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| 1 | Antioxidant and antimutagenic activities of bark extract of Terminalia arjuna显示文摘Objective:The alcoholic extract of stem bark of Terminalia arjuna(ALTA) was screened for antioxidant and antimutagenic(anticlastogenic) activity.Methods:Antioxidant property was determined by l,l,Diphynyl,2-Picryl hydrazyl(DPPH) assay,super oxide radical scavenging activity,lipid peroxidation assay and total polyphenolic content was determined by Folin-Ciocalteau’s reagent.Antimutagenic activity was evaluated using micronucleus test in mice. Results:The ALTA has shown potent antioxidant activity with EC50 of 2.491±0.160,50.110±0.150 & 71.000±0.250 in DPPH assay,superoxide radical scavenging activity and lipid peroxidation assay, which is comparable with ascorbic acid with EC50 of 2.471±0.140,40.500±0.390 and 63.000±0.360 respectively.In micronucleus test,ALTA(100 & 200 mg/kg,p.o.) showed significant reduction in percentage of micronucleus in both polychromatic erythrocytes(PCE) and normochromatie erythrocytes(NCE) and also shown significant reduction in P/N ratio.Conclusions:These results suggested that ALTA possess significant antioxidant and antimutagenic activity. | Gollapalle Lakshminarayana shastry Viswanatha Santosh Kumar Vaidya Ramesh C Nandakumar Krishnadas Srinath Rangappa | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 9 |
| 2 | 液相色谱-串联质谱法测定辣木及萝卜叶的提取物中所含的槲皮素、芦丁及山柰酚(英文)显示文摘目的:通过一种快速、敏感的液相色谱-串联质谱法测定辣木(Moringa oleifera Lam.)及萝卜(Raphinus sativus Linn.)叶的提取物中所含的槲皮素、芦丁及山柰酚。方法:使用冷浸法(90%乙醇)对辣木及萝卜叶进行提取。提取物与0.2%甲酸和氰化甲烷混合后以0.4mL/min的速度通过Phenomenex Gemini C18色谱层析柱,通过时间为5.01min。结果:串联质谱法测定的离子转换分别为槲皮素303.03~153.1,芦丁611.1~303.1,山柰酚287.1~153.2,内参180.1~110.1。对槲皮素、芦丁及山柰酚定量测量的最低浓度为5ng/mL,线性分布为5~2000ng/mL。槲皮素、芦丁及山柰酚的线性回归系数分别为0.9946、0.9951及0.9969。结论:本研究的结果证明了液相色谱-串联质谱法具有快速、灵敏的特点,对于同时测定辣木及萝卜叶的提取物中所含的槲皮素、芦丁及山柰酚有较好的特异性。 | Venkatapura C. Devaraj Burdipad G. Krishna Gollapalle L. Viswanatha | 2011 | 中西医结合学报2011，9，9： | 8 |
| 3 | Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats:possible role of decreased lecithin cholesterol acetyl transferase activity显示文摘Objective:To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats.Methods:Administration of dexamethasone was given at 10 mg/kg,sc.to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index.Results:Lemongrass oil(100 and 200 mg/kg,po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg,po.The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase(LCAT) activity.Conclusions:These results suggested that Lemon gross oil possess significant antihyperlipidemic activity. | VR Santhosh Kumar Md Naseeruddin Inamdar Nayeemunnisa GL Viswanatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 8 |
| 4 | Shape Control of Doped Semiconductor Nanocrystals (d-Dots)显示文摘Formation of Mn2+-doped ZnSe quantum dots(Mn:ZnSe d-dots)with both branched and nearly spherical shapes has been studied.Structure analysis indicates that the Mn2+dopants were localized in the core of a branched nanocrystal.The growth of branched d-dots,rather than spherical ones,was achieved by simply varying the concentration of two organic additives,fatty acids,and fatty amines.The photoluminescence properties of the branched nanocrystals were explored and compared with those of the nearly spherical particles. | Ranjani Viswanatha David M.Battaglia Mark E.Curtis Tetsuya D.Mishima Matthew B.Johnson Xiaogang Peng | 2008 | Nano Research2008，1，2： | 7 |
| 5 | Hepatoprotective activity of Hepax-A polyherbal formulation显示文摘Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in rats.Methods:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological study.Conclusions:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,p.o.on the liver of all the three experimental animal models. | VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath Sanjay Kumar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 6 | Science behind cisplatin-induced nephrotoxicity in humans:A clinical study显示文摘Objective:To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity.Methods:We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes,creatinine,blood urea nitrogen(BUN) and urine potassium,sodium and pH levels before and after the cisplatin chemotherapy.All the patients had cancer and were treated with 40-50 mg/day cisplatin.Renal injury was assessed by measuring serum electrolytes,creatinine,BUN levels and urine potassium,sodium and pH levels. Results:The five cycles of cisplatin based chemotherapy resulted in hypomagnesia(P=0.029), hypocalcaemia(P=0.001~*),hypophosphatemia(P=0.003*),hypokalemia(P=0.001~*)and increased serum creatinine(P=0.001~*)and BUN(P=0.292~*)levels.In urine analysis,decrease in potassium(P=0.024~*)was found,except potassium there was no significant changes in sodium and urine pH. Conclusions:The present study demonstrates that,acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances,when no corrective measures were initiated. | Arunkumar PA Viswanatha GL Radheshyam N Mukund H Belliyappa MS | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 3 |
| 7 | Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4显示文摘The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL-1 were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC(500 μg·mL-1) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide(CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro. | Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok | 2014 | Chinese Journal of Natural Medicines2014，12，12： | 2 |
| 8 | Drought-induced responses of photosynthesis and antioxidant metabolism in higher plants显示文摘 | Attipalli Ramachandra Reddy Kolluru Viswanatha Chaitanya Munusamy Vivekanandan | 2004 | Journal of Plant Physiology2004，，11： | 2 |
| 9 | Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica显示文摘Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase(LOX) inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract(MEMI),successive water extract (SWMI) and ethyl acetate fraction(EMEMI),n-butanol fraction(BMEMI) and water soluble fraction (WMEMI) of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions. | Mohan CG Deepak M Viswanatha GL Savinay G Hanumantharaju V Rajendra CE Praveen D Halemani | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 2 |
| 10 | Ameliorative effect of Koflet formulations against pyridine-induced pharyngitis in rats 显示文摘 | Viswanatha C L Rafiq M Thippeswamy A H M Yuvaraj H C Kavya K J Mirza R B Suryakant A Mohammed A Patki P S Pushpalatha H B Prafulla S C Shyam R | 2014 | Toxicology Reports2014，1，： | 1 |
| 11 | Epstein-Barr virus-associated intravascular large B-cell lymphoma presenting as acute renal failure in a patient with acquired immune deficiency syndrome 显示文摘 | Merchant SH Viswanatha DS Zumwalt RE | 2003 | Hum Patho12003，34，9： | 1 |
| 12 | Plasma spray formed near-net-shape MoSi2-Si3N4 bulk nanocomposites- structure property evaluation 显示文摘 | Hong S J Viswanatha V N Rea K et ol | 2005 | Materials Science and Engineering2005，404，： | 1 |
| 13 | Kinetics and ther- modynamics studies on the adsorption of Zn(Ⅱ) , Cd(Ⅱ) and Hg (Ⅱ) from aqueous solution using zinc oxide nanoparticles 显示文摘 | Sheela T Nayaka Y A Viswanatha R | 2012 | Powder Technology2012，217，： | 1 |
| 14 | Understanding the quantum size effects in ZnO nanocrystals显示文摘 | VISWANATHA R SAPRA S SATPATI B | 2004 | J Mater Chem2004，14，： | 1 |
| 15 | Hodgkin and non-Hodgkin lymphoma involving bone marrow 显示文摘 | Viswanatha D Foucar K | 2003 | Semin Diagn Pathol2003，20，3： | 1 |
| 16 | Anti-osteopo- rotic activity of methanolie exact of an India herbal formula NR/ CAL/06 in ovarieetomized rats 显示文摘 | Sfikanta P Nagrajappa SH Viswanatha GL | 2011 | J Chin Integr Med2011，9，10： | 1 |
| 17 | Overexpression of Isocitrate Lyase Is an Important Strategy in the Survival of Pseudomonas fluorescens Exposed to Aluminum显示文摘 | Hamel R Appanna V D Viswanatha T | 2004 | Biochemical and Biophysical Research Communications2004，317，： | 1 |
| 18 | The presence of CD34+ cell clusters predicts impending relapse in children with acute lymphoblastic leukemia receiving maintenance chemotherapy显示文摘 | Rimsza LM Viswanatha DS Winter SS | 1998 | Am J Clin Pathol1998，110，3： | 1 |
| 19 | Kinetics and thermodynamics of reactive and vat dyes adsorption on MgO nanoparticles显示文摘 | T.G. Venkatesha R. Viswanatha Y. Arthoba Nayaka B.K. Chethana | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 20 | Kinetics and thermody- namics studies on the adsorption ofZn( Ⅱ ), Cd( Ⅱ ) and Hg( Ⅱ ) from aqueous solution using zinc oxide nanoparticles 显示文摘 | Sheela T Nayaka Y A Viswanatha R | 2012 | Powder Technology2012，217，： | 1 |
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