOFFLER G WARGADALAM V J WINTER F | 2002 | Fuel2002，81，6： | 1 |
| 12 | Antibody framework residues affecting the conformation of the hypervariable loops显示文摘 | Foote J Winter G | 1992 | J Mol Biol1992，224，2： | 1 |
| 13 | Phage antibodies: filamentous phage displaying anti-body variable domains显示文摘 | Mccafferty J Griffiths A D Winter G | 1990 | Nature1990，348，： | 1 |
| 14 | Reduction of Aldehydes and Hydrogen Cyanide Yields in Mainstream Cigarette Smoke Using an A- mine Functionalised Ion Exchange Resin显示文摘 | BRANTON P J MCADAM K G WINTER D B | 2011 | Chem Central J2011，5，： | 1 |
| 15 | Phage anti- bodies: filamentous phage displaying antibody variable domains显示文摘 | McCafferty J Griffiths AD Winter G | 1990 | Nature1990，348，6301： | 1 |
| 16 | Driven-right-leg circuit design显示文摘 | WINTER B B WEBSTER J G | | 0，，01： | 1 |
| 17 | Total phosphorus budgets and nitrogen loads:Lake Simcoe,Ontario (1990 to 1998)显示文摘 | WINTER J G DILLON P J FUTTER M N | 2002 | Journal of Great Lakes Research2002，28，3： | 1 |
| 18 | Phage antibodies:filamentous phage displaying antibody variable domains显示文摘 | GRIFFITHS AD WINTER G | 1990 | Nature1990，348，： | 1 |
| 19 | A nonspecific phosphotyrosine phosphatase inhibitor,bis (maholato)oxovanadium(Ⅳ),improves glucose tolerance and prevents diabetes in zucker diabetic fatty rats显示文摘 | WINTER C L LANGE J S DAVIS M G | 2005 | Expl Biol Med2005，230，3： | 1 |
| 20 | The tolerability of rTMS treatment in schizophrenia with respect to congnitive function显示文摘 | Mittrach M Thiinker J Winterer G | 2010 | Pharmacopsychiatry2010，43，3： | 1 |
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