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| 1 | 中国农村合作医疗的受益公平性显示文摘在中国的大多数地区所建立的合作医疗都属于“低保费、高共付率”的形式。虽然低保费更有利于贫困的农民参加合作医疗,但是,高共付率会阻碍他们实际利用医疗服务。利用2002年中国贵州省开阳县冯三镇的家庭入户调查资料,采用logistic回归模型和“四部模型”研究农民参加合作医疗的概率、合作医疗参加者对卫生服务的利用、以及农民从合作医疗获得的净收益,探索这种“低保费、高共付率”设计的合作医疗的受益公平性。结果表明,在“低保费、高共付率”模式下,合作医疗受益存在着不公平性。基于研究结果提出了政策性建议。 | 汪宏 Winnie Yip 张里程 王禄生 萧庆伦 | 2005 | 中国卫生经济2005，24，2： | 70 |
| 2 | 农村居民主观幸福感与健康的相关性显示文摘目的分析农村居民主观幸福感与健康之间的相关性。方法采用昨日重现法和EQ5D量表分别对主观幸福感和健康进行测量,并对二者进行相关分析。结果调查居民中有27%产生过不愉快情绪,平均有47%的时间处于不幸福状态;分别有31.9%和17.9%居民感到疼痛/不舒服、焦虑/沮丧。结论主观幸福感与健康呈正相关关系。 | 王健 孟庆跃 Winnie Yip 贾莉英 王丽娜 | 2008 | 山东大学学报(医学版)2008，46，9： | 22 |
| 3 | 农村居民主观幸福感及其影响因素研究显示文摘和谐社会是社会发展目标和前进方向,我国有9亿农民,农民感觉幸福是和谐社会建设的关键。文章采用昨日重现法,对农村居民的主观幸福感及其影响因素进行了测量和分析。结果表明:被调查居民平均有12.79%的时间处于不幸福状态;有27.00%的居民U指数大于0,均数为47.03%,说明平均有47.03%的时间处于不幸福状态;不同特征人群的主观幸福感不同;Logistic回归分析发现调查县、文化程度、相对经济状况、失眠状况、心情抑郁和时间压力对主观幸福感有影响。 | 王健 孟庆跃 Winnie Yip 王丽娜 曲江斌 贾莉英 孙强 | 2009 | 中国卫生经济2009，28，3： | 20 |
| 4 | Review of renal cell carcinoma and its common subtypes in radiology显示文摘Representing 2%-3% of adult cancers, renal cell carcinoma(RCC) accounts for 90% of renal malignancies and is the most lethal neoplasm of the urologic system. Over the last 65 years, the incidence of RCC has increased at a rate of 2% per year. The increased incidence is at least partly due to improved tumor detection secondary to greater availability of high-resolution cross-sectional imaging modalities over the last few decades. Most RCCs are asymptomatic at discovery and are detected as unexpected findings on imaging performed for unrelated clinical indications. The 2004 World Health Organization Classification of adult renal tumors stratifies RCC into several distinct histologic subtypes of which clear cell, papillary and chromophobe tumors account for 70%, 10%-15%, and 5%, respectively. Knowledge of the RCC subtype is important because the various subtypes are associated with different biologic behavior, prognosis and treatment options. Furthermore, the common RCC subtypes can often be discriminated non-invasively based on gross morphologic imaging appearances, signal intensity on T2-weighted magnetic resonance images, and the degree of tumor enhancement on dynamic contrast-enhanced computed tomography or magnetic resonance imaging examinations. In this article, we review the incidence and survival data, risk factors, clinical and biochemical findings, imaging findings, staging, differential diagnosis, management options and posttreatment follow-up of RCC, with attention focused on the common subtypes. | Gavin Low Guan Huang Winnie Fu Zaahir Moloo Safwat Girgis | 2016 | World Journal of Radiology2016，8，5： | 20 |
| 5 | Lapatinib plus capecitabine in treating HER2-positive advanced breast cancer:efficacy,safety,and biomarker results from Chinese patients显示文摘Overexpression of human epidermal growth factor receptor-2(HER2) in metastatic breast cancer(MBC) is associated with poor prognosis.This single-arm open-label trial(EGF109491;NCT00508274) was designed to confirm the efficacy and safety of lapatinib in combination with capecitabine in 52 heavily pretreated Chinese patients with HER2-positive MBC.The primary endpoint was clinical benefit rate(CBR).Secondary endpoints included progression-free survival(PFS),time to response(TTR),duration of response(DoR),central nervous system(CNS) as first site of relapse,and safety.The results showed that there were 23 patients with partial responses and 7 patients with stable disease,resulting in a CBR of 57.7%.The median PFS was 6.34 months(95% confidence interval,4.93-9.82 months).The median TTR and DoR were 4.07 months(range,0.03-14.78 months) and 6.93 months(range,1.45-9.72 months),respectively.Thirteen(25.0%) patients had new lesions as disease progression.Among them,2(3.8%) patients had CNS disease reported as the first relapse.The most common toxicities were palmar-plantar erythrodysesthesia(59.6%),diarrhea(48.1%),rash(48.1%),hyperbilirubinemia(34.6%),and fatigue(30.8%).Exploratory analyses of oncogenic mutations of PIK3CA suggested that of 38 patients providing a tumor sample,baseline PIK3CA mutation status was not associated with CBR(P = 0.639) or PFS(P = 0.989).These data confirm that the lapatinib plus capecitabine combination is an effective and well-tolerated treatment option for Chinese women with heavily pretreated MBC,irrespective of PIK3CA status. | Bing-He Xu Ze-Fei Jiang Daniel Chua Zhi-Min Shao Rong-Cheng Luo Xiao-Jia Wang Dong-Geng Liu Winnie Yeo Shi-Ying Yu Beth Newstat Alka Preston Anne-Marie Martin Hai-Dong Chi Li wang | 2011 | Chinese Journal of Cancer2011，30，5： | 17 |
| 6 | 阿姆斯特丹城市道路线圈检测器布设方法研究显示文摘基于宏观基本图(Macroscopic Fundamental Diagram,MFD)的网络交通控制方法受到越来越多的国家的重视,它可以更有效的节约资源和提高效率。然而建立MFD需要以收集网络范围内详细的交通数据为前提,阿姆斯特丹的城市道路错综复杂,若在每个城市道路路段都布设线圈检测器需要巨大的经济支持和维护。基于Vissim的仿真实验的方法,建立阿姆斯特丹的MFD;通过实验方法确定城市道路中对于建立网络MFD起着显著的影响关键路段,为线圈检测器的布设提供了理论依据。 | 姬杨蓓蓓 Winnie Daame | 2010 | 重庆交通大学学报(自然科学版)2010，29，5： | 15 |
| 7 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 8 | 多方共赢的政策设计案例:宁夏盐池县县级医院包干制显示文摘2009年以来,我国多个地区都开展了各具特色的卫生改革尝试。总结这些改革的经验对于深化我国医药卫生体制有着积极意义。文章以宁夏回族自治区盐池县县级医院支付制度改革为核心,系统阐述了这次改革的政策安排并对政策效果进行了初步的评价。通过剖析这些安排对医疗服务提供者的激励作用,着重分析了这次改革如何实现'医、患、保多方共赢'的政策目标。 | 简伟研 Winnie Yip William Hsiao 陈文 胡敏 | 2014 | 中国卫生经济2014，33，11： | 11 |
| 9 | Value of quality of life analysis in liver cancer: A clinician's perspective显示文摘Health related quality of life(HRQOL) is increasingly recognized as an important clinical parameter and research endpoint in patients with hepatocellular carcinoma(HCC). HRQOL in HCC patients is multifaceted and affected by medical factor which encompasses HCC and its complications, oncological and palliative treatment for HCC, underlying liver disease, as well as the psychological, social or spiritual reaction to the disease. Many patients presented late with advanced disease and limited survival, plagued with multiple symptoms, rendering QOL a very important aspect in their general well being. Various instruments have been developed and validated to measure and report HRQOL in HCC patients, these included general HRQOL instruments, e.g., Short form(SF)-36, SF-12, Euro Qo L-5D, World Health Organization Quality of Life Assessment 100(WHOQOL-100), World Health Organization Quality of Life Assessment abbreviated version; general cancer HRQOL instruments, e.g., the European Organisation for Research and Treatment of Cancer(EORTC) QLQ-C30, Functional Assessment of Cancer Therapy(FACT)-General, Spitzer Quality of Life Index; and liver-cancer specific HRQOL instruments, e.g., EORTC QLQ-HCC18, FACT-Hepatobiliary(FACT-Hep), FACT-Hep Symptom Index, Trial Outcome Index. Important utilization of HRQOL in HCC patients included description of symptomatology and HRQOL of patients, treatment endpoint in clinical trial, prognostication of survival, benchmarking of palliative care service and health care valuation. In this review, difficulties regarding the use of HRQOL data in research and clinical practice, including choosing a suitable instrument, problems of missing data, data interpretation, analysis and presentation are examined. Potential solutions are also discussed. | Leung Li Winnie Yeo | 2017 | World Journal of Hepatology2017，9，20： | 10 |
| 10 | Recent Advances of Graphitic Carbon Nitride-Based Structures and Applications in Catalyst, Sensing, Imaging, and LEDs显示文摘The graphitic carbon nitride(g-C_3N_4) which is a two-dimensional conjugated polymer has drawn broad interdisciplinary attention as a low-cost, metal-free, and visible-light-responsive photocatalyst in the area of environmental remediation. The g-C_3N_4-based materials have excellent electronic band structures, electron-rich properties, basic surface functionalities, high physicochemical stabilities and are ‘‘earth-abundant.'' This review summarizes the latest progress related to the design and construction of g-C_3N_4-based materials and their applications including catalysis, sensing,imaging, and white-light-emitting diodes. An outlook on possible further developments in g-C_3N_4-based research for emerging properties and applications is also included. | Aiwu Wang Chundong Wang Li Fu Winnie Wong-Ng Yucheng Lan | 2017 | Nano-Micro Letters2017，9，4： | 9 |
| 11 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 12 | 如何提高农村基层医疗服务的效率和质量——宁夏新农合门诊按人头预付制改革设计与效果显示文摘本研究以宁夏回族自治区为案例,针对村医经济激励水平低下,按项目付费引发不恰当诊治行为,系统内缺乏引导供方提高自身服务效率和质量并促进服务与体系整合协调的经济激励等问题,从供方合理激励的角度出发,对新型农村合作医疗支付制度进行改革设计——以乡村为整体对乡镇卫生院和村卫生室提供的门诊服务实施基于绩效的按人头预付制。随后利用配对整群随机试验设计对改革效果进行评估和检验。研究发现,这一支付制度的实施有效降低了农村基本医疗服务中抗生素的使用率,优化了供方的处方行为,对降低村卫生室的单次门诊费用有一定作用,并且促进服务向村卫生室下沉。本文的政策分析和设计思路及严格的政策评估结果可以为我国支付制度的选择和发展提供政策参考和证据支持。 | 胡敏 Winnie C-M Yip 陈文 祝菁菁 | 2014 | 中国卫生政策研究2014，7，8： | 5 |
| 13 | 向基层机构倾斜的门诊报销制度对高血压患者门诊服务利用的影响显示文摘目的:研究向基层机构倾斜的门诊报销制度(即覆盖门诊服务且县、乡、村门诊报销比例由低到高的制度设计)对高血压患者门诊服务利用的影响。方法:从宁夏回族自治区'创新支付制度项目'获取2009年和2011年入户调查的面板数据,采用自然试验的设计,针对干预组和对照组,利用双重差分法(difference-in-differences)进行分析,其结果指标为自报高血压患者样本被调查前3个月内是否就诊及其主要就诊地点的选择。结果:相较于对照组,倾向于基层的新农合门诊覆盖使得干预组高血压患者被调查前3个月内从未就诊的概率下降10.2%,并使患者将村卫生室作为主要就诊地点的概率提高了15.7%。结论:门诊报销比例向基层机构倾斜,可以引导高血压患者在疾病风险较小时就近利用门诊服务。 | 汤淑女 简伟研 Winnie C-M Yip 郭岩 | 2014 | 北京大学学报(医学版)2014，46，3： | 5 |
| 14 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 15 | 农村通向全民健康覆盖的障碍及其原因分析--基于供需双方经济激励机制角度显示文摘以宁夏回族自治区为案例,本研究对五个样本县进行大规模家庭入户调查、乡镇卫生院和村卫生室机构调查,分析了西部农村通向全民健康覆盖之路的障碍,并从供需双方经济激励机制角度剖析其原因。分析认为西部农村面临基层门诊服务可及性不足,居民经济负担沉重;服务流向不合理,资源配置效率低下;基层供方服务技术效率和质量不佳等问题。造成这些障碍的原因包括:从需方角度来看,新农合保障'轻门诊重住院、轻基层重高层'的特点;从供方角度剖析,对村医经济激励效力低下,按项目付费提供不恰当的经济刺激,难以引导供方提高自身服务效率和质量,以及欠缺促进体系整合的激励。 | 胡敏 Winnie C-M Yip 陈文 萧庆伦 | 2014 | 中国卫生政策研究2014，7，8： | 4 |
| 16 | 如何增强农村基层门诊服务的可及性--宁夏新农合福利包改革设计与效果显示文摘在新医改进程中,各地需要立足现实,探索细致的改革策略及机制,以实现'保基本、强基层、建机制'的目标。本文以宁夏回族自治区为案例,对新农合保障范围和水平进行改革设计,纳入基层门诊服务并予以较高报销比例,随后进行自然实验设计,并利用2009—2012年入户调查面板数据以及倍差法对实际干预效果进行评估。研究发现,实施趋向于基层门诊服务的福利包增加了居民利用村卫生室门诊服务的可能性,但是这一影响随着人们的教育水平、收入水平、住所与医疗机构距离等的不同而不同。 | 祝菁菁 胡敏 Winnie C-M Yip 陈文 | 2014 | 中国卫生政策研究2014，7，8： | 4 |
| 17 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 18 | International validation of the Chinese University Prognostic Index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study显示文摘The outcome of hepatocellular carcinoma(HCC) patients significantly differs between western and eastern population centers. Our group previously developed and validated the Chinese University Prognostic Index(CUPI) for the prognostication of HCC among the Asian HCC patient population. In the current study, we aimed to validate the CUPI using an international cohort of patients with HCC and to compare the CUPI to two widely used staging systems, the Barcelona Clinic Liver Cancer(BCLC) classification and the Cancer of the Liver Italian Program(CLIP). To accomplish this goal, two cohorts of patients were enrolled in the United Kingdom(UK; n = 567; 2006-2011) and Hong Kong(HK; n = 517; 2007-2012). The baseline clinical data were recorded. The performances of the CUPI, BCLC, and CLIP were compared in terms of a concordance index(C-index) and were evaluated in subgroups of patients according to treatment intent. The results revealed that the median follow-up durations of the UK and HK cohorts were 27.9 and 29.8 months, respectively. The median overall survival of the UK and HK cohorts were 22.9 and 8.6 months, respectively. The CUPI stratified the patients in both cohorts into three risk subgroups corresponding to distinct outcomes. The median overall survival of the CUPI low-, intermediate-, and high-risk subgroups were 3.15, 1.24, and 0.29 years, respectively, in the UK cohort and were 2.07, 0.32, and 0.10 years, respectively, in the HK cohort. For the patients who underwent curative treatment, the prognostic performance did not differ between the three staging systems, and all were suboptimal. For those who underwent palliative treatment, the CUPI displayed the highest C-index, indicating that this staging system was the most informative for both cohorts. In conclusion, the CUPI is applicable to both western and eastern HCC patient populations. The performances of the three staging systems differed according to treatment intent, and the CUPI was demonstrated to be optimal for those undergoing palliative treatment. A more precise staging system for early-stage disease patients is required. | Stephen L.Chan Philip J.Johnson Frankie Mo Sarah Berhane Mabel Teng Anthony W.H.Chan Ming C.Poon Paul B.S.Lai Simon Yu Anthony T.C.Chan Winnie Yeo | 2014 | Chinese Journal of Cancer2014，33，10： | 4 |
| 19 | 呼吸前反馈调节、情景想象和过度通气显示文摘 | Ilse Van Diest 韩江娜 Karel P.Vande Woestijne Stephan Devriese Winnie Winters Omer Vanden Bergh | 2002 | 中华结核和呼吸杂志2002，25，5： | 4 |
| 20 | Hepatitis B virus infection and fatty liver in the general population显示文摘 | Vincent Wai-Sun Wong Grace Lai-Hung Wong Winnie Chiu-Wing Chu Angel Mei-Ling Chim Arlinking Ong David Ka-Wai Yeung Karen Kar-Lum Yiu Shirley Ho-Ting Chu Hoi-Yun Chan Jean Woo Francis Ka-Leung Chan Henry Lik-Yuen Chan | 2011 | Journal of Hepatology2011，，3： | 3 |
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