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| 1 | Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity显示文摘Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent. Whereas interstitial and intra-operative approaches have been investigated for the ablation of a broad range of superficial or bulky solid tumors such as breast cancer, the majority of approved photodynamic therapy protocols are for the treatment of superficial lesions of skin and luminal organs. This review article will discuss recent progress in research focused mainly on assessing the efficacies of various photosensitizers used in photodynamic therapy, as well as the combinatory strategies of various therapeutic modalities for improving treatments of parenchymal and/or stromal tissues of breast cancer solid tumors. Cytotoxic agents are used in cancer treatments for their effect on rapidly proliferating cancer cells. However, such therapeutics often lack specificity, which can lead to toxicity and undesirable side effects. Many approaches are designed to targettumors. Selective therapies can be established by focusing on distinctive intracellular(receptors, apoptotic pathways, multidrug resistance system, nitric oxidemediated stress) and environmental(glucose, pH) differences between tumor and healthy tissue. A rational design of effective combination regimens for breast cancer treatment involves a better understanding of the mechanisms and molecular interactions of cytotoxic agents that underlie drug resistance and sensitivity. | María Julia Lamberti Natalia Belén Rumie Vittar Viviana Alicia Rivarola | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 2 | The transcription factor GLI1 mediates TGF-β1 driven EMT in hepatocellular carcinoma via a SNAI1- dependent mechanism 显示文摘 | Zheng X Rumie Vittar NB Gai X | 2012 | Plos One2012，7，49： | 1 |
| 3 | Silencing surviving gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway 显示文摘 | Croci D O Cogno I S Vittar N B | 2008 | J Cell Bio- chem2008，105，2： | 1 |
| 4 | The transcription factor GLI1 mediates TGFOl driven EMT in hepatocel- lular carcinoma via a SNAil-dependent mechanism显示文摘 | Zheng X Vittar NB Gai X | 2012 | PLoS One2012，7，49： | 1 |
| 5 | Silencing survivin gene ex- pression promotes apoptosis of human breast cancer cells through a caspase-independent pathway显示文摘 | Croci DO Cogno IS Vittar NB | 2008 | J Cell Biochem2008，105，2： | 1 |
| 6 | The transcription factor GLI1 medi- ates TGFβ1 driven EMT in hepatocellular carcinoma via a Snail 1-de- pendent mechanism显示文摘 | Zheng X Vittar NBR Gai X | 2012 | PloS One2012，7，49： | 1 |
| 7 | Adrenomedullin is Up-regulated in Patients With Pancreatic Cancer and Causes Insulin Resistance in β Cells and Mice显示文摘 | Gaurav Aggarwal Vijaya Ramachandran Naureen Javeed Thiruvengadam Arumugam Shamit Dutta George G. Klee Eric W. Klee Thomas C. Smyrk William Bamlet Jing Jing Han Natalia B. Rumie Vittar Mariza de Andrade Debabrata Mukhopadhyay Gloria M. Petersen Martin E. F | 2012 | Gastroenterology2012，，6： | 1 |
| 8 | The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism显示文摘 | Zheng X Vittar NB Gai X | 2012 | PLoS One2012，7，49： | 1 |
| 9 | Caspase-independent apoptosis, in human MCF-7c3 breast cancer ceils, following photodynamic therapy, with a novel water-soluble phthalocyanine显示文摘 | Vittar NB Awruch J Azizuddin K | 2010 | Int J Biochem Cell Biol2010，42，7： | 1 |
| 10 | Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway显示文摘 | Croci D O Cogno I S Vittar N B Salvatierra E Trajtenberg F Podhajcer O L | 2008 | J Cell Biochem2008，105，： | 1 |
| 11 | The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAil-dependent mechanism 显示文摘 | Zheng X Vittar NB Gai X | 2012 | PLoS One2012，7，49： | 1 |
| 12 | Silencing survivin gene expression promotes apoptosis of human breast Cancer cells through a caspase-independent pathway显示文摘 | Croci DO Cogno IS Vittar NB | | 0，，2： | 1 |
| 13 | Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway 显示文摘 | Croci DO Cogno IS Vittar NB | 2008 | J Cell Biochem2008，105，2： | 1 |
| 14 | Development of a soft-sensor for particle size monitoring 显示文摘 | Del Vittar R G Thibauh J Del Villar R | 1996 | Minerals Engi- neering ( S0892-6875 )1996，9，1： | 1 |
| 15 | Silencing Survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway 显示文摘 | Croci D O Cogno I S Vittar N B | 2008 | J Cell Bioehem2008，105，2： | 1 |
| 16 | Caspase-independent apoptosis,in human MCF-7c3 breast cancer cells,following photodynamic therapy,with a novel water-soluble phthalocyanine显示文摘 | Vittar N B Awruch J Azizuddin K | | 0，，7： | 1 |
| 17 | Silencing survivin gene ex- pression promotes apoptosis of human breast cancer cells through a caspase-independent pathway 显示文摘 | Croci DO Cogno IS Vittar NB | 2008 | J Cell Biochem2008，105，2： | 1 |
| 18 | Optimization of photodynamie therapy response by survivin gene knockdown in human metastatic breast cancer T47D cells 显示文摘 | Cogno IS Vittar NB Rivarola VA | 2011 | J Photochem Photobiol B2011，104，： | 1 |
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