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| 1 | Co-effect of Demand-control-support Model and Effort-reward Imbalance Model on Depression Risk Estimation in Humans: Findings from Henan Province of China显示文摘Objective To investigate the co-effect of Demand-control-support(DCS) model and Effort-reward Imbalance(ERI) model on the risk estimation of depression in humans in comparison with the effects when they are used respectively. Methods A total of 3 632 males and 1 706 females from 13 factories and companies in Henan province were recruited in this cross-sectional study. Perceived job stress was evaluated with the Job Content Questionnaire and Effort-Reward Imbalance Questionnaire(Chinese version). Depressive symptoms were assessed by using the Center for Epidemiological Studies Depression Scale(CES-D). Results DC(demands/job control ratio) and ERI were shown to be independently associated with depressive symptoms. The outcome of low social support and overcommitment were similar. High DC and low social support(SS), high ERI and high overcommitment, and high DC and high ERI posed greater risks of depressive symptoms than each of them did alone.ERI model and SS model seem to be effective in estimating the risk of depressive symptoms if they are used respectively. Conclusion The DC had better performance when it was used in combination with low SS. The effect on physical demands was better than on psychological demands. The combination of DCS and ERI models could improve the risk estimate of depressive symptoms in humans. | YU Shan Fa NAKATA Akinori GU Gui Zhen SWANSON Naomi G ZHOU Wen Hui HE Li Hua WANG Sheng | 2013 | Biomedical and Environmental Sciences2013，26，12： | 8 |
| 2 | Screening Helicobacter pylori genes induced during infection of mouse stomachs显示文摘AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(H.pylori) as it relates to its survival in the host.METHODS:In vivo expression technology(IVET) systems are used to identify microbial virulence genes.We modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and pIVET12.Our novel IVET systems were developed by the fusion of random Sau3A DNA fragments of H.pylori and a tandem-reporter system of chloramphenicol acetyltransferase and beta-galactosidase.Additionally,each vector contains a kanamycin resistance gene.We used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that H.pylori expresses in vivo.Gene expression studies were conducted by infecting RAW 264.7 cells with H.pylori.This was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced genes.RESULTS:In this study,we have identified 31 in vivo induced(ivi) genes in the initial screens.These 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse stomachs.Virulence factors,vacA and cagA,were found in this screen and are known to play important roles in H.pylori infection,colonization and pathogenesis.Their detection validates the efficacy of these screening systems.Some of the identified ivi genes have already been implicated to play an important role in the pathogenesis of H.pylori and other bacterial pathogens such as Escherichia coli and Vibrio cholerae.Transcription profiles of allivi genes were confirmed by real time PCR analysis of H.pylori RNA isolated from H.pylori infected RAW 264.7 macrophages.We compared the expression profile of H.pylori and RAW 264.7 coculture with that of H.pylori only.Some genes such as cag A,vac A,lpx C,mur I,tlp C,trx B,sod B,tnp B,pgi,rbf A and inf B showed a 2-20 fold upregulation.Statistically significant upregulation was obtained for all the above mentioned genes(P < 0.05).tlp C,cag A,vac A,sod B,rbf A,inf B,tnp B,lpx C and mur I were also significantly upregulated(P < 0.01).These data suggest a strong correlation between results obtained in vitro in the macrophage cell line and in the intact animal.CONCLUSION:The positive identification of these genes demonstrates that our IVET systems are powerful tools for studying H.pylori gene expression in the host environment. | Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith Sharon H Jackson William G Coleman | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 3 | Molecular characterization of the murine Hif-1α locus显示文摘 | Luo G Gu Y Z Jain S | 1997 | Gene Exp1997，6，5： | 2 |
| 4 | Magnetically recoverable nanoparticles:highly efficient catalysts for asymmetric transfer hydrogenation of aromatic ketones in aqueous medium显示文摘 | LIU G GU H SUN Y | | 0，，08： | 2 |
| 5 | Magnetically recoverable SiO2-coated Fe3O4 nanoparticles:a new platform for asymmetric transfer hydrogenation of aromatic ketones in aqueous medium显示文摘 | SUN Y LIU G GU H | | 0，，09： | 2 |
| 6 | Introduction and constitutive expression of rice chitinase gene in bread wheat using biolistic bombardment and the bar gene as a selectable maker显示文摘 | Chen W P Gu X Liang G H Muthukrishnan S Chen P D Liu D J Giu B S | 1998 | Theor Appl Genet1998，97，12： | 2 |
| 7 | Secular change of annual and interannual variability in the tropics during the past century 显示文摘 | Gu D F Phlander S G H | 1995 | J Climate1995，8，4： | 2 |
| 8 | Microstructure and properties of Ti-Si-N nanocomposite films显示文摘 | Hu X P Li G Y Gu M Y | 2002 | J Vac Sci Tech A2002，20，6： | 2 |
| 9 | Parity anomaly of bound states and optical properties in semiconductor supcrlattices with structural defects 显示文摘 | WANG X H GU B Y YANG G Z | 1998 | Phys Rev B1998，58，8： | 1 |
| 10 | Mg-Ca-Zn bulk metallic glasses with high strength and significant ductility显示文摘 | GU X SHIFLET G J GUO F Q POON S J | 2005 | Journal of Materials Research2005，20，8： | 1 |
| 11 | Interaction of tetracycline with aluminum and iron hydrous oxides显示文摘 | Gu C Karthikeyan K G | 2005 | Environ Sci Technol2005，39，8： | 1 |
| 12 | Effects of positive end-expiratory pressure on systemic haemodynamics, with special interest to central venous and common iliac venous pressure in liver transplanted patients显示文摘 | Saner FH Pavlakovic G Gu Y et at | 2006 | Eur J Anaesthesiol2006，23，9： | 1 |
| 13 | A point interpolation method for two-dimension solids显示文摘 | Gu Y T | 2001 | International Journal for Numerical Methods in Engineering2001，50，： | 1 |
| 14 | Ethanol increases carotenoid production in Phaffia rhodozyma 显示文摘 | Gu W L An G H Johnson E A | 1997 | Journal of Industrial Microbiology & Biotechnology1997，19，： | 1 |
| 15 | Wave propagation in periodic stiffened shells: Spectral finite element modeling and experiments 显示文摘 | SOLAROLI G GU Z BAZ A RUZZENE M | 2003 | Journal of Vibration and Control2003，9，9： | 1 |
| 16 | A short note on quenching phenomena for semilinear parabolic equations 显示文摘 | Dai Q Y Gu Y G | 1997 | J Differential Equations1997，137，： | 1 |
| 17 | Environmental risk as- sessment: A critical approach of the European TGD in an in situ application 显示文摘 | Gu e rit 1 Boequen e G James A | 2008 | Ecotoxicology and Environmental Safety2008，71，9： | 1 |
| 18 | Migration based SAR imaging for ground penetrating radar system显示文摘 | Gu K Wang G Li J | 2004 | IEE Proc-Radar Sonar Navig2004，151，5： | 1 |
| 19 | Does PEEP impair the hepatic outflow in patients following liver transplantation?显示文摘 | Saner FH Pavlakovic G Gu Y | 2006 | Intensive Care Med2006，32，10： | 1 |
| 20 | Prostate cancer cells with stem cellcharacteristics reconstitute the original human tumor in vivo显示文摘 | Gu G Yuan J Wills M | 2007 | Cancer Res2007，67，10： | 1 |
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