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| 1 | Strategies for gastric cancer in the modern era显示文摘Gastric cancer is one of the most common neoplasms in Japan, and it is also the second leading cause of cancer-related deaths worldwide. Nowadays, infection with Helicobacter pylori (H. pylori) is a known risk factor for the development of gastric cancer. Therefore, gastric cancer should be considered as an infectious disease, and in fact, prophylactic eradication of H. pylori may prevent the development of metachronous gastric carcinoma. Before the role of H. pylori was understood, a different approach was used. Recently even after the cancer has developed, some newer therapeutic approaches have been pursued. These newer treatments have been summarized as 'minimally invasive therapies' and use endoscopic or laparoscopic techniques. In addition, robotic approaches are being developed that seem to hold a great potential to change the surgical approach. Since basic understanding and treatment of the disease have both changed signif icantly over the last decade, we present a review of current advances in gastric cancer research and therapy. | Satoru Takayama Takehiro Wakasugi Hitoshi Funahashi Hiromitsu Takeyama | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 5 |
| 2 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 3 | New approaches in laparoscopic surgery for colorectal diseases: The totally laparoscopic and single-incision approaches显示文摘More than 20 years have passed since the first report of laparoscopic colectomy in 1991. Thereafter, laparoscopic surgery for the management of colorectal diseases has been widely accepted as a prevailing option because of improved cosmetic outcomes, less postoperative pain, and shorter hospital stay in comparison with open surgery. To further the principle of minimally invasive surgery, two new approaches have been developed in this rapidly evolving field. The first is the totally laparoscopic approach. Currently most of standard techniques inevitably involve an abdominalincision for retrieval of the specimen and preparation for anastomosis, which might compromise the benefits of laparoscopic surgery. The totally laparoscopic approach dispenses with this incision by combining completely intraperitoneal anastomosis with retrieval of the specimen via a natural orifice, such as the anus or the vagina. Our new and reliable technique for intraperitoneal anastomosis is also described in detail in this article. The second is the single-incision approach. While three to six ports are needed in standard laparoscopic surgery, the single-incision approach uses the umbilicus as the sole access to the abdominal cavity. All of the laparoscopic procedures are performed entirely through the umbilicus, in which the surgical scar eventually becomes hidden, achieving virtually scarless surgery. This article reviews the current status of these two approaches and discusses the future of minimally invasive surgery for colorectal diseases. | Hiroki Akamatsu Masahiro Tanemura Kentaro Kishi Mitsuyoshi Tei Toru Masuzawa Masaki Wakasugi | 2015 | World Journal of Surgical Procedures2015，5，1： | 2 |
| 4 | Vasculogenic mimicry and pseudo-comedo formation in breast cancer显示文摘 | Shirakawa K Wakasugi H Heike Y | 2002 | International Journal of Cancer2002，，06： | 2 |
| 5 | Hyperdry human amniotic membrane application as a wound dressing for a full-thickness skin excision after a third-degree burn injury显示文摘Background:Severe burn injuries create large skin defects that render the host susceptible to bacterial infections.Burn wound infection often causes systemic sepsis and severe septicemia,resulting in an increase in the mortality of patients with severe burn injuries.Therefore,appropriate wound care is important to prevent infection and improve patient outcomes.However,it is difficult to heal a third-degree burn injury.The aim of this studywas to investigate whether hyperdry human amniotic membrane(HD-AM)could promote early granulation tissue formation after full-thickness skin excision in third-degree burn injury sites in mice.Methods:After the development of HD-AM and creation of a third-degree burn injury model,the HD-AM was either placed or not placed on the wound area in the HD-AM group or HD-AM group,respectively.The groups were prepared for evaluation on postoperative days 1,4 and 7.Azan staining was used for granulation tissue evaluation,and estimation of CD163,transforming growth factor beta-1(TGF-β1),vascular endothelial growth factor(VEGF),CD31,alpha-smooth muscle actin(α-SMA)and Iba1 expression was performed by immunohistochemical staining.Quantitative reverse-transcription polymerase chain reaction(PCR)was used to investigate gene expression of growth factors,cell migration chemokines and angiogenic and inflammatory markers.Results:The HD-AM group showed significant early and qualitatively good growth of granulation tissue on the full-thickness skin excision site.HD-AM promoted early-phase inflammatory cell infiltration,fibroblast migration and angiogenesis in the granulation tissue.Additionally,the early infiltration of cells of the immune system was observed.Conclusions:HD-AM may be useful as a new wound dressing material for full-thickness skin excision sites after third-degree burn injuries,and may be a new therapeutic technique for improving the survival rate of patients with severe burn injuries. | Jiro Oba Motonori Okabe Toshiko Yoshida Chika Soko Moustafa Fathy Koji Amano Daisuke Kobashi Masahiro Wakasugi Hiroshi Okudera | 2020 | Burns & Trauma2020，8，1： | 2 |
| 6 | Selective basket insertion into the left intrahepatic duct显示文摘 | Hirata N Kushida Y Wakasugi S | 1999 | Gastrointest Endosc1999，49，2： | 1 |
| 7 | Potential of ^99Tc^m-MIBI for detecting bone marrow metastases显示文摘 | Wakasugi S Noguti A Katoda T | 2002 | J Nucl Med2002，43，5： | 1 |
| 8 | Vasculogenic mimicry and pseudo-comedo formation in breast cancer显示文摘 | Shirakawa K Wakasugi H Heike Y | 2002 | Int J Cancer2002，99，6： | 1 |
| 9 | DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair显示文摘 | WAKASUGI M KAWASHIMA A MORIOKA H | | 0，，277： | 1 |
| 10 | Totally extrapefitoneal inguinal hernia repair in patients on antithrombotictherapy : a retrospective analysis 显示文摘 | Wakasugi M Akamatsu H Yoshidome K | 2013 | Surg Today2013，43，8： | 1 |
| 11 | The effect of general an- esthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vitro显示文摘 | Wakasugi M Hirota K Roth H | 1999 | Anesth Analg1999，88，3： | 1 |
| 12 | Frequency of classⅢandⅣnephritis in systemic lupus erythematosus without clinical renal involvement:An analysis of predictive measures显示文摘 | Wakasugi D Gono T Kawaguchi Y | 2012 | J Rheumatology2012，39，1： | 1 |
| 13 | Glass formation,physico-chemical properties,and structure of glasses based on Ga2S3-GeS2-Sb2S3 system显示文摘 | Ichikawa M Wakasugi T Kadono K | 2010 | J Non Cryst Solids2010，356，43： | 1 |
| 14 | Perioperative management of continuous ambulatory peritoneal dialysis patients undergoing inguinal hernia surgery 显示文摘 | Wakasugi M Hirata T Okamura Y | 2011 | Surg Today2011，41，2： | 1 |
| 15 | p21 (wafl/cipl) and p53 protein expression in breast cancer 显示文摘 | Wakasugi E Kobayashi T Tamaki Y | 1997 | Am J Clin Pathol1997，107，6： | 1 |
| 16 | Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor显示文摘 | Wakasugi K Nakano T Morishima I | 2003 | J Biol Chem2003，278，36： | 1 |
| 17 | Single-port laparoscopic colectomy is safe and feasible in patients with previous abdominal surgery显示文摘 | Tei M Wakasugi M Omori T | 2015 | Am J Surg2015，209，6： | 1 |
| 18 | Mitoehondrial DNA- like sequences in the human nuclear genome 显示文摘 | Fukuda M Wakasugi S Tsuzuki T | 1985 | J Mol Biol1985，186，： | 1 |
| 19 | P21(wafl/cipl)and P53 protein expression in breast cancer显示文摘 | WAKASUGI E KOBAYASHI T TAMAKI Y | 1997 | Am J Clin Pathol1997，107，6： | 1 |
| 20 | The Effects of Stronger Intellectual Property Rights on Technology Transfer:Evidence from Japanese Firm-level Data 显示文摘 | Wakasugi Ryuhei Banri Ito | 2009 | Journal of Technology Transfer2009，，34： | 1 |
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