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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photo emission computerized tomography 显示文摘 | Volk SA Kaendler SH Weber R | 1992 | Acta Psychiatr Scand1992，86，3： | 1 |
| 4 | Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium显示文摘 | Hudde T Rayner SA Comer RM Weber M Isaacs JD Waldmann H | 1999 | Gene Ther1999，6，5： | 1 |
| 5 | Compilation and assessment of recent positive matrix factorization and UNMIX receptor model studies on fine particulate matter source apportionment for the eastern United States 显示文摘 | ENGEL-COX JA WEBER SA | 2007 | J Air Waste Manag Assoc2007，57，11： | 1 |
| 6 | Swallowed foreign bodies in adults 显示文摘 | Ambe P Weber SA Schauer M | 2012 | Dtsch Arztebl Int2012，109，50： | 1 |
| 7 | Activated polyamidoamine dendriners a nonviral vector for gene transfer to the corneal endotheltum显示文摘 | Hudde T Rayner SA Comer RM Weber M Isaacs JD Waldmann H | 1999 | Gene Ther1999，6，： | 1 |
| 8 | B- and T-celldevelopment both involve activity of the unfolded proteinresponse pathway 显示文摘 | Brunsing R Omori SA Weber F | 2008 | J Biol Chem2008，283，17： | 1 |
| 9 | Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1 显示文摘 | Suls A SMullen SA Weber YG | 2009 | Ann Neurol2009，66，3： | 1 |
| 10 | Compilation and assessment of recent positive matrix factorization and UNMIX receptor model studies on fine particulate matter source apportionment for the eastern United States 显示文摘 | Engel-Cox JA Weber SA | 2007 | J Air Waste Manag Assoe2007，57，： | 1 |
| 11 | Colorimetric estimation of indoleacetic acid显示文摘 | Gordon SA Weber RP | 1951 | Plant Physiology1951，26，1： | 1 |
| 12 | Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 m RNA in the hippocampus显示文摘 | Frank MG Hershman SA Weber MD | 2014 | Psychoneuroendocrinology2014，40，： | 1 |
| 13 | Oro-genital lichen planus:report of two cases显示文摘 | Minicucci EM Weber SA Stolf HO | 2008 | Maturitas2008，59，2： | 1 |
| 14 | ERCC2:cDNA clo-ning and molecular characterization of a human nucleotide exci-sion repair gene with high homology to yeast RAD3显示文摘 | Weber CA Salazar EP Stewart SA | 2006 | EMBO2006，9，： | 1 |
| 15 | Compilation and assessment of recent positive matrix factorization and UNMIX receptor model studies on fine particulate matter source apportionment for the eastern United States显示文摘 | Engel-Cox jA Weber SA | 2007 | J Air Waste Manag Assoe2007，57，： | 1 |
| 16 | B- and T-cell development both involve acdvity of the unfolded protein response pathway 显示文摘 | Brunsing R Omofi SA Weber F | 2008 | J Binl Chem2008，283，17： | 1 |
| 17 | Modulation of murine tumor major histocompatibility antigens by cytokines in vivo and in vitro显示文摘 | Weber JS Rosenberg SA | 1988 | Cancer Res1988，48，20： | 1 |
| 18 | IPS Empress 2 porcelain erons and bridges显示文摘 | Edelh D Weber V Jovanovic SA | 2002 | J Multidiscipl Collab Prosthodont2002，2，1： | 1 |
| 19 | Early-Onset AbsenceEpilepsy Caused by Mutations in the Glucose TransporterGLUT1 显示文摘 | Suls A Mullen SA Weber YG | 2009 | Ann Neurol2009，66，： | 1 |
| 20 | 查看详情显示文摘 | BALBAN IA P WEBER SA MONTOVAN I J C | | 0，，： | 1 |
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