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| 1 | 铝合金的大功率扩散型CO_2激光粉末焊接技术显示文摘本试验研究采用 2 6 0 0W扩散型 (Slab)CO2 激光加工系统 ,利用喷射填充粉末激光焊接技术成功地进行了铝合金焊接 ;确定了试验材料激光焊接的能量阈值 ;通过工艺参数的优选获得了无明显焊接缺陷、正反两表面平滑连续的焊缝 ;焊接接头的力学性能检测表明 ,AA6 0 16铝合金 (厚度为 1 15mm)焊接接头抗拉强度不低于母材的可允许间隙可达 0 5mm(母材厚度的 44 % ) ;根据试验结果 ,推荐对于一定板厚的铝合金 ,应该经过试验确定不同激光功率时实现深熔焊的最小线能量 ,并且尽量选取较高的激光功率及较高的焊接速度 ,以确保取得最佳的焊接质量。 | 陈铠 王智勇 肖荣诗 施定远 左铁钏 Roth G Opowe H | 2000 | 激光杂志2000，21，5： | 14 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection显示文摘男、女的繁殖的道是有多样的功能的要求的复杂微型环境。当同时对潜在的病原体授与保护时,在繁殖的道的免疫系统举办为胎儿的 allograft 提供保护的环境的费力的任务。因此,它发展了改编的一个唯一的集合,首先在性荷尔蒙的影响下面,它从另外的 mucosal 地点使它不同。这里,我们讨论在男性和女繁殖的道是在场的免疫系统的各种各样的部件,包括在 homeostatic 条件下面的天生的可溶的因素和房间和体液、调停房间的适应免疫。我们考察在从全身的豁免展出区分并且讨论这些特征怎么被性荷尔蒙影响的男、女的繁殖的道显示出唯一的 phenotypic 和有免疫力的房间和回答的功能的特征的证据。我们也在跟随 HIV-1 感染的繁殖的道,性荷尔蒙和有免疫力的回答之中检验相互作用。男、女的繁殖的道的唯一的特征的改进理解将提供卓见进为性播送的感染的预防改进不孕的免疫学的原因和预防干预的设计的临床的处理。 | Philip V Nguyen Jessica K Kafka Victor H Ferreira Kristy Roth Charu Kaushic | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 4 | Genomic prediction of fruit texture and training population optimization towards the application of genomic selection in apple显示文摘Texture is a complex trait and a major component of fruit quality in apple.While the major effect of MdPG1,a gene controlling firmness,has already been exploited in elite cultivars,the genetic basis of crispness remains poorly understood.To further improve fruit texture,harnessing loci with minor effects via genomic selection is therefore necessary.In this study,we measured acoustic and mechanical features in 537 genotypes to dissect the firmness and crispness components of fruit texture.Predictions of across-year phenotypic values for these components were calculated using a model calibrated with 8,294 SNP markers.The best prediction accuracies following cross-validations within the training set of 259 genotypes were obtained for the acoustic linear distance(0.64).Predictions for biparental families using the entire training set varied from low to high accuracy,depending on the family considered.While adding siblings or half-siblings into the training set did not clearly improve predictions,we performed an optimization of the training set size and composition for each validation set.This allowed us to increase prediction accuracies by 0.17 on average,with a maximal accuracy of 0.81 when predicting firmness in the‘Gala’בPink Lady’family.Our results therefore identified key genetic parameters to consider when deploying genomic selection for texture in apple.In particular,we advise to rely on a large training population,with high phenotypic variability from which a‘tailored training population’can be extracted using a priori information on genetic relatedness,in order to predict a specific target population. | Morgane Roth Hélène Muranty Mario Di Guardo Walter Guerra Andrea Patocchi Fabrizio Costa | 2020 | Horticulture Research2020，7，1： | 4 |
| 5 | Pitch canker, a new disease of some southern pines显示文摘 | Hepting G H Roth E R | 1946 | J For1946，44，： | 2 |
| 6 | Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drag action显示文摘 | Jentsch J D Roth R H Taylor J R | 2000 | Prog Brain Res2000，126，： | 2 |
| 7 | Calibration of multi-beam laser tracking systems显示文摘 | ZHUANG Hanqi MOTAGHEDI S H ROTH Z S | 2003 | Robotics and Computer Integrated Manufacturing2003，19，4： | 1 |
| 8 | Ethanol production by continuous fermentation - pervaporation: a preliminary economic analysis显示文摘 | Dennis J O' Brien Lorie H Roth Andrew J McAloon | 2000 | Journal of Membrane Science2000，166，： | 1 |
| 9 | Slope stability analysis by strength reduction显示文摘 | DAWSON E M ROTH W H DRESCHER A | 1999 | Geotechnique1999，49，6： | 1 |
| 10 | Assessment of cardiac pre- load and left ventricular function under increasing levels of positive end expiratory pressure显示文摘 | Luecke T Roth H Henlnann P | 2004 | Intensive Care Med2004，30，1： | 1 |
| 11 | Growth and development in the rat during subcronic exposure to low levels of hydrogen sulfide 显示文摘 | Hayden LJ Goeden H Roth SH | 1990 | Toxicol And Health1990，6，34： | 1 |
| 12 | Comparison of radiation exposure of patients caused by selected interventional and angiography procedures-initial results显示文摘 | Seifert H Roth R Urbanczyk K | 1999 | Rofo1999，170，2： | 1 |
| 13 | Empirical evaluation of the relationship between soil dielectric constant and volumetric water content as the basis for calibrating soil moisture measurements by TDR显示文摘 | Roth C H Malicki M A Plagge R | 1992 | Soil Sci1992，43，： | 1 |
| 14 | The solubility of certain Diophantine inequalities显示文摘 | DAVENPORT H ROTH K F | 1955 | Mathematika1955，2，4： | 1 |
| 15 | The effect of general an- esthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vitro显示文摘 | Wakasugi M Hirota K Roth H | 1999 | Anesth Analg1999，88，3： | 1 |
| 16 | Quantitative morphology and network representation of soil pore structure显示文摘 | Vogel H J Roth K | | 0，，3： | 1 |
| 17 | PEEP decrease atelectasis and extravascular lung water but lung tissue volume in surfactant washout lung injury显示文摘 | Luecke T Roth H Hermann P | 2003 | Intensive Care Med2003，29，12： | 1 |
| 18 | Quantitalive morphology and network representation of soft pore structure显示文摘 | Vogel H J Roth K | 2001 | Advances in Water Resoutces2001，24，： | 1 |
| 19 | The method of normalization to determine invariants 显示文摘 | Rothe I Suesse H VossK | 1996 | IEEE Transactions on Pattern Analysis and Machine Intelligence1996，18，4： | 1 |
| 20 | The chemistry and technology of frying fat chemistry显示文摘 | ROTH H ROCK S | 1972 | Baker''s Dig1972，46，4： | 1 |
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