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| 1 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 2 | A papaya-specific gene, papain, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic papayas显示文摘 | XU Wentao BAI Weibin GUO Feng | 2008 | European Food Research and Technology2008，228，2： | 1 |
| 3 | A novel method for elimination of inconsistencies in ordinal classification with monotonicity constraints显示文摘 | Deng Weibin Wang Guoyin Hu Feng | 2013 | Fundamenta Informaticae2013，126，4： | 1 |
| 4 | New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16显示文摘Interferon gamma-inducible protein 16(IFI16)senses DNA in the cytoplasm and the nucleus by using two tandem hematopoietic interferon-inducible nuclear(HIN)domains,HINa and HINb,through the cooperative assembly of IFI16 filaments on double-stranded DNA(dsDNA).The role of HINa in sensing DNA is not clearly understood.Here,we describe the crystal structure of the HINa domain in complex with DNA at 2.55A°resolution and provide the first insight into the mode of DNA binding by the HINa domain.The structure reveals the presence of two oligosaccharide/nucleotide-binding(OB)folds with a unique DNA-binding surface.HINa uses loop L45 of the canonical OB2 fold to bind to the DNA backbone.The dsDNA is recognized as two single strands of DNA.Interestingly,deletion of HINb compromises the ability of IFI16 to induce IFN-b,while HINa mutants impaired in DNAbinding enhance the production of IFN-b.These results shed light on the roles of IFI16 HIN domains in DNA recognition and innate immune responses. | Xiangmin Ni Heng Ru Feng Ma Lixia Zhao Neil Shaw Yingang Feng Wei Ding Weibin Gong Qiaofeng Wang Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2016 | Journal of Molecular Cell Biology2016，8，1： | 1 |
| 5 | Metalens-based stereoscopic microscope显示文摘Stereoscopic microscopy is a promising technology to obtain three-dimensional microscopic images.Such microscopes are based on the parallax effect,and as such require two lenses to focus at two different points.Geometrical constraints,however,restrict their numerical apertures to about 0.2,thus limiting the system’s resolution.Higher numerical apertures(.35)can be achieved with designs using only one bulk lens,but such systems are0 times more costly than the conventional ones.Thus,there is a pressing need for alternative solutions to improve the resolution of stereoscopic systems.Here,we show that high-resolution and low-cost stereoscopic systems can be obtained using birefringent single-layer metalenses.We design and fabricate a birefringent metalens operating at 532 nm with a numerical aperture as high as 0.4.The metalens is then used to demonstrate high-resolution stereoscopic imaging of biological samples.The microscopic images are further displayed and perceived vividly in an autostereoscopic display.Our demonstration paves the way to a new strategy to achieve high-resolution and low-cost stereoscopic microscopes. | YONG LONG JIANCHAO ZHANG ZHIHAO LIU WEIBIN FENG SONGMING GUO QIAN SUN QINFEI WU XIANGYANG YU JIANYING ZHOU EMILIANO RMARTINS HAOWEN LIANG JUNTAO LI | 2022 | Photonics Research2022，10，6： | 1 |
| 6 | Small extracellular vesicles with nanomorphology memory promote osteogenesis显示文摘Nanotopographical cues endow biomaterials the ability to guide cell adhesion, proliferation, and differentiation. Cellular mechanical memory can maintain the cell status by retaining cellular information obtained from past mechanical microenvironments. Here, we propose a new concept “morphology memory of small extracellular vesicles (sEV)” for bone regeneration. We performed nanotopography on titanium plates through alkali and heat (Ti8) treatment to promote human mesenchymal stem cell (hMSC) differentiation. Next, we extracted the sEVs from the hMSC, which were cultured on the nanotopographical Ti plates for 21 days (Ti8-21-sEV). We demonstrated that Ti8-21-sEV had superior pro-osteogenesis ability in vitro and in vivo. RNA sequencing further confirmed that Ti8-21-sEV promote bone regeneration through osteogenic-related pathways, including the PI3K-AKT signaling pathway, MAPK signaling pathway, focal adhesion, and extracellular matrix-receptor interaction. Finally, we decorated the Ti8-21-sEV on a 3D printed porous polyetheretherketone scaffold. The femoral condyle defect model of rabbits was used to demonstrate that Ti8-21-sEV had the best bone ingrowth. In summary, our study demonstrated that the Ti8-21-sEV have memory function by copying the pro-osteogenesis information from the nanotopography. We expect that our study will encourage the discovery of other sEV with morphology memory for tissue regeneration. | Liang Ma Wencan Ke Zhiwei Liao Xiaobo Feng Jie Lei Kun Wang Bingjin Wang Gaocai Li Rongjin Luo Yunsong Shi Weifeng Zhang Yu Song Weibin Sheng Cao Yang | 2022 | Bioactive Materials2022，7，11： | 1 |
| 7 | Selective kernel networks for weakly supervised relation extraction显示文摘The purpose of relation extraction is to identify the semantic relations between entities in sentences that contain two entities.Recently,many variants of the convolution neural network(CNN)have been introduced to relation extraction for the extracting of features--the quality of the neural network model directly affects the final quality of relation extraction.However,the traditional convolution network uses a fixed convolution kernel,so it is difficult to choose the size of the convolution kernel dynamically,which results in networks with weak representation ability.To address this,a novel CNN is designed with selective kernel networks and multigranularity.In the process of feature extraction,the model can adaptively select the size of the convolution kernel,that is,give more weight to the appropriate convolution kernel.It is then combined with multigranularity convolution to obtain more abundant semantic information.Finally,a new pooling method is designed to obtain more comprehensive information and improve model performance.Experimental results indicate that this method is effective without excessively deep network layers,and it also outperforms several competitive baseline methods. | Ziyang Li Feng Hu Chilong Wang Weibin Deng Qinghua Zhang | 2021 | CAAI Transactions on Intelligence Technology2021，6，2： | 1 |
| 8 | Over-Smoothing Algorithm and Its Application to GCN Semi-supervised Classification显示文摘The feature information of the local graph structure and the nodes may be over-smoothing due to the large number of encodings,which causes the node characterization to converge to one or several values.In other words,nodes from different clusters become difficult to distinguish,as two different classes of nodes with closer topological distance are more likely to belong to the same class and vice versa.To alleviate this problem,an over-smoothing algorithm is proposed,and a method of reweighted mechanism is applied to make the tradeoff of the information representation of nodes and neighborhoods more reasonable.By improving several propagation models,including Chebyshev polynomial kernel model and Laplace linear 1st Chebyshev kernel model,a new model named RWGCN based on different propagation kernels was proposed logically.The experiments show that satisfactory results are achieved on the semi-supervised classification task of graph type data. | Mingzhi Dai Weibin Guo Xiang Feng | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 9 | Enhancing maize's nitrogen-fixing potential through ZmSBT3, a gene suppressing mucilage secretion∞显示文摘Maize(Zea mays)requires substantial amounts of nitrogen,posing a challenge for its cultivation.Recent work discovered that some ancient Mexican maize landraces harbored diazotrophic bacteria in mucilage secreted by their aerial roots.To see if this trait is retained in modern maize,we conducted a field study of aerial root mucilage(ARM)in 258 inbred lines.We observed that ARM secretion is common in modern maize,but the amount significantly varies,and only a few lines have retained the nitrogen‐fixing traits found in ancient landraces.The mucilage of the high‐ARM inbred line HN5‐724 had high nitrogen‐fixing enzyme activity and abundant diazotrophic bacteria.Our genome‐wide association study identified 17 candidate genes associated with ARM across three environments.Knockouts of one candidate gene,the subtilase family gene ZmSBT3,confirmed that it negatively regulates ARM secretion.Notably,the ZmSBT3 knockout lines had increased biomass and total nitrogen accumulation under nitrogen‐free culture conditions.High ARM was associated with three ZmSBT3 haplotypes that were gradually lost during maize domestication,being retained in only a few modern inbred lines such as HN5‐724.In summary,our results identify ZmSBT3 as a potential tool for enhancing ARM,and thus nitrogen fixation,in maize. | Jingyang Gao Peijiang Feng Jingli Zhang Chaopei Dong Zhao Wang Mingxiang Chen Zhongliang Yu Bowen Zhao Xin Hou Huijuan Wang Zhaokun Wu Razia Sultana Jemim Haidong Yu Doudou Sun Pei Jing Jiafa Chen Weibin Song Xuecai Zhang Zijian Zhou Jianyu Wu | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 10 | Acute adrenal insufficiency caused by antiphospholipid syndrome显示文摘Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are frequently discussed together and considered two closely related diseases.APS involves multiple organ systems,but APS-related endocrine manifestations are rare.^([1])Among them,adrenal insufficiency (AI) is the first endocrine manifestation of APS.The prompt diagnosis of AI is critical,as this disorder has high morbidity and mortality if left untreated.Here,we report a rare case of acute AI caused by APS secondary to SLE.CASEIn August 2022,a 39-year-old woman without a significant family history of medical diseases presented to our emergency department (ED) for low back pain,nausea,anorexia,fatigue,hypoglycemia,and hypotension.One month prior,she had fatigue,loss of appetite,low back pain,cough with sputum. | Yunfei Feng Weibin Zhou Daiqiong Fang | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 11 | Health promoting activities and corresponding mechanism of(–)-epicatechin-3-gallate显示文摘(–)-Epicatechin-3-gallate(ECG),a bioactive polyphenolic compound,has contributed a lot to the health benefits of green tea.Great attention has been focused on(–)-epigallocatechin-3-gallate(EGCG),but limited research has been performed towards ECG.Like EGCG,ECG also possesses various pharmacological and physiological properties,such as mediation of antioxidant activities,anti-inflammation response,regulation of cell proliferation and apoptosis,as well as anticancer properties during angiogenesis,invasion and metastasis stages.Nontoxic ECG has various molecular targets within the cells,including CYP enzymes,phaseⅡdetoxification and antioxidant enzymes,as well as pro-inflammatory mediators.The antineoplastic mechanism contains inhibition of phase 1 CYP enzymes,induction of phaseⅡdetoxification and antioxidant enzymes,high anti-inflammatory efficacy,arrest of cell cycle progression,regulation of apoptosis,as well as mediation of metastasis processes.In particular,the gallate moiety of ECG is critical for mediating inhibitory effects towards cancer cells.Besides regulation of intracellular signaling pathways,ECG also inhibits RNase A and matrix metalloproteinase enzymatic activity via chelating metals(copper and zinc)in cancer cells.This review has summarized recent studies on pharmacological properties of ECG,and discussed corresponding mechanism on modulation of cellular signaling events by ECG,hoping to broaden its multiple usage. | Zhiliang Li Changchun Feng Hongjin Dong Weibin Jin Wenying Zhang Jianfeng Zhan Shuzhen Wang | 2022 | Food Science and Human Wellness2022，11，3： | 0 |
| 12 | Biological Effects of Fractional Carbon-ion Beam Irradiation on Arabidopsis Thaliana显示文摘The prior low priming dose irradiation induced an adaptive response which can weaken the biological effectiveness of a subsequent high dose.It has been widely studied in mammalian cells and plants,and most of these works were focused on X rays and y rays,less work was conducted on the plants by using heavy ion beam rradiation. | Du Yan Chen Xia Feng Zhuo Ren Weibin Yu Lixia Jin Wenjie Zhou Libin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 13 | Preliminary Study of Building a Mathematical Model on Biological Effects of Radiation in Soybean显示文摘For several decades,lots of researchers,especially in the radiation biology,explored the mathematical models[1]which can describe the biological effects[2]well enough.However,many available mathematical models cannot describe the biological effects which researchers want to know accurately. | Feng Zhuo Chen Xia Ren Weibin Du Yan Yu Lixia Wang Zhuanzi Zhou Libin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 14 | Preliminary Study of Mutation Breeding Combining Heavy Ion Beam Irradiation and Plant Tissue Culture in Taraxacum kok-saghyz显示文摘Rubber dandelion(Taraxacum Kok-saghyz,TKS)is a valuable alternative source of natural rubber,thus it is very important and urgent to breed new varieties to increase the biomass or natural rubber content in its roots. | Chen Xia Du Yan Feng Zhuo Ren Weibin Yu Lixia Qu Ying Zhou Libin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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