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| 1 | Roux-en-Y versus BillrothⅠreconstruction after distal gastrectomy for gastric cancer:A meta-analysis显示文摘AIM:To conduct a meta-analysis to compare Rouxen-Y(R-Y) gastrojejunostomy with gastroduodenal Billroth Ⅰ(B-Ⅰ) anastomosis after distal gastrectomy(DG) for gastric cancer.METHODS:A literature search was performed to identify studies comparing R-Y with B-Ⅰ after DG for gastric cancer from January 1990 to November 2012 in Medline,Embase,Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials in The Cochrane Library.Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed or random effects model.Operative outcomes such as operation time,intraoperative blood loss and postoperative outcomes such as anastomotic leakage and stricture,bile reflux,remnant gastritis,reflux esophagitis,dumping symptoms,delayed gastric emptying and hospital stay were the main outcomes assessed.Meta-analyses were performed using RevMan 5.0 software(Cochrane library).RESULTS:Four randomized controlled trials(RCTs) and 9 non-randomized observational clinical studies(OCS) involving 478 and 1402 patients respectively were included.Meta-analysis of RCTs revealed that R-Y reconstruction was associated with a reduced bile reflux(OR 0.04,95%CI:0.01,0.14;P < 0.00 001) and remnant gastritis(OR 0.43,95%CI:0.28,0.66;P = 0.0001),however needing a longer operation time(WMD 40.02,95%CI:13.93,66.11;P = 0.003).Metaanalysis of OCS also revealed R-Y reconstruction had a lower incidence of bile reflux(OR 0.21,95%CI:0.08,0.54;P = 0.001),remnant gastritis(OR 0.18,95%CI:0.11,0.29;P < 0.00 001) and reflux esophagitis(OR 0.48,95%CI:0.26,0.89;P = 0.02).However,this reconstruction method was found to be associated with a longer operation time(WMD 31.30,95%CI:12.99,49.60;P = 0.0008).CONCLUSION:This systematic review point towards some clinical advantages that are rendered by R-Y compared to B-Ⅰ reconstruction post DG.However there is a need for further adequately powered,welldesigned RCTs comparing the same. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Quentin M Nunes Wei Huang Gang Mai Chun-Lu Tan Rajarshi Mukherjee Robert Sutton Wei-Ming Hu Xu-Bao Liu | 2013 | World Journal of Gastroenterology2013，19，7： | 33 |
| 2 | Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma显示文摘AIM:To conduct a meta-analysis to determine the safety and efficacy of laparoscopic liver resection(LLR) and open liver resection(OLR) for hepatocellular carcinoma(HCC).METHODS:PubMed(Medline),EMBASE and Science Citation Index Expanded and Cochrane Central Register of Controlled Trials in the Cochrane Library were searched systematically to identify relevant comparative studies reporting outcomes for both LLR and OLR for HCC between January 1992 and February 2012.Two authors independently assessed the trials for inclusion and extracted the data.Meta-analysis was performed using Review Manager Version 5.0 software(The Cochrane Collaboration,Oxford,United Kingdom).Pooled odds ratios(OR) or weighted mean differences(WMD) with 95%CI were calculated using either fixed effects(Mantel-Haenszel method) or random effects models(DerSimonian and Laird method).Evaluated endpoints were operative outcomes(operation time,intraoperative blood loss,blood transfusion requirement),postoperative outcomes(liver failure,cirrhotic decompensation/ascites,bile leakage,postoperative bleeding,pulmonary complications,intraabdominal abscess,mortality,hospital stay and oncologic outcomes(positive resection margins and tumor recurrence).RESULTS:Fifteen eligible non-randomized studies were identified,out of which,9 high-quality studies involving 550 patients were included,with 234 patients in the LLR group and 316 patients in the OLR group.LLR was associated with significantly lower intraoperative blood loss,based on six studies with 333 patients [WMD:-129.48 mL;95%CI:-224.76-(-34.21) mL;P = 0.008].Seven studies involving 416 patients were included to assess blood transfusion requirement between the two groups.The LLR group had lower blood transfusion requirement(OR:0.49;95%CI:0.26-0.91;P = 0.02).While analyzing hospital stay,six studies with 333 patients were included.Patients in the LLR group were found to have shorter hospital stay [WMD:-3.19 d;95%CI:-4.09-(-2.28) d;P < 0.00001] than their OLR counterpart.Seven studies including 416 patients were pooled together to estimate the odds of developing postoperative ascites in the patient groups.The LLR group appeared to have a lower incidence of postoperative ascites(OR:0.32;95%CI:0.16-0.61;P = 0.0006) as compared with OLR patients.Similarly,fewer patients had liver failure in the LLR group than in the OLR group(OR:0.15;95%CI:0.02-0.95;P =0.04).However,no significant differences were found between the two approaches with regards to operation time [WMD:4.69 min;95%CI:-22.62-32 min;P = 0.74],bile leakage(OR:0.55;95%CI:0.10-3.12;P = 0.50),postoperative bleeding(OR:0.54;95%CI:0.20-1.45;P = 0.22),pulmonary complications(OR:0.43;95%CI:0.18-1.04;P = 0.06),intra-abdominal abscesses(OR:0.21;95%CI:0.01-4.53;P = 0.32),mortality(OR:0.46;95%CI:0.14-1.51;P = 0.20),presence of positive resection margins(OR:0.59;95%CI:0.21-1.62;P = 0.31) and tumor recurrence(OR:0.95;95%CI:0.62-1.46;P = 0.81).CONCLUSION:LLR appears to be a safe and feasible option for resection of HCC in selected patients based on current evidence.However,further appropriately designed randomized controlled trials should be undertaken to ascertain these findings. | Jun-Jie Xiong Kiran Altaf Muhammad A Javed Wei Huang Rajarshi Mukherjee Gang Mai Robert Sutton Xu-Bao Liu Wei-Ming Hu | 2012 | World Journal of Gastroenterology2012，18，45： | 25 |
| 3 | Biosorption characteristics of unicellular green alga Chlorella sorokiniana immobilized in loofa sponge for removal of Cr(Ⅲ)显示文摘Loofa sponge(LS)immobilized biomass of Chlorella sorokiniana(LSIBCS),isolated from industrial wastewater,was investigated as a new biosorbent for the removal of Cr(Ⅲ)from aqueous solution.A comparison of the biosorption of Cr(Ⅲ)by LSIBCS and free biomass of C.sorokiniana(FBCS)from 10-300 mg Cr(Ⅲ)/L aqueous solutions showed an increase in uptake of 17.79% when the rnicroalgal biomass was immobilized onto loofa sponge.Maximum biosorption capacity for LSIBCS and FBCS was found to be 69.26 and 58.80 mg Cr(Ⅲ)/g biosorbent,respectively,whereas the amount of Cr(Ⅲ)ions adsorbed onto naked LS was 4.97 mg/g.The kinetics of Cr(Ⅲ)biosorption was extremely rapid and equilibrium was established in about 15 and 20 min by LSIBCS and FBCS, respectively.The biosorption equilibrium was well defined by Langrnuir adsorption isotherm model.The biosorption kinetics followed the pseudo-second order kinetic model.The biosorption was found to be pH dependent and the maximum sorption occurred at the solution pH 4.0.Desorption studies showed that 98% of the adsorbed Cr(Ⅲ)could be desorbed with 0.1 mol/L HNO_3,while other desorbing agents were less effective in the order:EDTA>H_2SO_4>CH_3COOH>HCl.The regenerated LSIBCS retained 92.68% of the initial Cr(Ⅲ)binding capacity up to five cycles of reuse in continuous flow-fixed bed columns.The study revealed that LSIBCS could be used as an effective biosorbent for the removal of Cr(Ⅲ)from wastewater. | AKHTAR Nasreen IQBAL Muhammad ZAFAR Saeed Iqbal IQBAL Javed | 2008 | Journal of Environmental Sciences2008，20，2： | 20 |
| 4 | Landslide susceptibility mapping using an integrated model of information value method and logistic regression in the Bailongjiang watershed,Gansu Province,China显示文摘Bailongjiang watershed in southern Gansu province, China, is one of the most landslide-prone regions in China, characterized by very high frequency of landslide occurrence. In order to predict the landslide occurrence, a comprehensive map of landslide susceptibility is required which may be significantly helpful in reducing loss of property and human life. In this study, an integrated model of information value method and logistic regression is proposed by using their merits at maximum and overcoming their weaknesses, which may enhance precision and accuracy of landslide susceptibility assessment. A detailed and reliable landslide inventory with 1587 landslides was prepared and randomly divided into two groups,(i) training dataset and(ii) testing dataset. Eight distinct landslide conditioning factors including lithology, slope gradient, aspect, elevation, distance to drainages,distance to faults, distance to roads and vegetation coverage were selected for landslide susceptibility mapping. The produced landslide susceptibility maps were validated by the success rate and prediction rate curves. The validation results show that the success rate and the prediction rate of the integrated model are 81.7 % and 84.6 %, respectively, which indicate that the proposed integrated method is reliable to produce an accurate landslide susceptibility map and the results may be used for landslides management and mitigation. | DU Guo-liang ZHANG Yong-shuang IQBAL Javed YANG Zhi-hua YAO Xin | 2017 | Journal of Mountain Science2017，14，2： | 16 |
| 5 | Chemopreventive Effects of Black Tea Polyphenols in Mouse Skin Model of Carcinogenesis显示文摘In the present investigations, the antitumorigenic effect of black tea polyphenols (BTP) in twcrstage mouse skin model of carcinogenesis was studied. The animals were initiated with a single 'subcarcinogenic' topical dose (52 μg/200 μl acetone ) of 7, 12-dimethylbenzanthracene (DMBA). To evaluate the anti-tumour initiating activity, BTP was topically applied twice a week for three weeks prior to DMBA application, followed by topical treatment with 12-o-tetradecanoyl phorbol-13-acetate (TPA) (5 μg/200 μl acetone, 2x/wk. ) as promoter. For evaluation of antitumor promoting activity, BTP was applied prior to each treatment of TPA. BTP application showed marked inhibitory effect as antitumour initiator as well as antitumour promoter in mouse skin medel of two-stage carcinogenesis. Since initiation involves genetic pathway and tumour promotion involves epigenetic pathway, it seems that BTP exerts its antitumorigenic effect by altering both genetic and epigenetic | SEEMA JAVED N. K. MEHROTRA AND YOGESHWER SHUKLA(Laboratory of Environmental Chrcinogenesis, Industrial Toxicology Research Centre, M. G. Marg, P. O. Box 80,Lucknow - 226001, India) | 1998 | Biomedical and Environmental Sciences1998，11，4： | 15 |
| 6 | Validation of the moderate severity category of acute pancreatitis defined by determinant-based classification显示文摘BACKGROUND: Recent international multidisciplinary consultation proposed the use of local(sterile or infected pancreatic necrosis) and/or systemic determinants(organ failure) in the stratification of acute pancreatitis. The present study was to validate the moderate severity category by international multidisciplinary consultation definitions.METHODS: Ninety-two consecutive patients with severe acute pancreatitis(according to the 1992 Atlanta classification) were classified into(i) moderate acute pancreatitis group with the presence of sterile(peri-) pancreatic necrosis and/or transient organ failure; and(ii) severe/critical acute pancreatitis group with the presence of sterile or infected pancreatic necrosis and/or persistent organ failure. Demographic and clinical outcomes were compared between the two groups.RESULTS: Compared with the severe/critical group(n=59), the moderate group(n=33) had lower clinical and computerized tomographic scores(both P<0.05). They also had a lower incidence of pancreatic necrosis(45.5% vs 71.2%, P=0.015),infection(9.1% vs 37.3%, P=0.004), ICU admission(0% vs27.1%, P=0.001), and shorter hospital stay(15±5 vs 27±12days; P<0.001). A subgroup analysis showed that the moderate group also had significantly lower ICU admission rates, shorter hospital stay and lower rate of infection compared with the severe group(n=51). No patients died in the moderate group but7 patients died in the severe/critical group(4 for severe group).CONCLUSIONS: Our data suggest that the definition of moderate acute pancreatitis, as suggested by the international multidisciplinary consultation as sterile(peri-) pancreatic necrosis and/or transient organ failure, is an accurate category of acute pancreatitis. | Tao Jin Wei Huang Xiao-Nan Yang Ping Xue Muhammad A Javed Kiran Altaf Robert Sutton Qing Xia | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 13 |
| 7 | Exosomes and their role in the micro-/macro-environment: acomprehensive review显示文摘The importance of extracellular vesicles(EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA, mRNA, miRNAs, and proteins to target cells. Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states. Of the different types of EVs, exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems. The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis, angiogenesis, immune modulation, and the tumor macro-/microenvironment. We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids, ease of uptake, and cellular content. Exosome use in diagnosis, prognosis, and in establishing treatment regimens has enormous potential to revolutionize patient care. | Naureen Javeed Debabrata Mukhopadhyay | 2017 | The Journal of Biomedical Research2017，31，5： | 13 |
| 8 | 空气局部放电衍生物气体生成规律的研究显示文摘分解气体分析法通过检测故障产生的气体组分诊断设备故障,是检测电力设备故障的重要方法,在一些应用场合具有不可替代的作用。然而目前该方法只在绝缘油、SF6等绝缘介质的场合有应用,对于空气这一最重要的绝缘介质少有应用。本文搭建空气局部放电过程模拟实验平台及气体产物检测系统,研究放电衍生物气体生成规律。分别采用两种检测方式对气体产物进行检测,结果显示O_3、NO、NO_2为空气放电的主要产物;在放电强度较低时,空气放电主要分解产物为O_3,放电强度进一步增大可以检测到氮氧化物NO和NO_2的产生,且臭氧O_3浓度远大于氮氧化物气体浓度;对于封闭空间,随着放电时间增长分解产物浓度增加,但趋向饱和,且随着施加电压增大,气体产物浓度增加;而在相同放电电压下,空气相对湿度变化对气体产物含量有明显影响,O_3、NO_2的浓度在相对湿度为18%时高于相对湿度为25%和44%时的值;而NO的浓度在相对湿度为44%时高于相对湿度为18%和25%时的值,同时差异较小。 | 李康 郭润睿 Hassan Javed 张国强 | 2017 | 电工电能新技术2017，36，8： | 10 |
| 9 | 赤霉素及噻苯隆处理对‘夏黑’葡萄果实品质的影响显示文摘松散的果穗有利于鲜食葡萄果粒的膨大和品质形成,还可减少果粒相互挤压破裂。但人工疏花和疏粒费时费力,成本高。为此,以4年生‘夏黑’葡萄为试验材料,调查赤霉酸(GA3)拉长穗轴效果,并探讨GA3和噻苯隆(TDZ)的保果和膨大处理对果实品质的影响。结果表明,在盛花前14 d用10~15 mg/L GA3溶液浸泡花穗可有效拉长花穗,满花时及花后10 d分别用25 mg/L GA3及25 mg/L GA3+3~5 mg/L TDZ溶液浸蘸拉长后的果穗,可提高坐果率和促进果粒膨大,增加粒质量、纵横径效果显著,但对果汁可溶性固形物积累有不良影响。 | 赵茂香 郑伟尉 HAFIZ Umer Javed | 2021 | 中外葡萄与葡萄酒2021，，1： | 10 |
| 10 | Stable chloroplast transformation of immature scutella and inflorescences in wheat (Triticum aestivum L.)显示文摘在小麦的叶绿体转变被 scutella 的轰炸分别地从不成熟的胚胎和不成熟的开花期完成。小麦叶绿体地点特定的表示向量, pBAGNRK,被放包含新霉素 phosphotransferase II (nptII ) 和绿色的一个表示盒子构造荧光灯蛋白质(gfp ) 作为选择和记者基因,分别地在在小麦的 atpB 和 rbcL 之间的 intergenic 分隔符叶绿体染色体。在 plastome 的 gfp 基因的集成被聚合酶链反应(PCR ) 识别分析并且作为一根探针的用 gfp 基因的南部的弄污。GFP 蛋白质的表示被西方的污点检验。三积极 transformants 被获得, atpB 和 rbcL (指向的地点) 的部分碎片的南部的污点探查证实他们之一是 homoplasmic。GFP 荧光的稳定的表示被共焦的显微镜学从 T1 子孙幼苗在叶纸巾证实。gfp 基因的 PCR 分析也在 T1 子孙证实了 transgene 的继承。这些结果加强小麦叶绿体转变的可行性并且也通过叶绿体转变在小麦为重要农学的特点的介绍给一个新奇方法。 | Cuiju Cui FeiSong Yi Tan Xuan Zhou Wen Zhao Fengyun Ma Yunyi Liu Javeed Hussain Yuesheng Wang Guangxiao Yang Guangyuan He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 10 |
| 11 | 先锋牧草-香根草联合固氮菌多样性显示文摘【目的】香根草(Vetiver zizanioides)是一种多年生禾本科草本植物,具有极强的生态适应性和抗逆能力,可作饲料和水土保持用。通过研究香根草联合固氮菌多样性,为进一步研究和应用打下基础。【方法】采用无氮培养基,首次从香根草中分离到47株联合固氮菌,分别应用SDS-PAGE全细胞蛋白质电泳、DNA指纹图谱、唯一碳源和16SrDNA全序列测定等方法,进行聚类和多样性分析。【结果】SDS-PAGE、IS-PCR和Bio-BIQA碳源利用的聚类结果基本一致,将供试菌株分为6个类群和4个单菌株;16SrDNA序列测定表明,从香根草中分离的菌株包括了佛莱辛草螺菌(Herbaspirillum frisingense)、中型假食酸菌(Pseudacidovorax intermedius)、恶臭假单胞菌(Pseudomonas putida)、荧光假单胞菌(Pseudomonas fluorescens)、越南伯克氏菌(Burkholderia vietnamiensis)、阴沟肠杆菌(Enterobacter cloacae)、路德维希肠杆菌(Enterobacter ludwigii)和松江壳聚糖降解菌(Mitsuaria chitosanitabida)等不同菌种。【结论】香根草联合固氮菌具有较大的资源多样性,对固氮菌资源的扩展和将来牧草上的应用具有重要意义。 | 赵现伟 Chaudhary Hassan Javed 何玉梅 张志英 彭桂香 谭志远 | 2009 | 微生物学报2009，49，11： | 9 |
| 12 | Long-term Activity of Earthquake-induced Landslides: A Case Study from Qionghai Lake basin, Southwest of China显示文摘Earthquake-triggered landslides are a major geological hazard in the eastern Tibetan Plateau, and have prolonged impact on earth surface processes and fluvial system. To determine how long co-seismic landslides affect basins, a massive number of landslides existing in Qionghai Lake Basin were investigated for landslide distribution characteristics and geomorphological evidences, with further comparison and analysis using historic seismic analog method. The landslides found in Qionghai Lake Basin showed clear features of seismic triggering with strongly controlled by Zemuhe fault. These landslides are still active at present. Some new slides generally occur in ancient slope failure zones causing serious secondary hazards in recent years. In this study we strengthen the idea that the landslides triggered by the 1850 Xichang earthquake(MS7.5) have long term activity and prolonged impact on the mountain disasters with a period of more than 160 years. Our results support growing evidence that co-seismic landslides have a prolonged effect on secondary disasters in a basin, and invite more careful consideration of the relationship between current basin condition and landslide history for a longer period. | WEI Xue-li CHEN Ning-sheng CHENG Qian-gong HE Na DENG Ming-feng TANOLI Javed Iqbal | 2014 | Journal of Mountain Science2014，11，3： | 9 |
| 13 | 基于主成分分析的云南玉溪市生态安全评价研究显示文摘以云南省为研究对象,采用PSR(压力Press—状态State—响应Response)模型建立玉溪市生态安全评价指标体系,运用主成分分析法对2005—2009年玉溪市的生态安全现状进行分析和综合评价。结果显示,压力指标呈逐年上升趋势,必须在控制人口数量的前提下,加快城市化进程;状态指标同样呈上升趋势,说明政府对公共设施的投入增加,经济发展和环境保护得到了关注;相应指标也呈上升趋势,说明政府为改善环境作出了努力。 | 杨乐 丁伟 于龙 施玉 Javed Ahmed Ujan | 2013 | 广东农业科学2013，40，6： | 9 |
| 14 | Hepatitis B virus therapy:What's the future holding for us?显示文摘Hepatitis B is one of the leading causes of liver cancer worldwide and unfortunately the number of people affected with hepatitis B virus(HBV) infection is still on the rise. Although the HBV has been known to cause fatal illness since decades but the population effected by this lethal virus have still only a few options for its management. The major treatment strategies include interferons and nucleos(t)ide analogues. These agents have so far produced unsatisfactory results in terms of complete virus eradication. Interferons cannot be used for long term therapy because of their potential side effects. Prolong treatment with nucleos(t)ide analogues has also been reported to cause serious side effects besides the increasing resistance by the virus. The need for new innovative solutions for treatment of HBV has been realized by global research institutes and pharmaceutical industry. Present review focuses in detail on the new ideas that are being transformed into therapeutic tools for use as future therapies in HBV infection. Modern drug designing and screening methods have made the drug discovery process shorter and more reliable. HBV therapeutics will take a new turn in coming years owing to these intelligent drug designing and screening methods. Future therapy of HBV is aiming to include the use of vaccines(both prophylactic and therapeutic), immunomodulators such as antibodies, non-nucleoside antivirals such as RNAi and inhibitors of viral life cycle. | Sobia Manzoor Muhammad Saalim Muhammad Imran Saleha Resham Javed Ashraf | 2015 | World Journal of Gastroenterology2015，21，44： | 9 |
| 15 | Plant-derived anticancer agents: A green anticancer approach显示文摘Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment methods.Phytochemicals are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed. | Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat Ali Sayed Afzal Shah Ali Talha Khalil | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，12： | 8 |
| 16 | Pancreaticoduodenectomy: a comparison of superior approach with classical Whipple's technique显示文摘BACKGROUND: Pancreaticoduodenectomy (PD) is the standard procedure for resecting tumors arising from the periampullary area and the pancreatic head. Nevertheless this procedure is inherently difficult and associated with high morbidity and mortality. Besides, the technique applied for exposing the portal and superior mesenteric veins is time-consuming, difficult and associated with the risk of major venous injury. Recently we have introduced a modified approach for making this part of the procedure quick, safe and bloodless, which constitutes the subject of this study. METHODS: Patients who underwent pylorus preserving pancreaticoduodenectomy (PPPD) either by superior approach technique (group 1) or by classical Whipple's technique (group 2) were retrospectively identified. Age-sex composition, body mass index (BMI), total operative time, operative blood loss, intraoperative blood transfusion requirement, morbidity, mortality and length of hospital stay were compared between the two groups. RESULTS: Between January 1997 and December 2011, 72 patients underwent PPPD by the superior approach technique (group 1) and 38 underwent PPPD by the classical Whipple's technique (group 2) at our institution. Statistically significant differences were observed in operative time (208.1±46.3 minutes in group 1 vs 322.0±33.8 minutes in group 2), operative blood loss (601.0±250.3 mL in group 1 vs 1371.5±471.8 mL in group 2), and intraoperative blood transfusion requirement [10 (13.9%) patients in group 1 and 24 (63.2%) in group 2]. Among 18 (16.4%) obese patients, significant differences in operativetime, operative blood loss and intraoperative blood transfusion requirement were observed between groups 1 and 2. There was no significant inter-group difference in complication rate among obese patients, but comparing obese patients with normal weight patients revealed higher rates of complications like pancreatic fistula (27.8% vs 6.5%), delayed gastric emptying (16.7% vs 5.4%), and infective complications like wound infection and intra abdominal collection (44.4% vs 5.4%). CONCLUSIONS: On the basis of analytical data, we conclude that the superior approach technique is effective for PD compared with the classical Whipple's technique. It allows fast, safe and virtually bloodless dissection for exposure of the superior mesenteric and portal veins during early steps of PD. PD is normally a difficult and tedious procedure carrying a remote risk of major venous injury leading to substantial blood loss. | Omar Javed Shah Mushtaq A Gagloo Irfan Jan Khan Rayees Ahmad Saleema Bano | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 8 |
| 17 | Management of hypersplenism in non-cirrhotic portal hypertension:a surgical series显示文摘BACKGROUND:Hypersplenism is commonly seen in patients with non-cirrhotic portal hypertension(NCPH).While a splenectomy alone can effectively relieve the hypersplenism,it does not address the underlying portal hypertension.The present study was undertaken to analyze the impact of shunt and non-shunt operations on the resolution of hypersplenism in patients with NCPH.The relationship of symptomatic hypersplenism,severe hypersplenism and number of peripheral cell line defects to the severity of portal hypertension and outcome was also assessed.METHODS:A retrospective analysis of NCPH patients with hypersplenism managed surgically between 1999 and 2009 at our center was done.Of 252 patients with NCPH,64(45 with extrahepatic portal vein obstruction and 19 with non-cirrhotic portal fibrosis) had hypersplenism and constituted the study group.Statistical analysis was done using GraphPad InStat.Categorical and continuous variables were compared using the chi-square test,ANOVA,and Student's t test.The MannWhitney U test and Kruskal-Wallis test were used to compare non-parametric variables.RESULTS:The mean age of patients in the study group was 21.81±6.1 years.Hypersplenism was symptomatic in 70.3% with an incidence of spontaneous bleeding at 26.5%,recurrent anemia at 34.4%,and recurrent infection at 29.7%.The mean duration of surgery was 4.16±1.9 hours,intraoperative blood loss was 457±126(50-2000) mL,and postoperative hospital stay 5.5±1.9 days.Following surgery,normalization of hypersplenism occurred in all patients.On long-term followup,none of the patients developed hepatic encephalopathy and 4 had a variceal re-bleeding(2 after a splenectomy alone,1 each after an esophago-gastric devascularization and proximal splenorenal shunt).Patients with severe hypersplenism and those with defects in all three peripheral blood cell lineages were older,had a longer duration of symptoms,and a higher incidence of variceal bleeding and postoperative morbidity.In addition,patients with triple cell line defects had elevated portal pressure(P=0.001),portal biliopathy(P=0.02),portal gastropathy(P=0.005) and intraoperative blood loss(P=0.001).CONCLUSIONS:Hypersplenism is effectively relieved by both shunt and non-shunt operations.A proximal splenorenal shunt not only relieves hypersplenism but also effectively addresses the potential complications of underlying portal hypertension and can be safely performed with good long-term outcome.Patients with hypersplenism who have defects in all three blood cell lineages have significantly elevated portal pressures and are at increased risk of complications of variceal bleeding,portal biliopathy and gastropathy. | Rajesh Rajalingam Amit Javed Dharmanjay Sharma Puja Sakhuja Shivendra Singh Hirdaya H Nag Anil K Agarwal | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 7 |
| 18 | Visual object tracking- classical and contemporary approaches显示文摘 | Ahmad ALI Abdul JALIL Jianwei NIU Xiaoke ZHAO Saima RATHORE Javed AHMED Muhammad AKSAM IFTIKHAR | 2016 | Frontiers of Computer Science2016，10，1： | 7 |
| 19 | Helicobacter pylori infection and micronutrient deficiencies显示文摘It is known that deficiencies of micronutrients due to infections increase morbidity and mortality. This phenomenon depicts itself conspicuously in developing countries.Deficiencies of iron, vitamins A, E, C, B12, etc are widely prevalent among populations living in the third world countries. Helicobacterpylori (Hpylori) infection has a high prevalence throughout the world. Deficiencies of several micronutrients due to Hpylori infection may be concomitantly present and vary from subtle sub-clinical states to severe clinical disorders. These essential trace elementsl micronutrients are involved in host defense mechanisms,maintaining epithelial cell integrity, glycoprotein synthesis,transport mechanisms, myocardial contractility, brain development, cholesterol and glucose metabolism. In this paper Hpyloriinfection in associaed with various micronutrients deficiencies is briefly reviewed. | Javed Yakoob Wasim Jafri Shahab Abid | 2003 | World Journal of Gastroenterology2003，9，10： | 7 |
| 20 | Thrombus aspiration during primary percutaneous coronary intervention for acute myocardial infarction:A review of clinical evidence and guidelines显示文摘Acute ST segment elevation myocardial infarction(STEMI) is characterized by complete thrombotic occlusion of a major coronary artery. Early recanalization of the infarct-related artery is most efficiently delivered by primary percutaneous coronary intervention(PPCI),however this does not always restore normal myocardial perfusion,mainly due to distal embolization of the thrombus and microvascular obstruction. Early evidence for manual thrombus aspiration during PPCI was promising and this was once considered an important aspect of the procedure,especially in patients with a high thrombus burden. However,a large body of evidence from recent major randomized controlled trials(notably TASTE and TOTAL) does not support the routine use of manual thrombus aspiration in patients with STEMI undergoing PPCI. | Muhammad Muzaffar Mahmood Jonathan Watt Javed M Ahmed | 2015 | World Journal of Cardiology2015，7，12： | 7 |
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