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| 1 | Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta‐analysis显示文摘 | PingWang DonghongKang WeiCao YanWang ZhiwenLiu | 2012 | Diabetes Metab Res Rev2012，，2： | 2 |
| 2 | Anticancer Drug Resistance of HeLa Cells Transfected With Rat Glutathione S-transferase pi Gene显示文摘To establish a cytologic expressing system of rat glutathione S-transferase pi (GST-pi) cDNA for detecting the resistance of HeLa cells to anticancer drugs. Methods The assessment was made with various anticancer drugs (adriamycin, mitomycin, cisplatinum and vincristine) that showed different cytotoxicities in transfectant HeLa cells with pSV-GT containing rat GST-pi cDNA (HeLa/pSV-GT) or control pSV-neo (HeLa/pSV-neo). Expression levels of GST-pi mRNA in HeLa/pSV-GT and HeLa/pSV-neo were measured by in situ hybridization using Digoxin-labelled cDNA probe. Results HeLa/pSV-GT expressed significantly high degree of GST-pi mRNA, whereas both HeLa/pSV-neo and HeLa cells had very low expression. Cytotoxicities of HeLa/pSV-GT and HeLa/pSV-neo with 4 anticancer drugs were measured by MTT assay. Drug concentrations for yielding 50% inhibition (IC50) in HeLa/pSV-GT by adriamycin, mitomycin and cisplatinum were 70.13 靏/mL, 10.95 靏/mL and 16.52 靏/mL, respectively. In contrast, IC50 in HeLa/pSV-neo was 10.34 靏/mL, 7.48 靏/mL and 13.70 靏/mL, respectively. The cytotoxicities of vincristine on both HeLa/pSV-GT and HeLa/pSV-neo were not significantly different. Conclusions Our findings suggest that HeLa/pSV-GT containing rat GST-pi cDNA is resistant to some anticancer drugs due to overexpression of GST-pi. Also, HeLa/pSV-GT cell line could serve as a useful cytogenetic model for further research. | WEICAO YANMENG QIANGWEI ZHAO-HUISHI LI-MEIJU FU-DEFANG | 2003 | Biomedical and Environmental Sciences2003，16，2： | 2 |
| 3 | The study of the MEMS gyro zero drift signal based on the adaptive Kalman filter显示文摘 | Chen Weicao Gao Guowei Wang Juan | 2012 | Key Engineering Materials2012，500，： | 1 |
| 4 | Correlation of transforming growth factor beta‐1 gene polymorphisms C‐509T and T869C and the risk of gastric cancer in China显示文摘 | TaoLi Bang‐WeiCao YueDai HongCui Hong‐LiYang Chang‐QingXu | 2008 | Journal of Gastroenterology and Hepatology2008，，： | 1 |
| 5 | Isolation, structural features and antitumor activities of sixpolysaccharides from Angelica sinensis (Oliv.) diels in vitro显示文摘AIM The previous work has demonstrated that the polysaccharides of Angelica sinensis (Oliv.) Diels have significantly antitumor activity and indicated that the activity is strongly dependent on their structures. However, the relationships between the structure and the activities are still ambiguous. Thus, at present, more efforts are being expended in seeking to isolate the polysaccharides from Angelica sinensis(Oliv.) Diels, measure their structural features and antitumor activities, and elucidate structure - activity relationships of polysaccharides. METHODS The roots of Angelica sinensis ( Oliv. ) Diels were extracted With water, separated by Sephacryl S-400 and DEAE-sephadex A-25 columns and further purifled on Sephadex G-100 column. | WeiCAO Xiao-qiangLI Tie-hongYANG Hui-tingFAN Qi-bingMEI | 2005 | 中国药理通讯2005，22，2： | 0 |
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