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| 1 | Current progress in use of adipose derived stem cells in peripheral nerve regeneration显示文摘Unlike central nervous system neurons; those in the peripheral nervous system have the potential for full regeneration after injury. Following injury, recovery is controlled by schwann cells which replicate and modulate the subsequent immune response. The level of nerve recovery is strongly linked to the severity of the initial injury despite the significant advancements in imaging and surgical techniques. Multiple experimental model shave been used with varying successes to augment the natural regenerative processes which occur following nerve injury. Stem cell therapy in peripheral nerve injury may be an important future intervention to improve the best attainable clinical results. In particular adipose derived stem cells(ADSCs) are multipotent mesenchymal stem cells similar to bone marrow derived stem cells, which are thought to have neurotrophic properties and the ability to differentiate into multiple lineages. They are ubiquitous within adipose tissue; they can form many structures resembling the mature adult peripheral nervous system. Following early in vitro work; multiple small and large animal in vivo models have been used in conjunction with conduits, autografts and allografts to successfully bridge the peripheral nerve gap. Some of the ADSC related neuroprotective and regenerative properties have been elucidated however much work remains before a model can be used successfully in human peripheral nerve injury(PNI). This review aims to provide a detailed overview of progress made in the use of ADSC in PNI, with discussion on the role of a tissue engineered approach for PNI repair. | Shomari DL Zack-Williams Peter E Butler Deepak M Kalaskar | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 2 | Multimodality imaging of ovarian cystic lesions: Review with an imaging based algorithmic approach显示文摘Ovarian cystic masses include a spectrum of benign, borderline and high grade malignant neoplasms. Imaging plays a crucial role in characterization and pretreatment planning of incidentally detected or suspected adnexal masses, as diagnosis of ovarian malignancy at an early stage is correlated with a better prognosis. Knowledge of differential diagnosis, imaging features, management trends and an algorithmic approach of such lesions is important for optimal clinical management. This article illustrates a multi-modality approach in the diagnosis of a spectrum of ovarian cystic masses and also proposes an algorithmic approach for the diagnosis of these lesions. | Ashish P Wasnik Christine O Menias Joel F Platt Usha R Lalchandani Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 7 |
| 3 | Sonohysterography: Principles, technique and role in diagnosis of endometrial pathology显示文摘Sonohysterography (SHG), which provides enhanced endometrial visualization during standard transvaginal ultrasonography, is a relatively safe procedure for the evaluation of endometrial pathology. It can be used to evaluate patients with abnormal vaginal bleeding or infertility. This modality offers real time imaging of the endometrium without exposure to ionizing radiation. SHG is typically used in patients for whom standard transvaginal ultrasonography does not show the endometrium well, show a potential abnormality for which further imaging is required, or in patients without endometrial pathology defined on routine transvaginal imaging but in whom there is a strong clinical suspicion of an abnormality. This article will discuss the utility of the sonohysterogram in evaluation of various endometrial pathologies. Imaging examples of these pathological entities will be illustrated as well. | Thomas Yang Amit Pandya Leonardo Marcal Ronald O Bude Joel F Platt Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 5 |
| 4 | Role of nanotopography in the development of tissue engineered 3D organs and tissues using mesenchymal stem cells显示文摘Recent regenerative medicine and tissue engineering strategies(using cells, scaffolds, medical devices and gene therapy) have led to fascinating progress of translation of basic research towards clinical applications. In the past decade, great deal of research has focused on developing various three dimensional(3D) organs, such as bone, skin, liver, kidney and ear,using such strategies in order to replace or regenerate damaged organs for the purpose of maintaining or restoring organs' functions that may have been lost due to aging, accident or disease. The surface properties of a material or a device are key aspects in determining the success of the implant in biomedicine, as the majority of biological reactions in human body occur on surfaces or interfaces. Furthermore, it has been established in the literature that cell adhesion and proliferation are, to a great extent, influenced by the micro- and nanosurface characteristics of biomaterials and devices. In addition, it has been shown that the functions of stem cells, mesenchymal stem cells in particular, could be regulated through physical interaction with specific nanotopographical cues. Therefore, guided stem cell proliferation, differentiation and function are of great importance in the regeneration of 3D tissues and organs using tissue engineering strategies. This review will provide an update on the impact of nanotopography on mesenchymal stem cells for the purpose of developing laboratory-based 3D organs and tissues, as well as the most recent research and case studies on this topic. | Shima Salmasi Deepak M Kalaskar Wai-Weng Yoon Gordon W Blunn Alexander M Seifalian | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 5 | Control of stem cell fate by engineering their micro and nanoenvironment显示文摘Stem cells are capable of long-term self-renewal and differentiation into specialised cell types, making them an ideal candidate for a cell source for regenerative medicine. The control of stem cell fate has become a major area of interest in the field of regenerative medicine and therapeutic intervention. Conventional methods of chemically inducing stem cells into specific lineages is being challenged by the advances in biomaterial technology, with evidence highlighting that material properties are capable of driving stem cell fate. Materials are being designed to mimic the clues stem cells receive in their in vivo stem cell niche including topographical and chemical instructions. Nanotopographical clues that mimic the extracellular matrix(ECM) in vivo have shown to regulate stem cell differentiation. The delivery of ECM components on biomaterials in the form of short peptides sequences has also proved successful in directing stem cell lineage. Growth factors responsible for controlling stem cell fate in vivo have also been delivered via biomaterials to provide clues to determine stem cell differentiation. An alternative approach to guide stem cells fate is to provide genetic clues including delivering DNA plasmids and small interfering RNAs via scaffolds. This review, aims to provide an overview of the topographical, chemical and molecular clues that biomaterials can provide to guide stem cell fate. The promising features and challenges of such approaches will be highlighted, to provide directions for future advancements in this exciting area of stem cell translation for regenerative medicine. | Michelle F Griffin Peter E Butler Alexander M Seifalian Deepak M Kalaskar | 2015 | World Journal of Stem Cells2015，7，1： | 3 |
| 6 | Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system:A mini-review显示文摘Mixed neuroendocrine-non-neuroendocrine neoplasms(MiNENs)are rare mixed tumors containing both neuroendocrine(NE)and non-NE components.Each component must occupy at least 30%of the tumor volume by definition.Recent molecular evidence suggests MiNENs are clonal neoplasms and potentially harbor targetable mutations similar to conventional carcinomas.There have been multiple changes in the nomenclature and classification of MiNENs which has created some confusion among pathologists on how to integrate the contributions of each component in a MiNEN,an issue which in turn has resulted in confusion in communication with front-line treating oncologists.This mini review summarizes our current understanding of MiNENs and outline diagnosis,prognosis,and management of these neoplasms.The authors emphasize the importance of treating the most aggressive component of the tumor regardless of its percentage volume. | Deepak Toor Jonathan M Loree Zu-Hua Gao Gang Wang Chen Zhou | 2022 | World Journal of Gastroenterology2022，28，19： | 2 |
| 7 | Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica显示文摘Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase(LOX) inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract(MEMI),successive water extract (SWMI) and ethyl acetate fraction(EMEMI),n-butanol fraction(BMEMI) and water soluble fraction (WMEMI) of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions. | Mohan CG Deepak M Viswanatha GL Savinay G Hanumantharaju V Rajendra CE Praveen D Halemani | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 2 |
| 8 | Design considerations and topology selection for 120 kW IGBT converter for EV fast charging显示文摘 | Nasser H Kutkut Deepak M Divan Donald W Novotny | 1998 | IEEE Transactions on Power Electronics1998，13，1： | 1 |
| 9 | Physiological and biochemical responses of two cultivars of two wheat to elevated levels of CO2 and SOz, singly and in eombination显示文摘 | AGRAWAL M DEEPAK S S | 2003 | Environmental Pollution2003，121，： | 1 |
| 10 | T - cell non - Hodgkin's lymphomas reported to the FDA AERS with tumor necrosis factor - alpha ( TNF - alpha) inhibitors : results of the REFURBISH study 显示文摘 | Deepak P Sifuentes H Sherid M | 2013 | AmJGastroenterol2013，108，1： | 1 |
| 11 | A Comparative Study of the Formulations and Benchmark Problems for the Topology Optimization of Compliant Mechanisms显示文摘 | Deepak S R Dinesh M Sahu D K | 2009 | Journal of Mechanisms and Robotics2009，2，1： | 1 |
| 12 | T-cell non-Hodgkin'slymphomas reported to the FDA AERS with tumor necrosisfactor-alpha (TNF-α) inhibitors: results of the REFURBISH study显示文摘 | Deepak P Sifuentes H Sherid M | 2013 | Am J Gastroenterol2013，108，1： | 1 |
| 13 | Studies on the physico-mechanical and thermal characteristics of blends of DGEBA epoxy, 3,4 epoxy cyclohexylmethyl, 3,4-epoxycylo- hexane carboxylate and carboxyl terminated butadiene co-ac- rylonitrile (CTBN) 显示文摘 | Garima Tripathi Deepak Srivastava M | 2008 | Mater Sci Eng A2008，496，15： | 1 |
| 14 | Bioactive Effects of tanshinone II A sulfate on adhesion molecule expressieic acid esters from Glycyrrhiza glabra显示文摘 | Dey S Deepak M Setty M | 2009 | Nat Prod Res2009，23，18： | 1 |
| 15 | Effect of modified atmosphere(MA) packaging on glutathione and some other qualitative parameters of hiratake mushroom显示文摘 | DEEPAK RAJ R MICHIHIKO S RYOICHI M | 2000 | J Jpn Soc Hortic Sci2000，69，4： | 1 |
| 16 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade显示文摘 | Peng Li Deepak Nijhawan Imawati Budihardjo Srinivasa M Srinivasula Manzoor Ahmad Emad S Alnemri Xiaodong Wang | 1997 | Cell1997，，4： | 1 |
| 17 | Effect of modified atmosphere (MA) packaging on glutathione and some other qualitative parameters of hiratake mushroom 显示文摘 | Deepak R R Michihiko S Ryoichi M | 2000 | J Jpn Soc Hortic Sci2000，69，4： | 1 |
| 18 | Physiological and biochemical responses of two cultivars of wheat to elevated levels of CO2 and SO2 ,singly and in combination显示文摘 | AGRAWAL M DEEPAK S S | 2003 | Environmental Pollution2003，121，： | 1 |
| 19 | Physiological and biochemical responses of two cultivars of wheat to elevated levels of CO2and SO2, singly and in combination显示文摘 | Agawal M Deepak S S | 2003 | Environmental Pollution2003，121，： | 1 |
| 20 | Stimulated erythro-poiesis with secondary iron loading lead to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression 显示文摘 | DAVID M F SARAH J W DEEPAK D | 2012 | Br J Haematol2012，175，： | 1 |
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