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| 1 | Potential risk factors for constipation in the community显示文摘Constipation is a common community health problem.There are many factors that are widely thought to be associated with constipation but real-world evidence of these associations is difficult to locate.These potential risk factors may be categorised as demographic,lifestyle and health-related factors.This review presents the available evidence for each factor by an assessment of quantitative data from cross-sectional studies of community-dwelling adults published over the last 30 years.It appears that there is evidence of an association between constipation and female gender,residential location,physical activity and some health-related factors such as self-rated health,some surgery,certain medical conditions and certain medications.The available evidence for most other factors is either conflicting or insufficient.Therefore,further research is necessary to determine if each factor is truly associated with constipation and whether it can be regarded as a potential risk factor.It is recommended that studies investigating a broad range of factors are conducted in populations in community settings.Multivariate analyses should be performed to account for all possible confounding factors.In this way,valuable evidence can be accumulated for a better understanding of potential risk factors for constipation in the community. | Barry L Werth Sybele-Anne Christopher | 2021 | World Journal of Gastroenterology2021，27，21： | 6 |
| 2 | Resin infiltration of deproteinised natural occlusal subsurface lesions improves initial quality of fissure sealing显示文摘The aim of this ex vivo study was to evaluate the infiltration capability and rate of microleakage of a low-viscous resin infiltrant combined with a flowable composite resin(RI/CR) when used with deproteinised and etched occlusal subsurface lesions(International Caries Detection and Assessment System code 2). This combined treatment procedure was compared with the exclusive use of flowable composite resin(CR) for fissure sealing. Twenty premolars and 20 molars revealing non-cavitated occlusal carious lesions were randomly divided into two groups and were meticulously cleaned and deproteinised using Na OCl(2%). After etching with HCl(15%), 10 premolar and 10 molar lesions were infiltrated(Icon/DMG; rhodamine B isothiocyanate(RITC)-labelled) followed by fissure sealing(G-?nial Flo/GC; experimental group, RI/CR). In the control group(CR), the carious fissures were only sealed. Specimens were cut perpendicular to the occlusal surface and through the area of the highest demineralisation(DIAGNOdent pen, Ka Vo). Using confocal laser-scanning microscopy, the specimens were assessed with regard to the percentage of caries infiltration, marginal adaption and internal integrity. Within the CR group, the carious lesions were not infiltrated. Both premolar(57.9% ± 23.1%) and molar lesions(35.3% ± 22.1%) of the RI/CR group were uniformly infiltrated to a substantial extent, albeit with significant differences(P = 0.034). Moreover, microleakage(n = 1) and the occurrence of voids(n = 2) were reduced in the RI/CR group compared with the CR group(5 and 17 specimens,respectively). The RI/CR approach increases the initial quality of fissure sealing and is recommended for the clinical control of occlusal caries. | Andrej M Kielbassa Ina Ulrich Rita Schmidl Christoph Schuller Wilhelm Frank Vanessa D Werth | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 3 | Uric acid and losartan显示文摘 | SICA D A SCHOOL WERTH A C | 2002 | Curr Opin Nephrol Hypertens2002，11，5： | 1 |
| 4 | Chemorheology of aqueous-based alumina-poly(rinyl alcohol) gelcasting suspensions显示文摘 | MORISSETTE SHENY L CARISEY T WERTH A L | 1999 | J Am Ceram Soc1999，82，3： | 1 |
| 5 | Efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ORTHO‐TEP registry显示文摘 | J. BEYER‐WESTENDORF J. LüTZNER L. DONATH O. C. RADKE E. KUHLISCH A. HARTMANN N. WEISS S. WERTH | 2012 | Journal of Thrombosis and Haemostasis2012，，10： | 1 |
| 6 | Cutaneous lupus erythematosus:a review显示文摘 | PATEL P WERTH V | 2002 | Dermatol Clin2002，20，3： | 1 |
| 7 | Evaluation of GRACE Filter Tools from a Hydrological Per- speetive 显示文摘 | Werth S Gintner A Schmidt R | 2009 | Geophysical Journal International2009，179，3： | 1 |
| 8 | Decline in long- term circadian rest-activity cycle organization in a patient with dementia显示文摘 | Werth E Savaskan E Knoblauch V | 2002 | J Geriatr Psychiatry Neurol2002，15，1： | 1 |
| 9 | Prevention and treat-ment of systemic glucocorticoid side effects显示文摘 | Moghadam-Kia S Werth VP | 2010 | Int 1 Derrnatol2010，49，3： | 1 |
| 10 | hDectin-1 is involved in uptake and cross-presentation of cellular antigens显示文摘 | Weck M M Appel S Werth D | 2008 | Blood2008，111，8： | 1 |
| 11 | Simultaneous production of hydrogen and synthesis gas by combining water splitting with partial oxidation of methane in a hollow-fiber membrane reactor显示文摘 | Jiang H Q Wang H H Werth S | 2008 | Angew Chem Int Ed2008，47，： | 1 |
| 12 | Proliferation of human primary vascular smooth muscle cells depends on serum response factor显示文摘 | Daniela Werth Gabriele Grassi Nina Konjer Barbara Dapas Rossella Farra Carlo Giansante Reinhard Kandolf Gianfranco Guarnieri Alfred Nordheim Olaf Heidenreich | 2010 | European Journal of Cell Biology2010，，2： | 1 |
| 13 | Root-derived carbon in soil respiration and microbial biomass determined by 14 C and 13 C显示文摘 | M. Werth Y. Kuzyakov | 2007 | Soil Biology and Biochemistry2007，，3： | 1 |
| 14 | Natural (^210Pb, ^7Be) and fallout (^137Cs,^239,240pu,^9OSr) radionuclides as geochemical tracers of sedimentation in Greifensee, Switzerland 显示文摘 | Wan G J Santsehi P H Sturm M Farrenkothen K Lueck A Werth W Schuler Ch | 1987 | Chem Geol1987，63，34： | 1 |
| 15 | Effects of tropical deforestation on globalhydroclimate: a multimodel ensemble analysis 显示文摘 | Hasler N Werth D Avissar R | 2009 | J Climate2009，22，： | 1 |
| 16 | Evaluation of GRACE filter tools from a hydrological perspective显示文摘 | WERTH S GUNTNER A SCHMIDT R et | 2009 | Geophysical journal international2009，179，3： | 1 |
| 17 | Stoukfurveranderungan chromosomen durch malachitgrun显示文摘 | KEYL H G WERTH G | 1959 | Naturwissenschaften1959，46，： | 1 |
| 18 | Photosensitiviy inrheumatic diseases显示文摘 | WERTH VP BASHIR M ZHANG W | 2004 | J Invest Dermatol Symp Proceedings2004，9，： | 1 |
| 19 | RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo显示文摘 | Urban-Klein B Werth S Abuharbeid S | | 0，，： | 1 |
| 20 | 用抗雌激素药物改善皮肌炎皮疹显示文摘Background: Dermatomyositis (DM) is an autoimmune disorder that occurs more often inwomen than men and causes highly symptomatic and inflammatory cutaneous and proximal muscle disease. Corticosteroids have been the treatment of choice for myositis in DM, and antimalarial agents for the skin disease of DM, with methotrexate sodium, azathioprine, mycophenolate mofetil, cyclosporine, and intravenous immunoglobulin used as steroid-sparing agents. Recently, reports supporting a role for anti-tumor necrosis factorα (TNF-α ) therapy in the treatment of DM have emerged. Observations: We describe 2 women who experienced an improvement in their DM-associated skin eruptions while taking antiestrogen medication. The first patient was taking tamoxifen, a selective estrogen receptor modulator that has been found to have anti-TNF-α properties. The second was taking anastrozole, an aromatase inhibitor. When tamoxifen therapy was discontinued after 4 years of use in the first patient, her DM rash worsened and remained difficult to control with conventional immunosuppressant medication. Conclusions: With the limited number of therapies available to manage DM skin eruptions, the discovery of novel agents effective in treating this disease is vital. Using antiestrogen medication in women with DM may result in a significant improvement in their rash, possibly via the inhibition of TNF-α production by immune or other cells. Further investigation into the use of antiestrogen therapy in DM is merited to evaluate longterm risks and benefits. | Sereda D. Werth V.P. 刘艳 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，3： | 1 |
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