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| 1 | Endoscopic papillectomy: Data of a prospective observational study显示文摘AIM:To investigate the clinical value of endoscopic papillectomy indicated by feasibility and safety of the procedure in various diseases of the papilla in a representative number of patients in a setting of daily clinical and endoscopic practice and care by means of a systematic prospective observational study. METHODS:Through a defined time period, all consecutive patients with tumor-like lesions of the papilla, who were considered for papillectomy, were enrolled in this systematic bicenter prospective observational study, and subdivided into 4 groups according to endoscopic and endoscopic ultrasonography (EUS) findings as well as histopathological diagnosis:adenoma; carcinoma/ neuroendocrine tumor (NET)/lymphoma; papilla into which catheter can not be introduced; adenomyomatosis, respectively. Treatment results and outcome were characterized by R0 resection, complication, recurrence rates and tumor-free survival.RESULTS:Over a 7-year period, 58 patients underwent endoscopic papillectomy. Main symptoms prompting to diagnostic measures were unclear abdominal pain in 50% and cholestasis with and without pain in 44%. Overall, 54/58 patients [inclusion rate, 93.1%; sex ratio, males/females = 25/29 (1:1.16); mean age, 65 (range, 22-88) years] were enrolled in the study. Prior to papillectomy, EUS was performed in 79.6% (n = 43/54). Group 1 (adenoma, n = 24/54; 44.4%):91.6% (n = 22/24) with R0 resection; tumor-free survival after a mean of 18.5 mo, 86.4% (n = 19/22); recurrence, 13.6% (n = 3/22); minor complications, 12.5% (n = 3/24). Group 2 (carcinoma/NET/lymphoma, n = 18/54; 33.3%):75.0% (n = 10/18) with R0 resection; tumor-free survival after a mean of 18.5 (range, 1-84) mo, 88.9% (n = 8/9); recurrence, 11.1% (n = 1/9). Group 3 (adenomyomatosis, n = 4/54; 7.4%). Group 4 (primarily no introducible catheter into the papilla, n = 8; 14.8%). The overall complication rate was 18.5% (n = 10/54; 1 subject with 2 complications):Bleeding, n = 3; pancreatitis, n = 7; perforation, n = 1 (intervention-related mortality, 0%). In summary, EUS is a sufficient diagnostic tool to preoperatively clarify diseases of the papilla including suspicious tumor stage in conjunction with postinterventional histopathological investigation of a specimen. Endoscopic papillectomy with curative intention is a feasible and safe approach to treat adenomas of the papilla. In high-risk patients with carcinoma of the papilla with no hints of deep infiltrating tumor growth, endoscopic papillectomy can be considered a reasonable treatment option with low risk and an approximately 80% probability of no recurrence if an R0 resection can be achieved. In patients with jaundice and in case the catheter can not be introduced into the papilla, papillectomy may help to get access to the bile duct. CONCLUSION:Endoscopic papillectomy is a challenging interventional approach but a suitable patientand local finding-adapted diagnostic and therapeutic tool with adequate risk-benefit ratio in experienced hands. | Uwe Will Anne-Kathrin Müller Frank Fueldner Igor Wanzar Frank Meyer | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 2 | Artificial neural networks in process esitmation and control显示文摘 | M J Wills G A Montague | 1992 | Automatica1992，28，6： | 2 |
| 3 | Determination of tate constants for the reactions of the CH2SH radical with O2,O3 and NO2 at 298 K 显示文摘 | RAHMAN M M BECKER E WILLE U | 1992 | Ber Bunsen-ges Phys Chem1992，96，： | 2 |
| 4 | Neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma: The need for patient-centered research显示文摘Pancreatic ductal adenocarcinoma is an aggressive cancer with high recurrence rates following surgical resection.While adjuvant chemotherapy improves survival,a significant proportion of patients are unable to initiate or complete all intended therapy following pancreatectomy due to postoperative complications or poor performance status.The administration of chemotherapy prior to surgical resection is an alternative strategy that ensures its early and near universal delivery as well as improves margin-negative resection rates and potentially improves long-term survival outcomes.Neoadjuvant therapy is increasingly being recommended to patients with pancreatic ductal adenocarcinoma,however,patient-centered research on its use is lacking.In this review,we highlight opportunities to focus research efforts in the domains of patient preferences,patient-reported outcomes,patient experience,and survivorship.Novel research in these areas may identify relevant barriers and facilitators to the use of neoadjuvant therapy thereby increasing its utilization,improve shareddecision making for patients and providers,and optimize the experience of those undergoing neoadjuvant therapy. | Jordan M Cloyd Allan Tsung John Hays Celia E Wills John FP Bridges | 2020 | World Journal of Gastroenterology2020，26，4： | 2 |
| 5 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 6 | Genotypic heterogeneity and phenotypie mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular taehycardia genetic testing显示文摘 | Tester DJ Arya P Will M | 2006 | Heart Rhythm2006，3，7： | 1 |
| 7 | New PDC bit design reduces vibrational problems显示文摘 | Graham M W Will L A | 1995 | Oil and Gas Journal1995，93，22： | 1 |
| 8 | Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA显示文摘 | Dandri M Burda MR Will H | 2000 | Hepatology2000，32，1： | 1 |
| 9 | Decision framework for chemotherapeutic interventions for metastatic non-small-cell lung cancer显示文摘 | Berthelot J M Will B P Evans W K | 2000 | J Natl Cancer Inst2000，92，16： | 1 |
| 10 | Prostate cancer cells with stem cellcharacteristics reconstitute the original human tumor in vivo显示文摘 | Gu G Yuan J Wills M | 2007 | Cancer Res2007，67，10： | 1 |
| 11 | A review on the morphology, molecular characterization, morphogenesis and pathogenesis of white spot syndrome virus显示文摘 | ESCOBEDO B C M ALDAY S V WILLE M | 2008 | Journal of Fish Diseases2008，31，1： | 1 |
| 12 | Virtual reality simulator for vitreoretinal surgery显示文摘 | Verma D Wills D Verma M | 2003 | Eye2003，17，1： | 1 |
| 13 | Increased matenal plasma leptin in early pregnancy and risk of gestational diabetes mellitus 显示文摘 | Qiu c Will iams M A Vadachkor ia S | 2004 | Obstet Gynecol2004，103，3： | 1 |
| 14 | Viral genome methylation differentially affects the ability of BZLF1versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication显示文摘 | WILLE C K NAWANDAR D M | 2013 | J Virol2013，87，： | 1 |
| 15 | Chemistry and clinical biology of the bryostatins 显示文摘 | Mutter R Wills M | 2000 | Bioorg Med Chem2000，8，： | 1 |
| 16 | Functional selectivity for glycerol of the nodulin 26 subfamily of plant membrane intrinsic proteins显示文摘 | Wallace I S Wills D M Guenther J F | 2002 | FEBS Lett2002，523，： | 1 |
| 17 | Drought is normal: the socio-technical evolution of drought and water demand in England and Wales, 1893-2006 显示文摘 | Vanessa T Heather C Will M | 2009 | Journal of Historical Geography2009，35，3： | 1 |
| 18 | Total-energy study of electronic structure and mechanical behavior of C15 Laves phase compounds:NbCr2 and HfV2显示文摘 | Ormeci A Chu F Wills J M | 1996 | Physical Review B1996，54，12： | 1 |
| 19 | Familial intracranial aneurysms:an analysis of 346 multiplex Finnish families显示文摘 | Wills S Ronkainen A van der Voet M | 2003 | Stroke2003，34，： | 1 |
| 20 | Retinol administration to superovulated ewes improves in vitro embryonic viability显示文摘 | Eberhardt D M Will W A Godkin J D | 1999 | Biology of Reproduction1999，60，： | 1 |
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