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| 1 | Solid lipid nanoparticles for nose to brain delivery of haloperidol:in vitro drug release and pharmacokinetics evaluation显示文摘In the present study,haloperidol(HP)-loaded solid lipid nanoparticles(SLNs)were prepared to enhance the uptake of HP to brain via intranasal(i.n.)delivery.SLNs were prepared by a modified emulsification-diffusion technique and evaluated for particle size,zeta potential,drug entrapment efficiency,in vitro drug release,and stability.All parameters were found to be in an acceptable range.In vitro drug release was found to be 94.1674.78%after 24 h and was fitted to the Higuchi model with a very high correlation coefficient(R2¼0.9941).Pharmacokinetics studies were performed on albino Wistar rats and the concentration of HP in brain and blood was measured by high performance liquid chromatography.The brain/blood ratio at 0.5 h for HP-SLNs i.n.,HP sol.i.n.and HP sol.i.v.was 1.61,0.17 and 0.031,respectively,indicating direct nose-to-brain transport,bypassing the blood-brain barrier.The maximum concentration(Cmax)in brain achieved from i.n.administration of HP-SLNs(329.17720.89 ng/mL,Tmax 2 h)was significantly higher than that achieved after i.v.(76.9577.62 ng/mL,Tmax 1 h),and i.n.(90.1376.28 ng/mL,Tmax 2 h)administration of HP sol.The highest drug-targeting efficiency(2362.43%)and direct transport percentage(95.77%)was found with HP-SLNs as compared to the other formulations.Higher DTE(%)and DTP(%)suggest that HP-SLNs have better brain targeting efficiency as compared to other formulations. | Mohd Yasir Udai Vir Singh Sara | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 5 |
| 2 | The Warburg effect: Insights from the past decade显示文摘 | Mohita Upadhyay Jasmine Samal Manish Kandpal Om Vir Singh Perumal Vivekanandan | 2012 | Pharmacology and Therapeutics2012，，： | 2 |
| 3 | Identification,synthesis and characterization of an unknown process related impurity in eslicarbazepine acetate active pharmaceutical ingredient by LC/ESI-IT/MS,~1H,^(13)C and ~1H-~1H COSY NMR显示文摘A new impurity was detected during high performance liquid chromatographic(HPLC) analysis of eslicarbazepine acetate active pharmaceutical ingredient.The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer(LC/ESI-IT/MS) analysis.Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using ~1H,^(13)C nuclear magnetic resonance spectrometry(NMR),~1H-~1H correlation spectroscopy(COSY) and infrared spectroscopy(IR).Based on the spectroscopic and spectrometric data,unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate. | Saji Thomas Saroj Kumar Paul Subhash Chandra Joshi Vineet Kumar Ashutosh Agarwal Dharam Vir | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 2 |
| 4 | Evaluation of Benzimidazol and other fungicides post-harvest spoilag of banana fruits caused Colletot richum musae显示文摘 | RAM V VIR D | 1983 | Pesticides1983，17，： | 1 |
| 5 | Effect of an intermittent lighting schedule on doe and suckling rabbit's performance显示文摘 | Virág Gy Papp Z Rafai P | | 0，，01： | 1 |
| 6 | Production of a defensin-like antifungal protein NFAP from Neosartorya fischeri in Pichia pastoris and its antifungal activity against filamentous fungal isolates from human infections显示文摘 | Máté Virágh Dóra V?r?s Zoltán Kele Laura Kovács ádám Fizil Gergely Lakatos Gergely Maróti Gyula Batta Csaba Vágv?lgyi László Galgóczy | 2014 | Protein Expression and Purification2014，，： | 1 |
| 7 | Inorganic nanotubes as nanoreactors:the first MoS2 nanopods显示文摘 | Remkar M Mrzel A Virek M | 2007 | Advanced Materials2007，19，： | 1 |
| 8 | Metals and apoptosis: Recent devdopments 显示文摘 | Suresh Vir Singh Rana | 2008 | Journal of Trace Elements in Medicine and Biology2008，22，： | 1 |
| 9 | Fine particle emissions in three different combustion conditions of a wood chip-fired appliance – Particulate physico-chemical properties and induced cell death显示文摘 | J. Leskinen J. Tissari O. Uski A. Virén T. Torvela T. Kaivosoja H. Lamberg I. Nuutinen T. Kettunen J. Joutsensaari P.I. Jalava O. Sippula M.-R. Hirvonen J. Jokiniemi | 2013 | Atmospheric Environment2013，，： | 1 |
| 10 | Effectiveness of biw eekly versus daily iron folic acid adminstration on anaemin status in preshool children显示文摘 | AwasthiS Verma T Vir S | 2005 | J Trop Pediatr2005，51，2： | 1 |
| 11 | Morphological basis of resistance in cotton to the whitefly Bemisia tabaci 显示文摘 | BUTTER N S Vir B K | 1989 | Phytoparasitica1989，17，4： | 1 |
| 12 | 查看详情显示文摘 | Virányi A Marth G Dancsó A Blaskó G T(o)ke L Nyerges M | | 0，，： | 1 |
| 13 | The Polycomb group proteinEZH2 directly controls DNA methylation显示文摘 | Viréd E Brenner C Deplus R | 2006 | Nature2006，439，7078： | 1 |
| 14 | The therapeutic potential of poly(ADP-ribose) polymerase inhibitors显示文摘 | Virág L Szabó C | | 0，，3： | 1 |
| 15 | 关于草药标准化的研究综述(英文)显示文摘由于自然产品有化学多样性的特点,使之具有很高的实用性,无论是作为纯天然化合物或是标准化植物提取物,它们都为新药的开发提供了很多可能。与现代西药比较,草药通常被用于治疗慢性疾病。规范化操作可保证植物的一个或多个活性成分及化合物的含量。在新药研发方面,植物药的开发成本较低且资源丰富,但植物的生长环境和基因等因素会在很大程度上影响植物提取物的生物化学成分。植物药的生产要求源植物在基因方面的单种栽培完全符合标准条件,以保证其生物化学指标的一致性,并可以优化植物药的安全性和有效性。本文旨在讨论如何改进植物药提取的规范化操作方法以及如何有效制备质量及效果稳定的植物药。 | Vandana Garg Vir Ji Dhar Anupam Sharma Rohit Dutt | 2012 | 中西医结合学报2012，10，10： | 1 |
| 16 | The polycomb group protein EZH2 directly controls DNA methylation显示文摘 | Vir E Brenner C Deplus R | 2006 | Nature2006，439，778： | 1 |
| 17 | Restricting excessive cardiac action potential and QT prolongation:a vital role for IKs in human ventricular muscle显示文摘 | Jost N Virág L Bitay M | 2005 | Circulation2005，112，10： | 1 |
| 18 | Neurological manifestations in speech aRer donkey bite:a rare case显示文摘 | Vir D Sachin Gupta D | 2010 | JAMA2010，24，4： | 1 |
| 19 | Dialysis Patients? Fluid Overload, Antihypertensive Medications, and Obesity显示文摘 | Mihály Tapolyai Mária Faludi Virág Réti Zsolt Lengvárszky Tibor Szarvas Klára Berta | 2011 | ASAIO Journal2011，，6： | 1 |
| 20 | Pólipo coanal unilateral benigno: revisión de 51 pacientes显示文摘 | David Virós Porcuna Joan R. Montserrat Gili Juan R. Gras Cabrerizo Montse López Vilas Albert Pujol Olmo | 2008 | Acta Otorrinolaringologica Espanola2008，，2： | 1 |
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