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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | 早发急性心肌梗死的长期结局和风险评估:10年随访研究显示文摘早发急性心肌梗死(acute myocardial infarction,AMI)是一种罕见的疾病,发病率和死亡率很高。该文在再灌注治疗广泛应用的大环境下,纳入前瞻性研究人群进行早发AMI的预后研究。方法:这项前瞻性多中心研究中连续纳入102例AMI存活者(≤40岁),临床预后通过奥地利死亡登记处和维也纳集中患者管理系统进行查询。 | 刘莉 叶鹏 Winter MP Blessberger H Alimohammadi A Pavo N Huber K Wojta J Lang IM Wiesbauer F Goliasch G | 2017 | 中华高血压杂志2017，25，4： | 5 |
| 3 | Soil microarthropods in longterm no-tillage and conventional corn production显示文摘 | Winter J P Voroney R P Ainsworth D A | 1990 | Canadian Journal of Soil Science1990，70，： | 1 |
| 4 | Kinetic analysis of the lower limbsduring walking:What information can be gained from athree-dimensional model显示文摘 | Eng J J Winter D A | 1995 | Biomech1995，28，6： | 1 |
| 5 | Urban heat island effect analysis for San Juan, Puerto Rico 显示文摘 | Velazquez Lozada A Gonzalez J E Winter A | 2006 | Atmospheric Environment2006，40，： | 1 |
| 6 | Pathways forconversion of char nitrogen to nitric oxide during pulver-ized coal combustion 显示文摘 | Molina A Murphy J J Winter F | 2009 | Combustion and Flame2009，156，3： | 1 |
| 7 | Carbon isotope composition of canopy leaves in a tropical forest in Panama throughout a seasonal cycle显示文摘 | Holtum J A M Winter K | 2005 | Trees2005，19，5： | 1 |
| 8 | The selection of fusion levels in thoracic idiopathic seoliosis显示文摘 | King H A Moe J H Bradford D S Winter R B | 1983 | J Bone Joint Surg Am1983，65，： | 1 |
| 9 | Injury-induced class 3 semaphorin expression in the rat spinal cord显示文摘 | De Winter F Oudega M Lankhorst A J | | 0，，01： | 1 |
| 10 | Stable hydrogen and oxygen isotope ratios of bottled waters of the world显示文摘 | Bowen G J Winter D A Spero H J | 2005 | Rapid communications in mass spectrometry2005，19，23： | 1 |
| 11 | BRAF mutations in colon cancer are not likely at- tributable to defective DNA mismatch repair显示文摘 | Wang L Cunningham J M Winters J L French A J Boardman L A | 2003 | Cancer Res2003，63，： | 1 |
| 12 | RBC alloantibody specificity and antigen potency in Olmsted County,Minnesota显示文摘 | WINTERS J L PINEDA A A GORDEN L D | 2001 | Transfusion2001，41，： | 1 |
| 13 | Macrophages and Brucella显示文摘 | Baldwin C L Winter A J | 1994 | Immunol Ser1994，60，： | 1 |
| 14 | Physical properties and rock physics models of sediment containing natural and laboratory-formed methane gas hydrate显示文摘 | Winters W J Pecher I A Waite W F Mason D H | | 0，，8： | 1 |
| 15 | Human beta-defensin-1,-2 ,and-3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation显示文摘 | Winter J Pantelis A Reich R | 2011 | Cancer Invest2011，29，3： | 1 |
| 16 | Environment or development? Lifetime net CO2 exchange and control of the expression of crassulacean acid metabolism in Mesembryanthemum crystallinum 显示文摘 | WINTER K HOLTUM J A M | 2007 | Plant Physiology2007，143，： | 1 |
| 17 | Phage antibodies: filamentous phage displaying anti-body variable domains显示文摘 | Mccafferty J Griffiths A D Winter G | 1990 | Nature1990，348，： | 1 |
| 18 | Methane gas hydrate effect on sediment acoustic and strength properties显示文摘 | Winters W J Waite W F Mason D H Gilbert L Y Pecher I A | | 0，，1： | 1 |
| 19 | Toxicity after three2di2 men2sional radiotherapy for p rostate cancer with RTOG 9406 dose level Ⅳ显示文摘 | Michalski J M Winter K Purdy J A | 2004 | Int J Radiat Oncol Biol Phys2004，58，： | 1 |
| 20 | Activated partialthromboplati time (aPTT) monitoring to achieve therapeutic anticoagulation befor and after introducing a nomogram for adjunctive hepar in treatmeen with thromobolytic therapy for acute myocardial infarction显示文摘 | Chamuleau Robbert J de Winter | 1998 | Inter Journal of Cardiology1998，6724，： | 1 |
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