|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aromatic amino acid metabolism during liver failure显示文摘 | Dejong CH van de Poll MC Soeters PB etal | 2007 | Journal of Nutrition2007，137，61： | 1 |
| 2 | Aromatic Amino Acid Metabolism during Liver Failure显示文摘 | Dejong CH Van de Poll MC Soeters PB | 2007 | The Journal of Nutrition2007，137，6： | 1 |
| 3 | Disappearing colorectal liver metastases after chemotherapy: should we be concerned?显示文摘 | van Vledder MG dejong MC Pawlik TM | 2010 | J Gastrointest Surg2010，14，11： | 1 |
| 4 | Liver -directed therapy for hepatic metastases in patients undergoing pancreaticoouodenectomv, a dual - center analysis显示文摘 | deJONG MC FARNELL MB SCLABAS G | 2010 | Ann Surg2010，252，1： | 1 |
| 5 | Bone mineral density in patients with rheumatoid arthritis: relation between disease severity and low bone mineral density显示文摘 | Lodder MC deJong Z Kostense PJ | 2004 | Ann Rheum Dis2004，63，12： | 1 |
| 6 | Aromatic amino acid metabolism during liver failure显示文摘 | Dejong CH Van de Poll MC Soeters PB | 2007 | J Nutr2007，137，61： | 1 |
| 7 | Aromatic amino acid metabolism during liver failure 显示文摘 | Dejong CH van de Poll MC Soeters PB | 2007 | J Nutr2007，137，61： | 1 |
| 8 | Diagnostic perform?ance of stress myocardial perfusion imaging for coronary artery disease: a systematic review and meta-analysis显示文摘 | deJong MC Genders TS van Geuns RJ | 2012 | Eur Radiol2012，22，9： | 1 |
| 9 | Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans显示文摘Background and Aim:Animal studies indicated that systemic ophthalmic acid(OPH)is a biomarker for hepatic glutathione(GSH)homeostasis,an important determinant of liver function.We aimed to clarify whether OPH levels can be used as a read-out for hepatic GSH homeostasis after paracetamol(APAP)challenges during pylorus-preserving pancreaticoduodenectomy(PPPD)or partial hepatectomy(PH).Methods:Nineteen patients undergoing PPPD(n=7,control group)or PH(n=12)were included.APAP(1000 mg)was administered intravenously before resection(first challenge),and six and twelve hours later,with sequential blood sampling during this period.Arterial,hepatic and portal venous blood samples and liver biopsies were taken on three occasions during the first APAP challenge.Plasma and hepatic OPH and GSH levels were quantified,and venous-arterial differences were calculated to study hepatic release.Results:Systemic GSH levels decreased during the course of the APAP challenge in both surgical groups,without notable change in OPH levels.Hepatic GSH and OPH content was not affected within^3 hours after administration of the first APAP dose in patients undergoing PPPD or PH.In this period,net release of OPH by the liver was observed only in patients undergoing PPPD.Conclusions:The drop in circulating GSH levels following APAP administrations,did not result in an increase in plasma OPH in both patients with an intact liver and in those undergoing liver resection.Hepatic content of GSH and OPH was not affected during the first APAP dose.It is uncertain whether hepatic GSH homeostasis was sufficiently challenged in the present study.Relevance for patients:In the present study,plasma OPH seemed not useful as a marker for GSH depletion because APAP administration during liver surgery did not lead to(immediate)GSH depletion or increased OPH levels.Based on stable levels of hepatic GSH,OPH and thiyl radicals during surgery,standard APAP administration seems to be safe in a postoperative care program with regards to GSH homeostasis in this specific population.However,no general statements can be made on the basis of the current experiment,since GSH homeostasis and susceptibility to xenobiotic toxicity are influenced by several metabolic and genetic factors. | Kim MC van Mierlo Simon AWG Dello Mechteld C de Jong Hans MH van Eijk Theo M de Kok Jacob J Briedé Frank G Schaap Steven WM Olde Damink Cornelius HC Dejong | 2017 | Journal of Clinical & Translational Research2017，3，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员